Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJE1_LEIMU

TriTrypDb:

LmxM.01.0540

Length:

701

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJE1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJE1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	277	281	PF00656	0.593
CLV_C14_Caspase3-7	586	590	PF00656	0.841
CLV_C14_Caspase3-7	613	617	PF00656	0.673
CLV_NRD_NRD_1	108	110	PF00675	0.648
CLV_NRD_NRD_1	124	126	PF00675	0.674
CLV_NRD_NRD_1	16	18	PF00675	0.610
CLV_NRD_NRD_1	377	379	PF00675	0.801
CLV_NRD_NRD_1	480	482	PF00675	0.680
CLV_NRD_NRD_1	50	52	PF00675	0.614
CLV_NRD_NRD_1	611	613	PF00675	0.694
CLV_NRD_NRD_1	644	646	PF00675	0.621
CLV_NRD_NRD_1	686	688	PF00675	0.788
CLV_NRD_NRD_1	69	71	PF00675	0.719
CLV_PCSK_FUR_1	375	379	PF00082	0.807
CLV_PCSK_FUR_1	609	613	PF00082	0.677
CLV_PCSK_KEX2_1	108	110	PF00082	0.648
CLV_PCSK_KEX2_1	16	18	PF00082	0.610
CLV_PCSK_KEX2_1	235	237	PF00082	0.611
CLV_PCSK_KEX2_1	377	379	PF00082	0.812
CLV_PCSK_KEX2_1	480	482	PF00082	0.680
CLV_PCSK_KEX2_1	50	52	PF00082	0.614
CLV_PCSK_KEX2_1	611	613	PF00082	0.687
CLV_PCSK_KEX2_1	644	646	PF00082	0.619
CLV_PCSK_KEX2_1	680	682	PF00082	0.743
CLV_PCSK_KEX2_1	686	688	PF00082	0.738
CLV_PCSK_KEX2_1	69	71	PF00082	0.719
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.611
CLV_PCSK_PC1ET2_1	680	682	PF00082	0.684
CLV_PCSK_PC7_1	607	613	PF00082	0.544
CLV_PCSK_SKI1_1	211	215	PF00082	0.521
CLV_PCSK_SKI1_1	448	452	PF00082	0.772
CLV_PCSK_SKI1_1	647	651	PF00082	0.674
CLV_PCSK_SKI1_1	669	673	PF00082	0.565
CLV_PCSK_SKI1_1	72	76	PF00082	0.567
CLV_PCSK_SKI1_1	91	95	PF00082	0.647
CLV_Separin_Metazoa	175	179	PF03568	0.541
CLV_Separin_Metazoa	683	687	PF03568	0.627
DEG_APCC_DBOX_1	235	243	PF00400	0.457
DEG_APCC_DBOX_1	49	57	PF00400	0.677
DOC_CKS1_1	204	209	PF01111	0.707
DOC_CKS1_1	245	250	PF01111	0.552
DOC_MAPK_gen_1	235	242	PF00069	0.574
DOC_MAPK_gen_1	659	668	PF00069	0.652
DOC_MAPK_gen_1	686	693	PF00069	0.657
DOC_MAPK_MEF2A_6	686	695	PF00069	0.647
DOC_PP2B_LxvP_1	494	497	PF13499	0.517
DOC_PP4_FxxP_1	166	169	PF00568	0.659
DOC_PP4_FxxP_1	9	12	PF00568	0.637
DOC_USP7_MATH_1	100	104	PF00917	0.616
DOC_USP7_MATH_1	137	141	PF00917	0.716
DOC_USP7_MATH_1	220	224	PF00917	0.660
DOC_USP7_MATH_1	39	43	PF00917	0.440
DOC_USP7_MATH_1	473	477	PF00917	0.566
DOC_USP7_MATH_1	486	490	PF00917	0.656
DOC_USP7_MATH_1	498	502	PF00917	0.591
DOC_USP7_MATH_1	551	555	PF00917	0.719
DOC_USP7_MATH_1	590	594	PF00917	0.729
DOC_USP7_MATH_1	596	600	PF00917	0.734
