Dynein heavy chain 7, axonemal

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJC7_LEIMU

TriTrypDb:

LmxM.01.0390

Length:

822

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJC7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJC7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	146	148	PF00675	0.717
CLV_NRD_NRD_1	166	168	PF00675	0.360
CLV_NRD_NRD_1	185	187	PF00675	0.438
CLV_NRD_NRD_1	314	316	PF00675	0.389
CLV_NRD_NRD_1	381	383	PF00675	0.650
CLV_NRD_NRD_1	571	573	PF00675	0.567
CLV_NRD_NRD_1	625	627	PF00675	0.533
CLV_NRD_NRD_1	643	645	PF00675	0.461
CLV_NRD_NRD_1	655	657	PF00675	0.458
CLV_NRD_NRD_1	736	738	PF00675	0.375
CLV_NRD_NRD_1	780	782	PF00675	0.658
CLV_PCSK_KEX2_1	146	148	PF00082	0.612
CLV_PCSK_KEX2_1	166	168	PF00082	0.370
CLV_PCSK_KEX2_1	314	316	PF00082	0.389
CLV_PCSK_KEX2_1	351	353	PF00082	0.551
CLV_PCSK_KEX2_1	381	383	PF00082	0.650
CLV_PCSK_KEX2_1	450	452	PF00082	0.607
CLV_PCSK_KEX2_1	571	573	PF00082	0.538
CLV_PCSK_KEX2_1	655	657	PF00082	0.468
CLV_PCSK_KEX2_1	780	782	PF00082	0.658
CLV_PCSK_PC1ET2_1	351	353	PF00082	0.551
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.607
CLV_PCSK_PC7_1	162	168	PF00082	0.512
CLV_PCSK_SKI1_1	166	170	PF00082	0.600
CLV_PCSK_SKI1_1	314	318	PF00082	0.459
CLV_PCSK_SKI1_1	343	347	PF00082	0.588
CLV_PCSK_SKI1_1	365	369	PF00082	0.521
CLV_PCSK_SKI1_1	371	375	PF00082	0.518
CLV_PCSK_SKI1_1	451	455	PF00082	0.533
CLV_PCSK_SKI1_1	470	474	PF00082	0.484
CLV_PCSK_SKI1_1	529	533	PF00082	0.572
CLV_PCSK_SKI1_1	574	578	PF00082	0.518
CLV_PCSK_SKI1_1	627	631	PF00082	0.411
CLV_PCSK_SKI1_1	644	648	PF00082	0.480
CLV_PCSK_SKI1_1	707	711	PF00082	0.450
CLV_PCSK_SKI1_1	805	809	PF00082	0.641
CLV_Separin_Metazoa	791	795	PF03568	0.506
DEG_APCC_DBOX_1	166	174	PF00400	0.599
DEG_APCC_DBOX_1	725	733	PF00400	0.502
DEG_Nend_UBRbox_3	1	3	PF02207	0.774
DOC_CKS1_1	757	762	PF01111	0.554
DOC_CYCLIN_RxL_1	641	651	PF00134	0.527
DOC_CYCLIN_RxL_1	802	810	PF00134	0.639
DOC_MAPK_gen_1	222	230	PF00069	0.656
DOC_MAPK_gen_1	351	359	PF00069	0.604
DOC_MAPK_MEF2A_6	222	230	PF00069	0.656
DOC_PP1_RVXF_1	185	192	PF00149	0.602
DOC_PP2B_LxvP_1	772	775	PF13499	0.559
DOC_PP2B_LxvP_1	819	822	PF13499	0.629
DOC_PP4_FxxP_1	359	362	PF00568	0.520
DOC_USP7_MATH_1	290	294	PF00917	0.664
DOC_USP7_MATH_1	345	349	PF00917	0.491
DOC_USP7_MATH_1	373	377	PF00917	0.604
DOC_USP7_MATH_1	411	415	PF00917	0.614
DOC_USP7_MATH_1	45	49	PF00917	0.655
DOC_USP7_MATH_1	50	54	PF00917	0.606
DOC_USP7_MATH_1	511	515	PF00917	0.614
DOC_USP7_MATH_1	622	626	PF00917	0.543
DOC_USP7_MATH_1	74	78	PF00917	0.657
DOC_USP7_MATH_1	814	818	PF00917	0.662
DOC_WW_Pin1_4	1	6	PF00397	0.737
DOC_WW_Pin1_4	10	15	PF00397	0.634
DOC_WW_Pin1_4	120	125	PF00397	0.547
DOC_WW_Pin1_4	264	269	PF00397	0.684
DOC_WW_Pin1_4	64	69	PF00397	0.788
DOC_WW_Pin1_4	756	761	PF00397	0.594
