RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative

Species:

Leishmania mexicana

UniProt:

E9AJD0_LEIMU

TriTrypDb:

LmxM.01.0430

Length:

751

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AJD0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJD0

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0007165	signal transduction	2	1
GO:0007264	small GTPase mediated signal transduction	4	1
GO:0007265	Ras protein signal transduction	5	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0035556	intracellular signal transduction	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0008270	zinc ion binding	6	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0003824	catalytic activity	1	2
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0061630	ubiquitin protein ligase activity	5	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.525
CLV_C14_Caspase3-7	227	231	PF00656	0.606
CLV_C14_Caspase3-7	284	288	PF00656	0.763
CLV_C14_Caspase3-7	563	567	PF00656	0.775
CLV_C14_Caspase3-7	98	102	PF00656	0.615
CLV_NRD_NRD_1	114	116	PF00675	0.656
CLV_NRD_NRD_1	222	224	PF00675	0.703
CLV_NRD_NRD_1	301	303	PF00675	0.801
CLV_NRD_NRD_1	330	332	PF00675	0.599
CLV_NRD_NRD_1	339	341	PF00675	0.837
CLV_NRD_NRD_1	466	468	PF00675	0.335
CLV_NRD_NRD_1	615	617	PF00675	0.645
CLV_NRD_NRD_1	629	631	PF00675	0.690
CLV_NRD_NRD_1	655	657	PF00675	0.606
CLV_NRD_NRD_1	659	661	PF00675	0.607
CLV_NRD_NRD_1	723	725	PF00675	0.601
CLV_PCSK_FUR_1	464	468	PF00082	0.346
CLV_PCSK_FUR_1	611	615	PF00082	0.570
CLV_PCSK_FUR_1	656	660	PF00082	0.607
CLV_PCSK_KEX2_1	222	224	PF00082	0.670
CLV_PCSK_KEX2_1	301	303	PF00082	0.801
CLV_PCSK_KEX2_1	330	332	PF00082	0.599
CLV_PCSK_KEX2_1	466	468	PF00082	0.335
CLV_PCSK_KEX2_1	613	615	PF00082	0.620
CLV_PCSK_KEX2_1	629	631	PF00082	0.605
CLV_PCSK_KEX2_1	655	657	PF00082	0.606
CLV_PCSK_KEX2_1	658	660	PF00082	0.604
CLV_PCSK_PC7_1	611	617	PF00082	0.564
CLV_PCSK_PC7_1	655	661	PF00082	0.604
CLV_PCSK_SKI1_1	11	15	PF00082	0.466
CLV_PCSK_SKI1_1	188	192	PF00082	0.493
CLV_PCSK_SKI1_1	496	500	PF00082	0.346
CLV_PCSK_SKI1_1	659	663	PF00082	0.606
CLV_Separin_Metazoa	158	162	PF03568	0.511
DEG_Nend_UBRbox_2	1	3	PF02207	0.626
DEG_SCF_FBW7_1	62	69	PF00400	0.471
DEG_SPOP_SBC_1	535	539	PF00917	0.810
DOC_CKS1_1	323	328	PF01111	0.826
DOC_CYCLIN_yCln2_LP_2	199	205	PF00134	0.677
DOC_CYCLIN_yCln2_LP_2	21	24	PF00134	0.648
DOC_MAPK_gen_1	222	228	PF00069	0.505
DOC_PP2B_LxvP_1	199	202	PF13499	0.695
DOC_PP2B_LxvP_1	21	24	PF13499	0.648
DOC_PP2B_LxvP_1	371	374	PF13499	0.559
DOC_SPAK_OSR1_1	430	434	PF12202	0.550
DOC_USP7_MATH_1	109	113	PF00917	0.712
DOC_USP7_MATH_1	123	127	PF00917	0.636
DOC_USP7_MATH_1	234	238	PF00917	0.564
DOC_USP7_MATH_1	242	246	PF00917	0.605
