Putative acidocalcisomal exopolyphosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acidocalcisomal exopolyphosphatase, putative

Species:

Leishmania mexicana

UniProt:

E9AJB7_LEIMU

TriTrypDb:

LmxM.01.0310

Length:

387

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9AJB7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJB7

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006797	polyphosphate metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004309	exopolyphosphatase activity	6	8
GO:0005488	binding	1	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.407
CLV_C14_Caspase3-7	334	338	PF00656	0.477
CLV_NRD_NRD_1	10	12	PF00675	0.383
CLV_NRD_NRD_1	244	246	PF00675	0.216
CLV_NRD_NRD_1	367	369	PF00675	0.235
CLV_PCSK_KEX2_1	10	12	PF00082	0.348
CLV_PCSK_KEX2_1	244	246	PF00082	0.216
CLV_PCSK_SKI1_1	11	15	PF00082	0.446
CLV_PCSK_SKI1_1	196	200	PF00082	0.378
CLV_Separin_Metazoa	241	245	PF03568	0.426
DEG_APCC_DBOX_1	9	17	PF00400	0.376
DOC_CYCLIN_yCln2_LP_2	180	186	PF00134	0.264
DOC_MAPK_DCC_7	15	25	PF00069	0.394
DOC_MAPK_gen_1	229	237	PF00069	0.472
DOC_MAPK_MEF2A_6	231	239	PF00069	0.447
DOC_MAPK_RevD_3	182	197	PF00069	0.236
DOC_PP1_RVXF_1	312	319	PF00149	0.447
DOC_PP2B_LxvP_1	180	183	PF13499	0.287
DOC_PP2B_LxvP_1	237	240	PF13499	0.472
DOC_PP4_FxxP_1	327	330	PF00568	0.434
DOC_PP4_FxxP_1	55	58	PF00568	0.467
DOC_USP7_MATH_1	155	159	PF00917	0.388
DOC_USP7_MATH_1	350	354	PF00917	0.446
DOC_USP7_UBL2_3	15	19	PF12436	0.457
DOC_USP7_UBL2_3	307	311	PF12436	0.497
DOC_WW_Pin1_4	196	201	PF00397	0.416
DOC_WW_Pin1_4	332	337	PF00397	0.346
LIG_BIR_II_1	1	5	PF00653	0.372
LIG_EH1_1	278	286	PF00400	0.497
LIG_FHA_1	263	269	PF00498	0.510
LIG_FHA_1	381	387	PF00498	0.553
LIG_FHA_2	197	203	PF00498	0.320
LIG_GBD_Chelix_1	37	45	PF00786	0.234
LIG_LIR_Apic_2	326	330	PF02991	0.434
LIG_LIR_Nem_3	246	250	PF02991	0.416
LIG_LIR_Nem_3	326	331	PF02991	0.503
LIG_LIR_Nem_3	340	344	PF02991	0.392
LIG_LIR_Nem_3	353	359	PF02991	0.404
LIG_PDZ_Class_1	382	387	PF00595	0.549
LIG_Pex14_2	327	331	PF04695	0.434
LIG_Rb_pABgroove_1	41	49	PF01858	0.467
LIG_SH2_SRC	143	146	PF00017	0.342
LIG_SH2_SRC	354	357	PF00017	0.434
LIG_SH2_STAT3	291	294	PF00017	0.545
LIG_SH2_STAT5	143	146	PF00017	0.447
LIG_SH2_STAT5	291	294	PF00017	0.537
LIG_SH2_STAT5	42	45	PF00017	0.418
LIG_SH3_3	171	177	PF00018	0.491
LIG_SUMO_SIM_anti_2	280	287	PF11976	0.554
LIG_SUMO_SIM_par_1	182	188	PF11976	0.268
LIG_SUMO_SIM_par_1	232	238	PF11976	0.491
LIG_UBA3_1	223	231	PF00899	0.295
LIG_WRC_WIRS_1	324	329	PF05994	0.461
MOD_CK1_1	158	164	PF00069	0.424
MOD_CK1_1	262	268	PF00069	0.466
MOD_CK1_1	340	346	PF00069	0.392
MOD_CK1_1	362	368	PF00069	0.450
MOD_CK2_1	235	241	PF00069	0.473
MOD_GlcNHglycan	1	4	PF01048	0.418
MOD_GlcNHglycan	103	107	PF01048	0.193
MOD_GlcNHglycan	157	160	PF01048	0.216
MOD_GSK3_1	259	266	PF00069	0.520
MOD_GSK3_1	342	349	PF00069	0.453
MOD_GSK3_1	355	362	PF00069	0.441
MOD_GSK3_1	84	91	PF00069	0.427
MOD_N-GLC_1	107	112	PF02516	0.267
MOD_NEK2_1	107	112	PF00069	0.429
MOD_NEK2_1	235	240	PF00069	0.458
MOD_NEK2_1	88	93	PF00069	0.447
MOD_PIKK_1	253	259	PF00454	0.434
MOD_Plk_1	102	108	PF00069	0.394
MOD_Plk_1	84	90	PF00069	0.510
MOD_Plk_4	107	113	PF00069	0.545
MOD_Plk_4	158	164	PF00069	0.424
MOD_Plk_4	175	181	PF00069	0.279
MOD_Plk_4	21	27	PF00069	0.353
MOD_Plk_4	33	39	PF00069	0.384
MOD_Plk_4	84	90	PF00069	0.452
MOD_ProDKin_1	196	202	PF00069	0.407
MOD_ProDKin_1	332	338	PF00069	0.346
MOD_SUMO_rev_2	241	250	PF00179	0.459
TRG_ENDOCYTIC_2	206	209	PF00928	0.393
TRG_ENDOCYTIC_2	247	250	PF00928	0.416
TRG_ENDOCYTIC_2	42	45	PF00928	0.442
TRG_ER_diArg_1	243	245	PF00400	0.416
TRG_ER_diArg_1	9	11	PF00400	0.383
TRG_NES_CRM1_1	103	115	PF08389	0.472
TRG_NES_CRM1_1	274	287	PF08389	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I007	Leptomonas seymouri	57%	100%
A0A0S4IZ18	Bodo saltans	38%	100%
A0A1X0P2Z3	Trypanosomatidae	44%	100%
A0A3S5H4U4	Leishmania donovani	93%	100%
A0A422NY62	Trypanosoma rangeli	43%	100%
A4H355	Leishmania braziliensis	84%	100%
A4HRF2	Leishmania infantum	92%	100%
C9ZXE4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AC20	Leishmania major	94%	100%
O14094	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
P38698	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	97%
Q5E9Y6	Bos taurus	25%	85%
Q6AYG3	Rattus norvegicus	27%	85%
Q86TP1	Homo sapiens	27%	85%
Q8BIW1	Mus musculus	27%	85%