Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF791), putative

Species:

Leishmania mexicana

UniProt:

E9AJD1_LEIMU

TriTrypDb:

LmxM.01.0440

Length:

582

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AJD1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJD1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	6
GO:0008509	monoatomic anion transmembrane transporter activity	4	6
GO:0015075	monoatomic ion transmembrane transporter activity	3	6
GO:0015098	molybdate ion transmembrane transporter activity	5	6
GO:0015103	inorganic anion transmembrane transporter activity	4	6
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	6
GO:0022857	transmembrane transporter activity	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	284	288	PF00656	0.732
CLV_C14_Caspase3-7	63	67	PF00656	0.405
CLV_NRD_NRD_1	115	117	PF00675	0.376
CLV_NRD_NRD_1	526	528	PF00675	0.516
CLV_PCSK_KEX2_1	115	117	PF00082	0.353
CLV_PCSK_KEX2_1	526	528	PF00082	0.509
CLV_PCSK_SKI1_1	54	58	PF00082	0.405
DEG_COP1_1	360	369	PF00400	0.405
DEG_MDM2_SWIB_1	243	251	PF02201	0.284
DEG_MDM2_SWIB_1	496	504	PF02201	0.346
DEG_Nend_UBRbox_2	1	3	PF02207	0.529
DEG_SCF_FBW7_1	221	228	PF00400	0.405
DOC_CDC14_PxL_1	363	371	PF14671	0.405
DOC_CKS1_1	222	227	PF01111	0.272
DOC_CYCLIN_yCln2_LP_2	30	36	PF00134	0.362
DOC_MAPK_gen_1	115	123	PF00069	0.494
DOC_MAPK_gen_1	46	55	PF00069	0.642
DOC_MAPK_JIP1_4	206	212	PF00069	0.546
DOC_MAPK_MEF2A_6	115	123	PF00069	0.543
DOC_MAPK_MEF2A_6	347	354	PF00069	0.546
DOC_MAPK_MEF2A_6	424	432	PF00069	0.463
DOC_MAPK_MEF2A_6	46	55	PF00069	0.607
DOC_MAPK_NFAT4_5	116	124	PF00069	0.546
DOC_PP2B_LxvP_1	339	342	PF13499	0.675
DOC_PP2B_LxvP_1	364	367	PF13499	0.405
DOC_PP4_FxxP_1	29	32	PF00568	0.405
DOC_PP4_FxxP_1	395	398	PF00568	0.405
DOC_USP7_MATH_1	129	133	PF00917	0.411
DOC_USP7_MATH_1	14	18	PF00917	0.480
DOC_USP7_MATH_1	149	153	PF00917	0.221
DOC_USP7_MATH_1	225	229	PF00917	0.449
DOC_USP7_MATH_1	253	257	PF00917	0.710
DOC_USP7_MATH_1	266	270	PF00917	0.653
DOC_USP7_MATH_1	288	292	PF00917	0.733
DOC_USP7_MATH_1	304	308	PF00917	0.584
DOC_USP7_MATH_1	313	317	PF00917	0.716
DOC_USP7_MATH_1	60	64	PF00917	0.405
DOC_WW_Pin1_4	221	226	PF00397	0.405
DOC_WW_Pin1_4	317	322	PF00397	0.541
LIG_14-3-3_CanoR_1	115	123	PF00244	0.494
LIG_14-3-3_CanoR_1	317	321	PF00244	0.640
LIG_14-3-3_CanoR_1	418	428	PF00244	0.515
LIG_APCC_ABBA_1	369	374	PF00400	0.346
LIG_BRCT_BRCA1_1	374	378	PF00533	0.346
LIG_BRCT_BRCA1_1	70	74	PF00533	0.405
LIG_BRCT_BRCA1_1	87	91	PF00533	0.221
LIG_Clathr_ClatBox_1	504	508	PF01394	0.344
