Zinc finger (CCCH type) motif-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CUE domain/Domain of unknown function (DUF1771)/Smr domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AJA7_LEIMU

TriTrypDb:

LmxM.01.0210

Length:

896

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJA7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJA7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	10
GO:0032182	ubiquitin-like protein binding	3	10
GO:0043130	ubiquitin binding	4	10
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004519	endonuclease activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.431
CLV_C14_Caspase3-7	199	203	PF00656	0.633
CLV_C14_Caspase3-7	265	269	PF00656	0.647
CLV_C14_Caspase3-7	395	399	PF00656	0.709
CLV_C14_Caspase3-7	425	429	PF00656	0.722
CLV_C14_Caspase3-7	433	437	PF00656	0.698
CLV_C14_Caspase3-7	766	770	PF00656	0.292
CLV_NRD_NRD_1	220	222	PF00675	0.653
CLV_NRD_NRD_1	326	328	PF00675	0.734
CLV_NRD_NRD_1	363	365	PF00675	0.584
CLV_NRD_NRD_1	402	404	PF00675	0.743
CLV_NRD_NRD_1	421	423	PF00675	0.609
CLV_NRD_NRD_1	741	743	PF00675	0.277
CLV_NRD_NRD_1	781	783	PF00675	0.469
CLV_NRD_NRD_1	827	829	PF00675	0.271
CLV_NRD_NRD_1	98	100	PF00675	0.559
CLV_PCSK_KEX2_1	2	4	PF00082	0.724
CLV_PCSK_KEX2_1	220	222	PF00082	0.653
CLV_PCSK_KEX2_1	326	328	PF00082	0.716
CLV_PCSK_KEX2_1	363	365	PF00082	0.555
CLV_PCSK_KEX2_1	741	743	PF00082	0.271
CLV_PCSK_KEX2_1	781	783	PF00082	0.444
CLV_PCSK_KEX2_1	827	829	PF00082	0.274
CLV_PCSK_KEX2_1	98	100	PF00082	0.585
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.724
CLV_PCSK_SKI1_1	422	426	PF00082	0.563
CLV_PCSK_SKI1_1	666	670	PF00082	0.384
CLV_PCSK_SKI1_1	841	845	PF00082	0.318
CLV_PCSK_SKI1_1	878	882	PF00082	0.388
DEG_Nend_UBRbox_1	1	4	PF02207	0.683
DEG_SCF_TRCP1_1	428	434	PF00400	0.502
DEG_SPOP_SBC_1	311	315	PF00917	0.725
DEG_SPOP_SBC_1	523	527	PF00917	0.442
DEG_SPOP_SBC_1	61	65	PF00917	0.623
DEG_SPOP_SBC_1	81	85	PF00917	0.442
DOC_ANK_TNKS_1	388	395	PF00023	0.424
DOC_CYCLIN_RxL_1	663	673	PF00134	0.395
DOC_MAPK_gen_1	627	635	PF00069	0.549
DOC_MAPK_gen_1	789	798	PF00069	0.289
DOC_MAPK_gen_1	878	887	PF00069	0.423
DOC_MAPK_MEF2A_6	352	360	PF00069	0.369
DOC_MAPK_MEF2A_6	627	635	PF00069	0.426
DOC_MAPK_MEF2A_6	881	889	PF00069	0.399
DOC_PP2B_LxvP_1	222	225	PF13499	0.581
DOC_PP2B_LxvP_1	442	445	PF13499	0.637
DOC_USP7_MATH_1	274	278	PF00917	0.571
DOC_USP7_MATH_1	309	313	PF00917	0.743
DOC_USP7_MATH_1	443	447	PF00917	0.750
DOC_USP7_MATH_1	456	460	PF00917	0.602
DOC_USP7_MATH_1	538	542	PF00917	0.490