LIG_14-3-3_CanoR_1	128	132	PF00244	0.598
LIG_14-3-3_CanoR_1	166	171	PF00244	0.584
LIG_14-3-3_CanoR_1	186	190	PF00244	0.372
LIG_14-3-3_CanoR_1	225	229	PF00244	0.635
LIG_14-3-3_CanoR_1	451	459	PF00244	0.530
LIG_14-3-3_CanoR_1	529	537	PF00244	0.587
LIG_14-3-3_CanoR_1	626	636	PF00244	0.418
LIG_14-3-3_CanoR_1	737	746	PF00244	0.343
LIG_14-3-3_CanoR_1	764	770	PF00244	0.564
LIG_Actin_WH2_2	597	614	PF00022	0.533
LIG_BIR_III_2	773	777	PF00653	0.587
LIG_BRCT_BRCA1_1	12	16	PF00533	0.666
LIG_Clathr_ClatBox_1	729	733	PF01394	0.443
LIG_deltaCOP1_diTrp_1	703	709	PF00928	0.562
LIG_FHA_1	112	118	PF00498	0.644
LIG_FHA_1	140	146	PF00498	0.567
LIG_FHA_1	329	335	PF00498	0.464
LIG_FHA_1	458	464	PF00498	0.491
LIG_FHA_1	580	586	PF00498	0.552
LIG_FHA_1	628	634	PF00498	0.366
LIG_FHA_1	671	677	PF00498	0.419
LIG_FHA_1	753	759	PF00498	0.481
LIG_FHA_2	167	173	PF00498	0.582
LIG_FHA_2	480	486	PF00498	0.544
LIG_FHA_2	530	536	PF00498	0.561
LIG_FHA_2	558	564	PF00498	0.593
LIG_FHA_2	600	606	PF00498	0.490
LIG_LIR_Gen_1	116	127	PF02991	0.399
LIG_LIR_Gen_1	130	137	PF02991	0.478
LIG_LIR_Gen_1	227	237	PF02991	0.628
LIG_LIR_Gen_1	456	466	PF02991	0.451
LIG_LIR_Gen_1	691	699	PF02991	0.436
LIG_LIR_Gen_1	759	769	PF02991	0.563
LIG_LIR_Nem_3	116	122	PF02991	0.419
LIG_LIR_Nem_3	130	134	PF02991	0.537
LIG_LIR_Nem_3	150	156	PF02991	0.520
LIG_LIR_Nem_3	227	233	PF02991	0.610
LIG_LIR_Nem_3	456	462	PF02991	0.427
LIG_LIR_Nem_3	691	697	PF02991	0.429
LIG_LIR_Nem_3	733	739	PF02991	0.427
LIG_LIR_Nem_3	759	765	PF02991	0.567
LIG_MLH1_MIPbox_1	12	16	PF16413	0.666
LIG_MYND_3	346	350	PF01753	0.531
LIG_NRBOX	457	463	PF00104	0.509
LIG_NRBOX	631	637	PF00104	0.548
LIG_PCNA_PIPBox_1	592	601	PF02747	0.564
LIG_PCNA_yPIPBox_3	794	808	PF02747	0.654
LIG_Pex14_1	705	709	PF04695	0.512
LIG_Pex14_2	127	131	PF04695	0.612
LIG_Rb_pABgroove_1	641	649	PF01858	0.533
LIG_RPA_C_Fungi	621	633	PF08784	0.564
LIG_SH2_NCK_1	587	591	PF00017	0.549
LIG_SH2_SRC	587	590	PF00017	0.550
LIG_SH2_STAP1	619	623	PF00017	0.331
LIG_SH2_STAP1	690	694	PF00017	0.448
LIG_SH2_STAT3	15	18	PF00017	0.701
LIG_SH2_STAT5	15	18	PF00017	0.666
LIG_SH3_3	428	434	PF00018	0.523
LIG_SH3_3	67	73	PF00018	0.625
LIG_SH3_3	754	760	PF00018	0.536
LIG_SUMO_SIM_anti_2	300	305	PF11976	0.431
LIG_SUMO_SIM_par_1	459	465	PF11976	0.488
LIG_TRAF2_1	268	271	PF00917	0.565
LIG_TRAF2_1	533	536	PF00917	0.563
LIG_UBA3_1	462	470	PF00899	0.431
MOD_CDK_SPK_2	1	6	PF00069	0.526
MOD_CK1_1	139	145	PF00069	0.600
MOD_CK1_1	245	251	PF00069	0.731
MOD_CK1_1	280	286	PF00069	0.663
MOD_CK1_1	497	503	PF00069	0.510
MOD_CK1_1	701	707	PF00069	0.603
MOD_CK2_1	438	444	PF00069	0.668
MOD_CK2_1	479	485	PF00069	0.458
MOD_CK2_1	511	517	PF00069	0.560
MOD_CK2_1	529	535	PF00069	0.392
MOD_CK2_1	557	563	PF00069	0.541
MOD_CK2_1	599	605	PF00069	0.490
MOD_GlcNHglycan	138	141	PF01048	0.605