LIG_CSL_BTD_1	364	367	PF09270	0.405
LIG_deltaCOP1_diTrp_1	20	29	PF00928	0.464
LIG_deltaCOP1_diTrp_1	497	506	PF00928	0.346
LIG_FHA_1	149	155	PF00498	0.459
LIG_FHA_1	222	228	PF00498	0.405
LIG_FHA_1	358	364	PF00498	0.405
LIG_FHA_1	366	372	PF00498	0.322
LIG_FHA_1	392	398	PF00498	0.405
LIG_FHA_1	429	435	PF00498	0.405
LIG_FHA_1	472	478	PF00498	0.368
LIG_FHA_1	511	517	PF00498	0.435
LIG_FHA_1	564	570	PF00498	0.678
LIG_FHA_1	95	101	PF00498	0.414
LIG_FHA_2	154	160	PF00498	0.481
LIG_FHA_2	420	426	PF00498	0.549
LIG_LIR_Apic_2	393	398	PF02991	0.546
LIG_LIR_Apic_2	423	429	PF02991	0.466
LIG_LIR_Gen_1	497	507	PF02991	0.346
LIG_LIR_LC3C_4	406	411	PF02991	0.356
LIG_LIR_Nem_3	37	42	PF02991	0.405
LIG_LIR_Nem_3	375	381	PF02991	0.346
LIG_LIR_Nem_3	497	503	PF02991	0.346
LIG_LIR_Nem_3	568	574	PF02991	0.607
LIG_LIR_Nem_3	95	101	PF02991	0.223
LIG_MLH1_MIPbox_1	87	91	PF16413	0.312
LIG_MYND_1	28	32	PF01753	0.405
LIG_MYND_3	366	370	PF01753	0.405
LIG_NRBOX	408	414	PF00104	0.356
LIG_NRBOX	465	471	PF00104	0.356
LIG_Pex14_1	453	457	PF04695	0.674
LIG_Pex14_2	243	247	PF04695	0.356
LIG_Pex14_2	354	358	PF04695	0.405
LIG_Pex14_2	378	382	PF04695	0.405
LIG_Pex14_2	496	500	PF04695	0.346
LIG_SH2_CRK	426	430	PF00017	0.481
LIG_SH2_NCK_1	328	332	PF00017	0.528
LIG_SH2_SRC	328	331	PF00017	0.656
LIG_SH2_SRC	372	375	PF00017	0.312
LIG_SH2_SRC	426	429	PF00017	0.459
LIG_SH2_STAP1	328	332	PF00017	0.577
LIG_SH2_STAP1	372	376	PF00017	0.312
LIG_SH2_STAP1	80	84	PF00017	0.381
LIG_SH2_STAT5	239	242	PF00017	0.405
LIG_SH2_STAT5	310	313	PF00017	0.587
LIG_SH2_STAT5	344	347	PF00017	0.708
LIG_SH3_3	101	107	PF00018	0.229
LIG_SH3_3	219	225	PF00018	0.272
LIG_SH3_3	532	538	PF00018	0.653
LIG_SH3_3	559	565	PF00018	0.607
LIG_SH3_3	8	14	PF00018	0.513
LIG_SUMO_SIM_anti_2	135	140	PF11976	0.223
LIG_SUMO_SIM_anti_2	463	468	PF11976	0.265
LIG_SUMO_SIM_par_1	367	375	PF11976	0.405
LIG_SUMO_SIM_par_1	408	414	PF11976	0.405
LIG_SUMO_SIM_par_1	60	66	PF11976	0.483
LIG_TYR_ITIM	237	242	PF00017	0.405
LIG_TYR_ITIM	96	101	PF00017	0.223
LIG_UBA3_1	466	471	PF00899	0.405
LIG_WRC_WIRS_1	387	392	PF05994	0.405
MOD_CDC14_SPxK_1	320	323	PF00782	0.600
MOD_CDK_SPxK_1	317	323	PF00069	0.603
MOD_CK1_1	132	138	PF00069	0.464
MOD_CK1_1	152	158	PF00069	0.284
MOD_CK1_1	290	296	PF00069	0.724
MOD_CK1_1	3	9	PF00069	0.384
MOD_CK1_1	309	315	PF00069	0.753
MOD_CK1_1	316	322	PF00069	0.639
MOD_CK1_1	335	341	PF00069	0.685
MOD_CK1_1	393	399	PF00069	0.546
MOD_CK1_1	416	422	PF00069	0.346
MOD_CK1_1	460	466	PF00069	0.524
MOD_CK1_1	85	91	PF00069	0.353
