Dymeclin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Dymeclin

Gene product:

Dyggve-Melchior-Clausen syndrome protein, putative

Species:

Leishmania mexicana

UniProt:

E9AJC6_LEIMU

TriTrypDb:

LmxM.01.0380

Length:

829

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AJC6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJC6

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0007030	Golgi organization	5	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	421	425	PF00656	0.346
CLV_C14_Caspase3-7	729	733	PF00656	0.723
CLV_NRD_NRD_1	5	7	PF00675	0.439
CLV_NRD_NRD_1	552	554	PF00675	0.173
CLV_NRD_NRD_1	698	700	PF00675	0.277
CLV_NRD_NRD_1	736	738	PF00675	0.499
CLV_NRD_NRD_1	746	748	PF00675	0.420
CLV_NRD_NRD_1	81	83	PF00675	0.358
CLV_PCSK_KEX2_1	552	554	PF00082	0.169
CLV_PCSK_KEX2_1	698	700	PF00082	0.275
CLV_PCSK_KEX2_1	736	738	PF00082	0.499
CLV_PCSK_KEX2_1	81	83	PF00082	0.358
CLV_PCSK_SKI1_1	106	110	PF00082	0.322
CLV_PCSK_SKI1_1	150	154	PF00082	0.291
CLV_PCSK_SKI1_1	174	178	PF00082	0.339
CLV_PCSK_SKI1_1	244	248	PF00082	0.218
CLV_PCSK_SKI1_1	317	321	PF00082	0.291
CLV_PCSK_SKI1_1	416	420	PF00082	0.457
CLV_PCSK_SKI1_1	437	441	PF00082	0.476
CLV_PCSK_SKI1_1	479	483	PF00082	0.356
CLV_PCSK_SKI1_1	664	668	PF00082	0.306
CLV_PCSK_SKI1_1	70	74	PF00082	0.262
CLV_Separin_Metazoa	171	175	PF03568	0.527
CLV_Separin_Metazoa	78	82	PF03568	0.474
DOC_ANK_TNKS_1	613	620	PF00023	0.483
DOC_CKS1_1	84	89	PF01111	0.362
DOC_CYCLIN_RxL_1	169	181	PF00134	0.539
DOC_CYCLIN_RxL_1	67	77	PF00134	0.484
DOC_MAPK_FxFP_2	445	448	PF00069	0.262
DOC_MAPK_gen_1	113	122	PF00069	0.369
DOC_MAPK_gen_1	68	75	PF00069	0.481
DOC_MAPK_MEF2A_6	443	452	PF00069	0.339
DOC_PP1_RVXF_1	435	441	PF00149	0.291
DOC_PP1_RVXF_1	66	72	PF00149	0.454
DOC_PP2B_LxvP_1	268	271	PF13499	0.491
DOC_PP4_FxxP_1	445	448	PF00568	0.248
DOC_PP4_FxxP_1	796	799	PF00568	0.525
DOC_USP7_MATH_1	125	129	PF00917	0.362
DOC_USP7_MATH_1	16	20	PF00917	0.623
DOC_USP7_MATH_1	160	164	PF00917	0.518
DOC_USP7_MATH_1	281	285	PF00917	0.427
DOC_USP7_MATH_1	487	491	PF00917	0.513
DOC_USP7_MATH_1	592	596	PF00917	0.540
DOC_WW_Pin1_4	202	207	PF00397	0.539
DOC_WW_Pin1_4	228	233	PF00397	0.483
DOC_WW_Pin1_4	333	338	PF00397	0.407
DOC_WW_Pin1_4	346	351	PF00397	0.480
DOC_WW_Pin1_4	471	476	PF00397	0.539
DOC_WW_Pin1_4	686	691	PF00397	0.504
DOC_WW_Pin1_4	83	88	PF00397	0.362
DOC_WW_Pin1_4	91	96	PF00397	0.539
LIG_14-3-3_CanoR_1	150	156	PF00244	0.526
LIG_14-3-3_CanoR_1	174	180	PF00244	0.575
LIG_14-3-3_CanoR_1	258	267	PF00244	0.493
LIG_14-3-3_CanoR_1	317	326	PF00244	0.522
LIG_14-3-3_CanoR_1	443	448	PF00244	0.309
LIG_14-3-3_CanoR_1	552	558	PF00244	0.507
