Beta_helix domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Right handed beta helix region, putative

Species:

Leishmania mexicana

UniProt:

E9AJB1_LEIMU

TriTrypDb:

LmxM.01.0250

Length:

799

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJB1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.721
CLV_C14_Caspase3-7	357	361	PF00656	0.786
CLV_C14_Caspase3-7	633	637	PF00656	0.575
CLV_NRD_NRD_1	121	123	PF00675	0.415
CLV_NRD_NRD_1	248	250	PF00675	0.735
CLV_NRD_NRD_1	268	270	PF00675	0.729
CLV_NRD_NRD_1	277	279	PF00675	0.857
CLV_NRD_NRD_1	368	370	PF00675	0.860
CLV_NRD_NRD_1	435	437	PF00675	0.725
CLV_NRD_NRD_1	512	514	PF00675	0.674
CLV_PCSK_KEX2_1	121	123	PF00082	0.415
CLV_PCSK_KEX2_1	248	250	PF00082	0.735
CLV_PCSK_KEX2_1	277	279	PF00082	0.772
CLV_PCSK_KEX2_1	368	370	PF00082	0.855
CLV_PCSK_KEX2_1	435	437	PF00082	0.725
CLV_PCSK_KEX2_1	511	513	PF00082	0.582
CLV_PCSK_SKI1_1	214	218	PF00082	0.560
CLV_Separin_Metazoa	196	200	PF03568	0.667
DEG_APCC_DBOX_1	588	596	PF00400	0.481
DEG_SPOP_SBC_1	380	384	PF00917	0.625
DEG_SPOP_SBC_1	387	391	PF00917	0.662
DOC_ANK_TNKS_1	75	82	PF00023	0.531
DOC_CDC14_PxL_1	623	631	PF14671	0.673
DOC_CKS1_1	441	446	PF01111	0.851
DOC_CKS1_1	516	521	PF01111	0.368
DOC_CYCLIN_RxL_1	211	222	PF00134	0.668
DOC_MAPK_gen_1	121	131	PF00069	0.624
DOC_MAPK_gen_1	167	177	PF00069	0.713
DOC_MAPK_gen_1	248	254	PF00069	0.736
DOC_MAPK_gen_1	693	703	PF00069	0.446
DOC_MAPK_gen_1	719	725	PF00069	0.240
DOC_MAPK_MEF2A_6	199	207	PF00069	0.656
DOC_PP1_RVXF_1	161	167	PF00149	0.629
DOC_PP2B_LxvP_1	239	242	PF13499	0.563
DOC_USP7_MATH_1	113	117	PF00917	0.583
DOC_USP7_MATH_1	21	25	PF00917	0.801
DOC_USP7_MATH_1	255	259	PF00917	0.547
DOC_USP7_MATH_1	284	288	PF00917	0.816
DOC_USP7_MATH_1	316	320	PF00917	0.858
DOC_USP7_MATH_1	333	337	PF00917	0.736
DOC_USP7_MATH_1	341	345	PF00917	0.829
DOC_USP7_MATH_1	350	354	PF00917	0.699
DOC_USP7_MATH_1	361	365	PF00917	0.529
DOC_USP7_MATH_1	380	384	PF00917	0.544
DOC_USP7_MATH_1	387	391	PF00917	0.796
DOC_USP7_MATH_1	456	460	PF00917	0.737
DOC_USP7_MATH_1	477	481	PF00917	0.666
DOC_USP7_MATH_1	61	65	PF00917	0.735
DOC_USP7_MATH_1	613	617	PF00917	0.725
DOC_USP7_MATH_1	619	623	PF00917	0.649
DOC_WW_Pin1_4	103	108	PF00397	0.580
DOC_WW_Pin1_4	153	158	PF00397	0.800
DOC_WW_Pin1_4	234	239	PF00397	0.569
DOC_WW_Pin1_4	262	267	PF00397	0.600
DOC_WW_Pin1_4	337	342	PF00397	0.657
DOC_WW_Pin1_4	390	395	PF00397	0.825
DOC_WW_Pin1_4	415	420	PF00397	0.860
DOC_WW_Pin1_4	424	429	PF00397	0.719
DOC_WW_Pin1_4	437	442	PF00397	0.650
