Putative cyclophilin type peptidyl-prolyl cis-trans isomerase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclophilin type peptidyl-prolyl cis-trans isomerase, putative

Species:

Leishmania mexicana

UniProt:

E9AJA8_LEIMU

TriTrypDb:

LmxM.01.0220

Length:

334

Annotations

LeishMANIAdb annotations

A large collection of conserved eukaryotic peptidyl-prolyl cis-trans isomerases. Some members of this group are secreted (into the ER).. Localization: Cytoplasmic (by homology) / ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	5
GO:0005737	cytoplasm	2	3
GO:0005930	axoneme	2	1

Expansion

Sequence features

E9AJA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJA8

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	23
GO:0006807	nitrogen compound metabolic process	2	23
GO:0008152	metabolic process	1	23
GO:0018193	peptidyl-amino acid modification	5	23
GO:0018208	peptidyl-proline modification	6	23
GO:0019538	protein metabolic process	3	23
GO:0036211	protein modification process	4	23
GO:0043170	macromolecule metabolic process	3	23
GO:0043412	macromolecule modification	4	23
GO:0044238	primary metabolic process	2	23
GO:0071704	organic substance metabolic process	2	23
GO:1901564	organonitrogen compound metabolic process	3	23
GO:0006457	protein folding	2	10
GO:0009987	cellular process	1	10

