Putative DNA excision/repair protein SNF2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA excision/repair protein SNF2, putative

Species:

Leishmania mexicana

UniProt:

E9AJB0_LEIMU

TriTrypDb:

LmxM.01.0240

Length:

927

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJB0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJB0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0008094	ATP-dependent activity, acting on DNA	2	10
GO:0016491	oxidoreductase activity	2	10
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0051213	dioxygenase activity	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:0140097	catalytic activity, acting on DNA	3	10
GO:0140640	catalytic activity, acting on a nucleic acid	2	10
GO:0140657	ATP-dependent activity	1	10
GO:0140658	ATP-dependent chromatin remodeler activity	3	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10
GO:0015616	DNA translocase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	524	528	PF00656	0.475
CLV_C14_Caspase3-7	702	706	PF00656	0.379
CLV_C14_Caspase3-7	712	716	PF00656	0.589
CLV_C14_Caspase3-7	763	767	PF00656	0.597
CLV_C14_Caspase3-7	79	83	PF00656	0.449
CLV_NRD_NRD_1	206	208	PF00675	0.276
CLV_NRD_NRD_1	214	216	PF00675	0.259
CLV_NRD_NRD_1	348	350	PF00675	0.234
CLV_NRD_NRD_1	496	498	PF00675	0.218
CLV_NRD_NRD_1	534	536	PF00675	0.275
CLV_NRD_NRD_1	595	597	PF00675	0.401
CLV_NRD_NRD_1	695	697	PF00675	0.508
CLV_NRD_NRD_1	778	780	PF00675	0.654
CLV_PCSK_FUR_1	207	211	PF00082	0.276
CLV_PCSK_FUR_1	776	780	PF00082	0.610
CLV_PCSK_KEX2_1	209	211	PF00082	0.225
CLV_PCSK_KEX2_1	348	350	PF00082	0.224
CLV_PCSK_KEX2_1	534	536	PF00082	0.275
CLV_PCSK_KEX2_1	595	597	PF00082	0.401
CLV_PCSK_KEX2_1	620	622	PF00082	0.519
CLV_PCSK_KEX2_1	695	697	PF00082	0.508
CLV_PCSK_KEX2_1	776	778	PF00082	0.657
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.225
CLV_PCSK_PC1ET2_1	620	622	PF00082	0.519
CLV_PCSK_PC7_1	591	597	PF00082	0.317
CLV_PCSK_PC7_1	691	697	PF00082	0.415
CLV_PCSK_SKI1_1	21	25	PF00082	0.452
CLV_PCSK_SKI1_1	264	268	PF00082	0.300
CLV_PCSK_SKI1_1	274	278	PF00082	0.318
CLV_PCSK_SKI1_1	506	510	PF00082	0.224
CLV_PCSK_SKI1_1	602	606	PF00082	0.305
CLV_PCSK_SKI1_1	641	645	PF00082	0.596
CLV_PCSK_SKI1_1	653	657	PF00082	0.464
CLV_PCSK_SKI1_1	661	665	PF00082	0.400
DEG_APCC_DBOX_1	217	225	PF00400	0.475
DEG_APCC_DBOX_1	656	664	PF00400	0.427
DEG_APCC_DBOX_1	690	698	PF00400	0.391