DOC_USP7_MATH_1	30	34	PF00917	0.643
DOC_USP7_MATH_1	333	337	PF00917	0.759
DOC_USP7_MATH_1	361	365	PF00917	0.534
DOC_USP7_MATH_1	420	424	PF00917	0.411
DOC_USP7_MATH_1	535	539	PF00917	0.825
DOC_USP7_MATH_1	747	751	PF00917	0.649
DOC_USP7_MATH_1	75	79	PF00917	0.662
DOC_USP7_MATH_2	66	72	PF00917	0.519
DOC_WW_Pin1_4	116	121	PF00397	0.642
DOC_WW_Pin1_4	312	317	PF00397	0.779
DOC_WW_Pin1_4	322	327	PF00397	0.617
DOC_WW_Pin1_4	329	334	PF00397	0.753
DOC_WW_Pin1_4	359	364	PF00397	0.713
DOC_WW_Pin1_4	366	371	PF00397	0.674
DOC_WW_Pin1_4	517	522	PF00397	0.741
DOC_WW_Pin1_4	549	554	PF00397	0.740
DOC_WW_Pin1_4	62	67	PF00397	0.557
DOC_WW_Pin1_4	633	638	PF00397	0.635
DOC_WW_Pin1_4	80	85	PF00397	0.506
LIG_14-3-3_CanoR_1	317	323	PF00244	0.836
LIG_14-3-3_CanoR_1	365	373	PF00244	0.529
LIG_14-3-3_CanoR_1	430	434	PF00244	0.500
LIG_14-3-3_CanoR_1	491	499	PF00244	0.614
LIG_14-3-3_CanoR_1	560	565	PF00244	0.670
LIG_14-3-3_CanoR_1	649	653	PF00244	0.427
LIG_APCC_ABBA_1	497	502	PF00400	0.546
LIG_APCC_ABBAyCdc20_2	496	502	PF00400	0.546
LIG_BIR_III_2	208	212	PF00653	0.628
LIG_BRCT_BRCA1_1	385	389	PF00533	0.574
LIG_BRCT_BRCA1_1	494	498	PF00533	0.546
LIG_Clathr_ClatBox_1	54	58	PF01394	0.524
LIG_FHA_1	12	18	PF00498	0.620
LIG_FHA_1	152	158	PF00498	0.563
LIG_FHA_1	198	204	PF00498	0.567
LIG_FHA_1	38	44	PF00498	0.566
LIG_FHA_1	389	395	PF00498	0.450
LIG_FHA_1	4	10	PF00498	0.645
LIG_FHA_1	485	491	PF00498	0.475
LIG_FHA_1	588	594	PF00498	0.543
LIG_FHA_1	667	673	PF00498	0.666
LIG_FHA_1	717	723	PF00498	0.661
LIG_FHA_1	81	87	PF00498	0.527
LIG_FHA_2	120	126	PF00498	0.545
LIG_FHA_2	445	451	PF00498	0.546
LIG_FHA_2	63	69	PF00498	0.585
LIG_FHA_2	649	655	PF00498	0.421
LIG_LIR_Gen_1	154	164	PF02991	0.595
LIG_LIR_Gen_1	256	266	PF02991	0.727
LIG_LIR_Gen_1	386	397	PF02991	0.394
LIG_LIR_Gen_1	414	424	PF02991	0.515
LIG_LIR_Gen_1	432	440	PF02991	0.382
LIG_LIR_Gen_1	447	456	PF02991	0.546
LIG_LIR_Nem_3	154	159	PF02991	0.648
LIG_LIR_Nem_3	256	261	PF02991	0.705
LIG_LIR_Nem_3	386	392	PF02991	0.534
LIG_LIR_Nem_3	414	419	PF02991	0.515
LIG_LIR_Nem_3	432	437	PF02991	0.391
LIG_LIR_Nem_3	447	451	PF02991	0.546
LIG_PCNA_PIPBox_1	697	706	PF02747	0.537
LIG_PDZ_Class_1	746	751	PF00595	0.544
LIG_SH2_CRK	172	176	PF00017	0.492
LIG_SH2_CRK	416	420	PF00017	0.411
LIG_SH2_CRK	434	438	PF00017	0.572
LIG_SH2_STAP1	448	452	PF00017	0.546
LIG_SH2_STAP1	589	593	PF00017	0.546
LIG_SH2_STAP1	604	608	PF00017	0.565
LIG_SH2_STAT3	110	113	PF00017	0.510
LIG_SH2_STAT3	588	591	PF00017	0.651
LIG_SH2_STAT5	164	167	PF00017	0.560
LIG_SH2_STAT5	172	175	PF00017	0.497
LIG_SH2_STAT5	205	208	PF00017	0.677
LIG_SH2_STAT5	398	401	PF00017	0.512
LIG_SH2_STAT5	589	592	PF00017	0.545
LIG_SH2_STAT5	665	668	PF00017	0.661
LIG_SH3_2	84	89	PF14604	0.525