MOD_CK2_1	153	159	PF00069	0.545
MOD_CK2_1	290	296	PF00069	0.676
MOD_CK2_1	411	417	PF00069	0.344
MOD_CK2_1	572	578	PF00069	0.599
MOD_Cter_Amidation	524	527	PF01082	0.454
MOD_GlcNHglycan	131	134	PF01048	0.507
MOD_GlcNHglycan	146	149	PF01048	0.284
MOD_GlcNHglycan	151	154	PF01048	0.202
MOD_GlcNHglycan	172	175	PF01048	0.449
MOD_GlcNHglycan	195	198	PF01048	0.465
MOD_GlcNHglycan	255	258	PF01048	0.517
MOD_GlcNHglycan	281	284	PF01048	0.523
MOD_GlcNHglycan	290	293	PF01048	0.450
MOD_GlcNHglycan	311	314	PF01048	0.540
MOD_GlcNHglycan	36	39	PF01048	0.421
MOD_GlcNHglycan	459	462	PF01048	0.501
MOD_GlcNHglycan	539	542	PF01048	0.553
MOD_GlcNHglycan	84	87	PF01048	0.629
MOD_GSK3_1	144	151	PF00069	0.420
MOD_GSK3_1	193	200	PF00069	0.663
MOD_GSK3_1	210	217	PF00069	0.225
MOD_GSK3_1	221	228	PF00069	0.292
MOD_GSK3_1	286	293	PF00069	0.738
MOD_GSK3_1	309	316	PF00069	0.732
MOD_GSK3_1	331	338	PF00069	0.619
MOD_GSK3_1	386	393	PF00069	0.495
MOD_GSK3_1	416	423	PF00069	0.346
MOD_GSK3_1	456	463	PF00069	0.737
MOD_GSK3_1	563	570	PF00069	0.712
MOD_LATS_1	279	285	PF00433	0.748
MOD_N-GLC_1	3	8	PF02516	0.680
MOD_NEK2_1	193	198	PF00069	0.731
MOD_NEK2_1	210	215	PF00069	0.248
MOD_NEK2_1	295	300	PF00069	0.697
MOD_NEK2_1	34	39	PF00069	0.350
MOD_NEK2_1	359	364	PF00069	0.422
MOD_NEK2_1	386	391	PF00069	0.437
MOD_NEK2_1	439	444	PF00069	0.405
MOD_NEK2_1	68	73	PF00069	0.405
MOD_NEK2_1	82	87	PF00069	0.321
MOD_NEK2_2	14	19	PF00069	0.444
MOD_NEK2_2	332	337	PF00069	0.687
MOD_PIKK_1	214	220	PF00454	0.405
MOD_PIKK_1	510	516	PF00454	0.435
MOD_PKA_2	114	120	PF00069	0.494
MOD_PKA_2	22	28	PF00069	0.216
MOD_PKA_2	316	322	PF00069	0.625
MOD_Plk_1	3	9	PF00069	0.481
MOD_Plk_1	372	378	PF00069	0.346
MOD_Plk_1	416	422	PF00069	0.303
MOD_Plk_4	14	20	PF00069	0.477
MOD_Plk_4	153	159	PF00069	0.540
MOD_Plk_4	197	203	PF00069	0.607
MOD_Plk_4	22	28	PF00069	0.319
MOD_Plk_4	359	365	PF00069	0.392
MOD_Plk_4	386	392	PF00069	0.405
MOD_Plk_4	428	434	PF00069	0.346
MOD_Plk_4	448	454	PF00069	0.553
MOD_Plk_4	462	468	PF00069	0.230
MOD_Plk_4	94	100	PF00069	0.405
MOD_ProDKin_1	221	227	PF00069	0.405
MOD_ProDKin_1	317	323	PF00069	0.541
TRG_ENDOCYTIC_2	239	242	PF00928	0.405
TRG_ENDOCYTIC_2	571	574	PF00928	0.603
TRG_ENDOCYTIC_2	98	101	PF00928	0.223
TRG_ER_diArg_1	48	51	PF00400	0.608
TRG_Pf-PMV_PEXEL_1	347	351	PF00026	0.312
TRG_PTS1	579	582	PF00515	0.689

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H4V2	Leishmania donovani	86%	99%
A4H370	Leishmania braziliensis	71%	100%
A4HRG7	Leishmania infantum	86%	99%
E9AC35	Leishmania major	84%	100%