Pseudouridylate synthase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pseudouridylate synthase-like protein

Species:

Leishmania mexicana

UniProt:

E9AJB4_LEIMU

TriTrypDb:

LmxM.01.0280

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJB4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJB4

PDB structure(s): 7am2_BZ

Function

Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000154	rRNA modification	6	1
GO:0000455	enzyme-directed rRNA pseudouridine synthesis	8	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0031118	rRNA pseudouridine synthesis	7	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0009982	pseudouridine synthase activity	4	12
GO:0016853	isomerase activity	2	12
GO:0016866	intramolecular transferase activity	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0106029	tRNA pseudouridine synthase activity	5	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140101	catalytic activity, acting on a tRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	150	152	PF00675	0.698
CLV_NRD_NRD_1	2	4	PF00675	0.680
CLV_NRD_NRD_1	320	322	PF00675	0.256
CLV_NRD_NRD_1	34	36	PF00675	0.636
CLV_NRD_NRD_1	359	361	PF00675	0.480
CLV_NRD_NRD_1	369	371	PF00675	0.305
CLV_NRD_NRD_1	49	51	PF00675	0.526
CLV_NRD_NRD_1	97	99	PF00675	0.447
CLV_PCSK_KEX2_1	103	105	PF00082	0.331
CLV_PCSK_KEX2_1	150	152	PF00082	0.698
CLV_PCSK_KEX2_1	2	4	PF00082	0.680
CLV_PCSK_KEX2_1	244	246	PF00082	0.256
CLV_PCSK_KEX2_1	32	34	PF00082	0.661
CLV_PCSK_KEX2_1	320	322	PF00082	0.256
CLV_PCSK_KEX2_1	399	401	PF00082	0.546
CLV_PCSK_KEX2_1	86	88	PF00082	0.453
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.351
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.256
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.682
CLV_PCSK_PC1ET2_1	399	401	PF00082	0.546
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.464
CLV_PCSK_PC7_1	146	152	PF00082	0.552
CLV_PCSK_PC7_1	240	246	PF00082	0.256
CLV_PCSK_SKI1_1	3	7	PF00082	0.658
CLV_PCSK_SKI1_1	396	400	PF00082	0.416
DEG_COP1_1	113	123	PF00400	0.437
DEG_Nend_UBRbox_1	1	4	PF02207	0.700
DOC_CYCLIN_yCln2_LP_2	200	206	PF00134	0.542
DOC_CYCLIN_yCln2_LP_2	401	407	PF00134	0.560
DOC_MAPK_gen_1	102	114	PF00069	0.416
DOC_MAPK_gen_1	2	8	PF00069	0.619
DOC_MAPK_gen_1	32	42	PF00069	0.596
DOC_MAPK_gen_1	360	367	PF00069	0.493
DOC_MAPK_HePTP_8	30	42	PF00069	0.627
DOC_MAPK_MEF2A_6	33	42	PF00069	0.619
DOC_MAPK_MEF2A_6	360	367	PF00069	0.499
DOC_MAPK_NFAT4_5	35	43	PF00069	0.628
DOC_MAPK_RevD_3	19	34	PF00069	0.424
DOC_PP1_RVXF_1	109	115	PF00149	0.409
DOC_PP1_RVXF_1	397	404	PF00149	0.408
DOC_PP2B_LxvP_1	130	133	PF13499	0.494
DOC_PP2B_LxvP_1	332	335	PF13499	0.491
DOC_PP4_FxxP_1	355	358	PF00568	0.386
DOC_USP7_MATH_1	121	125	PF00917	0.507