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	23
GO:0003824	catalytic activity	1	23
GO:0016853	isomerase activity	2	23
GO:0016859	cis-trans isomerase activity	3	23
GO:0140096	catalytic activity, acting on a protein	2	23
GO:0005488	binding	1	2
GO:0016018	cyclosporin A binding	4	2
GO:0033218	amide binding	2	2
GO:0042277	peptide binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	220	224	PF00656	0.242
CLV_NRD_NRD_1	51	53	PF00675	0.375
CLV_PCSK_KEX2_1	136	138	PF00082	0.330
CLV_PCSK_KEX2_1	51	53	PF00082	0.372
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.301
CLV_PCSK_SKI1_1	105	109	PF00082	0.448
CLV_PCSK_SKI1_1	140	144	PF00082	0.410
CLV_PCSK_SKI1_1	219	223	PF00082	0.373
CLV_Separin_Metazoa	43	47	PF03568	0.314
DOC_MAPK_gen_1	146	155	PF00069	0.306
DOC_MAPK_HePTP_8	310	322	PF00069	0.195
DOC_MAPK_MEF2A_6	148	157	PF00069	0.307
DOC_MAPK_MEF2A_6	313	322	PF00069	0.195
DOC_PP1_RVXF_1	162	168	PF00149	0.295
DOC_PP1_RVXF_1	288	295	PF00149	0.339
DOC_PP2B_LxvP_1	42	45	PF13499	0.320
DOC_USP7_MATH_1	197	201	PF00917	0.388
DOC_USP7_MATH_1	318	322	PF00917	0.219
DOC_USP7_MATH_1	54	58	PF00917	0.399
LIG_14-3-3_CanoR_1	105	113	PF00244	0.515
LIG_14-3-3_CanoR_1	114	124	PF00244	0.435
LIG_14-3-3_CanoR_1	282	287	PF00244	0.294
LIG_BIR_III_4	258	262	PF00653	0.236
LIG_BRCT_BRCA1_1	273	277	PF00533	0.442
LIG_FHA_1	193	199	PF00498	0.158
LIG_FHA_1	250	256	PF00498	0.369
LIG_FHA_2	116	122	PF00498	0.498
LIG_FHA_2	12	18	PF00498	0.505
LIG_FHA_2	218	224	PF00498	0.251
LIG_FHA_2	323	329	PF00498	0.317
LIG_LIR_Apic_2	199	205	PF02991	0.219
LIG_LIR_Apic_2	250	256	PF02991	0.280
LIG_LIR_Gen_1	168	176	PF02991	0.308
LIG_LIR_Gen_1	275	284	PF02991	0.259
LIG_LIR_Gen_1	34	44	PF02991	0.336
LIG_LIR_Nem_3	168	173	PF02991	0.352
LIG_LIR_Nem_3	215	221	PF02991	0.228
LIG_LIR_Nem_3	275	281	PF02991	0.392
LIG_LIR_Nem_3	34	39	PF02991	0.336
LIG_LIR_Nem_3	5	10	PF02991	0.439
LIG_PDZ_Class_1	329	334	PF00595	0.344
LIG_Pex14_1	166	170	PF04695	0.348
LIG_PTB_Apo_2	26	33	PF02174	0.314
LIG_PTB_Phospho_1	26	32	PF10480	0.320
LIG_REV1ctd_RIR_1	215	223	PF16727	0.222
LIG_SH2_CRK	10	14	PF00017	0.439
LIG_SH2_CRK	170	174	PF00017	0.256
LIG_SH2_CRK	202	206	PF00017	0.171
LIG_SH2_CRK	253	257	PF00017	0.256
LIG_SH2_CRK	36	40	PF00017	0.315
LIG_SH2_GRB2like	27	30	PF00017	0.344
LIG_SH2_NCK_1	170	174	PF00017	0.242
LIG_SH2_NCK_1	202	206	PF00017	0.158
LIG_SH2_PTP2	278	281	PF00017	0.325
LIG_SH2_STAP1	170	174	PF00017	0.236
LIG_SH2_STAP1	36	40	PF00017	0.403
LIG_SH2_STAT3	131	134	PF00017	0.303
LIG_SH2_STAT5	131	134	PF00017	0.508
LIG_SH2_STAT5	150	153	PF00017	0.209
LIG_SH2_STAT5	27	30	PF00017	0.294
LIG_SH2_STAT5	278	281	PF00017	0.250
LIG_SH2_STAT5	291	294	PF00017	0.250
LIG_SUMO_SIM_par_1	194	200	PF11976	0.247
LIG_TRFH_1	202	206	PF08558	0.158
LIG_TYR_ITSM	6	13	PF00017	0.418
LIG_WRC_WIRS_1	4	9	PF05994	0.325
MOD_CK1_1	117	123	PF00069	0.282
MOD_CK1_1	75	81	PF00069	0.521
MOD_CK1_1	83	89	PF00069	0.470
MOD_CK2_1	68	74	PF00069	0.537
MOD_CK2_1	96	102	PF00069	0.686
MOD_Cter_Amidation	134	137	PF01082	0.284
MOD_GlcNHglycan	274	277	PF01048	0.384
MOD_GlcNHglycan	56	59	PF01048	0.406
MOD_GlcNHglycan	74	77	PF01048	0.557
MOD_GlcNHglycan	82	85	PF01048	0.502
MOD_GlcNHglycan	98	101	PF01048	0.616
MOD_GSK3_1	185	192	PF00069	0.359
MOD_GSK3_1	213	220	PF00069	0.280
MOD_GSK3_1	229	236	PF00069	0.418
MOD_GSK3_1	318	325	PF00069	0.412
MOD_GSK3_1	68	75	PF00069	0.741
MOD_GSK3_1	76	83	PF00069	0.507
MOD_N-GLC_1	114	119	PF02516	0.526
MOD_N-GLC_1	272	277	PF02516	0.314
MOD_N-GLC_2	180	182	PF02516	0.297
MOD_NEK2_1	142	147	PF00069	0.504
MOD_NEK2_1	217	222	PF00069	0.301
MOD_NEK2_1	277	282	PF00069	0.306
MOD_NEK2_1	72	77	PF00069	0.564
MOD_NEK2_2	197	202	PF00069	0.219
MOD_NEK2_2	239	244	PF00069	0.330
MOD_PIKK_1	60	66	PF00454	0.463
MOD_PKA_2	185	191	PF00069	0.413
MOD_Plk_1	2	8	PF00069	0.317
MOD_Plk_1	249	255	PF00069	0.281
MOD_Plk_1	272	278	PF00069	0.195
MOD_Plk_1	68	74	PF00069	0.716
MOD_Plk_4	108	114	PF00069	0.408
MOD_Plk_4	185	191	PF00069	0.288
MOD_Plk_4	197	203	PF00069	0.355
MOD_Plk_4	213	219	PF00069	0.207
MOD_Plk_4	282	288	PF00069	0.257
MOD_Plk_4	318	324	PF00069	0.334
MOD_SUMO_for_1	40	43	PF00179	0.329
MOD_SUMO_rev_2	117	124	PF00179	0.422
TRG_DiLeu_BaEn_1	102	107	PF01217	0.408
TRG_DiLeu_LyEn_5	102	107	PF01217	0.380
TRG_ENDOCYTIC_2	10	13	PF00928	0.430
TRG_ENDOCYTIC_2	150	153	PF00928	0.354
TRG_ENDOCYTIC_2	170	173	PF00928	0.236
TRG_ENDOCYTIC_2	278	281	PF00928	0.236
TRG_ENDOCYTIC_2	291	294	PF00928	0.234
TRG_ENDOCYTIC_2	36	39	PF00928	0.330
TRG_Pf-PMV_PEXEL_1	105	110	PF00026	0.334
TRG_Pf-PMV_PEXEL_1	219	223	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL84	Leptomonas seymouri	55%	100%
A0A0N1PDY0	Leptomonas seymouri	26%	100%
A0A0S4IKA5	Bodo saltans	38%	100%
A0A3Q8ICB3	Leishmania donovani	29%	100%
A0A3R7M7E5	Trypanosoma rangeli	44%	100%
A0A3S5H7U6	Leishmania donovani	36%	100%
A0A3S7X325	Leishmania donovani	23%	100%
A0A3S7X410	Leishmania donovani	35%	100%
A0A3S7XB52	Leishmania donovani	35%	100%
A0A451EJ79	Leishmania donovani	90%	100%
A4H346	Leishmania braziliensis	81%	100%
A4HCI8	Leishmania braziliensis	28%	100%
A4HHU7	Leishmania braziliensis	25%	100%
A4HIW9	Leishmania braziliensis	34%	100%
A4HRE3	Leishmania infantum	90%	100%
A4I004	Leishmania infantum	29%	100%
A4I4Z7	Leishmania infantum	23%	100%
A4I698	Leishmania infantum	35%	100%
A4I935	Leishmania infantum	36%	100%
A4IDA1	Leishmania infantum	35%	100%
C9ZQE6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
C9ZXF5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AC11	Leishmania major	89%	100%
E9AT91	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AVX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B0C7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B1F3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9B400	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
P0C1I2	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	31%	100%
Q26548	Schistosoma mansoni	29%	100%
Q4Q1A6	Leishmania major	35%	100%
Q4Q6Q9	Leishmania major	35%	100%
Q4Q7V7	Leishmania major	24%	100%
Q4QBK2	Leishmania major	29%	100%
Q8IXY8	Homo sapiens	30%	100%
V5B9Y6	Trypanosoma cruzi	43%	100%
V5BM49	Trypanosoma cruzi	29%	100%