DOC_USP7_MATH_1	655	659	PF00917	0.793
DOC_WW_Pin1_4	130	135	PF00397	0.530
DOC_WW_Pin1_4	140	145	PF00397	0.535
DOC_WW_Pin1_4	203	208	PF00397	0.717
DOC_WW_Pin1_4	244	249	PF00397	0.565
DOC_WW_Pin1_4	345	350	PF00397	0.497
DOC_WW_Pin1_4	411	416	PF00397	0.730
DOC_WW_Pin1_4	450	455	PF00397	0.726
DOC_WW_Pin1_4	513	518	PF00397	0.687
DOC_WW_Pin1_4	526	531	PF00397	0.628
DOC_WW_Pin1_4	547	552	PF00397	0.682
DOC_WW_Pin1_4	577	582	PF00397	0.701
DOC_WW_Pin1_4	617	622	PF00397	0.730
LIG_14-3-3_CanoR_1	125	132	PF00244	0.653
LIG_14-3-3_CanoR_1	136	146	PF00244	0.614
LIG_14-3-3_CanoR_1	205	214	PF00244	0.664
LIG_14-3-3_CanoR_1	383	392	PF00244	0.691
LIG_14-3-3_CanoR_1	401	407	PF00244	0.501
LIG_14-3-3_CanoR_1	523	530	PF00244	0.682
LIG_14-3-3_CanoR_1	560	568	PF00244	0.634
LIG_14-3-3_CanoR_1	573	581	PF00244	0.647
LIG_14-3-3_CanoR_1	647	655	PF00244	0.780
LIG_14-3-3_CanoR_1	91	96	PF00244	0.644
LIG_Actin_WH2_2	369	385	PF00022	0.512
LIG_Actin_WH2_2	665	682	PF00022	0.621
LIG_BIR_III_4	533	537	PF00653	0.567
LIG_BIR_III_4	589	593	PF00653	0.677
LIG_BRCT_BRCA1_1	274	278	PF00533	0.520
LIG_Clathr_ClatBox_1	692	696	PF01394	0.435
LIG_deltaCOP1_diTrp_1	33	38	PF00928	0.632
LIG_FHA_1	141	147	PF00498	0.544
LIG_FHA_1	207	213	PF00498	0.609
LIG_FHA_1	293	299	PF00498	0.572
LIG_FHA_1	301	307	PF00498	0.519
LIG_FHA_1	358	364	PF00498	0.680
LIG_FHA_1	377	383	PF00498	0.512
LIG_FHA_1	392	398	PF00498	0.631
LIG_FHA_1	460	466	PF00498	0.695
LIG_FHA_1	489	495	PF00498	0.611
LIG_FHA_1	92	98	PF00498	0.754
LIG_FHA_2	116	122	PF00498	0.652
LIG_FHA_2	275	281	PF00498	0.679
LIG_FHA_2	584	590	PF00498	0.843
LIG_LIR_Apic_2	163	169	PF02991	0.647
LIG_LIR_Apic_2	650	655	PF02991	0.665
LIG_LIR_Apic_2	8	13	PF02991	0.667
LIG_LIR_Gen_1	331	338	PF02991	0.619
LIG_LIR_Nem_3	153	159	PF02991	0.493
LIG_LIR_Nem_3	331	337	PF02991	0.621
LIG_MYND_1	690	694	PF01753	0.454
LIG_PCNA_PIPBox_1	261	270	PF02747	0.455
LIG_Pex14_1	34	38	PF04695	0.631
LIG_PTB_Apo_2	566	573	PF02174	0.519
LIG_PTB_Phospho_1	566	572	PF10480	0.518
LIG_SH2_CRK	652	656	PF00017	0.637
LIG_SH2_GRB2like	300	303	PF00017	0.568
LIG_SH2_SRC	267	270	PF00017	0.593
LIG_SH2_STAP1	334	338	PF00017	0.621
LIG_SH2_STAP1	402	406	PF00017	0.684
LIG_SH2_STAP1	664	668	PF00017	0.662
LIG_SH2_STAT5	123	126	PF00017	0.667
LIG_SH2_STAT5	156	159	PF00017	0.667
LIG_SH2_STAT5	267	270	PF00017	0.593
LIG_SH2_STAT5	300	303	PF00017	0.568
LIG_SH2_STAT5	371	374	PF00017	0.663
LIG_SH2_STAT5	478	481	PF00017	0.525
LIG_SH3_3	131	137	PF00018	0.534