LIG_14-3-3_CanoR_1	819	828	PF00244	0.604
LIG_Actin_WH2_2	536	551	PF00022	0.477
LIG_Actin_WH2_2	598	616	PF00022	0.539
LIG_Actin_WH2_2	93	108	PF00022	0.504
LIG_APCC_ABBA_1	195	200	PF00400	0.444
LIG_BRCT_BRCA1_1	445	449	PF00533	0.248
LIG_BRCT_BRCA1_1	792	796	PF00533	0.533
LIG_BRCT_BRCA1_1	9	13	PF00533	0.602
LIG_DLG_GKlike_1	239	246	PF00625	0.362
LIG_FHA_1	12	18	PF00498	0.602
LIG_FHA_1	142	148	PF00498	0.529
LIG_FHA_1	192	198	PF00498	0.483
LIG_FHA_1	273	279	PF00498	0.568
LIG_FHA_1	292	298	PF00498	0.388
LIG_FHA_1	318	324	PF00498	0.558
LIG_FHA_1	408	414	PF00498	0.352
LIG_FHA_1	454	460	PF00498	0.297
LIG_FHA_1	472	478	PF00498	0.539
LIG_FHA_1	543	549	PF00498	0.519
LIG_FHA_1	552	558	PF00498	0.490
LIG_FHA_1	64	70	PF00498	0.455
LIG_FHA_1	661	667	PF00498	0.537
LIG_FHA_1	92	98	PF00498	0.463
LIG_FHA_2	166	172	PF00498	0.457
LIG_FHA_2	419	425	PF00498	0.261
LIG_FHA_2	592	598	PF00498	0.566
LIG_FHA_2	649	655	PF00498	0.362
LIG_GBD_Chelix_1	396	404	PF00786	0.457
LIG_LIR_Apic_2	221	225	PF02991	0.405
LIG_LIR_Apic_2	793	799	PF02991	0.529
LIG_LIR_Gen_1	151	161	PF02991	0.390
LIG_LIR_Gen_1	196	206	PF02991	0.448
LIG_LIR_Gen_1	310	319	PF02991	0.539
LIG_LIR_Gen_1	352	360	PF02991	0.509
LIG_LIR_Gen_1	380	389	PF02991	0.328
LIG_LIR_Gen_1	446	457	PF02991	0.331
LIG_LIR_Gen_1	786	794	PF02991	0.579
LIG_LIR_Nem_3	151	156	PF02991	0.401
LIG_LIR_Nem_3	196	201	PF02991	0.452
LIG_LIR_Nem_3	242	246	PF02991	0.481
LIG_LIR_Nem_3	310	315	PF02991	0.539
LIG_LIR_Nem_3	352	356	PF02991	0.509
LIG_LIR_Nem_3	365	370	PF02991	0.387
LIG_LIR_Nem_3	380	385	PF02991	0.250
LIG_LIR_Nem_3	446	452	PF02991	0.289
LIG_LIR_Nem_3	786	790	PF02991	0.577
LIG_LIR_Nem_3	793	797	PF02991	0.521
LIG_LYPXL_SIV_4	658	666	PF13949	0.362
LIG_LYPXL_yS_3	447	450	PF13949	0.308
LIG_MLH1_MIPbox_1	9	13	PF16413	0.602
LIG_NRBOX	172	178	PF00104	0.539
LIG_NRBOX	211	217	PF00104	0.510
LIG_NRBOX	369	375	PF00104	0.364
LIG_NRBOX	399	405	PF00104	0.257
LIG_PCNA_yPIPBox_3	505	518	PF02747	0.248
LIG_Pex14_2	243	247	PF04695	0.546
LIG_Pex14_2	445	449	PF04695	0.248
LIG_Pex14_2	796	800	PF04695	0.528
LIG_SH2_NCK_1	659	663	PF00017	0.457
LIG_SH2_PTP2	375	378	PF00017	0.334
LIG_SH2_STAP1	485	489	PF00017	0.539
LIG_SH2_STAP1	636	640	PF00017	0.439
LIG_SH2_STAT3	535	538	PF00017	0.462
LIG_SH2_STAT3	609	612	PF00017	0.491
LIG_SH2_STAT5	12	15	PF00017	0.513
LIG_SH2_STAT5	266	269	PF00017	0.539
LIG_SH2_STAT5	341	344	PF00017	0.456
LIG_SH2_STAT5	375	378	PF00017	0.289
LIG_SH2_STAT5	535	538	PF00017	0.484
LIG_SH2_STAT5	609	612	PF00017	0.491
LIG_SH2_STAT5	640	643	PF00017	0.534
LIG_SH3_3	154	160	PF00018	0.462
LIG_SH3_3	251	257	PF00018	0.457
LIG_SH3_3	295	301	PF00018	0.491
