Putative CLC-type chloride channel

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CLC-type chloride channel, putative

Species:

Leishmania mexicana

UniProt:

E9AJA4_LEIMU

TriTrypDb:

LmxM.01.0180

Length:

770

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005768	endosome	7	1
GO:0005769	early endosome	8	1
GO:0005794	Golgi apparatus	5	1
GO:0005886	plasma membrane	3	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

E9AJA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJA4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	12
GO:0005216	monoatomic ion channel activity	4	12
GO:0005244	voltage-gated monoatomic ion channel activity	4	12
GO:0005247	voltage-gated chloride channel activity	6	12
GO:0005253	monoatomic anion channel activity	5	12
GO:0005254	chloride channel activity	6	12
GO:0008308	voltage-gated monoatomic anion channel activity	5	12
GO:0008509	monoatomic anion transmembrane transporter activity	4	12
GO:0015075	monoatomic ion transmembrane transporter activity	3	12
GO:0015103	inorganic anion transmembrane transporter activity	4	12
GO:0015108	chloride transmembrane transporter activity	5	12
GO:0015267	channel activity	4	12
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	12
GO:0022803	passive transmembrane transporter activity	3	12
GO:0022832	voltage-gated channel activity	6	12
GO:0022836	gated channel activity	5	12
GO:0022857	transmembrane transporter activity	2	12
GO:0005451	obsolete monoatomic cation:proton antiporter activity	5	1
GO:0008324	monoatomic cation transmembrane transporter activity	4	1
GO:0015078	proton transmembrane transporter activity	5	1
GO:0015291	secondary active transmembrane transporter activity	4	1
GO:0015297	antiporter activity	5	1
GO:0015298	obsolete solute:monoatomic cation antiporter activity	5	1
GO:0015299	obsolete solute:proton antiporter activity	6	1
GO:0022804	active transmembrane transporter activity	3	1
GO:0022853	active monoatomic ion transmembrane transporter activity	4	1
GO:0022890	inorganic cation transmembrane transporter activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	357	363	PF00089	0.138
CLV_NRD_NRD_1	364	366	PF00675	0.215
CLV_NRD_NRD_1	60	62	PF00675	0.359
CLV_NRD_NRD_1	743	745	PF00675	0.438
CLV_NRD_NRD_1	751	753	PF00675	0.378
CLV_PCSK_FUR_1	741	745	PF00082	0.463
CLV_PCSK_KEX2_1	202	204	PF00082	0.214
CLV_PCSK_KEX2_1	570	572	PF00082	0.239
CLV_PCSK_KEX2_1	59	61	PF00082	0.389
CLV_PCSK_KEX2_1	631	633	PF00082	0.368
CLV_PCSK_KEX2_1	743	745	PF00082	0.435
CLV_PCSK_KEX2_1	751	753	PF00082	0.377