DOC_USP7_MATH_1	229	233	PF00917	0.383
DOC_USP7_UBL2_3	99	103	PF12436	0.466
DOC_WW_Pin1_4	284	289	PF00397	0.440
LIG_14-3-3_CanoR_1	107	114	PF00244	0.409
LIG_14-3-3_CanoR_1	150	155	PF00244	0.471
LIG_14-3-3_CanoR_1	205	214	PF00244	0.561
LIG_APCC_ABBA_1	267	272	PF00400	0.456
LIG_APCC_ABBA_1	352	357	PF00400	0.399
LIG_APCC_ABBA_1	390	395	PF00400	0.382
LIG_APCC_ABBAyCdc20_2	266	272	PF00400	0.456
LIG_EVH1_2	260	264	PF00568	0.542
LIG_FHA_1	107	113	PF00498	0.407
LIG_FHA_1	151	157	PF00498	0.473
LIG_FHA_1	196	202	PF00498	0.490
LIG_FHA_1	385	391	PF00498	0.372
LIG_G3BP_FGDF_1	306	311	PF02136	0.481
LIG_GBD_Chelix_1	193	201	PF00786	0.342
LIG_LIR_Apic_2	353	358	PF02991	0.402
LIG_LIR_Gen_1	113	121	PF02991	0.376
LIG_LIR_Gen_1	310	317	PF02991	0.452
LIG_LIR_Gen_1	382	391	PF02991	0.357
LIG_LIR_Gen_1	54	65	PF02991	0.420
LIG_LIR_Gen_1	79	89	PF02991	0.402
LIG_LIR_LC3C_4	115	119	PF02991	0.370
LIG_LIR_Nem_3	113	117	PF02991	0.386
LIG_LIR_Nem_3	250	255	PF02991	0.465
LIG_LIR_Nem_3	307	311	PF02991	0.450
LIG_LIR_Nem_3	313	317	PF02991	0.452
LIG_LIR_Nem_3	382	386	PF02991	0.371
LIG_LIR_Nem_3	395	401	PF02991	0.433
LIG_LIR_Nem_3	54	60	PF02991	0.412
LIG_LIR_Nem_3	79	85	PF02991	0.472
LIG_MYND_1	19	23	PF01753	0.419
LIG_MYND_3	18	22	PF01753	0.406
LIG_Pex14_1	10	14	PF04695	0.651
LIG_PTB_Apo_2	246	253	PF02174	0.456
LIG_PTB_Phospho_1	246	252	PF10480	0.456
LIG_SH2_CRK	105	109	PF00017	0.471
LIG_SH2_CRK	57	61	PF00017	0.513
LIG_SH2_GRB2like	206	209	PF00017	0.467
LIG_SH2_STAT5	105	108	PF00017	0.467
LIG_SH2_STAT5	206	209	PF00017	0.467
LIG_SH3_3	115	121	PF00018	0.401
LIG_SH3_3	182	188	PF00018	0.456
LIG_SH3_3	254	260	PF00018	0.456
LIG_SH3_3	280	286	PF00018	0.481
LIG_SH3_3	383	389	PF00018	0.383
LIG_SH3_3	407	413	PF00018	0.413
LIG_SH3_5	78	82	PF00018	0.520
LIG_SUMO_SIM_anti_2	115	122	PF11976	0.368
LIG_SUMO_SIM_anti_2	173	179	PF11976	0.308
LIG_SUMO_SIM_par_1	115	122	PF11976	0.368
LIG_TRAF2_1	44	47	PF00917	0.552
LIG_TYR_ITIM	55	60	PF00017	0.410
LIG_UBA3_1	237	244	PF00899	0.308
LIG_WRC_WIRS_1	308	313	PF05994	0.303
MOD_CK1_1	140	146	PF00069	0.698
MOD_CK1_1	310	316	PF00069	0.324
MOD_CK1_1	49	55	PF00069	0.525
MOD_CK2_1	121	127	PF00069	0.485
MOD_CK2_1	131	137	PF00069	0.542
MOD_CK2_1	301	307	PF00069	0.324
MOD_Cter_Amidation	100	103	PF01082	0.469
MOD_GlcNHglycan	133	136	PF01048	0.501
MOD_GlcNHglycan	156	159	PF01048	0.521
MOD_GlcNHglycan	181	184	PF01048	0.393
MOD_GlcNHglycan	221	225	PF01048	0.324
MOD_GlcNHglycan	303	306	PF01048	0.324
MOD_GlcNHglycan	345	348	PF01048	0.395
MOD_GSK3_1	137	144	PF00069	0.638
MOD_GSK3_1	150	157	PF00069	0.504
MOD_N-GLC_1	195	200	PF02516	0.365
MOD_N-GLC_1	301	306	PF02516	0.324
MOD_NEK2_1	138	143	PF00069	0.635
MOD_NEK2_1	154	159	PF00069	0.319
MOD_NEK2_1	228	233	PF00069	0.308