LIG_SH3_3	320	326	PF00018	0.832
LIG_SH3_3	620	626	PF00018	0.452
LIG_SH3_3	81	87	PF00018	0.527
LIG_SUMO_SIM_anti_2	154	161	PF11976	0.524
LIG_SUMO_SIM_anti_2	502	510	PF11976	0.553
LIG_SUMO_SIM_anti_2	669	674	PF11976	0.653
LIG_SUMO_SIM_par_1	210	215	PF11976	0.627
LIG_SUMO_SIM_par_1	252	259	PF11976	0.660
LIG_SUMO_SIM_par_1	52	58	PF11976	0.533
LIG_TRAF2_1	190	193	PF00917	0.551
LIG_TRAF2_1	538	541	PF00917	0.664
LIG_TRAF2_1	580	583	PF00917	0.572
LIG_TRAF2_1	734	737	PF00917	0.594
LIG_WW_3	240	244	PF00397	0.642
MOD_CDK_SPK_2	312	317	PF00069	0.560
MOD_CDK_SPxK_1	359	365	PF00069	0.573
MOD_CK1_1	119	125	PF00069	0.753
MOD_CK1_1	126	132	PF00069	0.791
MOD_CK1_1	133	139	PF00069	0.512
MOD_CK1_1	315	321	PF00069	0.773
MOD_CK1_1	348	354	PF00069	0.691
MOD_CK1_1	364	370	PF00069	0.572
MOD_CK1_1	477	483	PF00069	0.411
MOD_CK1_1	520	526	PF00069	0.748
MOD_CK1_1	633	639	PF00069	0.651
MOD_CK1_1	642	648	PF00069	0.724
MOD_CK1_1	71	77	PF00069	0.623
MOD_CK1_1	78	84	PF00069	0.574
MOD_CK2_1	119	125	PF00069	0.578
MOD_CK2_1	152	158	PF00069	0.590
MOD_CK2_1	186	192	PF00069	0.402
MOD_CK2_1	253	259	PF00069	0.716
MOD_CK2_1	534	540	PF00069	0.806
MOD_CK2_1	577	583	PF00069	0.678
MOD_CK2_1	62	68	PF00069	0.527
MOD_CK2_1	648	654	PF00069	0.428
MOD_CMANNOS	35	38	PF00535	0.544
MOD_Cter_Amidation	627	630	PF01082	0.735
MOD_GlcNHglycan	107	110	PF01048	0.653
MOD_GlcNHglycan	135	138	PF01048	0.637
MOD_GlcNHglycan	188	191	PF01048	0.338
MOD_GlcNHglycan	232	237	PF01048	0.546
MOD_GlcNHglycan	244	247	PF01048	0.694
MOD_GlcNHglycan	272	275	PF01048	0.837
MOD_GlcNHglycan	283	286	PF01048	0.769
MOD_GlcNHglycan	320	323	PF01048	0.767
MOD_GlcNHglycan	351	354	PF01048	0.640
MOD_GlcNHglycan	385	388	PF01048	0.569
MOD_GlcNHglycan	399	402	PF01048	0.394
MOD_GlcNHglycan	420	423	PF01048	0.411
MOD_GlcNHglycan	476	479	PF01048	0.411
MOD_GlcNHglycan	531	534	PF01048	0.747
MOD_GlcNHglycan	632	635	PF01048	0.691
MOD_GlcNHglycan	641	644	PF01048	0.616
MOD_GlcNHglycan	705	708	PF01048	0.520
MOD_GlcNHglycan	77	80	PF01048	0.590
MOD_GSK3_1	105	112	PF00069	0.760
MOD_GSK3_1	119	126	PF00069	0.697
MOD_GSK3_1	127	134	PF00069	0.776
MOD_GSK3_1	318	325	PF00069	0.729
MOD_GSK3_1	329	336	PF00069	0.772
MOD_GSK3_1	345	352	PF00069	0.709
MOD_GSK3_1	359	366	PF00069	0.635
MOD_GSK3_1	37	44	PF00069	0.610
MOD_GSK3_1	397	404	PF00069	0.512
MOD_GSK3_1	407	414	PF00069	0.347
MOD_GSK3_1	45	52	PF00069	0.543
MOD_GSK3_1	473	480	PF00069	0.392
MOD_GSK3_1	525	532	PF00069	0.793
MOD_GSK3_1	547	554	PF00069	0.752
MOD_GSK3_1	560	567	PF00069	0.609
MOD_GSK3_1	62	69	PF00069	0.641
MOD_GSK3_1	639	646	PF00069	0.461
MOD_GSK3_1	699	706	PF00069	0.636
MOD_GSK3_1	71	78	PF00069	0.576
MOD_GSK3_1	85	92	PF00069	0.601
MOD_N-GLC_1	491	496	PF02516	0.411
MOD_N-GLC_1	577	582	PF02516	0.584