LIG_SH3_3	48	54	PF00018	0.523
LIG_SH3_3	514	520	PF00018	0.289
LIG_SH3_3	81	87	PF00018	0.491
LIG_SH3_3	822	828	PF00018	0.736
LIG_SUMO_SIM_anti_2	168	174	PF11976	0.472
LIG_SUMO_SIM_anti_2	210	216	PF11976	0.457
LIG_SUMO_SIM_anti_2	352	359	PF11976	0.581
LIG_SUMO_SIM_anti_2	454	462	PF11976	0.290
LIG_SUMO_SIM_anti_2	692	698	PF11976	0.463
LIG_SUMO_SIM_anti_2	780	786	PF11976	0.705
LIG_SUMO_SIM_par_1	266	273	PF11976	0.527
LIG_SUMO_SIM_par_1	454	462	PF11976	0.310
LIG_SUMO_SIM_par_1	495	500	PF11976	0.370
LIG_TRAF2_1	139	142	PF00917	0.362
LIG_TRAF2_1	689	692	PF00917	0.507
LIG_TRAF2_1	786	789	PF00917	0.666
LIG_TYR_ITIM	373	378	PF00017	0.289
LIG_TYR_ITIM	634	639	PF00017	0.448
LIG_UBA3_1	104	113	PF00899	0.578
LIG_UBA3_1	322	331	PF00899	0.448
LIG_UBA3_1	666	675	PF00899	0.527
MOD_CK1_1	272	278	PF00069	0.560
MOD_CK1_1	349	355	PF00069	0.469
MOD_CK1_1	580	586	PF00069	0.553
MOD_CK1_1	710	716	PF00069	0.683
MOD_CK1_1	757	763	PF00069	0.741
MOD_CK2_1	125	131	PF00069	0.438
MOD_CK2_1	165	171	PF00069	0.537
MOD_CK2_1	307	313	PF00069	0.462
MOD_CK2_1	591	597	PF00069	0.553
MOD_CK2_1	648	654	PF00069	0.447
MOD_CK2_1	686	692	PF00069	0.510
MOD_CK2_1	783	789	PF00069	0.647
MOD_GlcNHglycan	115	118	PF01048	0.322
MOD_GlcNHglycan	162	165	PF01048	0.320
MOD_GlcNHglycan	181	184	PF01048	0.155
MOD_GlcNHglycan	272	275	PF01048	0.337
MOD_GlcNHglycan	278	281	PF01048	0.329
MOD_GlcNHglycan	283	286	PF01048	0.326
MOD_GlcNHglycan	289	292	PF01048	0.317
MOD_GlcNHglycan	486	490	PF01048	0.291
MOD_GlcNHglycan	554	557	PF01048	0.272
MOD_GlcNHglycan	585	588	PF01048	0.334
MOD_GlcNHglycan	594	597	PF01048	0.314
MOD_GlcNHglycan	715	718	PF01048	0.569
MOD_GlcNHglycan	722	726	PF01048	0.615
MOD_GlcNHglycan	741	744	PF01048	0.508
MOD_GlcNHglycan	759	762	PF01048	0.515
MOD_GlcNHglycan	806	809	PF01048	0.469
MOD_GSK3_1	109	116	PF00069	0.499
MOD_GSK3_1	125	132	PF00069	0.397
MOD_GSK3_1	175	182	PF00069	0.482
MOD_GSK3_1	272	279	PF00069	0.526
MOD_GSK3_1	287	294	PF00069	0.545
MOD_GSK3_1	342	349	PF00069	0.517
MOD_GSK3_1	407	414	PF00069	0.263
MOD_GSK3_1	552	559	PF00069	0.499
MOD_GSK3_1	577	584	PF00069	0.580
MOD_GSK3_1	587	594	PF00069	0.568
MOD_GSK3_1	7	14	PF00069	0.583
MOD_GSK3_1	707	714	PF00069	0.716
MOD_GSK3_1	750	757	PF00069	0.764
MOD_GSK3_1	773	780	PF00069	0.697
MOD_N-GLC_1	407	412	PF02516	0.535
MOD_N-GLC_1	739	744	PF02516	0.485
MOD_N-GLC_2	307	309	PF02516	0.257
MOD_NEK2_1	109	114	PF00069	0.520
MOD_NEK2_1	148	153	PF00069	0.471
MOD_NEK2_1	175	180	PF00069	0.426
MOD_NEK2_1	201	206	PF00069	0.481
MOD_NEK2_1	215	220	PF00069	0.430
MOD_NEK2_1	250	255	PF00069	0.490
MOD_NEK2_1	305	310	PF00069	0.539
MOD_NEK2_1	356	361	PF00069	0.465
MOD_NEK2_1	384	389	PF00069	0.250