MOD_GlcNHglycan	244	247	PF01048	0.674
MOD_GlcNHglycan	261	264	PF01048	0.623
MOD_GlcNHglycan	413	416	PF01048	0.669
MOD_GlcNHglycan	567	571	PF01048	0.558
MOD_GlcNHglycan	700	703	PF01048	0.529
MOD_GlcNHglycan	711	714	PF01048	0.479
MOD_GlcNHglycan	739	742	PF01048	0.374
MOD_GlcNHglycan	76	79	PF01048	0.710
MOD_GSK3_1	107	114	PF00069	0.662
MOD_GSK3_1	123	130	PF00069	0.502
MOD_GSK3_1	224	231	PF00069	0.682
MOD_GSK3_1	434	441	PF00069	0.662
MOD_GSK3_1	490	497	PF00069	0.558
MOD_GSK3_1	64	71	PF00069	0.728
MOD_GSK3_1	752	759	PF00069	0.315
MOD_N-GLC_1	627	632	PF02516	0.422
MOD_N-GLC_1	720	725	PF02516	0.486
MOD_N-GLC_2	82	84	PF02516	0.455
MOD_NEK2_1	228	233	PF00069	0.598
MOD_NEK2_1	277	282	PF00069	0.719
MOD_NEK2_1	323	328	PF00069	0.567
MOD_NEK2_1	494	499	PF00069	0.544
MOD_NEK2_1	537	542	PF00069	0.544
MOD_NEK2_1	548	553	PF00069	0.396
MOD_NEK2_1	599	604	PF00069	0.475
MOD_NEK2_1	765	770	PF00069	0.513
MOD_NEK2_2	479	484	PF00069	0.468
MOD_PIKK_1	280	286	PF00454	0.734
MOD_PIKK_1	588	594	PF00454	0.524
MOD_PKA_1	166	172	PF00069	0.543
MOD_PKA_1	737	743	PF00069	0.272
MOD_PKA_2	106	112	PF00069	0.726
MOD_PKA_2	127	133	PF00069	0.662
MOD_PKA_2	166	172	PF00069	0.543
MOD_PKA_2	185	191	PF00069	0.356
MOD_PKA_2	224	230	PF00069	0.691
MOD_PKA_2	323	329	PF00069	0.582
MOD_PKA_2	426	432	PF00069	0.531
MOD_Plk_1	228	234	PF00069	0.651
MOD_Plk_1	505	511	PF00069	0.553
MOD_Plk_1	537	543	PF00069	0.561
MOD_Plk_1	627	633	PF00069	0.421
MOD_Plk_2-3	224	230	PF00069	0.583
MOD_Plk_4	113	119	PF00069	0.473
MOD_Plk_4	185	191	PF00069	0.599
MOD_Plk_4	537	543	PF00069	0.566
MOD_Plk_4	814	820	PF00069	0.607
MOD_ProDKin_1	1	7	PF00069	0.734
MOD_ProDKin_1	10	16	PF00069	0.635
MOD_ProDKin_1	120	126	PF00069	0.544
MOD_ProDKin_1	264	270	PF00069	0.686
MOD_ProDKin_1	64	70	PF00069	0.788
MOD_ProDKin_1	756	762	PF00069	0.588
MOD_SUMO_for_1	297	300	PF00179	0.441
MOD_SUMO_rev_2	203	212	PF00179	0.606
TRG_DiLeu_BaEn_1	761	766	PF01217	0.561
TRG_DiLeu_LyEn_5	761	766	PF01217	0.561
TRG_ENDOCYTIC_2	395	398	PF00928	0.645
TRG_ENDOCYTIC_2	694	697	PF00928	0.470
TRG_ER_diArg_1	145	147	PF00400	0.628
TRG_ER_diArg_1	165	167	PF00400	0.372
TRG_ER_diArg_1	313	315	PF00400	0.402
TRG_ER_diArg_1	381	383	PF00400	0.586
TRG_ER_diArg_1	571	574	PF00400	0.526
TRG_ER_diArg_1	655	657	PF00400	0.473
TRG_ER_diArg_1	780	782	PF00400	0.663
TRG_Pf-PMV_PEXEL_1	396	400	PF00026	0.673
TRG_Pf-PMV_PEXEL_1	644	648	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	805	810	PF00026	0.646

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDX8	Leptomonas seymouri	46%	100%
A0A0S4JLD6	Bodo saltans	25%	100%
A0A451EJ96	Leishmania donovani	87%	100%
A4H365	Leishmania braziliensis	67%	97%
A4HRG2	Leishmania infantum	87%	100%
C9ZXI7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AC30	Leishmania major	87%	100%
V5DD57	Trypanosoma cruzi	26%	100%