MOD_NEK2_1	144	149	PF00069	0.629
MOD_NEK2_1	197	202	PF00069	0.592
MOD_NEK2_1	3	8	PF00069	0.635
MOD_NEK2_1	37	42	PF00069	0.500
MOD_NEK2_1	397	402	PF00069	0.512
MOD_NEK2_1	411	416	PF00069	0.282
MOD_NEK2_1	47	52	PF00069	0.545
MOD_NEK2_1	547	552	PF00069	0.781
MOD_NEK2_1	67	72	PF00069	0.485
MOD_NEK2_1	683	688	PF00069	0.514
MOD_NEK2_1	699	704	PF00069	0.607
MOD_NEK2_2	407	412	PF00069	0.394
MOD_NEK2_2	429	434	PF00069	0.547
MOD_NEK2_2	643	648	PF00069	0.442
MOD_PIKK_1	109	115	PF00454	0.506
MOD_PIKK_1	587	593	PF00454	0.644
MOD_PIKK_1	60	66	PF00454	0.523
MOD_PIKK_1	716	722	PF00454	0.525
MOD_PK_1	53	59	PF00069	0.534
MOD_PKA_2	142	148	PF00069	0.726
MOD_PKA_2	242	248	PF00069	0.635
MOD_PKA_2	295	301	PF00069	0.724
MOD_PKA_2	348	354	PF00069	0.637
MOD_PKA_2	364	370	PF00069	0.526
MOD_PKA_2	429	435	PF00069	0.495
MOD_PKA_2	648	654	PF00069	0.428
MOD_PKB_1	489	497	PF00069	0.512
MOD_PKB_1	558	566	PF00069	0.726
MOD_PKB_1	658	666	PF00069	0.698
MOD_Plk_1	151	157	PF00069	0.615
MOD_Plk_2-3	152	158	PF00069	0.681
MOD_Plk_2-3	283	289	PF00069	0.835
MOD_Plk_4	152	158	PF00069	0.681
MOD_Plk_4	253	259	PF00069	0.641
MOD_Plk_4	31	37	PF00069	0.588
MOD_Plk_4	564	570	PF00069	0.756
MOD_Plk_4	643	649	PF00069	0.469
MOD_ProDKin_1	116	122	PF00069	0.646
MOD_ProDKin_1	312	318	PF00069	0.778
MOD_ProDKin_1	322	328	PF00069	0.615
MOD_ProDKin_1	329	335	PF00069	0.753
MOD_ProDKin_1	359	365	PF00069	0.714
MOD_ProDKin_1	366	372	PF00069	0.676
MOD_ProDKin_1	517	523	PF00069	0.741
MOD_ProDKin_1	549	555	PF00069	0.739
MOD_ProDKin_1	62	68	PF00069	0.566
MOD_ProDKin_1	633	639	PF00069	0.630
MOD_ProDKin_1	80	86	PF00069	0.506
MOD_SUMO_rev_2	108	117	PF00179	0.698
MOD_SUMO_rev_2	599	609	PF00179	0.422
TRG_DiLeu_BaEn_1	502	507	PF01217	0.525
TRG_DiLeu_BaEn_1	739	744	PF01217	0.570
TRG_DiLeu_BaEn_4	192	198	PF01217	0.612
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.625
TRG_DiLeu_BaLyEn_6	380	385	PF01217	0.461
TRG_ENDOCYTIC_2	172	175	PF00928	0.497
TRG_ENDOCYTIC_2	416	419	PF00928	0.411
TRG_ENDOCYTIC_2	434	437	PF00928	0.579
TRG_ENDOCYTIC_2	448	451	PF00928	0.411
TRG_ENDOCYTIC_2	589	592	PF00928	0.646
TRG_ENDOCYTIC_2	680	683	PF00928	0.554
TRG_ER_diArg_1	141	144	PF00400	0.644
TRG_ER_diArg_1	464	467	PF00400	0.390
TRG_ER_diArg_1	558	561	PF00400	0.735
TRG_ER_diArg_1	611	614	PF00400	0.613
TRG_ER_diArg_1	655	658	PF00400	0.601
TRG_ER_diArg_1	659	661	PF00400	0.607
TRG_ER_diArg_1	715	718	PF00400	0.547
TRG_Pf-PMV_PEXEL_1	594	598	PF00026	0.563
TRG_Pf-PMV_PEXEL_1	660	664	PF00026	0.571

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2L0	Leptomonas seymouri	47%	88%
A0A3S5H4V1	Leishmania donovani	82%	100%
A4H369	Leishmania braziliensis	70%	99%
A4HRG6	Leishmania infantum	82%	100%
E9AC34	Leishmania major	79%	96%