Enkurin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Calmodulin-binding, putative

Species:

Leishmania mexicana

UniProt:

E9AJB2_LEIMU

TriTrypDb:

LmxM.01.0260

Length:

279

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0005874	microtubule	6	1
GO:0005881	cytoplasmic microtubule	7	1
GO:0005930	axoneme	2	1
GO:0036064	ciliary basal body	3	1
GO:0097542	ciliary tip	2	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	3
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

E9AJB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJB2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.467
CLV_C14_Caspase3-7	68	72	PF00656	0.433
CLV_NRD_NRD_1	122	124	PF00675	0.615
CLV_NRD_NRD_1	180	182	PF00675	0.267
CLV_NRD_NRD_1	210	212	PF00675	0.292
CLV_NRD_NRD_1	222	224	PF00675	0.231
CLV_NRD_NRD_1	23	25	PF00675	0.561
CLV_NRD_NRD_1	251	253	PF00675	0.288
CLV_NRD_NRD_1	32	34	PF00675	0.472
CLV_NRD_NRD_1	39	41	PF00675	0.306
CLV_PCSK_FUR_1	21	25	PF00082	0.562
CLV_PCSK_KEX2_1	122	124	PF00082	0.615
CLV_PCSK_KEX2_1	210	212	PF00082	0.342
CLV_PCSK_KEX2_1	222	224	PF00082	0.228
CLV_PCSK_KEX2_1	23	25	PF00082	0.561
CLV_PCSK_KEX2_1	250	252	PF00082	0.267
CLV_PCSK_KEX2_1	32	34	PF00082	0.472
CLV_PCSK_KEX2_1	39	41	PF00082	0.306
DEG_SPOP_SBC_1	111	115	PF00917	0.505
DOC_MAPK_RevD_3	236	251	PF00069	0.399
DOC_PP2B_LxvP_1	274	277	PF13499	0.379
DOC_USP7_MATH_1	112	116	PF00917	0.737
DOC_USP7_MATH_1	131	135	PF00917	0.589
DOC_USP7_MATH_1	144	148	PF00917	0.718
DOC_USP7_MATH_1	63	67	PF00917	0.723
DOC_USP7_MATH_1	86	90	PF00917	0.686
DOC_USP7_UBL2_3	267	271	PF12436	0.345
DOC_WW_Pin1_4	137	142	PF00397	0.616
LIG_14-3-3_CanoR_1	200	205	PF00244	0.399
LIG_14-3-3_CanoR_1	265	275	PF00244	0.315
LIG_BRCT_BRCA1_1	86	90	PF00533	0.556
LIG_FHA_1	154	160	PF00498	0.545
LIG_FHA_1	242	248	PF00498	0.267
LIG_FHA_2	112	118	PF00498	0.470
LIG_LIR_Nem_3	273	278	PF02991	0.539
LIG_SH2_NCK_1	45	49	PF00017	0.460
LIG_SH2_SRC	45	48	PF00017	0.574
LIG_SH2_STAT3	177	180	PF00017	0.285
LIG_SH2_STAT5	177	180	PF00017	0.267
LIG_SH2_STAT5	78	81	PF00017	0.577
LIG_SH3_3	138	144	PF00018	0.646
LIG_SxIP_EBH_1	198	211	PF03271	0.399
LIG_TRAF2_1	213	216	PF00917	0.267
LIG_TRAF2_1	253	256	PF00917	0.333
MOD_CK1_1	115	121	PF00069	0.535
MOD_CK1_1	147	153	PF00069	0.703
MOD_CK1_1	66	72	PF00069	0.566
MOD_CK2_1	210	216	PF00069	0.267
MOD_GlcNHglycan	107	110	PF01048	0.663
MOD_GlcNHglycan	114	117	PF01048	0.664
MOD_GlcNHglycan	134	137	PF01048	0.635
MOD_GlcNHglycan	149	152	PF01048	0.624
MOD_GlcNHglycan	57	60	PF01048	0.699
MOD_GSK3_1	111	118	PF00069	0.759
MOD_GSK3_1	266	273	PF00069	0.377
MOD_GSK3_1	63	70	PF00069	0.697
MOD_N-GLC_1	8	13	PF02516	0.451
MOD_NEK2_1	38	43	PF00069	0.494
MOD_NEK2_1	8	13	PF00069	0.362
MOD_PIKK_1	241	247	PF00454	0.298
MOD_PIKK_1	8	14	PF00454	0.344
MOD_PIKK_1	84	90	PF00454	0.600
MOD_PKA_1	210	216	PF00069	0.311
MOD_PKA_2	210	216	PF00069	0.399
MOD_PKA_2	38	44	PF00069	0.523
MOD_PKA_2	63	69	PF00069	0.516
MOD_PKB_1	198	206	PF00069	0.351
MOD_Plk_1	8	14	PF00069	0.344
MOD_Plk_4	162	168	PF00069	0.424
MOD_Plk_4	200	206	PF00069	0.449
MOD_Plk_4	270	276	PF00069	0.468
MOD_ProDKin_1	137	143	PF00069	0.619
MOD_SUMO_rev_2	213	218	PF00179	0.287
TRG_ENDOCYTIC_2	45	48	PF00928	0.459
TRG_ER_diArg_1	171	174	PF00400	0.591
TRG_ER_diArg_1	21	24	PF00400	0.579
TRG_ER_diArg_1	210	212	PF00400	0.379
TRG_ER_diArg_1	221	223	PF00400	0.280
TRG_ER_diArg_1	250	252	PF00400	0.352
TRG_ER_diArg_1	31	33	PF00400	0.582
TRG_ER_diArg_1	38	40	PF00400	0.560
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.333
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.357
TRG_Pf-PMV_PEXEL_1	23	27	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	252	256	PF00026	0.401

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6N2	Leptomonas seymouri	56%	95%
A0A0S4J2X9	Bodo saltans	37%	100%
A0A1X0P2S2	Trypanosomatidae	40%	100%
A0A422NYA8	Trypanosoma rangeli	36%	100%
A0A451EJ82	Leishmania donovani	87%	99%
A4HRE7	Leishmania infantum	87%	99%
C9ZXF2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AC15	Leishmania major	87%	100%