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.257
CLV_PCSK_PC1ET2_1	570	572	PF00082	0.239
CLV_PCSK_PC1ET2_1	631	633	PF00082	0.231
CLV_PCSK_PC7_1	55	61	PF00082	0.295
CLV_PCSK_SKI1_1	424	428	PF00082	0.456
CLV_PCSK_SKI1_1	586	590	PF00082	0.313
CLV_PCSK_SKI1_1	690	694	PF00082	0.342
DEG_SCF_FBW7_1	390	395	PF00400	0.281
DEG_SPOP_SBC_1	67	71	PF00917	0.577
DOC_CKS1_1	389	394	PF01111	0.252
DOC_CYCLIN_RxL_1	688	698	PF00134	0.481
DOC_MAPK_gen_1	570	577	PF00069	0.584
DOC_MAPK_gen_1	718	724	PF00069	0.469
DOC_MAPK_MEF2A_6	229	236	PF00069	0.214
DOC_PP1_RVXF_1	318	325	PF00149	0.209
DOC_PP4_FxxP_1	273	276	PF00568	0.252
DOC_PP4_FxxP_1	335	338	PF00568	0.214
DOC_PP4_FxxP_1	389	392	PF00568	0.268
DOC_USP7_MATH_1	10	14	PF00917	0.717
DOC_USP7_MATH_1	112	116	PF00917	0.384
DOC_USP7_MATH_1	182	186	PF00917	0.475
DOC_USP7_MATH_1	247	251	PF00917	0.316
DOC_USP7_MATH_1	342	346	PF00917	0.145
DOC_USP7_MATH_1	392	396	PF00917	0.271
DOC_USP7_MATH_1	642	646	PF00917	0.543
DOC_USP7_MATH_1	659	663	PF00917	0.639
DOC_USP7_MATH_1	66	70	PF00917	0.700
DOC_USP7_MATH_1	685	689	PF00917	0.557
DOC_WW_Pin1_4	388	393	PF00397	0.252
DOC_WW_Pin1_4	407	412	PF00397	0.246
DOC_WW_Pin1_4	615	620	PF00397	0.452
DOC_WW_Pin1_4	655	660	PF00397	0.515
DOC_WW_Pin1_4	77	82	PF00397	0.592
LIG_14-3-3_CanoR_1	424	430	PF00244	0.331
LIG_14-3-3_CanoR_1	643	649	PF00244	0.607
LIG_14-3-3_CanoR_1	654	659	PF00244	0.540
LIG_APCC_ABBA_1	99	104	PF00400	0.264
LIG_BIR_II_1	1	5	PF00653	0.584
LIG_BRCT_BRCA1_1	289	293	PF00533	0.516
LIG_BRCT_BRCA1_1	330	334	PF00533	0.138
LIG_BRCT_BRCA1_1	480	484	PF00533	0.241
LIG_Clathr_ClatBox_1	680	684	PF01394	0.586
LIG_eIF4E_1	291	297	PF01652	0.457
LIG_FHA_1	210	216	PF00498	0.312
LIG_FHA_1	27	33	PF00498	0.586
LIG_FHA_1	303	309	PF00498	0.262
LIG_FHA_1	316	322	PF00498	0.199
LIG_FHA_1	382	388	PF00498	0.346
LIG_FHA_1	513	519	PF00498	0.260
LIG_FHA_1	524	530	PF00498	0.404
LIG_FHA_1	552	558	PF00498	0.504
LIG_FHA_1	671	677	PF00498	0.519
LIG_FHA_1	699	705	PF00498	0.576
LIG_FHA_1	73	79	PF00498	0.656
LIG_FHA_1	755	761	PF00498	0.664
LIG_FHA_2	664	670	PF00498	0.642
LIG_KLC1_Yacidic_2	572	576	PF13176	0.615
LIG_LIR_Apic_2	528	534	PF02991	0.415
LIG_LIR_Gen_1	164	173	PF02991	0.283
LIG_LIR_Gen_1	230	240	PF02991	0.230
LIG_LIR_Gen_1	331	340	PF02991	0.166
LIG_LIR_Gen_1	352	361	PF02991	0.305
LIG_LIR_Gen_1	37	46	PF02991	0.529
LIG_LIR_Gen_1	434	444	PF02991	0.375
LIG_LIR_Gen_1	572	582	PF02991	0.566
LIG_LIR_Gen_1	651	659	PF02991	0.543
LIG_LIR_Gen_1	664	675	PF02991	0.560
LIG_LIR_Gen_1	720	727	PF02991	0.503
LIG_LIR_Gen_1	84	95	PF02991	0.283
LIG_LIR_LC3C_4	29	33	PF02991	0.601
LIG_LIR_Nem_3	141	145	PF02991	0.259