DOC_USP7_MATH_1	61	65	PF00917	0.731
DOC_USP7_MATH_1	71	75	PF00917	0.695
DOC_USP7_MATH_1	729	733	PF00917	0.292
DOC_USP7_MATH_1	764	768	PF00917	0.292
DOC_USP7_UBL2_3	18	22	PF12436	0.463
DOC_WW_Pin1_4	246	251	PF00397	0.575
DOC_WW_Pin1_4	285	290	PF00397	0.674
DOC_WW_Pin1_4	312	317	PF00397	0.679
DOC_WW_Pin1_4	618	623	PF00397	0.553
DOC_WW_Pin1_4	88	93	PF00397	0.645
LIG_14-3-3_CanoR_1	14	20	PF00244	0.436
LIG_14-3-3_CanoR_1	364	374	PF00244	0.491
LIG_14-3-3_CanoR_1	422	427	PF00244	0.599
LIG_14-3-3_CanoR_1	513	521	PF00244	0.355
LIG_14-3-3_CanoR_1	656	664	PF00244	0.486
LIG_14-3-3_CanoR_1	774	783	PF00244	0.468
LIG_14-3-3_CanoR_1	802	811	PF00244	0.451
LIG_14-3-3_CanoR_1	830	840	PF00244	0.171
LIG_14-3-3_CanoR_1	890	896	PF00244	0.356
LIG_Actin_WH2_2	443	460	PF00022	0.568
LIG_BIR_III_2	167	171	PF00653	0.523
LIG_BIR_III_4	398	402	PF00653	0.622
LIG_BRCT_BRCA1_1	339	343	PF00533	0.513
LIG_BRCT_BRCA1_1	83	87	PF00533	0.588
LIG_Clathr_ClatBox_1	668	672	PF01394	0.511
LIG_EVH1_2	250	254	PF00568	0.581
LIG_FHA_1	24	30	PF00498	0.404
LIG_FHA_1	656	662	PF00498	0.458
LIG_FHA_1	663	669	PF00498	0.486
LIG_FHA_1	696	702	PF00498	0.561
LIG_FHA_1	750	756	PF00498	0.292
LIG_FHA_1	770	776	PF00498	0.193
LIG_FHA_1	806	812	PF00498	0.393
LIG_FHA_1	81	87	PF00498	0.713
LIG_FHA_1	886	892	PF00498	0.505
LIG_FHA_2	160	166	PF00498	0.405
LIG_FHA_2	376	382	PF00498	0.564
LIG_FHA_2	423	429	PF00498	0.755
LIG_FHA_2	431	437	PF00498	0.680
LIG_FHA_2	524	530	PF00498	0.551
LIG_FHA_2	619	625	PF00498	0.612
LIG_FHA_2	712	718	PF00498	0.589
LIG_FHA_2	858	864	PF00498	0.425
LIG_LIR_Apic_2	241	245	PF02991	0.624
LIG_LIR_Apic_2	686	692	PF02991	0.628
LIG_LIR_Gen_1	230	240	PF02991	0.721
LIG_LIR_Gen_1	595	603	PF02991	0.348
LIG_LIR_Gen_1	786	795	PF02991	0.290
LIG_LIR_Nem_3	113	119	PF02991	0.468
LIG_LIR_Nem_3	230	235	PF02991	0.726
LIG_LIR_Nem_3	249	255	PF02991	0.733
LIG_LIR_Nem_3	288	293	PF02991	0.740
LIG_LIR_Nem_3	490	495	PF02991	0.458
LIG_LIR_Nem_3	572	577	PF02991	0.337
LIG_LIR_Nem_3	595	600	PF02991	0.288
LIG_LIR_Nem_3	722	727	PF02991	0.507
LIG_LIR_Nem_3	739	743	PF02991	0.187
LIG_LIR_Nem_3	786	790	PF02991	0.290
LIG_LIR_Nem_3	856	861	PF02991	0.318
LIG_LYPXL_S_1	857	861	PF13949	0.314
LIG_LYPXL_yS_3	858	861	PF13949	0.314
LIG_MYND_3	444	448	PF01753	0.460
LIG_PCNA_yPIPBox_3	818	830	PF02747	0.171
LIG_SH2_CRK	119	123	PF00017	0.430
LIG_SH2_CRK	597	601	PF00017	0.271
LIG_SH2_CRK	787	791	PF00017	0.314
LIG_SH2_PTP2	884	887	PF00017	0.403
LIG_SH2_SRC	884	887	PF00017	0.403
LIG_SH2_STAT5	119	122	PF00017	0.489
LIG_SH2_STAT5	158	161	PF00017	0.523