DEG_Nend_UBRbox_2	1	3	PF02207	0.653
DEG_SPOP_SBC_1	23	27	PF00917	0.608
DEG_SPOP_SBC_1	32	36	PF00917	0.602
DOC_CKS1_1	642	647	PF01111	0.534
DOC_CYCLIN_RxL_1	495	505	PF00134	0.437
DOC_MAPK_DCC_7	216	226	PF00069	0.507
DOC_MAPK_gen_1	504	511	PF00069	0.426
DOC_MAPK_gen_1	541	550	PF00069	0.350
DOC_MAPK_gen_1	595	601	PF00069	0.356
DOC_MAPK_MEF2A_6	218	226	PF00069	0.466
DOC_MAPK_MEF2A_6	363	372	PF00069	0.423
DOC_MAPK_MEF2A_6	481	490	PF00069	0.293
DOC_MAPK_MEF2A_6	544	552	PF00069	0.393
DOC_PP1_RVXF_1	496	503	PF00149	0.424
DOC_PP2B_LxvP_1	173	176	PF13499	0.507
DOC_PP2B_LxvP_1	860	863	PF13499	0.572
DOC_PP4_FxxP_1	110	113	PF00568	0.391
DOC_USP7_MATH_1	23	27	PF00917	0.624
DOC_USP7_MATH_1	33	37	PF00917	0.586
DOC_USP7_MATH_1	624	628	PF00917	0.495
DOC_USP7_MATH_1	751	755	PF00917	0.493
DOC_USP7_MATH_1	833	837	PF00917	0.712
DOC_USP7_MATH_1	856	860	PF00917	0.536
DOC_USP7_MATH_1	894	898	PF00917	0.374
DOC_USP7_MATH_1	93	97	PF00917	0.616
DOC_WW_Pin1_4	11	16	PF00397	0.633
DOC_WW_Pin1_4	277	282	PF00397	0.424
DOC_WW_Pin1_4	34	39	PF00397	0.700
DOC_WW_Pin1_4	527	532	PF00397	0.559
DOC_WW_Pin1_4	641	646	PF00397	0.690
DOC_WW_Pin1_4	727	732	PF00397	0.657
DOC_WW_Pin1_4	742	747	PF00397	0.630
DOC_WW_Pin1_4	749	754	PF00397	0.639
DOC_WW_Pin1_4	829	834	PF00397	0.642
DOC_WW_Pin1_4	97	102	PF00397	0.726
LIG_14-3-3_CanoR_1	264	270	PF00244	0.350
LIG_14-3-3_CanoR_1	371	379	PF00244	0.528
LIG_14-3-3_CanoR_1	415	419	PF00244	0.451
LIG_14-3-3_CanoR_1	491	500	PF00244	0.455
LIG_14-3-3_CanoR_1	504	509	PF00244	0.444
LIG_14-3-3_CanoR_1	520	526	PF00244	0.499
LIG_14-3-3_CanoR_1	602	609	PF00244	0.307
LIG_14-3-3_CanoR_1	672	680	PF00244	0.531
LIG_14-3-3_CanoR_1	838	848	PF00244	0.544
LIG_14-3-3_CterR_2	924	927	PF00244	0.522
LIG_BIR_III_4	646	650	PF00653	0.555
LIG_BIR_III_4	715	719	PF00653	0.569
LIG_BRCT_BRCA1_1	916	920	PF00533	0.590
LIG_deltaCOP1_diTrp_1	287	295	PF00928	0.424
LIG_DLG_GKlike_1	504	511	PF00625	0.350
LIG_FHA_1	150	156	PF00498	0.424
LIG_FHA_1	168	174	PF00498	0.424
LIG_FHA_1	194	200	PF00498	0.400
LIG_FHA_1	226	232	PF00498	0.446
LIG_FHA_1	430	436	PF00498	0.507
LIG_FHA_1	552	558	PF00498	0.439
LIG_FHA_1	709	715	PF00498	0.620
LIG_FHA_1	786	792	PF00498	0.606
LIG_FHA_1	815	821	PF00498	0.564
LIG_FHA_1	844	850	PF00498	0.562
LIG_FHA_1	97	103	PF00498	0.533
LIG_FHA_2	240	246	PF00498	0.475
LIG_FHA_2	283	289	PF00498	0.576
LIG_FHA_2	403	409	PF00498	0.475
LIG_FHA_2	522	528	PF00498	0.497