LIG_SH3_3	152	158	PF00018	0.708
LIG_SH3_3	166	172	PF00018	0.629
LIG_SH3_3	242	248	PF00018	0.560
LIG_SH3_3	312	318	PF00018	0.658
LIG_SH3_3	438	444	PF00018	0.680
LIG_SH3_3	688	694	PF00018	0.645
LIG_SH3_3	8	14	PF00018	0.582
LIG_TRAF2_1	405	408	PF00917	0.524
LIG_TRFH_1	365	369	PF08558	0.674
LIG_UBA3_1	239	244	PF00899	0.482
LIG_WW_3	175	179	PF00397	0.541
LIG_WW_3	683	687	PF00397	0.567
MOD_CDC14_SPxK_1	133	136	PF00782	0.541
MOD_CDC14_SPxK_1	624	627	PF00782	0.671
MOD_CDK_SPK_2	617	622	PF00069	0.588
MOD_CDK_SPxK_1	130	136	PF00069	0.533
MOD_CDK_SPxK_1	621	627	PF00069	0.675
MOD_CDK_SPxxK_3	244	251	PF00069	0.554
MOD_CK1_1	115	121	PF00069	0.556
MOD_CK1_1	127	133	PF00069	0.625
MOD_CK1_1	140	146	PF00069	0.573
MOD_CK1_1	243	249	PF00069	0.660
MOD_CK1_1	343	349	PF00069	0.483
MOD_CK1_1	384	390	PF00069	0.699
MOD_CK1_1	482	488	PF00069	0.815
MOD_CK1_1	489	495	PF00069	0.711
MOD_CK1_1	526	532	PF00069	0.724
MOD_CK1_1	547	553	PF00069	0.779
MOD_CK1_1	575	581	PF00069	0.674
MOD_CK1_1	658	664	PF00069	0.644
MOD_CK1_1	674	680	PF00069	0.504
MOD_CK2_1	115	121	PF00069	0.646
MOD_CK2_1	402	408	PF00069	0.700
MOD_CK2_1	497	503	PF00069	0.723
MOD_GlcNHglycan	102	105	PF01048	0.538
MOD_GlcNHglycan	114	117	PF01048	0.610
MOD_GlcNHglycan	126	129	PF01048	0.664
MOD_GlcNHglycan	139	142	PF01048	0.631
MOD_GlcNHglycan	148	151	PF01048	0.576
MOD_GlcNHglycan	342	345	PF01048	0.616
MOD_GlcNHglycan	402	405	PF01048	0.628
MOD_GlcNHglycan	428	431	PF01048	0.617
MOD_GlcNHglycan	441	444	PF01048	0.602
MOD_GlcNHglycan	474	478	PF01048	0.681
MOD_GlcNHglycan	481	484	PF01048	0.759
MOD_GlcNHglycan	520	523	PF01048	0.675
MOD_GlcNHglycan	602	605	PF01048	0.762
MOD_GlcNHglycan	633	637	PF01048	0.589
MOD_GlcNHglycan	66	69	PF01048	0.620
MOD_GlcNHglycan	88	91	PF01048	0.716
MOD_GSK3_1	132	139	PF00069	0.724
MOD_GSK3_1	240	247	PF00069	0.707
MOD_GSK3_1	287	294	PF00069	0.633
MOD_GSK3_1	343	350	PF00069	0.644
MOD_GSK3_1	353	360	PF00069	0.606
MOD_GSK3_1	363	370	PF00069	0.493
MOD_GSK3_1	381	388	PF00069	0.521
MOD_GSK3_1	396	403	PF00069	0.684
MOD_GSK3_1	410	417	PF00069	0.665
MOD_GSK3_1	418	425	PF00069	0.715
MOD_GSK3_1	439	446	PF00069	0.780
MOD_GSK3_1	455	462	PF00069	0.624
MOD_GSK3_1	482	489	PF00069	0.716
MOD_GSK3_1	518	525	PF00069	0.789
MOD_GSK3_1	547	554	PF00069	0.705
MOD_GSK3_1	571	578	PF00069	0.702
MOD_GSK3_1	579	586	PF00069	0.636
MOD_GSK3_1	596	603	PF00069	0.777
MOD_GSK3_1	617	624	PF00069	0.738
MOD_GSK3_1	64	71	PF00069	0.614
MOD_GSK3_1	82	89	PF00069	0.751