DOC_WW_Pin1_4	464	469	PF00397	0.777
DOC_WW_Pin1_4	473	478	PF00397	0.770
DOC_WW_Pin1_4	482	487	PF00397	0.779
DOC_WW_Pin1_4	489	494	PF00397	0.745
DOC_WW_Pin1_4	501	506	PF00397	0.584
DOC_WW_Pin1_4	515	520	PF00397	0.407
DOC_WW_Pin1_4	89	94	PF00397	0.665
DOC_WW_Pin1_4	95	100	PF00397	0.636
LIG_14-3-3_CanoR_1	11	20	PF00244	0.812
LIG_14-3-3_CanoR_1	163	167	PF00244	0.504
LIG_14-3-3_CanoR_1	199	207	PF00244	0.656
LIG_14-3-3_CanoR_1	34	38	PF00244	0.829
LIG_14-3-3_CanoR_1	368	376	PF00244	0.849
LIG_14-3-3_CanoR_1	388	396	PF00244	0.860
LIG_14-3-3_CanoR_1	422	427	PF00244	0.784
LIG_14-3-3_CanoR_1	472	477	PF00244	0.659
LIG_14-3-3_CanoR_1	620	630	PF00244	0.623
LIG_14-3-3_CanoR_1	702	710	PF00244	0.446
LIG_14-3-3_CanoR_1	757	765	PF00244	0.462
LIG_14-3-3_CanoR_1	775	780	PF00244	0.298
LIG_14-3-3_CanoR_1	782	786	PF00244	0.405
LIG_CSL_BTD_1	516	519	PF09270	0.657
LIG_FHA_1	159	165	PF00498	0.652
LIG_FHA_1	421	427	PF00498	0.842
LIG_FHA_1	626	632	PF00498	0.337
LIG_FHA_1	663	669	PF00498	0.465
LIG_FHA_1	760	766	PF00498	0.529
LIG_FHA_1	776	782	PF00498	0.265
LIG_FHA_2	229	235	PF00498	0.721
LIG_FHA_2	319	325	PF00498	0.779
LIG_FHA_2	397	403	PF00498	0.674
LIG_FHA_2	712	718	PF00498	0.529
LIG_LIR_Gen_1	183	194	PF02991	0.477
LIG_LIR_Gen_1	201	212	PF02991	0.649
LIG_LIR_Gen_1	213	219	PF02991	0.471
LIG_LIR_Nem_3	183	189	PF02991	0.506
LIG_LIR_Nem_3	201	207	PF02991	0.651
LIG_LIR_Nem_3	213	218	PF02991	0.474
LIG_LYPXL_SIV_4	563	571	PF13949	0.615
LIG_NRBOX	193	199	PF00104	0.684
LIG_Pex14_2	204	208	PF04695	0.644
LIG_SH2_CRK	186	190	PF00017	0.494
LIG_SH2_GRB2like	186	189	PF00017	0.501
LIG_SH2_NCK_1	186	190	PF00017	0.494
LIG_SH2_SRC	186	189	PF00017	0.501
LIG_SH2_SRC	680	683	PF00017	0.446
LIG_SH2_STAP1	547	551	PF00017	0.579
LIG_SH2_STAT5	680	683	PF00017	0.529
LIG_SH2_STAT5	709	712	PF00017	0.378
LIG_SH2_STAT5	785	788	PF00017	0.529
LIG_SH3_3	239	245	PF00018	0.676
LIG_SH3_3	249	255	PF00018	0.815
LIG_SH3_3	327	333	PF00018	0.852
LIG_SH3_3	438	444	PF00018	0.858
LIG_SH3_3	471	477	PF00018	0.700
LIG_SH3_3	483	489	PF00018	0.846
LIG_SH3_3	502	508	PF00018	0.701
LIG_SH3_3	537	543	PF00018	0.573
LIG_SH3_3	567	573	PF00018	0.587
LIG_SH3_3	57	63	PF00018	0.553
LIG_SH3_3	624	630	PF00018	0.678
LIG_SUMO_SIM_par_1	630	636	PF11976	0.573
LIG_TRAF2_1	219	222	PF00917	0.670
LIG_TRAF2_1	714	717	PF00917	0.529
LIG_TRAF2_1	752	755	PF00917	0.488
LIG_TYR_ITIM	545	550	PF00017	0.574
LIG_WW_3	385	389	PF00397	0.812
LIG_WW_3	394	398	PF00397	0.751
LIG_WW_3	485	489	PF00397	0.843
MOD_CDK_SPK_2	158	163	PF00069	0.742
