Thioredoxin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Thioredoxin

Gene product:

thioredoxin, putative

Species:

Leishmania mexicana

UniProt:

E9AJB3_LEIMU

TriTrypDb:

LmxM.01.0270

Length:

107

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AJB3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJB3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0015035	protein-disulfide reductase activity	3	8
GO:0015036	disulfide oxidoreductase activity	4	8
GO:0016491	oxidoreductase activity	2	8
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	8
GO:0140096	catalytic activity, acting on a protein	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	52	56	PF00082	0.380
DOC_USP7_MATH_1	33	37	PF00917	0.214
DOC_USP7_UBL2_3	35	39	PF12436	0.441
LIG_14-3-3_CanoR_1	43	47	PF00244	0.460
LIG_FHA_1	18	24	PF00498	0.475
LIG_FHA_1	60	66	PF00498	0.421
LIG_FHA_1	73	79	PF00498	0.361
LIG_LIR_Apic_2	27	33	PF02991	0.361
LIG_LIR_Gen_1	45	56	PF02991	0.398
LIG_LIR_Gen_1	75	84	PF02991	0.380
LIG_LIR_Nem_3	10	15	PF02991	0.361
LIG_LIR_Nem_3	45	51	PF02991	0.363
LIG_LIR_Nem_3	75	79	PF02991	0.380
LIG_Pex14_2	26	30	PF04695	0.361
LIG_PTB_Apo_2	47	54	PF02174	0.455
LIG_SH2_SRC	87	90	PF00017	0.473
LIG_SH2_STAT5	87	90	PF00017	0.420
LIG_SUMO_SIM_anti_2	20	25	PF11976	0.506
LIG_WRC_WIRS_1	73	78	PF05994	0.361
MOD_GlcNHglycan	26	29	PF01048	0.434
MOD_GSK3_1	42	49	PF00069	0.337
MOD_GSK3_1	59	66	PF00069	0.364
MOD_N-GLC_1	59	64	PF02516	0.380
MOD_PKA_2	42	48	PF00069	0.499
MOD_Plk_2-3	42	48	PF00069	0.380
MOD_Plk_4	19	25	PF00069	0.434
MOD_Plk_4	72	78	PF00069	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL85	Leptomonas seymouri	33%	69%
A0A0N1PD08	Leptomonas seymouri	82%	100%
A0A0S4IQ93	Bodo saltans	26%	77%
A0A0S4ISI9	Bodo saltans	39%	70%
A0A0S4IZF8	Bodo saltans	67%	100%
A0A1X0P2Q9	Trypanosomatidae	66%	100%
A0A3Q8IGH5	Leishmania donovani	36%	69%
A0A3R7NZW1	Trypanosoma rangeli	67%	100%
A0A3S5H4U0	Leishmania donovani	97%	100%
A4H351	Leishmania braziliensis	95%	100%
A4HRE8	Leishmania infantum	97%	100%
C9K7C5	Alternaria alternata	35%	91%
C9ZXF0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AC16	Leishmania major	95%	100%
O14463	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
O17486	Echinococcus granulosus	38%	100%
O22022	Cyanidioschyzon merolae (strain NIES-3377 / 10D)	35%	100%
O64394	Triticum aestivum	32%	84%
O64432	Brassica campestris	31%	87%
O65049	Picea mariana	32%	86%
O84544	Chlamydia trachomatis (strain D/UW-3/Cx)	33%	100%
O94504	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	80%
O96952	Geodia cydonium	39%	100%
O97508	Equus caballus	41%	100%
O97680	Bos taurus	43%	100%
P00275	Corynebacterium nephridii	35%	100%
P08628	Oryctolagus cuniculus	44%	100%
P08629	Gallus gallus	36%	100%
P0A617	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	36%	92%
P0AGG4	Escherichia coli (strain K12)	31%	77%
P0AGG5	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	31%	77%
P0AGG6	Escherichia coli O157:H7	31%	77%
P0AGG7	Shigella flexneri	31%	77%
P10599	Homo sapiens	44%	100%
