Beta eliminating lyase,putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

beta eliminating lyase,putative

Species:

Leishmania mexicana

UniProt:

E9AJD5_LEIMU

TriTrypDb:

LmxM.01.0480

Length:

369

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJD5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJD5

PDB structure(s): 1svv_A , 1svv_B

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	6
GO:0006520	amino acid metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0019752	carboxylic acid metabolic process	5	6
GO:0043436	oxoacid metabolic process	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044281	small molecule metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016829	lyase activity	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	358	360	PF00675	0.581
CLV_PCSK_KEX2_1	349	351	PF00082	0.505
CLV_PCSK_PC1ET2_1	349	351	PF00082	0.505
CLV_PCSK_SKI1_1	112	116	PF00082	0.487
CLV_PCSK_SKI1_1	240	244	PF00082	0.418
CLV_PCSK_SKI1_1	350	354	PF00082	0.425
DEG_Nend_UBRbox_2	1	3	PF02207	0.553
DOC_CYCLIN_RxL_1	23	34	PF00134	0.530
DOC_MAPK_MEF2A_6	171	179	PF00069	0.530
DOC_MAPK_MEF2A_6	246	254	PF00069	0.521
DOC_PP1_RVXF_1	285	291	PF00149	0.530
DOC_PP4_FxxP_1	114	117	PF00568	0.302
DOC_USP7_MATH_1	134	138	PF00917	0.255
DOC_USP7_MATH_1	289	293	PF00917	0.433
DOC_WW_Pin1_4	187	192	PF00397	0.433
DOC_WW_Pin1_4	359	364	PF00397	0.466
LIG_14-3-3_CanoR_1	11	16	PF00244	0.376
LIG_14-3-3_CanoR_1	183	192	PF00244	0.507
LIG_14-3-3_CanoR_1	202	209	PF00244	0.433
LIG_14-3-3_CanoR_1	329	335	PF00244	0.462
LIG_14-3-3_CanoR_1	350	357	PF00244	0.451
LIG_Actin_WH2_2	109	126	PF00022	0.405
LIG_APCC_ABBA_1	175	180	PF00400	0.433
LIG_APCC_ABBAyCdc20_2	259	265	PF00400	0.530
LIG_BRCT_BRCA1_1	260	264	PF00533	0.255
LIG_BRCT_BRCA1_1	309	313	PF00533	0.461
LIG_FHA_1	101	107	PF00498	0.433
LIG_FHA_1	149	155	PF00498	0.433
LIG_FHA_1	73	79	PF00498	0.530
LIG_FHA_2	157	163	PF00498	0.391
LIG_LIR_Gen_1	310	321	PF02991	0.479
LIG_LIR_Nem_3	260	266	PF02991	0.530
LIG_LIR_Nem_3	310	316	PF02991	0.523
LIG_MLH1_MIPbox_1	260	264	PF16413	0.255
LIG_RPA_C_Fungi	338	350	PF08784	0.304
LIG_SH2_CRK	13	17	PF00017	0.595
LIG_SH2_STAT3	158	161	PF00017	0.530
LIG_SH2_STAT5	147	150	PF00017	0.433
LIG_SH2_STAT5	158	161	PF00017	0.433
LIG_SH2_STAT5	176	179	PF00017	0.465
LIG_SH2_STAT5	208	211	PF00017	0.433
LIG_SUMO_SIM_anti_2	220	227	PF11976	0.530
LIG_SUMO_SIM_par_1	220	227	PF11976	0.530
LIG_TRAF2_1	159	162	PF00917	0.530
LIG_TRAF2_1	335	338	PF00917	0.431
LIG_UBA3_1	206	213	PF00899	0.433
LIG_UBA3_1	222	230	PF00899	0.433
LIG_UBA3_1	305	311	PF00899	0.472
MOD_CK1_1	149	155	PF00069	0.433
MOD_CK1_1	186	192	PF00069	0.433
MOD_CK1_1	333	339	PF00069	0.482
MOD_CK1_1	70	76	PF00069	0.433
MOD_CK2_1	156	162	PF00069	0.433
MOD_CK2_1	96	102	PF00069	0.433
MOD_GlcNHglycan	129	132	PF01048	0.530
MOD_GlcNHglycan	185	188	PF01048	0.433
MOD_GlcNHglycan	62	65	PF01048	0.399
MOD_GlcNHglycan	69	72	PF01048	0.390
MOD_GSK3_1	149	156	PF00069	0.383
MOD_GSK3_1	183	190	PF00069	0.433
MOD_GSK3_1	329	336	PF00069	0.461
MOD_GSK3_1	359	366	PF00069	0.473
MOD_GSK3_1	96	103	PF00069	0.433
MOD_N-GLC_1	134	139	PF02516	0.530
MOD_N-GLC_1	149	154	PF02516	0.433
MOD_N-GLC_1	34	39	PF02516	0.530
MOD_NEK2_1	1	6	PF00069	0.781
MOD_NEK2_1	258	263	PF00069	0.267
MOD_NEK2_1	301	306	PF00069	0.586
MOD_NEK2_1	330	335	PF00069	0.460
MOD_NEK2_1	351	356	PF00069	0.589
MOD_PIKK_1	153	159	PF00454	0.433
MOD_PIKK_1	34	40	PF00454	0.530
MOD_PIKK_1	70	76	PF00454	0.433
MOD_PKA_2	201	207	PF00069	0.433
MOD_Plk_1	164	170	PF00069	0.405
MOD_Plk_1	17	23	PF00069	0.542
MOD_Plk_1	193	199	PF00069	0.433
MOD_Plk_1	301	307	PF00069	0.590
MOD_Plk_1	322	328	PF00069	0.470
MOD_Plk_2-3	314	320	PF00069	0.610
MOD_Plk_4	11	17	PF00069	0.464
MOD_Plk_4	164	170	PF00069	0.325
MOD_Plk_4	258	264	PF00069	0.255
MOD_Plk_4	301	307	PF00069	0.590
MOD_ProDKin_1	187	193	PF00069	0.433
MOD_ProDKin_1	359	365	PF00069	0.471
TRG_DiLeu_BaEn_1	220	225	PF01217	0.405
TRG_DiLeu_BaEn_1	50	55	PF01217	0.283
TRG_DiLeu_BaEn_2	339	345	PF01217	0.574
TRG_DiLeu_LyEn_5	50	55	PF01217	0.283
TRG_ENDOCYTIC_2	13	16	PF00928	0.500
TRG_ENDOCYTIC_2	176	179	PF00928	0.530
TRG_NES_CRM1_1	308	319	PF08389	0.464
TRG_Pf-PMV_PEXEL_1	234	239	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	53	57	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9M0	Leptomonas seymouri	66%	96%
A0A3S5H4V5	Leishmania donovani	92%	100%
A4HRH1	Leishmania infantum	92%	100%
E9AC39	Leishmania major	91%	100%
O50584	Pseudomonas sp. (strain NCIMB 10558)	30%	100%
O74267	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	24%	97%
Q9HTF1	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	30%	100%