Alpha/beta-hydrolase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

alpha/beta-hydrolase-like protein

Species:

Leishmania mexicana

UniProt:

E9AJD2_LEIMU

TriTrypDb:

LmxM.01.0450

Length:

213

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

E9AJD2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJD2

PDB structure(s): 3r2j_A , 3r2j_B , 3r2j_C , 3r2j_D

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009165	nucleotide biosynthetic process	6	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0005488	binding	1	1
GO:0008936	nicotinamidase activity	5	1
GO:0016787	hydrolase activity	2	6
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	1
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	165	169	PF00656	0.442
CLV_NRD_NRD_1	115	117	PF00675	0.318
CLV_NRD_NRD_1	149	151	PF00675	0.260
CLV_PCSK_KEX2_1	149	151	PF00082	0.260
CLV_PCSK_SKI1_1	149	153	PF00082	0.260
DEG_SCF_FBW7_1	13	20	PF00400	0.411
DOC_CKS1_1	14	19	PF01111	0.349
DOC_PP2B_LxvP_1	88	91	PF13499	0.342
DOC_PP4_FxxP_1	37	40	PF00568	0.442
DOC_USP7_MATH_1	40	44	PF00917	0.467

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P300	Leptomonas seymouri	59%	100%
A0A1X0P2N6	Trypanosomatidae	45%	79%
A0A3S5H4V3	Leishmania donovani	81%	98%
A0A422NY51	Trypanosoma rangeli	44%	88%
A4H371	Leishmania braziliensis	71%	100%
A4HRG8	Leishmania infantum	81%	98%
C9ZXJ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AC36	Leishmania major	80%	100%
I6XD65	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	43%	100%
P21369	Escherichia coli (strain K12)	42%	100%

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