P10639	Mus musculus	43%	100%
P11232	Rattus norvegicus	43%	100%
P22217	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	100%
P22803	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
P25372	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	84%
P29429	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	33%	97%
P29445	Dictyostelium discoideum	42%	100%
P29447	Dictyostelium discoideum	40%	100%
P29448	Arabidopsis thaliana	36%	94%
P29449	Nicotiana tabacum	33%	85%
P29451	Macaca mulatta	44%	100%
P34723	Penicillium chrysogenum	33%	100%
P37395	Cyanidium caldarium	35%	100%
P42115	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	30%	84%
P47370	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	32%	100%
P47938	Drosophila melanogaster	35%	100%
P50254	Neopyropia yezoensis	29%	100%
P50338	Griffithsia pacifica	27%	98%
P50413	Ovis aries	41%	100%
P51225	Porphyra purpurea	28%	100%
P52230	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	29%	97%
P52231	Synechocystis sp. (strain PCC 6803 / Kazusa)	29%	100%
P52233	Acidithiobacillus ferridurans	33%	99%
P60226	Drosophila yakuba	35%	100%
P66928	Helicobacter pylori (strain ATCC 700392 / 26695)	31%	100%
P66929	Helicobacter pylori (strain J99 / ATCC 700824)	31%	100%
P68176	Brassica oleracea	31%	87%
P68177	Brassica napus	31%	87%
P75512	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	32%	100%
P82460	Sus scrofa	44%	100%
P85801	Populus jackii	27%	77%
P9WG66	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	36%	92%
P9WG67	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	36%	92%
Q05739	Streptomyces clavuligerus	29%	100%
Q07090	Nicotiana tabacum	34%	91%
Q09433	Caenorhabditis elegans	29%	93%
Q0DKF1	Oryza sativa subsp. japonica	25%	81%
Q1RQI9	Malassezia sympodialis	33%	100%
Q1RQJ0	Neosartorya fumigata	40%	97%
Q1RQJ1	Neosartorya fumigata	36%	99%
Q38879	Arabidopsis thaliana	36%	80%
Q39239	Arabidopsis thaliana	35%	90%
Q39241	Arabidopsis thaliana	29%	91%
Q39362	Brassica napus	35%	90%
Q42403	Arabidopsis thaliana	28%	91%
Q43636	Ricinus communis	36%	91%
Q5R9M3	Pongo abelii	43%	100%
Q5UR29	Acanthamoeba polyphaga mimivirus	36%	78%
Q69AB1	Rattus norvegicus	35%	84%
Q69AB2	Mus musculus	35%	84%
Q6XHI1	Drosophila yakuba	33%	100%
Q6Z4I3	Oryza sativa subsp. japonica	42%	78%
Q75GM1	Oryza sativa subsp. japonica	24%	79%
Q7KQL8	Plasmodium falciparum (isolate 3D7)	32%	100%
Q7M1B9	Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)	33%	97%
Q851R5	Oryza sativa subsp. japonica	34%	80%
Q8IFW4	Drosophila melanogaster	36%	68%
Q8LDI5	Arabidopsis thaliana	28%	91%
Q93VQ9	Arabidopsis thaliana	30%	67%
Q96419	Fagopyrum esculentum	32%	92%
Q98TX1	Ophiophagus hannah	33%	100%
Q9AS75	Oryza sativa subsp. japonica	25%	82%
Q9BDJ3	Callithrix jacchus	44%	100%
Q9C9Y6	Arabidopsis thaliana	33%	76%
Q9CAS1	Arabidopsis thaliana	29%	72%
Q9CM49	Pasteurella multocida (strain Pm70)	33%	100%
Q9DGI3	Ictalurus punctatus	36%	100%
Q9LXZ8	Arabidopsis thaliana	28%	69%
Q9UW02	Coprinus comatus	27%	100%
Q9V429	Drosophila melanogaster	33%	100%
Q9XIF4	Arabidopsis thaliana	33%	83%