LIG_FHA_2	606	612	PF00498	0.316
LIG_IBAR_NPY_1	464	466	PF08397	0.475
LIG_LIR_Apic_2	12	16	PF02991	0.477
LIG_LIR_Gen_1	245	254	PF02991	0.424
LIG_LIR_Gen_1	285	293	PF02991	0.427
LIG_LIR_LC3C_4	170	175	PF02991	0.475
LIG_LIR_Nem_3	227	232	PF02991	0.416
LIG_LIR_Nem_3	245	249	PF02991	0.524
LIG_LIR_Nem_3	287	293	PF02991	0.449
LIG_LIR_Nem_3	650	655	PF02991	0.473
LIG_NRBOX	485	491	PF00104	0.215
LIG_NRBOX	507	513	PF00104	0.433
LIG_NRBOX	6	12	PF00104	0.666
LIG_PCNA_PIPBox_1	289	298	PF02747	0.507
LIG_PDZ_Class_1	922	927	PF00595	0.515
LIG_Pex14_1	183	187	PF04695	0.475
LIG_Pex14_2	286	290	PF04695	0.454
LIG_PTB_Apo_2	613	620	PF02174	0.363
LIG_Rb_pABgroove_1	658	666	PF01858	0.332
LIG_RPA_C_Fungi	591	603	PF08784	0.359
LIG_RPA_C_Fungi	894	906	PF08784	0.359
LIG_SH2_CRK	219	223	PF00017	0.300
LIG_SH2_CRK	229	233	PF00017	0.239
LIG_SH2_CRK	380	384	PF00017	0.157
LIG_SH2_CRK	466	470	PF00017	0.460
LIG_SH2_PTP2	246	249	PF00017	0.376
LIG_SH2_STAP1	163	167	PF00017	0.332
LIG_SH2_STAP1	380	384	PF00017	0.376
LIG_SH2_STAT3	121	124	PF00017	0.386
LIG_SH2_STAT3	163	166	PF00017	0.376
LIG_SH2_STAT3	614	617	PF00017	0.353
LIG_SH2_STAT5	246	249	PF00017	0.290
LIG_SH2_STAT5	654	657	PF00017	0.470
LIG_SH3_3	12	18	PF00018	0.568
LIG_SH3_3	171	177	PF00018	0.376
LIG_SH3_3	428	434	PF00018	0.157
LIG_SH3_3	639	645	PF00018	0.709
LIG_SH3_3	741	747	PF00018	0.801
LIG_SH3_3	874	880	PF00018	0.567
LIG_SH3_3	98	104	PF00018	0.637
LIG_SUMO_SIM_anti_2	170	176	PF11976	0.263
LIG_SUMO_SIM_anti_2	568	574	PF11976	0.261
LIG_SUMO_SIM_anti_2	676	682	PF11976	0.570
LIG_SUMO_SIM_anti_2	819	824	PF11976	0.561
LIG_SUMO_SIM_par_1	178	184	PF11976	0.358
LIG_SUMO_SIM_par_1	432	439	PF11976	0.263
LIG_SUMO_SIM_par_1	568	574	PF11976	0.322
LIG_SUMO_SIM_par_1	879	887	PF11976	0.436
LIG_TRAF2_1	53	56	PF00917	0.622
LIG_TRAF2_1	608	611	PF00917	0.305
LIG_TRFH_1	110	114	PF08558	0.398
LIG_TYR_ITIM	244	249	PF00017	0.376
LIG_UBA3_1	300	305	PF00899	0.285
LIG_WRC_WIRS_1	283	288	PF05994	0.356
LIG_WRC_WIRS_1	511	516	PF05994	0.332
MOD_CDC14_SPxK_1	734	737	PF00782	0.590
MOD_CDK_SPxK_1	731	737	PF00069	0.593
MOD_CDK_SPxxK_3	527	534	PF00069	0.332
MOD_CK1_1	265	271	PF00069	0.407
MOD_CK1_1	27	33	PF00069	0.652
MOD_CK1_1	36	42	PF00069	0.616
MOD_CK1_1	749	755	PF00069	0.630
MOD_CK1_1	799	805	PF00069	0.720
MOD_CK1_1	832	838	PF00069	0.546
MOD_CK1_1	839	845	PF00069	0.559
MOD_CK1_1	882	888	PF00069	0.743
MOD_CK1_1	96	102	PF00069	0.643