LIG_SH2_STAT5	242	245	PF00017	0.659
LIG_SH2_STAT5	408	411	PF00017	0.546
LIG_SH2_STAT5	647	650	PF00017	0.493
LIG_SH2_STAT5	748	751	PF00017	0.271
LIG_SH2_STAT5	884	887	PF00017	0.391
LIG_SH3_2	303	308	PF14604	0.673
LIG_SH3_3	281	287	PF00018	0.592
LIG_SH3_3	300	306	PF00018	0.512
LIG_SH3_3	313	319	PF00018	0.735
LIG_SH3_3	573	579	PF00018	0.236
LIG_SH3_3	630	636	PF00018	0.396
LIG_SH3_3	688	694	PF00018	0.690
LIG_SH3_3	886	892	PF00018	0.506
LIG_SUMO_SIM_par_1	566	572	PF11976	0.411
LIG_SUMO_SIM_par_1	578	583	PF11976	0.422
LIG_SUMO_SIM_par_1	667	673	PF11976	0.582
LIG_SUMO_SIM_par_1	794	799	PF11976	0.271
LIG_TRAF2_1	541	544	PF00917	0.497
LIG_TRAF2_1	715	718	PF00917	0.582
LIG_TYR_ITIM	785	790	PF00017	0.349
MOD_CDK_SPxK_1	285	291	PF00069	0.620
MOD_CK1_1	238	244	PF00069	0.570
MOD_CK1_1	312	318	PF00069	0.680
MOD_CK1_1	477	483	PF00069	0.583
MOD_CK1_1	614	620	PF00069	0.557
MOD_CK1_1	64	70	PF00069	0.622
MOD_CK1_1	655	661	PF00069	0.425
MOD_CK1_1	670	676	PF00069	0.603
MOD_CK2_1	238	244	PF00069	0.712
MOD_CK2_1	365	371	PF00069	0.575
MOD_CK2_1	375	381	PF00069	0.438
MOD_CK2_1	475	481	PF00069	0.601
MOD_CK2_1	523	529	PF00069	0.529
MOD_CK2_1	538	544	PF00069	0.385
MOD_CK2_1	711	717	PF00069	0.639
MOD_CK2_1	857	863	PF00069	0.292
MOD_Cter_Amidation	779	782	PF01082	0.335
MOD_GlcNHglycan	276	279	PF01048	0.605
MOD_GlcNHglycan	296	299	PF01048	0.727
MOD_GlcNHglycan	367	370	PF01048	0.543
MOD_GlcNHglycan	428	431	PF01048	0.609
MOD_GlcNHglycan	477	480	PF01048	0.597
MOD_GlcNHglycan	5	8	PF01048	0.554
MOD_GlcNHglycan	506	509	PF01048	0.483
MOD_GlcNHglycan	540	543	PF01048	0.502
MOD_GlcNHglycan	609	612	PF01048	0.589
MOD_GlcNHglycan	613	616	PF01048	0.645
MOD_GlcNHglycan	644	647	PF01048	0.403
MOD_GlcNHglycan	68	71	PF01048	0.724
MOD_GlcNHglycan	707	710	PF01048	0.655
MOD_GlcNHglycan	717	722	PF01048	0.492
MOD_GlcNHglycan	724	727	PF01048	0.347
MOD_GlcNHglycan	766	769	PF01048	0.373
MOD_GlcNHglycan	871	874	PF01048	0.454
MOD_GSK3_1	186	193	PF00069	0.608
MOD_GSK3_1	310	317	PF00069	0.708
MOD_GSK3_1	418	425	PF00069	0.819
MOD_GSK3_1	426	433	PF00069	0.701
MOD_GSK3_1	60	67	PF00069	0.706
MOD_GSK3_1	607	614	PF00069	0.513
MOD_GSK3_1	71	78	PF00069	0.656
MOD_GSK3_1	712	719	PF00069	0.692
MOD_GSK3_1	759	766	PF00069	0.292
MOD_GSK3_1	802	809	PF00069	0.460
MOD_GSK3_1	853	860	PF00069	0.348
MOD_LATS_1	839	845	PF00433	0.292
MOD_N-GLC_1	75	80	PF02516	0.604
MOD_NEK2_1	134	139	PF00069	0.431
MOD_NEK2_1	387	392	PF00069	0.696
MOD_NEK2_1	504	509	PF00069	0.475
MOD_NEK2_1	749	754	PF00069	0.292
MOD_NEK2_1	75	80	PF00069	0.716