MOD_NEK2_1	124	129	PF00069	0.798
MOD_NEK2_1	146	151	PF00069	0.670
MOD_NEK2_1	160	165	PF00069	0.530
MOD_NEK2_1	214	219	PF00069	0.611
MOD_NEK2_1	240	245	PF00069	0.672
MOD_NEK2_1	363	368	PF00069	0.675
MOD_NEK2_1	376	381	PF00069	0.568
MOD_NEK2_1	38	43	PF00069	0.579
MOD_NEK2_1	382	387	PF00069	0.513
MOD_NEK2_1	410	415	PF00069	0.705
MOD_NEK2_1	472	477	PF00069	0.654
MOD_NEK2_1	479	484	PF00069	0.596
MOD_NEK2_1	571	576	PF00069	0.705
MOD_PIKK_1	246	252	PF00454	0.576
MOD_PIKK_1	386	392	PF00454	0.678
MOD_PIKK_1	448	454	PF00454	0.671
MOD_PKA_2	124	130	PF00069	0.644
MOD_PKA_2	340	346	PF00069	0.463
MOD_PKA_2	367	373	PF00069	0.678
MOD_PKA_2	376	382	PF00069	0.611
MOD_PKA_2	400	406	PF00069	0.643
MOD_PKA_2	479	485	PF00069	0.671
MOD_PKA_2	522	528	PF00069	0.650
MOD_PKA_2	544	550	PF00069	0.602
MOD_PKA_2	559	565	PF00069	0.631
MOD_PKA_2	572	578	PF00069	0.600
MOD_PKA_2	68	74	PF00069	0.692
MOD_PKB_1	645	653	PF00069	0.542
MOD_PKB_1	70	78	PF00069	0.547
MOD_Plk_1	39	45	PF00069	0.440
MOD_Plk_1	455	461	PF00069	0.696
MOD_Plk_1	473	479	PF00069	0.522
MOD_Plk_1	674	680	PF00069	0.625
MOD_Plk_2-3	274	280	PF00069	0.546
MOD_Plk_4	127	133	PF00069	0.514
MOD_Plk_4	160	166	PF00069	0.642
MOD_Plk_4	263	269	PF00069	0.532
MOD_Plk_4	367	373	PF00069	0.678
MOD_Plk_4	674	680	PF00069	0.691
MOD_ProDKin_1	130	136	PF00069	0.533
MOD_ProDKin_1	140	146	PF00069	0.534
MOD_ProDKin_1	203	209	PF00069	0.710
MOD_ProDKin_1	244	250	PF00069	0.565
MOD_ProDKin_1	345	351	PF00069	0.498
MOD_ProDKin_1	411	417	PF00069	0.733
MOD_ProDKin_1	450	456	PF00069	0.727
MOD_ProDKin_1	513	519	PF00069	0.688
MOD_ProDKin_1	526	532	PF00069	0.628
MOD_ProDKin_1	547	553	PF00069	0.677
MOD_ProDKin_1	577	583	PF00069	0.705
MOD_ProDKin_1	617	623	PF00069	0.733
MOD_SUMO_for_1	354	357	PF00179	0.611
MOD_SUMO_rev_2	227	237	PF00179	0.613
TRG_DiLeu_BaLyEn_6	563	568	PF01217	0.655
TRG_ENDOCYTIC_2	334	337	PF00928	0.623
TRG_ER_diArg_1	177	180	PF00400	0.782
TRG_ER_diArg_1	375	378	PF00400	0.794
TRG_ER_diArg_1	479	481	PF00400	0.654
TRG_ER_diArg_1	50	52	PF00400	0.611
TRG_ER_diArg_1	609	612	PF00400	0.688
TRG_ER_diArg_1	626	629	PF00400	0.550
TRG_ER_diArg_1	644	647	PF00400	0.592
TRG_ER_diArg_1	666	669	PF00400	0.633
TRG_ER_diArg_1	685	687	PF00400	0.629
TRG_ER_diArg_1	69	72	PF00400	0.713
TRG_Pf-PMV_PEXEL_1	448	452	PF00026	0.557

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H4V8	Leishmania donovani	82%	100%
A4H377	Leishmania braziliensis	57%	96%
A4HRH7	Leishmania infantum	82%	100%
E9AC45	Leishmania major	76%	94%