CCHC-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJE2_LEIMU

TriTrypDb:

LmxM.01.0550

Length:

378

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJE2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJE2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0005488	binding	1	7
GO:0008270	zinc ion binding	6	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	234	238	PF00656	0.737
CLV_C14_Caspase3-7	36	40	PF00656	0.453
CLV_NRD_NRD_1	52	54	PF00675	0.391
CLV_PCSK_KEX2_1	209	211	PF00082	0.736
CLV_PCSK_KEX2_1	224	226	PF00082	0.650
CLV_PCSK_KEX2_1	230	232	PF00082	0.608
CLV_PCSK_KEX2_1	52	54	PF00082	0.409
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.736
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.650
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.608
CLV_PCSK_PC7_1	48	54	PF00082	0.311
CLV_PCSK_SKI1_1	345	349	PF00082	0.671
CLV_PCSK_SKI1_1	53	57	PF00082	0.381
CLV_PCSK_SKI1_1	63	67	PF00082	0.363
DEG_APCC_DBOX_1	62	70	PF00400	0.257
DOC_CDC14_PxL_1	171	179	PF14671	0.506
DOC_MAPK_gen_1	180	188	PF00069	0.464
DOC_MAPK_gen_1	52	59	PF00069	0.440
DOC_MAPK_MEF2A_6	180	188	PF00069	0.535
DOC_MAPK_MEF2A_6	52	59	PF00069	0.511
DOC_MAPK_NFAT4_5	52	60	PF00069	0.514
DOC_PP2B_LxvP_1	133	136	PF13499	0.647
DOC_PP4_FxxP_1	134	137	PF00568	0.645
DOC_USP7_MATH_1	13	17	PF00917	0.743
DOC_USP7_MATH_1	258	262	PF00917	0.658
DOC_USP7_MATH_1	318	322	PF00917	0.640
DOC_USP7_MATH_1	33	37	PF00917	0.359
DOC_USP7_MATH_1	38	42	PF00917	0.327
DOC_USP7_UBL2_3	358	362	PF12436	0.455
DOC_WW_Pin1_4	241	246	PF00397	0.756
DOC_WW_Pin1_4	340	345	PF00397	0.672
LIG_14-3-3_CanoR_1	3	11	PF00244	0.687
LIG_14-3-3_CanoR_1	48	52	PF00244	0.479
LIG_BIR_II_1	1	5	PF00653	0.745
LIG_BIR_III_4	101	105	PF00653	0.489
LIG_BRCT_BRCA1_1	167	171	PF00533	0.586
LIG_CaM_IQ_9	40	55	PF13499	0.252
LIG_FHA_1	237	243	PF00498	0.755
LIG_FHA_2	127	133	PF00498	0.550
LIG_FHA_2	17	23	PF00498	0.447
LIG_FHA_2	210	216	PF00498	0.647
LIG_FHA_2	230	236	PF00498	0.666
LIG_FHA_2	354	360	PF00498	0.586
LIG_LIR_Apic_2	132	137	PF02991	0.628
LIG_LIR_Gen_1	122	133	PF02991	0.592
LIG_LIR_Gen_1	168	178	PF02991	0.546
LIG_LIR_Gen_1	39	47	PF02991	0.384
LIG_LIR_Nem_3	168	174	PF02991	0.546
LIG_LIR_Nem_3	28	32	PF02991	0.404
LIG_LIR_Nem_3	39	45	PF02991	0.349
LIG_LIR_Nem_3	54	59	PF02991	0.399
LIG_SH2_STAT5	176	179	PF00017	0.532
LIG_SH2_STAT5	363	366	PF00017	0.517
LIG_SH3_3	314	320	PF00018	0.595
LIG_SH3_3	336	342	PF00018	0.554
LIG_SH3_3	7	13	PF00018	0.662
LIG_SH3_3	86	92	PF00018	0.536
LIG_SH3_4	350	357	PF00018	0.567
LIG_TRAF2_1	149	152	PF00917	0.705
MOD_CDK_SPK_2	340	345	PF00069	0.622
MOD_CK1_1	142	148	PF00069	0.730
MOD_CK1_1	16	22	PF00069	0.498
MOD_CK1_1	299	305	PF00069	0.511
MOD_CK1_1	307	313	PF00069	0.726
MOD_CK2_1	16	22	PF00069	0.458
MOD_CK2_1	209	215	PF00069	0.789
MOD_Cter_Amidation	228	231	PF01082	0.651
MOD_GlcNHglycan	101	105	PF01048	0.762
MOD_GlcNHglycan	139	142	PF01048	0.618
MOD_GlcNHglycan	144	147	PF01048	0.722
MOD_GlcNHglycan	188	191	PF01048	0.527
MOD_GlcNHglycan	198	201	PF01048	0.601
MOD_GlcNHglycan	218	221	PF01048	0.798
MOD_GlcNHglycan	260	263	PF01048	0.754
MOD_GlcNHglycan	287	290	PF01048	0.451
MOD_GlcNHglycan	297	301	PF01048	0.593
MOD_GlcNHglycan	309	312	PF01048	0.544
MOD_GlcNHglycan	70	73	PF01048	0.556
MOD_GSK3_1	13	20	PF00069	0.579
MOD_GSK3_1	165	172	PF00069	0.533
MOD_GSK3_1	225	232	PF00069	0.741
MOD_GSK3_1	236	243	PF00069	0.659
MOD_GSK3_1	296	303	PF00069	0.556
MOD_GSK3_1	306	313	PF00069	0.642
MOD_GSK3_1	47	54	PF00069	0.488
MOD_LATS_1	207	213	PF00433	0.598
MOD_N-GLC_1	307	312	PF02516	0.484
MOD_NEK2_1	1	6	PF00069	0.708
MOD_NEK2_1	169	174	PF00069	0.479
MOD_NEK2_1	196	201	PF00069	0.592
MOD_NEK2_1	47	52	PF00069	0.498
MOD_PIKK_1	139	145	PF00454	0.641
MOD_PKA_1	209	215	PF00069	0.795
MOD_PKA_2	209	215	PF00069	0.665
MOD_PKA_2	354	360	PF00069	0.532
MOD_PKA_2	47	53	PF00069	0.477
MOD_Plk_1	169	175	PF00069	0.507
MOD_Plk_1	38	44	PF00069	0.368
MOD_Plk_2-3	126	132	PF00069	0.558
MOD_Plk_4	25	31	PF00069	0.434
MOD_Plk_4	38	44	PF00069	0.305
MOD_ProDKin_1	241	247	PF00069	0.757
MOD_ProDKin_1	340	346	PF00069	0.671
TRG_ER_diArg_1	51	53	PF00400	0.391
TRG_ER_diArg_1	61	64	PF00400	0.407

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P578	Leptomonas seymouri	41%	97%
A0A3R7NL08	Trypanosoma rangeli	34%	100%
A0A3S5H4V9	Leishmania donovani	81%	100%
A4H378	Leishmania braziliensis	56%	100%
A4HRH8	Leishmania infantum	84%	100%
E9AC46	Leishmania major	85%	100%
V5BH18	Trypanosoma cruzi	29%	100%