MOD_NEK2_1	87	92	PF00069	0.680
MOD_NEK2_2	140	145	PF00069	0.376
MOD_NEK2_2	82	87	PF00069	0.581
MOD_NEK2_2	853	858	PF00069	0.349
MOD_OFUCOSY	107	114	PF10250	0.509
MOD_OFUCOSY	138	144	PF10250	0.414
MOD_OFUCOSY	334	341	PF10250	0.373
MOD_PIKK_1	23	29	PF00454	0.463
MOD_PIKK_1	584	590	PF00454	0.404
MOD_PIKK_1	749	755	PF00454	0.335
MOD_PK_1	876	882	PF00069	0.406
MOD_PKA_1	2	8	PF00069	0.427
MOD_PKA_1	422	428	PF00069	0.506
MOD_PKA_2	13	19	PF00069	0.434
MOD_PKA_2	146	152	PF00069	0.478
MOD_PKA_2	2	8	PF00069	0.481
MOD_PKA_2	235	241	PF00069	0.687
MOD_PKA_2	365	371	PF00069	0.450
MOD_PKA_2	406	412	PF00069	0.763
MOD_PKA_2	430	436	PF00069	0.720
MOD_PKA_2	504	510	PF00069	0.515
MOD_PKA_2	512	518	PF00069	0.460
MOD_PKA_2	655	661	PF00069	0.480
MOD_PKB_1	373	381	PF00069	0.466
MOD_Plk_1	885	891	PF00069	0.568
MOD_Plk_2-3	667	673	PF00069	0.584
MOD_Plk_4	566	572	PF00069	0.284
MOD_Plk_4	82	88	PF00069	0.636
MOD_Plk_4	853	859	PF00069	0.368
MOD_ProDKin_1	246	252	PF00069	0.579
MOD_ProDKin_1	285	291	PF00069	0.675
MOD_ProDKin_1	312	318	PF00069	0.679
MOD_ProDKin_1	618	624	PF00069	0.540
MOD_ProDKin_1	88	94	PF00069	0.640
TRG_DiLeu_BaEn_1	745	750	PF01217	0.464
TRG_DiLeu_BaEn_2	480	486	PF01217	0.523
TRG_DiLeu_BaLyEn_6	223	228	PF01217	0.573
TRG_ENDOCYTIC_2	119	122	PF00928	0.395
TRG_ENDOCYTIC_2	255	258	PF00928	0.478
TRG_ENDOCYTIC_2	597	600	PF00928	0.271
TRG_ENDOCYTIC_2	787	790	PF00928	0.290
TRG_ENDOCYTIC_2	858	861	PF00928	0.293
TRG_ENDOCYTIC_2	884	887	PF00928	0.368
TRG_ER_diArg_1	179	182	PF00400	0.461
TRG_ER_diArg_1	220	222	PF00400	0.659
TRG_ER_diArg_1	326	329	PF00400	0.706
TRG_ER_diArg_1	363	366	PF00400	0.547
TRG_ER_diArg_1	53	56	PF00400	0.521
TRG_ER_diArg_1	740	742	PF00400	0.271
TRG_ER_diArg_1	754	757	PF00400	0.271
TRG_ER_diArg_1	781	783	PF00400	0.475
TRG_ER_diArg_1	826	828	PF00400	0.274
TRG_ER_diArg_1	97	99	PF00400	0.636
TRG_NES_CRM1_1	529	543	PF08389	0.344
TRG_Pf-PMV_PEXEL_1	41	46	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	756	760	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	774	779	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	781	786	PF00026	0.286

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE15	Leptomonas seymouri	49%	99%
A0A1X0P3G2	Trypanosomatidae	33%	100%
A0A3R7KV90	Trypanosoma rangeli	35%	100%
A0A3S5H4T8	Leishmania donovani	92%	100%
A4H345	Leishmania braziliensis	74%	99%
A4HRE2	Leishmania infantum	92%	100%
C9ZXF6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AC10	Leishmania major	91%	100%
V5D5T7	Trypanosoma cruzi	35%	100%