Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJC2_LEIMU

TriTrypDb:

LmxM.01.0340

Length:

258

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9AJC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJC2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.382
CLV_NRD_NRD_1	213	215	PF00675	0.465
CLV_NRD_NRD_1	39	41	PF00675	0.449
CLV_PCSK_FUR_1	10	14	PF00082	0.395
CLV_PCSK_FUR_1	211	215	PF00082	0.351
CLV_PCSK_KEX2_1	12	14	PF00082	0.395
CLV_PCSK_KEX2_1	211	213	PF00082	0.422
CLV_PCSK_SKI1_1	154	158	PF00082	0.349
CLV_PCSK_SKI1_1	61	65	PF00082	0.544
DEG_SPOP_SBC_1	88	92	PF00917	0.608
DOC_CDC14_PxL_1	226	234	PF14671	0.444
DOC_CKS1_1	189	194	PF01111	0.414
DOC_CYCLIN_yClb5_NLxxxL_5	236	245	PF00134	0.543
DOC_CYCLIN_yCln2_LP_2	215	221	PF00134	0.655
DOC_MAPK_MEF2A_6	135	144	PF00069	0.653
DOC_MAPK_MEF2A_6	213	222	PF00069	0.570
DOC_PP2B_LxvP_1	215	218	PF13499	0.661
DOC_USP7_MATH_1	228	232	PF00917	0.444
DOC_USP7_MATH_1	62	66	PF00917	0.700
DOC_USP7_MATH_1	78	82	PF00917	0.758
DOC_USP7_MATH_1	86	90	PF00917	0.783
DOC_USP7_UBL2_3	41	45	PF12436	0.647
DOC_WW_Pin1_4	112	117	PF00397	0.763
DOC_WW_Pin1_4	188	193	PF00397	0.352
DOC_WW_Pin1_4	50	55	PF00397	0.780
LIG_14-3-3_CanoR_1	212	218	PF00244	0.612
LIG_14-3-3_CanoR_1	61	67	PF00244	0.705
LIG_APCC_ABBA_1	145	150	PF00400	0.646
LIG_BIR_II_1	1	5	PF00653	0.718
LIG_BIR_III_2	227	231	PF00653	0.444
LIG_FHA_1	3	9	PF00498	0.682
LIG_FHA_2	113	119	PF00498	0.564
LIG_FHA_2	176	182	PF00498	0.415
LIG_FHA_2	71	77	PF00498	0.755
LIG_GBD_Chelix_1	237	245	PF00786	0.543
LIG_LIR_Gen_1	43	54	PF02991	0.681
LIG_LIR_Nem_3	43	49	PF02991	0.612
LIG_PDZ_Class_2	253	258	PF00595	0.462
LIG_Pex14_2	144	148	PF04695	0.668
LIG_REV1ctd_RIR_1	141	150	PF16727	0.674
LIG_SH2_CRK	15	19	PF00017	0.601
LIG_SH2_PTP2	223	226	PF00017	0.408
LIG_SH2_STAT5	223	226	PF00017	0.270
LIG_SH3_3	176	182	PF00018	0.388
LIG_SH3_3	48	54	PF00018	0.673
LIG_SH3_3	64	70	PF00018	0.747
LIG_SH3_3	74	80	PF00018	0.802
LIG_SH3_3	95	101	PF00018	0.760
LIG_SUMO_SIM_anti_2	242	247	PF11976	0.432
LIG_TRAF2_1	73	76	PF00917	0.786
MOD_CK1_1	188	194	PF00069	0.424
MOD_CK1_1	2	8	PF00069	0.671
MOD_CK1_1	206	212	PF00069	0.603
MOD_CK1_1	28	34	PF00069	0.697
MOD_CK1_1	87	93	PF00069	0.691
MOD_CK2_1	1	7	PF00069	0.744
MOD_CK2_1	70	76	PF00069	0.783
MOD_CK2_1	87	93	PF00069	0.676
MOD_GlcNHglycan	215	218	PF01048	0.429
MOD_GlcNHglycan	27	30	PF01048	0.510
MOD_GlcNHglycan	64	67	PF01048	0.554
MOD_GlcNHglycan	70	73	PF01048	0.606
MOD_GlcNHglycan	86	89	PF01048	0.380
MOD_GSK3_1	148	155	PF00069	0.612
MOD_GSK3_1	181	188	PF00069	0.455
MOD_GSK3_1	199	206	PF00069	0.188
MOD_GSK3_1	21	28	PF00069	0.707
MOD_GSK3_1	84	91	PF00069	0.711
MOD_N-GLC_1	148	153	PF02516	0.412
MOD_N-GLC_1	239	244	PF02516	0.600
MOD_NEK2_1	1	6	PF00069	0.695
MOD_NEK2_1	148	153	PF00069	0.657
MOD_NEK2_1	175	180	PF00069	0.443
MOD_NEK2_1	241	246	PF00069	0.371
MOD_NEK2_1	25	30	PF00069	0.732
MOD_PIKK_1	206	212	PF00454	0.608
MOD_PKA_1	213	219	PF00069	0.609
MOD_PKA_2	21	27	PF00069	0.696
MOD_PKA_2	213	219	PF00069	0.526
MOD_PKB_1	211	219	PF00069	0.532
MOD_Plk_1	2	8	PF00069	0.647
MOD_Plk_1	239	245	PF00069	0.402
MOD_Plk_4	152	158	PF00069	0.528
MOD_Plk_4	175	181	PF00069	0.380
MOD_Plk_4	185	191	PF00069	0.301
MOD_Plk_4	241	247	PF00069	0.403
MOD_ProDKin_1	112	118	PF00069	0.763
MOD_ProDKin_1	188	194	PF00069	0.352
MOD_ProDKin_1	50	56	PF00069	0.783
MOD_SUMO_rev_2	37	47	PF00179	0.644
TRG_DiLeu_BaEn_4	37	43	PF01217	0.633
TRG_ENDOCYTIC_2	15	18	PF00928	0.581
TRG_ENDOCYTIC_2	223	226	PF00928	0.344
TRG_ENDOCYTIC_2	46	49	PF00928	0.613
TRG_ER_diArg_1	10	13	PF00400	0.596
TRG_ER_diArg_1	211	214	PF00400	0.666
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.460

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8C0	Leptomonas seymouri	41%	97%
A0A1X0P2R1	Trypanosomatidae	27%	100%
A0A3R7NR92	Trypanosoma rangeli	27%	95%
A0A3S5H4U7	Leishmania donovani	84%	100%
A4H360	Leishmania braziliensis	62%	100%
A4HRF7	Leishmania infantum	85%	100%
E9AC25	Leishmania major	85%	100%
V5AQ19	Trypanosoma cruzi	28%	88%