Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJC4_LEIMU

TriTrypDb:

LmxM.01.0360

Length:

191

Annotations

LeishMANIAdb annotations

This protein appears to have an Ala-rich signal peptide and a single TM segment

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AJC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJC4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	75	79	PF00656	0.713
CLV_NRD_NRD_1	142	144	PF00675	0.561
CLV_NRD_NRD_1	179	181	PF00675	0.726
CLV_NRD_NRD_1	188	190	PF00675	0.707
CLV_NRD_NRD_1	66	68	PF00675	0.377
CLV_PCSK_FUR_1	177	181	PF00082	0.593
CLV_PCSK_FUR_1	74	78	PF00082	0.508
CLV_PCSK_KEX2_1	142	144	PF00082	0.548
CLV_PCSK_KEX2_1	177	179	PF00082	0.731
CLV_PCSK_KEX2_1	18	20	PF00082	0.537
CLV_PCSK_KEX2_1	188	190	PF00082	0.701
CLV_PCSK_KEX2_1	66	68	PF00082	0.424
CLV_PCSK_KEX2_1	76	78	PF00082	0.505
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.503
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.480
CLV_PCSK_SKI1_1	7	11	PF00082	0.531
DEG_SPOP_SBC_1	167	171	PF00917	0.405
DOC_MAPK_gen_1	118	127	PF00069	0.546
DOC_MAPK_RevD_3	53	67	PF00069	0.572
DOC_PP2B_LxvP_1	23	26	PF13499	0.701
DOC_PP4_MxPP_1	1	4	PF00568	0.703
DOC_USP7_MATH_1	167	171	PF00917	0.457
DOC_USP7_UBL2_3	72	76	PF12436	0.661
DOC_WW_Pin1_4	54	59	PF00397	0.669
LIG_14-3-3_CanoR_1	41	49	PF00244	0.774
LIG_14-3-3_CanoR_1	66	70	PF00244	0.619
LIG_Actin_WH2_2	28	43	PF00022	0.709
LIG_BIR_II_1	1	5	PF00653	0.692
LIG_BIR_III_1	1	5	PF00653	0.692
LIG_BIR_III_3	1	5	PF00653	0.692
LIG_EH_1	138	142	PF12763	0.422
LIG_FHA_1	31	37	PF00498	0.634
LIG_FHA_1	8	14	PF00498	0.710
LIG_FHA_2	66	72	PF00498	0.730
LIG_FXI_DFP_1	89	93	PF00024	0.511
LIG_LIR_Apic_2	144	149	PF02991	0.487
LIG_LIR_Gen_1	68	75	PF02991	0.655
LIG_LIR_Gen_1	86	96	PF02991	0.608
LIG_LIR_Nem_3	68	73	PF02991	0.651
LIG_LIR_Nem_3	86	92	PF02991	0.613
LIG_Pex14_2	123	127	PF04695	0.223
LIG_SH2_CRK	70	74	PF00017	0.686
LIG_SH2_STAT5	136	139	PF00017	0.511
LIG_SH3_2	93	98	PF14604	0.703
LIG_SH3_3	134	140	PF00018	0.405
LIG_SH3_3	46	52	PF00018	0.698
LIG_SH3_3	90	96	PF00018	0.715
LIG_TRFH_1	136	140	PF08558	0.471
LIG_TYR_ITSM	66	73	PF00017	0.651
MOD_CK1_1	169	175	PF00069	0.455
MOD_CK1_1	39	45	PF00069	0.725
MOD_CK1_1	65	71	PF00069	0.616
MOD_CK2_1	108	114	PF00069	0.580
MOD_CK2_1	77	83	PF00069	0.744
MOD_GlcNHglycan	110	113	PF01048	0.329
MOD_GlcNHglycan	131	134	PF01048	0.242
MOD_GSK3_1	166	173	PF00069	0.415
MOD_GSK3_1	36	43	PF00069	0.760
MOD_N-GLC_1	108	113	PF02516	0.383
MOD_NEK2_1	129	134	PF00069	0.223
MOD_NEK2_1	166	171	PF00069	0.403
MOD_NEK2_1	31	36	PF00069	0.698
MOD_NEK2_1	40	45	PF00069	0.625
MOD_NEK2_1	62	67	PF00069	0.781
MOD_PKA_2	14	20	PF00069	0.710
MOD_PKA_2	40	46	PF00069	0.707
MOD_PKA_2	65	71	PF00069	0.559
MOD_Plk_1	108	114	PF00069	0.580
MOD_Plk_4	31	37	PF00069	0.678
MOD_ProDKin_1	54	60	PF00069	0.669
MOD_SUMO_rev_2	150	160	PF00179	0.460
TRG_ENDOCYTIC_2	70	73	PF00928	0.684
TRG_ER_diArg_1	141	143	PF00400	0.348
TRG_ER_diArg_1	177	180	PF00400	0.529
TRG_ER_diArg_1	187	189	PF00400	0.507
TRG_ER_diArg_1	98	101	PF00400	0.707

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H4U8	Leishmania donovani	83%	100%
A4H362	Leishmania braziliensis	69%	100%
A4HRF9	Leishmania infantum	84%	100%
E9AC27	Leishmania major	83%	99%