cwf21 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJA5_LEIMU

TriTrypDb:

LmxM.01.0190

Length:

196

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AJA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJA5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.520
CLV_NRD_NRD_1	113	115	PF00675	0.487
CLV_NRD_NRD_1	172	174	PF00675	0.526
CLV_NRD_NRD_1	187	189	PF00675	0.552
CLV_NRD_NRD_1	53	55	PF00675	0.653
CLV_PCSK_FUR_1	185	189	PF00082	0.557
CLV_PCSK_KEX2_1	112	114	PF00082	0.502
CLV_PCSK_KEX2_1	171	173	PF00082	0.528
CLV_PCSK_KEX2_1	184	186	PF00082	0.485
CLV_PCSK_KEX2_1	187	189	PF00082	0.468
CLV_PCSK_KEX2_1	53	55	PF00082	0.654
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.431
CLV_PCSK_PC1ET2_1	184	186	PF00082	0.481
CLV_PCSK_SKI1_1	113	117	PF00082	0.536
CLV_PCSK_SKI1_1	78	82	PF00082	0.381
DEG_Nend_Nbox_1	1	3	PF02207	0.484
DEG_SPOP_SBC_1	136	140	PF00917	0.641
DEG_SPOP_SBC_1	141	145	PF00917	0.667
DOC_MAPK_gen_1	70	79	PF00069	0.416
DOC_MAPK_MEF2A_6	70	79	PF00069	0.375
DOC_USP7_UBL2_3	112	116	PF12436	0.538
LIG_Actin_WH2_2	59	75	PF00022	0.440
LIG_APCC_ABBA_1	79	84	PF00400	0.392
LIG_APCC_ABBAyCdc20_2	78	84	PF00400	0.367
LIG_FHA_1	137	143	PF00498	0.528
LIG_FHA_1	27	33	PF00498	0.641
LIG_LIR_Gen_1	102	111	PF02991	0.470
LIG_LIR_Nem_3	102	107	PF02991	0.472
LIG_Pex14_2	130	134	PF04695	0.431
LIG_RPA_C_Fungi	109	121	PF08784	0.304
LIG_SH2_CRK	104	108	PF00017	0.472
LIG_SH2_STAP1	104	108	PF00017	0.412
LIG_SH2_STAT5	18	21	PF00017	0.459
LIG_TRAF2_1	158	161	PF00917	0.624
LIG_TRAF2_1	167	170	PF00917	0.467
LIG_TRAF2_1	33	36	PF00917	0.603
MOD_CK1_1	140	146	PF00069	0.605
MOD_CK2_1	155	161	PF00069	0.574
MOD_GlcNHglycan	139	142	PF01048	0.551
MOD_GlcNHglycan	144	147	PF01048	0.648
MOD_GlcNHglycan	15	18	PF01048	0.427
MOD_GlcNHglycan	152	155	PF01048	0.686
MOD_GSK3_1	136	143	PF00069	0.631
MOD_NEK2_1	103	108	PF00069	0.357
MOD_NEK2_1	155	160	PF00069	0.629
MOD_PKA_2	150	156	PF00069	0.662
MOD_Plk_1	155	161	PF00069	0.516
MOD_Plk_2-3	92	98	PF00069	0.458
MOD_Plk_4	103	109	PF00069	0.380
TRG_ENDOCYTIC_2	104	107	PF00928	0.442
TRG_ENDOCYTIC_2	2	5	PF00928	0.457
TRG_ER_diArg_1	113	115	PF00400	0.484
TRG_ER_diArg_1	171	173	PF00400	0.556
TRG_ER_diArg_1	185	188	PF00400	0.517
TRG_ER_diArg_1	21	24	PF00400	0.533
TRG_ER_diArg_1	75	78	PF00400	0.459
TRG_NLS_Bipartite_1	171	188	PF00514	0.509
TRG_NLS_MonoExtC_3	111	116	PF00514	0.417
TRG_NLS_MonoExtC_3	183	188	PF00514	0.489
TRG_Pf-PMV_PEXEL_1	113	118	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8C9	Leptomonas seymouri	66%	100%
A0A0S4IKH1	Bodo saltans	36%	95%
A0A1X0P2X2	Trypanosomatidae	44%	100%
A0A3R7MZG4	Trypanosoma rangeli	44%	100%
A0A3S5H4T7	Leishmania donovani	93%	95%
A4H343	Leishmania braziliensis	79%	98%
A4HRE0	Leishmania infantum	93%	95%
C9ZXF8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AC08	Leishmania major	91%	100%
Q38FI2	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	44%	100%