MOD_NEK2_1	395	400	PF00069	0.226
MOD_NEK2_1	404	409	PF00069	0.145
MOD_NEK2_1	417	422	PF00069	0.234
MOD_NEK2_1	452	457	PF00069	0.276
MOD_NEK2_1	543	548	PF00069	0.491
MOD_NEK2_1	558	563	PF00069	0.466
MOD_NEK2_1	801	806	PF00069	0.470
MOD_PIKK_1	459	465	PF00454	0.284
MOD_PIKK_1	707	713	PF00454	0.767
MOD_PK_1	754	760	PF00069	0.570
MOD_PKA_1	552	558	PF00069	0.418
MOD_PKA_2	109	115	PF00069	0.529
MOD_PKA_2	223	229	PF00069	0.423
MOD_PKA_2	411	417	PF00069	0.356
MOD_PKA_2	551	557	PF00069	0.499
MOD_PKA_2	818	824	PF00069	0.660
MOD_Plk_1	191	197	PF00069	0.524
MOD_Plk_1	748	754	PF00069	0.678
MOD_Plk_1	764	770	PF00069	0.572
MOD_Plk_2-3	730	736	PF00069	0.636
MOD_Plk_2-3	777	783	PF00069	0.715
MOD_Plk_4	215	221	PF00069	0.509
MOD_Plk_4	349	355	PF00069	0.524
MOD_Plk_4	368	374	PF00069	0.253
MOD_Plk_4	384	390	PF00069	0.214
MOD_Plk_4	453	459	PF00069	0.300
MOD_Plk_4	754	760	PF00069	0.700
MOD_Plk_4	801	807	PF00069	0.545
MOD_ProDKin_1	202	208	PF00069	0.539
MOD_ProDKin_1	228	234	PF00069	0.483
MOD_ProDKin_1	333	339	PF00069	0.407
MOD_ProDKin_1	346	352	PF00069	0.480
MOD_ProDKin_1	471	477	PF00069	0.539
MOD_ProDKin_1	686	692	PF00069	0.504
MOD_ProDKin_1	83	89	PF00069	0.362
MOD_ProDKin_1	91	97	PF00069	0.539
MOD_SUMO_rev_2	742	750	PF00179	0.592
TRG_DiLeu_BaEn_1	171	176	PF01217	0.432
TRG_DiLeu_BaEn_1	391	396	PF01217	0.348
TRG_DiLeu_BaLyEn_6	203	208	PF01217	0.553
TRG_DiLeu_BaLyEn_6	466	471	PF01217	0.491
TRG_DiLeu_LyEn_5	171	176	PF01217	0.527
TRG_ENDOCYTIC_2	375	378	PF00928	0.274
TRG_ENDOCYTIC_2	382	385	PF00928	0.237
TRG_ENDOCYTIC_2	447	450	PF00928	0.308
TRG_ENDOCYTIC_2	636	639	PF00928	0.439
TRG_ENDOCYTIC_2	787	790	PF00928	0.586
TRG_ENDOCYTIC_2	794	797	PF00928	0.521
TRG_ER_diArg_1	551	553	PF00400	0.375
TRG_ER_diArg_1	641	644	PF00400	0.446
TRG_ER_diArg_1	68	71	PF00400	0.449
TRG_ER_diArg_1	697	699	PF00400	0.478
TRG_ER_diArg_1	80	82	PF00400	0.492
TRG_ER_FFAT_2	8	18	PF00635	0.558
TRG_NES_CRM1_1	604	618	PF08389	0.491
TRG_NLS_MonoExtC_3	548	553	PF00514	0.375
TRG_Pf-PMV_PEXEL_1	437	441	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	505	509	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	614	618	PF00026	0.288
TRG_Pf-PMV_PEXEL_1	644	648	PF00026	0.240

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6M9	Leptomonas seymouri	53%	98%
A0A0S4JPV7	Bodo saltans	26%	100%
A0A1X0P2R5	Trypanosomatidae	32%	100%
A0A3S5H4V0	Leishmania donovani	88%	100%
A0A422NY99	Trypanosoma rangeli	33%	100%
A4H364	Leishmania braziliensis	73%	98%
A4HRG1	Leishmania infantum	88%	100%
C9ZXI6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AC29	Leishmania major	85%	98%
V5AX12	Trypanosoma cruzi	34%	100%