Protein-serine/threonine kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJC8_LEIMU

TriTrypDb:

LmxM.01.0400

Length:

553

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AJC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJC8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0031123	RNA 3'-end processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071076	RNA 3' uridylation	8	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0050265	RNA uridylyltransferase activity	4	1
GO:0070569	uridylyltransferase activity	5	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	239	243	PF00656	0.509
CLV_NRD_NRD_1	155	157	PF00675	0.684
CLV_NRD_NRD_1	191	193	PF00675	0.403
CLV_NRD_NRD_1	279	281	PF00675	0.589
CLV_NRD_NRD_1	336	338	PF00675	0.586
CLV_NRD_NRD_1	418	420	PF00675	0.456
CLV_NRD_NRD_1	514	516	PF00675	0.599
CLV_PCSK_KEX2_1	155	157	PF00082	0.684
CLV_PCSK_KEX2_1	191	193	PF00082	0.403
CLV_PCSK_KEX2_1	279	281	PF00082	0.616
CLV_PCSK_KEX2_1	335	337	PF00082	0.570
CLV_PCSK_KEX2_1	418	420	PF00082	0.462
CLV_PCSK_KEX2_1	514	516	PF00082	0.596
CLV_PCSK_PC7_1	151	157	PF00082	0.604
CLV_PCSK_PC7_1	331	337	PF00082	0.527
CLV_PCSK_SKI1_1	273	277	PF00082	0.536
CLV_PCSK_SKI1_1	287	291	PF00082	0.712
CLV_PCSK_SKI1_1	438	442	PF00082	0.352
DEG_APCC_DBOX_1	418	426	PF00400	0.380
DEG_Nend_UBRbox_1	1	4	PF02207	0.529
DEG_SPOP_SBC_1	483	487	PF00917	0.477
DEG_SPOP_SBC_1	94	98	PF00917	0.592
DOC_CYCLIN_RxL_1	433	443	PF00134	0.426
DOC_CYCLIN_yCln2_LP_2	176	182	PF00134	0.385
DOC_CYCLIN_yCln2_LP_2	442	448	PF00134	0.389
DOC_PP1_RVXF_1	128	135	PF00149	0.642
DOC_PP2B_LxvP_1	143	146	PF13499	0.539
DOC_PP2B_LxvP_1	176	179	PF13499	0.468
DOC_PP2B_LxvP_1	292	295	PF13499	0.632
DOC_PP2B_LxvP_1	77	80	PF13499	0.653
DOC_PP4_FxxP_1	134	137	PF00568	0.533
DOC_USP7_MATH_1	23	27	PF00917	0.548
DOC_USP7_MATH_1	244	248	PF00917	0.743
DOC_USP7_MATH_1	344	348	PF00917	0.601
DOC_USP7_MATH_1	353	357	PF00917	0.509
DOC_USP7_MATH_1	362	366	PF00917	0.303
DOC_USP7_MATH_1	381	385	PF00917	0.435
DOC_USP7_MATH_1	84	88	PF00917	0.645
DOC_WW_Pin1_4	349	354	PF00397	0.427
DOC_WW_Pin1_4	484	489	PF00397	0.599
LIG_14-3-3_CanoR_1	343	349	PF00244	0.510
LIG_14-3-3_CanoR_1	361	367	PF00244	0.249
LIG_14-3-3_CanoR_1	393	400	PF00244	0.296
LIG_14-3-3_CanoR_1	409	414	PF00244	0.559
LIG_14-3-3_CanoR_1	514	522	PF00244	0.437
LIG_14-3-3_CanoR_1	68	76	PF00244	0.546
LIG_APCC_ABBA_1	468	473	PF00400	0.369
LIG_eIF4E_1	144	150	PF01652	0.494
LIG_FHA_1	209	215	PF00498	0.516
LIG_FHA_1	447	453	PF00498	0.386
LIG_FHA_1	484	490	PF00498	0.571
LIG_FHA_2	205	211	PF00498	0.310
LIG_LIR_Nem_3	70	76	PF02991	0.549
LIG_NRBOX	172	178	PF00104	0.381
LIG_PCNA_yPIPBox_3	151	161	PF02747	0.418
LIG_PCNA_yPIPBox_3	273	285	PF02747	0.507
