LMWPc domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Low molecular weight phosphotyrosine protein phosphatase, putative

Species:

Leishmania mexicana

UniProt:

E9AJA6_LEIMU

TriTrypDb:

LmxM.01.0200

Length:

298

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJA6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0004725	protein tyrosine phosphatase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	178	182	PF00656	0.435
CLV_NRD_NRD_1	105	107	PF00675	0.290
CLV_NRD_NRD_1	131	133	PF00675	0.566
CLV_NRD_NRD_1	202	204	PF00675	0.452
CLV_NRD_NRD_1	224	226	PF00675	0.488
CLV_NRD_NRD_1	232	234	PF00675	0.445
CLV_PCSK_KEX2_1	105	107	PF00082	0.289
CLV_PCSK_KEX2_1	131	133	PF00082	0.549
CLV_PCSK_KEX2_1	232	234	PF00082	0.480
CLV_PCSK_SKI1_1	242	246	PF00082	0.550
CLV_PCSK_SKI1_1	259	263	PF00082	0.285
CLV_PCSK_SKI1_1	58	62	PF00082	0.297
DEG_APCC_DBOX_1	258	266	PF00400	0.446
DEG_SCF_FBW7_1	9	16	PF00400	0.499
DEG_SPOP_SBC_1	154	158	PF00917	0.599
DOC_CKS1_1	10	15	PF01111	0.501
DOC_MAPK_gen_1	105	115	PF00069	0.389
DOC_MAPK_MEF2A_6	108	117	PF00069	0.389
DOC_PP2B_LxvP_1	5	8	PF13499	0.428
DOC_PP4_FxxP_1	160	163	PF00568	0.567
DOC_PP4_MxPP_1	1	4	PF00568	0.418
DOC_USP7_MATH_1	139	143	PF00917	0.665
DOC_WW_Pin1_4	166	171	PF00397	0.511
DOC_WW_Pin1_4	187	192	PF00397	0.407
DOC_WW_Pin1_4	9	14	PF00397	0.487
LIG_14-3-3_CanoR_1	183	189	PF00244	0.545
LIG_14-3-3_CanoR_1	31	41	PF00244	0.523
LIG_14-3-3_CanoR_1	95	104	PF00244	0.424
LIG_Actin_WH2_2	212	227	PF00022	0.530
LIG_CSL_BTD_1	188	191	PF09270	0.402
LIG_eIF4E_1	210	216	PF01652	0.392
LIG_FHA_1	108	114	PF00498	0.333
LIG_FHA_1	200	206	PF00498	0.600
LIG_FHA_2	245	251	PF00498	0.544
LIG_FHA_2	278	284	PF00498	0.561
LIG_FHA_2	286	292	PF00498	0.583
LIG_GBD_Chelix_1	265	273	PF00786	0.466
LIG_HCF-1_HBM_1	207	210	PF13415	0.433
LIG_LIR_Apic_2	157	163	PF02991	0.561
LIG_LIR_Gen_1	112	121	PF02991	0.333
LIG_LIR_Gen_1	213	224	PF02991	0.414
LIG_LIR_Gen_1	288	295	PF02991	0.488
LIG_LIR_Nem_3	109	114	PF02991	0.314
LIG_LIR_Nem_3	213	219	PF02991	0.399
LIG_LIR_Nem_3	288	293	PF02991	0.425
LIG_PDZ_Class_1	293	298	PF00595	0.476
LIG_Pex14_2	56	60	PF04695	0.433
LIG_RPA_C_Fungi	90	102	PF08784	0.351
LIG_SH2_NCK_1	290	294	PF00017	0.543
LIG_SH2_PTP2	114	117	PF00017	0.313
LIG_SH2_STAP1	111	115	PF00017	0.338
LIG_SH2_STAP1	290	294	PF00017	0.580
LIG_SH2_STAT5	114	117	PF00017	0.313
LIG_SH2_STAT5	121	124	PF00017	0.313
LIG_SH2_STAT5	133	136	PF00017	0.533
LIG_SH3_3	114	120	PF00018	0.415
LIG_SH3_3	144	150	PF00018	0.442
LIG_SH3_3	188	194	PF00018	0.416
LIG_TYR_ITSM	286	293	PF00017	0.283
MOD_CDK_SPK_2	187	192	PF00069	0.407
MOD_CK1_1	152	158	PF00069	0.618
MOD_CK1_1	176	182	PF00069	0.441
MOD_CK1_1	32	38	PF00069	0.393
MOD_CK1_1	94	100	PF00069	0.312
MOD_CK2_1	244	250	PF00069	0.488
MOD_CK2_1	285	291	PF00069	0.443
MOD_CMANNOS	186	189	PF00535	0.410
MOD_GlcNHglycan	166	169	PF01048	0.489
MOD_GlcNHglycan	68	71	PF01048	0.301
MOD_GSK3_1	119	126	PF00069	0.338
MOD_GSK3_1	149	156	PF00069	0.694
MOD_GSK3_1	173	180	PF00069	0.572
MOD_GSK3_1	25	32	PF00069	0.482
MOD_GSK3_1	9	16	PF00069	0.630
MOD_GSK3_1	91	98	PF00069	0.357
MOD_LATS_1	27	33	PF00433	0.487
MOD_N-GLC_1	25	30	PF02516	0.532
MOD_NEK2_1	164	169	PF00069	0.557
MOD_NEK2_1	261	266	PF00069	0.526
MOD_NEK2_1	66	71	PF00069	0.333
MOD_PIKK_1	133	139	PF00454	0.582
MOD_PIKK_1	173	179	PF00454	0.484
MOD_PIKK_1	237	243	PF00454	0.498
MOD_PIKK_1	47	53	PF00454	0.297
MOD_PKA_1	131	137	PF00069	0.566
MOD_PKA_2	107	113	PF00069	0.242
MOD_PKA_2	123	129	PF00069	0.441
MOD_PKA_2	131	137	PF00069	0.523
MOD_PKA_2	182	188	PF00069	0.554
MOD_PKA_2	199	205	PF00069	0.571
MOD_PKA_2	94	100	PF00069	0.446
MOD_Plk_1	283	289	PF00069	0.447
MOD_Plk_4	277	283	PF00069	0.507
MOD_ProDKin_1	166	172	PF00069	0.513
MOD_ProDKin_1	187	193	PF00069	0.407
MOD_ProDKin_1	9	15	PF00069	0.489
MOD_SUMO_rev_2	246	253	PF00179	0.515
TRG_DiLeu_BaLyEn_6	160	165	PF01217	0.484
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.431
TRG_ENDOCYTIC_2	114	117	PF00928	0.332
TRG_ENDOCYTIC_2	290	293	PF00928	0.547
TRG_ER_diArg_1	104	106	PF00400	0.315
TRG_ER_diArg_1	131	133	PF00400	0.602
TRG_ER_diArg_1	217	220	PF00400	0.455
TRG_ER_diArg_1	232	234	PF00400	0.356
TRG_Pf-PMV_PEXEL_1	203	207	PF00026	0.585
TRG_Pf-PMV_PEXEL_1	271	276	PF00026	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILJ3	Leptomonas seymouri	61%	100%
A0A0S4ING3	Bodo saltans	45%	100%
A0A1X0P2S0	Trypanosomatidae	46%	89%
A0A422NY87	Trypanosoma rangeli	48%	100%
A0A451EJ77	Leishmania donovani	96%	98%
A4H344	Leishmania braziliensis	85%	100%
A4HRE1	Leishmania infantum	95%	98%
C9ZXF7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AC09	Leishmania major	93%	100%
V5AQ10	Trypanosoma cruzi	50%	100%