MOD_CDK_SPK_2	428	433	PF00069	0.820
MOD_CDK_SPxK_1	482	488	PF00069	0.846
MOD_CDK_SPxxK_3	153	160	PF00069	0.802
MOD_CDK_SPxxK_3	262	269	PF00069	0.552
MOD_CDK_SPxxK_3	390	397	PF00069	0.777
MOD_CDK_SPxxK_3	415	422	PF00069	0.863
MOD_CDK_SPxxK_3	428	435	PF00069	0.646
MOD_CDK_SPxxK_3	504	511	PF00069	0.767
MOD_CK1_1	15	21	PF00069	0.819
MOD_CK1_1	153	159	PF00069	0.781
MOD_CK1_1	24	30	PF00069	0.677
MOD_CK1_1	315	321	PF00069	0.855
MOD_CK1_1	336	342	PF00069	0.766
MOD_CK1_1	390	396	PF00069	0.807
MOD_CK1_1	427	433	PF00069	0.817
MOD_CK1_1	437	443	PF00069	0.657
MOD_CK1_1	504	510	PF00069	0.722
MOD_CK1_1	56	62	PF00069	0.556
MOD_CK1_1	621	627	PF00069	0.736
MOD_CK2_1	170	176	PF00069	0.714
MOD_CK2_1	228	234	PF00069	0.633
MOD_CK2_1	24	30	PF00069	0.743
MOD_CK2_1	240	246	PF00069	0.646
MOD_CK2_1	318	324	PF00069	0.817
MOD_CK2_1	585	591	PF00069	0.582
MOD_CK2_1	710	716	PF00069	0.400
MOD_CK2_1	758	764	PF00069	0.350
MOD_Cter_Amidation	267	270	PF01082	0.671
MOD_Cter_Amidation	433	436	PF01082	0.685
MOD_GlcNHglycan	115	118	PF01048	0.428
MOD_GlcNHglycan	150	153	PF01048	0.777
MOD_GlcNHglycan	171	175	PF01048	0.709
MOD_GlcNHglycan	23	26	PF01048	0.787
MOD_GlcNHglycan	27	30	PF01048	0.726
MOD_GlcNHglycan	271	274	PF01048	0.668
MOD_GlcNHglycan	286	289	PF01048	0.786
MOD_GlcNHglycan	313	317	PF01048	0.778
MOD_GlcNHglycan	330	333	PF01048	0.543
MOD_GlcNHglycan	343	346	PF01048	0.855
MOD_GlcNHglycan	390	393	PF01048	0.834
MOD_GlcNHglycan	436	439	PF01048	0.871
MOD_GlcNHglycan	458	461	PF01048	0.838
MOD_GlcNHglycan	534	537	PF01048	0.607
MOD_GlcNHglycan	561	564	PF01048	0.460
MOD_GlcNHglycan	77	80	PF01048	0.709
MOD_GlcNHglycan	82	85	PF01048	0.664
MOD_GSK3_1	101	108	PF00069	0.591
MOD_GSK3_1	12	19	PF00069	0.711
MOD_GSK3_1	158	165	PF00069	0.706
MOD_GSK3_1	20	27	PF00069	0.791
MOD_GSK3_1	206	213	PF00069	0.542
MOD_GSK3_1	269	276	PF00069	0.617
MOD_GSK3_1	312	319	PF00069	0.850
MOD_GSK3_1	33	40	PF00069	0.648
MOD_GSK3_1	333	340	PF00069	0.642
MOD_GSK3_1	386	393	PF00069	0.768
MOD_GSK3_1	413	420	PF00069	0.860
MOD_GSK3_1	424	431	PF00069	0.685
MOD_GSK3_1	456	463	PF00069	0.706
MOD_GSK3_1	473	480	PF00069	0.558
MOD_GSK3_1	51	58	PF00069	0.758
MOD_GSK3_1	618	625	PF00069	0.722
MOD_GSK3_1	71	78	PF00069	0.521
MOD_GSK3_1	91	98	PF00069	0.637
MOD_LATS_1	366	372	PF00433	0.773
MOD_N-GLC_1	16	21	PF02516	0.533
MOD_N-GLC_1	472	477	PF02516	0.673
MOD_NEK2_1	101	106	PF00069	0.602
MOD_NEK2_1	150	155	PF00069	0.663
MOD_NEK2_1	198	203	PF00069	0.520
MOD_NEK2_1	20	25	PF00069	0.638
MOD_NEK2_1	381	386	PF00069	0.753