MOD_CK2_1	358	364	PF00069	0.332
MOD_CK2_1	382	388	PF00069	0.247
MOD_CK2_1	402	408	PF00069	0.219
MOD_CK2_1	50	56	PF00069	0.634
MOD_CK2_1	527	533	PF00069	0.329
MOD_CK2_1	605	611	PF00069	0.312
MOD_CK2_1	670	676	PF00069	0.530
MOD_DYRK1A_RPxSP_1	641	645	PF00069	0.549
MOD_GlcNHglycan	105	108	PF01048	0.579
MOD_GlcNHglycan	264	267	PF01048	0.289
MOD_GlcNHglycan	269	272	PF01048	0.306
MOD_GlcNHglycan	311	314	PF01048	0.332
MOD_GlcNHglycan	322	326	PF01048	0.223
MOD_GlcNHglycan	390	393	PF01048	0.384
MOD_GlcNHglycan	423	426	PF01048	0.330
MOD_GlcNHglycan	567	570	PF01048	0.257
MOD_GlcNHglycan	579	582	PF01048	0.253
MOD_GlcNHglycan	731	734	PF01048	0.651
MOD_GlcNHglycan	78	81	PF01048	0.516
MOD_GlcNHglycan	798	801	PF01048	0.608
MOD_GlcNHglycan	838	841	PF01048	0.661
MOD_GlcNHglycan	856	859	PF01048	0.557
MOD_GlcNHglycan	896	899	PF01048	0.486
MOD_GlcNHglycan	916	919	PF01048	0.433
MOD_GlcNHglycan	93	96	PF01048	0.613
MOD_GSK3_1	23	30	PF00069	0.518
MOD_GSK3_1	32	39	PF00069	0.564
MOD_GSK3_1	496	503	PF00069	0.322
MOD_GSK3_1	573	580	PF00069	0.275
MOD_GSK3_1	58	65	PF00069	0.561
MOD_GSK3_1	637	644	PF00069	0.532
MOD_GSK3_1	723	730	PF00069	0.637
MOD_GSK3_1	731	738	PF00069	0.613
MOD_GSK3_1	742	749	PF00069	0.598
MOD_GSK3_1	823	830	PF00069	0.577
MOD_GSK3_1	832	839	PF00069	0.530
MOD_GSK3_1	843	850	PF00069	0.518
MOD_GSK3_1	909	916	PF00069	0.611
MOD_GSK3_1	919	926	PF00069	0.563
MOD_GSK3_1	93	100	PF00069	0.526
MOD_N-GLC_2	259	261	PF02516	0.285
MOD_N-GLC_2	706	708	PF02516	0.390
MOD_N-GLC_2	74	76	PF02516	0.453
MOD_NEK2_1	149	154	PF00069	0.260
MOD_NEK2_1	167	172	PF00069	0.260
MOD_NEK2_1	225	230	PF00069	0.277
MOD_NEK2_1	239	244	PF00069	0.365
MOD_NEK2_1	267	272	PF00069	0.155
MOD_NEK2_1	296	301	PF00069	0.330
MOD_NEK2_1	413	418	PF00069	0.262
MOD_NEK2_1	436	441	PF00069	0.290
MOD_NEK2_1	453	458	PF00069	0.557
MOD_NEK2_1	500	505	PF00069	0.268
MOD_NEK2_1	521	526	PF00069	0.332
MOD_NEK2_1	552	557	PF00069	0.284
MOD_NEK2_1	823	828	PF00069	0.599
MOD_NEK2_2	624	629	PF00069	0.472
MOD_NEK2_2	833	838	PF00069	0.464
MOD_PIKK_1	439	445	PF00454	0.356
MOD_PIKK_1	521	527	PF00454	0.332
MOD_PIKK_1	552	558	PF00454	0.260
MOD_PIKK_1	746	752	PF00454	0.723
MOD_PIKK_1	823	829	PF00454	0.578
MOD_PK_1	67	73	PF00069	0.438
MOD_PK_1	740	746	PF00069	0.620
MOD_PKA_2	370	376	PF00069	0.376
MOD_PKA_2	414	420	PF00069	0.157
MOD_PKA_2	496	502	PF00069	0.302
MOD_PKA_2	519	525	PF00069	0.450