LIG_PCNA_yPIPBox_3	358	367	PF02747	0.268
LIG_Pex14_1	57	61	PF04695	0.442
LIG_SH2_CRK	144	148	PF00017	0.557
LIG_SH2_NCK_1	42	46	PF00017	0.517
LIG_SH2_SRC	144	147	PF00017	0.598
LIG_SH2_SRC	398	401	PF00017	0.459
LIG_SH2_STAP1	163	167	PF00017	0.392
LIG_SH2_STAP1	448	452	PF00017	0.274
LIG_SH2_STAT3	357	360	PF00017	0.295
LIG_SH2_STAT3	547	550	PF00017	0.369
LIG_SH2_STAT5	202	205	PF00017	0.351
LIG_SH2_STAT5	371	374	PF00017	0.368
LIG_SH2_STAT5	448	451	PF00017	0.277
LIG_SH2_STAT5	547	550	PF00017	0.490
LIG_SH3_1	397	403	PF00018	0.506
LIG_SH3_3	107	113	PF00018	0.613
LIG_SH3_3	256	262	PF00018	0.646
LIG_SH3_3	292	298	PF00018	0.633
LIG_SH3_3	375	381	PF00018	0.449
LIG_SH3_3	397	403	PF00018	0.509
LIG_TRAF2_1	310	313	PF00917	0.664
LIG_WW_3	406	410	PF00397	0.502
MOD_CK1_1	247	253	PF00069	0.765
MOD_CK1_1	25	31	PF00069	0.579
MOD_CK1_1	296	302	PF00069	0.626
MOD_CK1_1	502	508	PF00069	0.529
MOD_CK2_1	112	118	PF00069	0.614
MOD_CK2_1	204	210	PF00069	0.290
MOD_CK2_1	381	387	PF00069	0.450
MOD_GlcNHglycan	114	117	PF01048	0.580
MOD_GlcNHglycan	244	247	PF01048	0.607
MOD_GlcNHglycan	249	252	PF01048	0.664
MOD_GlcNHglycan	29	32	PF01048	0.495
MOD_GlcNHglycan	298	301	PF01048	0.693
MOD_GlcNHglycan	373	376	PF01048	0.467
MOD_GlcNHglycan	477	480	PF01048	0.550
MOD_GSK3_1	112	119	PF00069	0.703
MOD_GSK3_1	204	211	PF00069	0.434
MOD_GSK3_1	23	30	PF00069	0.446
MOD_GSK3_1	247	254	PF00069	0.735
MOD_GSK3_1	349	356	PF00069	0.402
MOD_GSK3_1	446	453	PF00069	0.371
MOD_GSK3_1	80	87	PF00069	0.573
MOD_GSK3_1	89	96	PF00069	0.685
MOD_NEK2_1	117	122	PF00069	0.587
MOD_NEK2_1	132	137	PF00069	0.478
MOD_NEK2_1	330	335	PF00069	0.605
MOD_NEK2_1	44	49	PF00069	0.356
MOD_NEK2_1	440	445	PF00069	0.370
MOD_NEK2_2	268	273	PF00069	0.514
MOD_PIKK_1	117	123	PF00454	0.579
MOD_PIKK_1	379	385	PF00454	0.501
MOD_PIKK_1	401	407	PF00454	0.416
MOD_PKA_2	330	336	PF00069	0.543
MOD_PKA_2	392	398	PF00069	0.286
MOD_PKA_2	513	519	PF00069	0.439
MOD_PKA_2	67	73	PF00069	0.581
MOD_PKB_1	341	349	PF00069	0.390
MOD_Plk_2-3	159	165	PF00069	0.401
MOD_Plk_4	168	174	PF00069	0.455
MOD_Plk_4	362	368	PF00069	0.490
MOD_ProDKin_1	349	355	PF00069	0.422
MOD_ProDKin_1	484	490	PF00069	0.601
TRG_DiLeu_BaLyEn_6	136	141	PF01217	0.573
TRG_ER_diArg_1	155	157	PF00400	0.629
TRG_ER_diArg_1	279	282	PF00400	0.630
TRG_ER_diArg_1	326	329	PF00400	0.600
TRG_ER_diArg_1	334	337	PF00400	0.536
TRG_ER_diArg_1	417	419	PF00400	0.479
TRG_ER_diArg_1	51	54	PF00400	0.587
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	544	549	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL81	Leptomonas seymouri	38%	94%
A0A451EJ97	Leishmania donovani	81%	97%
A4H366	Leishmania braziliensis	67%	100%
A4HRG3	Leishmania infantum	82%	87%
E9AC31	Leishmania major	79%	99%