Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJC0_LEIMU

TriTrypDb:

LmxM.01.0330

Length:

210

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005737	cytoplasm	2	1
GO:0005787	signal peptidase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1905368	peptidase complex	3	1

Expansion

Sequence features

E9AJC0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJC0

Function

Biological processes
Term	Name	Level	Count
GO:0006465	signal peptide processing	5	1
GO:0006508	proteolysis	4	1
GO:0006518	peptide metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043603	amide metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008233	peptidase activity	3	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	128	130	PF00675	0.379
CLV_PCSK_SKI1_1	129	133	PF00082	0.356
CLV_PCSK_SKI1_1	30	34	PF00082	0.391
CLV_PCSK_SKI1_1	54	58	PF00082	0.287
CLV_PCSK_SKI1_1	59	63	PF00082	0.330
DOC_MAPK_FxFP_2	187	190	PF00069	0.525
DOC_MAPK_gen_1	129	138	PF00069	0.512
DOC_MAPK_MEF2A_6	132	140	PF00069	0.498
DOC_PP4_FxxP_1	163	166	PF00568	0.612
DOC_PP4_FxxP_1	187	190	PF00568	0.509
DOC_USP7_MATH_1	203	207	PF00917	0.551
DOC_WW_Pin1_4	116	121	PF00397	0.586
DOC_WW_Pin1_4	161	166	PF00397	0.580
LIG_14-3-3_CanoR_1	139	146	PF00244	0.555
LIG_14-3-3_CanoR_1	30	39	PF00244	0.544
LIG_BIR_II_1	1	5	PF00653	0.688
LIG_BRCT_BRCA1_1	159	163	PF00533	0.585
LIG_BRCT_BRCA1_1	183	187	PF00533	0.613
LIG_BRCT_BRCA1_1	84	88	PF00533	0.349
LIG_Clathr_ClatBox_1	149	153	PF01394	0.485
LIG_FHA_1	111	117	PF00498	0.518
LIG_FHA_1	31	37	PF00498	0.521
LIG_FHA_1	60	66	PF00498	0.349
LIG_FHA_2	2	8	PF00498	0.623
LIG_LIR_Apic_2	160	166	PF02991	0.617
LIG_LIR_Apic_2	184	190	PF02991	0.522
LIG_LIR_Gen_1	84	94	PF02991	0.250
LIG_LIR_Nem_3	143	149	PF02991	0.656
LIG_LIR_Nem_3	175	181	PF02991	0.528
LIG_LIR_Nem_3	38	42	PF02991	0.583
LIG_LIR_Nem_3	84	89	PF02991	0.334
LIG_PCNA_yPIPBox_3	194	208	PF02747	0.592
LIG_SH2_CRK	146	150	PF00017	0.436
LIG_SH2_NCK_1	169	173	PF00017	0.539
LIG_SH2_STAT5	39	42	PF00017	0.510
LIG_SH2_STAT5	70	73	PF00017	0.387
LIG_SH3_2	120	125	PF14604	0.469
LIG_SH3_3	117	123	PF00018	0.479
LIG_SH3_3	74	80	PF00018	0.261
LIG_TYR_ITIM	40	45	PF00017	0.548
LIG_WW_1	166	169	PF00397	0.391
MOD_CDC14_SPxK_1	119	122	PF00782	0.331
MOD_CDK_SPxK_1	116	122	PF00069	0.321
MOD_CK2_1	1	7	PF00069	0.610
MOD_CK2_1	167	173	PF00069	0.449
MOD_GlcNHglycan	77	80	PF01048	0.449
MOD_GSK3_1	157	164	PF00069	0.513
MOD_NEK2_1	1	6	PF00069	0.654
MOD_NEK2_1	110	115	PF00069	0.258
MOD_NEK2_1	181	186	PF00069	0.507
MOD_NEK2_1	75	80	PF00069	0.428
MOD_NEK2_1	81	86	PF00069	0.274
MOD_NEK2_1	97	102	PF00069	0.316
MOD_PIKK_1	138	144	PF00454	0.467
MOD_PIKK_1	167	173	PF00454	0.552
MOD_PKA_2	138	144	PF00069	0.407
MOD_PKA_2	75	81	PF00069	0.275
MOD_Plk_1	172	178	PF00069	0.473
MOD_Plk_4	1	7	PF00069	0.566
MOD_Plk_4	141	147	PF00069	0.344
MOD_Plk_4	82	88	PF00069	0.340
MOD_Plk_4	97	103	PF00069	0.408
MOD_ProDKin_1	116	122	PF00069	0.474
MOD_ProDKin_1	161	167	PF00069	0.463
MOD_SUMO_for_1	150	153	PF00179	0.373
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.320
TRG_DiLeu_BaLyEn_6	77	82	PF01217	0.177
TRG_ENDOCYTIC_2	146	149	PF00928	0.283
TRG_ENDOCYTIC_2	169	172	PF00928	0.382
TRG_ENDOCYTIC_2	178	181	PF00928	0.354
TRG_ENDOCYTIC_2	42	45	PF00928	0.435
TRG_ER_diLys_1	207	210	PF00400	0.537
TRG_NES_CRM1_1	143	155	PF08389	0.251
TRG_Pf-PMV_PEXEL_1	129	134	PF00026	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JMH0	Bodo saltans	29%	77%
A0A1X0P325	Trypanosomatidae	33%	94%
A0A3S5H4U6	Leishmania donovani	91%	100%
A0A3S5ISA1	Trypanosoma rangeli	31%	92%
A4H358	Leishmania braziliensis	75%	100%
A4HRF5	Leishmania infantum	91%	100%
C9ZXH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	95%
E9AC23	Leishmania major	90%	100%