MOD_NEK2_1	394	399	PF00069	0.381
MOD_PIKK_1	141	147	PF00454	0.690
MOD_PIKK_1	206	212	PF00454	0.455
MOD_PIKK_1	58	64	PF00454	0.415
MOD_PIKK_1	71	77	PF00454	0.407
MOD_PKA_1	103	109	PF00069	0.417
MOD_PKA_1	150	156	PF00069	0.500
MOD_PKA_2	103	109	PF00069	0.424
MOD_PKA_2	150	156	PF00069	0.448
MOD_PKA_2	204	210	PF00069	0.450
MOD_PKA_2	229	235	PF00069	0.278
MOD_PKA_2	49	55	PF00069	0.547
MOD_Plk_1	301	307	PF00069	0.324
MOD_Plk_1	394	400	PF00069	0.406
MOD_Plk_4	10	16	PF00069	0.554
MOD_Plk_4	121	127	PF00069	0.448
MOD_Plk_4	247	253	PF00069	0.324
MOD_Plk_4	307	313	PF00069	0.303
MOD_Plk_4	350	356	PF00069	0.405
MOD_ProDKin_1	284	290	PF00069	0.286
MOD_SUMO_for_1	170	173	PF00179	0.401
TRG_DiLeu_BaEn_1	113	118	PF01217	0.390
TRG_DiLeu_BaEn_2	306	312	PF01217	0.308
TRG_DiLeu_BaLyEn_6	332	337	PF01217	0.394
TRG_DiLeu_BaLyEn_6	407	412	PF01217	0.397
TRG_ENDOCYTIC_2	105	108	PF00928	0.467
TRG_ENDOCYTIC_2	252	255	PF00928	0.308
TRG_ENDOCYTIC_2	57	60	PF00928	0.511
TRG_ENDOCYTIC_2	82	85	PF00928	0.402
TRG_ER_diArg_1	1	3	PF00400	0.651
TRG_ER_diArg_1	266	269	PF00400	0.308
TRG_ER_diArg_1	33	35	PF00400	0.598
TRG_NLS_Bipartite_1	86	106	PF00514	0.449
TRG_NLS_MonoExtN_4	99	106	PF00514	0.452
TRG_Pf-PMV_PEXEL_1	16	20	PF00026	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I599	Leptomonas seymouri	89%	100%
A0A0S4J1Y1	Bodo saltans	68%	100%
A0A1X0P2Q5	Trypanosomatidae	73%	100%
A0A3S5H4U1	Leishmania donovani	97%	100%
A0A422NY76	Trypanosoma rangeli	76%	100%
A4H352	Leishmania braziliensis	93%	100%
A4HRE9	Leishmania infantum	97%	100%
C9ZXE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
E9AC17	Leishmania major	97%	100%
P0AA39	Escherichia coli (strain K12)	22%	100%
P0AA40	Shigella flexneri	22%	100%
P44433	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	22%	100%
P59835	Haemophilus ducreyi (strain 35000HP / ATCC 700724)	23%	100%
P74346	Synechocystis sp. (strain PCC 6803 / Kazusa)	25%	100%
Q4QQT0	Rattus norvegicus	27%	100%
Q5E9Z1	Bos taurus	25%	100%
Q6DBR0	Danio rerio	27%	100%
Q87N15	Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)	21%	100%
Q89AH2	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	21%	100%
Q8D8G1	Vibrio vulnificus (strain CMCP6)	20%	100%
Q8FIP7	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	22%	100%
Q8X8J3	Escherichia coli O157:H7	22%	100%
Q8Z7J7	Salmonella typhi	22%	100%
Q8ZQ16	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	22%	100%
Q9CM51	Pasteurella multocida (strain Pm70)	22%	100%
Q9CWX4	Mus musculus	26%	100%
Q9HZM9	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	21%	100%
Q9KQH0	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	21%	100%
Q9LT72	Arabidopsis thaliana	26%	87%
V5B9Z1	Trypanosoma cruzi	74%	100%