DUF1279 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJB8_LEIMU

TriTrypDb:

LmxM.01.0315

Length:

143

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AJB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJB8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	127	129	PF00082	0.502
CLV_PCSK_PC1ET2_1	127	129	PF00082	0.406
CLV_PCSK_SKI1_1	132	136	PF00082	0.344
DEG_Nend_Nbox_1	1	3	PF02207	0.669
DOC_CDC14_PxL_1	120	128	PF14671	0.477
DOC_CKS1_1	110	115	PF01111	0.304
DOC_CYCLIN_RxL_1	4	16	PF00134	0.536
DOC_CYCLIN_yCln2_LP_2	110	116	PF00134	0.304
DOC_MAPK_DCC_7	4	14	PF00069	0.542
DOC_MAPK_gen_1	4	14	PF00069	0.542
DOC_WW_Pin1_4	109	114	PF00397	0.304
LIG_14-3-3_CanoR_1	128	134	PF00244	0.537
LIG_14-3-3_CanoR_1	17	22	PF00244	0.661
LIG_CSL_BTD_1	110	113	PF09270	0.304
LIG_FHA_1	21	27	PF00498	0.565
LIG_FHA_1	37	43	PF00498	0.369
LIG_FHA_1	46	52	PF00498	0.315
LIG_GBD_Chelix_1	43	51	PF00786	0.304
LIG_LIR_Gen_1	105	114	PF02991	0.304
LIG_LIR_Gen_1	71	79	PF02991	0.384
LIG_LIR_Gen_1	83	92	PF02991	0.404
LIG_LIR_Nem_3	105	110	PF02991	0.317
LIG_LIR_Nem_3	122	126	PF02991	0.663
LIG_LIR_Nem_3	33	38	PF02991	0.325
LIG_LIR_Nem_3	71	76	PF02991	0.391
LIG_LIR_Nem_3	83	87	PF02991	0.457
LIG_LYPXL_yS_3	123	126	PF13949	0.595
LIG_NRBOX	42	48	PF00104	0.369
LIG_PCNA_PIPBox_1	58	67	PF02747	0.420
LIG_PCNA_yPIPBox_3	58	72	PF02747	0.422
LIG_Pex14_2	107	111	PF04695	0.304
LIG_SH2_PTP2	73	76	PF00017	0.378
LIG_SH2_STAT3	55	58	PF00017	0.442
LIG_SH2_STAT5	125	128	PF00017	0.557
LIG_SH2_STAT5	36	39	PF00017	0.304
LIG_SH2_STAT5	55	58	PF00017	0.413
LIG_SH2_STAT5	73	76	PF00017	0.309
LIG_SH3_3	111	117	PF00018	0.369
LIG_SH3_3	136	142	PF00018	0.628
LIG_SH3_3	5	11	PF00018	0.631
LIG_SUMO_SIM_par_1	10	16	PF11976	0.534
LIG_SUMO_SIM_par_1	22	27	PF11976	0.510
LIG_UBA3_1	61	66	PF00899	0.409
MOD_CK1_1	109	115	PF00069	0.304
MOD_CK1_1	20	26	PF00069	0.711
MOD_GlcNHglycan	135	138	PF01048	0.371
MOD_GlcNHglycan	93	96	PF01048	0.558
MOD_GSK3_1	102	109	PF00069	0.307
MOD_GSK3_1	13	20	PF00069	0.690
MOD_GSK3_1	133	140	PF00069	0.605
MOD_GSK3_1	64	71	PF00069	0.391
MOD_LATS_1	15	21	PF00433	0.595
MOD_N-GLC_1	99	104	PF02516	0.583
MOD_NEK2_1	106	111	PF00069	0.319
MOD_NEK2_1	133	138	PF00069	0.539
MOD_NEK2_1	64	69	PF00069	0.435
MOD_NEK2_1	91	96	PF00069	0.401
MOD_PIKK_1	127	133	PF00454	0.618
MOD_PKA_1	127	133	PF00069	0.588
MOD_PKA_2	127	133	PF00069	0.588
MOD_Plk_2-3	75	81	PF00069	0.455
MOD_Plk_4	102	108	PF00069	0.402
MOD_Plk_4	30	36	PF00069	0.600
MOD_ProDKin_1	109	115	PF00069	0.304
MOD_SUMO_rev_2	75	83	PF00179	0.389
TRG_ENDOCYTIC_2	123	126	PF00928	0.655
TRG_ENDOCYTIC_2	35	38	PF00928	0.304
TRG_ENDOCYTIC_2	53	56	PF00928	0.452
TRG_ENDOCYTIC_2	73	76	PF00928	0.352

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IR53	Bodo saltans	41%	74%
A0A451EJ88	Leishmania donovani	92%	100%
A4H356	Leishmania braziliensis	76%	100%
E9AC21	Leishmania major	93%	100%
E9AG17	Leishmania infantum	92%	100%