MOD_NEK2_1	640	645	PF00069	0.567
MOD_NEK2_1	704	709	PF00069	0.529
MOD_NEK2_1	733	738	PF00069	0.369
MOD_NEK2_1	774	779	PF00069	0.446
MOD_NEK2_2	255	260	PF00069	0.545
MOD_OFUCOSY	90	95	PF10250	0.518
MOD_PIKK_1	206	212	PF00454	0.649
MOD_PIKK_1	240	246	PF00454	0.628
MOD_PIKK_1	318	324	PF00454	0.631
MOD_PIKK_1	518	524	PF00454	0.656
MOD_PKA_1	269	275	PF00069	0.563
MOD_PKA_1	368	374	PF00069	0.851
MOD_PKA_2	162	168	PF00069	0.592
MOD_PKA_2	198	204	PF00069	0.656
MOD_PKA_2	309	315	PF00069	0.677
MOD_PKA_2	33	39	PF00069	0.825
MOD_PKA_2	367	373	PF00069	0.854
MOD_PKA_2	387	393	PF00069	0.867
MOD_PKA_2	396	402	PF00069	0.712
MOD_PKA_2	421	427	PF00069	0.695
MOD_PKA_2	434	440	PF00069	0.657
MOD_PKA_2	447	453	PF00069	0.558
MOD_PKA_2	456	462	PF00069	0.591
MOD_PKA_2	571	577	PF00069	0.607
MOD_PKA_2	619	625	PF00069	0.667
MOD_PKA_2	689	695	PF00069	0.529
MOD_PKA_2	75	81	PF00069	0.613
MOD_PKA_2	774	780	PF00069	0.529
MOD_PKA_2	781	787	PF00069	0.413
MOD_Plk_1	16	22	PF00069	0.820
MOD_Plk_1	170	176	PF00069	0.796
MOD_Plk_1	359	365	PF00069	0.779
MOD_Plk_1	711	717	PF00069	0.500
MOD_Plk_4	325	331	PF00069	0.772
MOD_Plk_4	613	619	PF00069	0.443
MOD_Plk_4	704	710	PF00069	0.529
MOD_Plk_4	734	740	PF00069	0.529
MOD_Plk_4	781	787	PF00069	0.400
MOD_ProDKin_1	103	109	PF00069	0.573
MOD_ProDKin_1	153	159	PF00069	0.799
MOD_ProDKin_1	234	240	PF00069	0.575
MOD_ProDKin_1	262	268	PF00069	0.603
MOD_ProDKin_1	337	343	PF00069	0.654
MOD_ProDKin_1	390	396	PF00069	0.824
MOD_ProDKin_1	415	421	PF00069	0.861
MOD_ProDKin_1	424	430	PF00069	0.718
MOD_ProDKin_1	437	443	PF00069	0.649
MOD_ProDKin_1	464	470	PF00069	0.778
MOD_ProDKin_1	473	479	PF00069	0.771
MOD_ProDKin_1	482	488	PF00069	0.780
MOD_ProDKin_1	489	495	PF00069	0.748
MOD_ProDKin_1	501	507	PF00069	0.577
MOD_ProDKin_1	515	521	PF00069	0.414
MOD_ProDKin_1	89	95	PF00069	0.666
MOD_SUMO_rev_2	588	595	PF00179	0.564
TRG_DiLeu_BaEn_1	127	132	PF01217	0.702
TRG_DiLeu_BaEn_1	193	198	PF01217	0.681
TRG_DiLeu_BaEn_1	221	226	PF01217	0.391
TRG_DiLeu_BaLyEn_6	627	632	PF01217	0.611
TRG_ENDOCYTIC_2	186	189	PF00928	0.501
TRG_ENDOCYTIC_2	547	550	PF00928	0.573
TRG_ER_diArg_1	121	124	PF00400	0.422
TRG_ER_diArg_1	511	513	PF00400	0.705
TRG_ER_diArg_1	581	584	PF00400	0.583
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.698
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.856

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A451EJ81	Leishmania donovani	86%	100%
A4H350	Leishmania braziliensis	65%	100%
A4HRE6	Leishmania infantum	86%	86%
E9AC14	Leishmania major	85%	99%