MOD_PKA_2	671	677	PF00069	0.556
MOD_PKA_2	863	869	PF00069	0.580
MOD_PKA_2	909	915	PF00069	0.681
MOD_PKB_1	760	768	PF00069	0.604
MOD_Plk_1	413	419	PF00069	0.227
MOD_Plk_1	453	459	PF00069	0.316
MOD_Plk_1	735	741	PF00069	0.604
MOD_Plk_1	782	788	PF00069	0.598
MOD_Plk_4	168	174	PF00069	0.324
MOD_Plk_4	175	181	PF00069	0.250
MOD_Plk_4	239	245	PF00069	0.332
MOD_Plk_4	296	302	PF00069	0.260
MOD_Plk_4	311	317	PF00069	0.260
MOD_Plk_4	436	442	PF00069	0.296
MOD_Plk_4	448	454	PF00069	0.460
MOD_Plk_4	496	502	PF00069	0.279
MOD_Plk_4	504	510	PF00069	0.268
MOD_Plk_4	879	885	PF00069	0.505
MOD_ProDKin_1	11	17	PF00069	0.632
MOD_ProDKin_1	277	283	PF00069	0.260
MOD_ProDKin_1	34	40	PF00069	0.703
MOD_ProDKin_1	527	533	PF00069	0.449
MOD_ProDKin_1	641	647	PF00069	0.685
MOD_ProDKin_1	727	733	PF00069	0.655
MOD_ProDKin_1	742	748	PF00069	0.626
MOD_ProDKin_1	749	755	PF00069	0.641
MOD_ProDKin_1	829	835	PF00069	0.646
MOD_ProDKin_1	97	103	PF00069	0.724
MOD_SUMO_rev_2	81	89	PF00179	0.456
TRG_DiLeu_BaEn_1	2	7	PF01217	0.573
TRG_DiLeu_BaEn_1	676	681	PF01217	0.474
TRG_DiLeu_BaLyEn_6	431	436	PF01217	0.376
TRG_ENDOCYTIC_2	229	232	PF00928	0.268
TRG_ENDOCYTIC_2	246	249	PF00928	0.396
TRG_ENDOCYTIC_2	380	383	PF00928	0.284
TRG_ENDOCYTIC_2	652	655	PF00928	0.468
TRG_ER_diArg_1	347	349	PF00400	0.260
TRG_ER_diArg_1	694	696	PF00400	0.506
TRG_ER_diArg_1	759	762	PF00400	0.700
TRG_ER_diArg_1	776	779	PF00400	0.491
TRG_NES_CRM1_1	238	251	PF08389	0.314
TRG_NLS_MonoCore_2	206	211	PF00514	0.356
TRG_NLS_MonoExtN_4	206	212	PF00514	0.370
TRG_NLS_MonoExtN_4	213	219	PF00514	0.385
TRG_Pf-PMV_PEXEL_1	641	646	PF00026	0.475
TRG_PTS1	924	927	PF00515	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYE0	Leptomonas seymouri	60%	95%
A0A1X0P3S9	Trypanosomatidae	49%	100%
A0A3R7MS90	Trypanosoma rangeli	52%	100%
A0A451EJ80	Leishmania donovani	88%	100%
A4H349	Leishmania braziliensis	79%	100%
A4HGB7	Leishmania braziliensis	23%	100%
A4HRE5	Leishmania infantum	88%	100%
A6QQR4	Bos taurus	31%	75%
E9AC13	Leishmania major	87%	100%
P34739	Drosophila melanogaster	22%	87%
Q2NKX8	Homo sapiens	32%	74%
Q7F2E4	Oryza sativa subsp. japonica	28%	78%
Q7S1P9	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	23%	75%
Q8BHK9	Mus musculus	32%	75%
Q8W103	Arabidopsis thaliana	31%	85%
Q9M297	Arabidopsis thaliana	21%	74%
Q9UNY4	Homo sapiens	26%	80%
Q9XFH4	Arabidopsis thaliana	25%	100%
V5B5G3	Trypanosoma cruzi	51%	100%