LIG_LIR_Nem_3	158	162	PF02991	0.252
LIG_LIR_Nem_3	179	183	PF02991	0.479
LIG_LIR_Nem_3	230	236	PF02991	0.230
LIG_LIR_Nem_3	290	296	PF02991	0.419
LIG_LIR_Nem_3	331	337	PF02991	0.166
LIG_LIR_Nem_3	345	349	PF02991	0.325
LIG_LIR_Nem_3	352	357	PF02991	0.302
LIG_LIR_Nem_3	37	43	PF02991	0.572
LIG_LIR_Nem_3	370	375	PF02991	0.452
LIG_LIR_Nem_3	434	440	PF02991	0.375
LIG_LIR_Nem_3	572	577	PF02991	0.588
LIG_LIR_Nem_3	611	616	PF02991	0.487
LIG_LIR_Nem_3	651	655	PF02991	0.522
LIG_LIR_Nem_3	664	670	PF02991	0.584
LIG_LIR_Nem_3	710	715	PF02991	0.461
LIG_LIR_Nem_3	720	724	PF02991	0.473
LIG_LIR_Nem_3	74	79	PF02991	0.660
LIG_MYND_1	565	569	PF01753	0.470
LIG_Pex14_1	109	113	PF04695	0.299
LIG_Pex14_1	142	146	PF04695	0.276
LIG_Pex14_2	467	471	PF04695	0.398
LIG_Pex14_2	573	577	PF04695	0.601
LIG_PTB_Apo_2	582	589	PF02174	0.589
LIG_REV1ctd_RIR_1	143	153	PF16727	0.297
LIG_RPA_C_Fungi	55	67	PF08784	0.449
LIG_SH2_CRK	499	503	PF00017	0.252
LIG_SH2_CRK	531	535	PF00017	0.395
LIG_SH2_NCK_1	499	503	PF00017	0.252
LIG_SH2_SRC	328	331	PF00017	0.145
LIG_SH2_SRC	499	502	PF00017	0.252
LIG_SH2_SRC	555	558	PF00017	0.335
LIG_SH2_SRC	566	569	PF00017	0.347
LIG_SH2_SRC	627	630	PF00017	0.333
LIG_SH2_STAP1	478	482	PF00017	0.264
LIG_SH2_STAP1	488	492	PF00017	0.264
LIG_SH2_STAT3	594	597	PF00017	0.471
LIG_SH2_STAT5	162	165	PF00017	0.293
LIG_SH2_STAT5	175	178	PF00017	0.302
LIG_SH2_STAT5	204	207	PF00017	0.252
LIG_SH2_STAT5	442	445	PF00017	0.395
LIG_SH2_STAT5	482	485	PF00017	0.297
LIG_SH2_STAT5	566	569	PF00017	0.443
LIG_SH2_STAT5	574	577	PF00017	0.444
LIG_SH2_STAT5	652	655	PF00017	0.422
LIG_SH2_STAT5	694	697	PF00017	0.369
LIG_SH3_3	613	619	PF00018	0.289
LIG_SH3_3	75	81	PF00018	0.486
LIG_SUMO_SIM_anti_2	376	381	PF11976	0.350
LIG_SUMO_SIM_anti_2	397	404	PF11976	0.289
LIG_TRAF2_1	473	476	PF00917	0.287
LIG_UBA3_1	692	697	PF00899	0.357
LIG_Vh1_VBS_1	501	519	PF01044	0.268
LIG_WRC_WIRS_1	162	167	PF05994	0.269
LIG_WRC_WIRS_1	343	348	PF05994	0.259
LIG_WRC_WIRS_1	444	449	PF05994	0.287
MOD_CK1_1	13	19	PF00069	0.479
MOD_CK1_1	164	170	PF00069	0.395
MOD_CK1_1	220	226	PF00069	0.275
MOD_CK1_1	352	358	PF00069	0.398
MOD_CK1_1	47	53	PF00069	0.569
MOD_CK1_1	620	626	PF00069	0.429
MOD_CK1_1	698	704	PF00069	0.374
MOD_CK1_1	77	83	PF00069	0.549
MOD_CK2_1	138	144	PF00069	0.332
MOD_CK2_1	394	400	PF00069	0.261
MOD_CK2_1	45	51	PF00069	0.448
MOD_CK2_1	663	669	PF00069	0.530
MOD_CK2_1	707	713	PF00069	0.368
MOD_Cter_Amidation	749	752	PF01082	0.344
MOD_GlcNHglycan	110	113	PF01048	0.331
MOD_GlcNHglycan	114	117	PF01048	0.317
MOD_GlcNHglycan	12	15	PF01048	0.500
MOD_GlcNHglycan	18	21	PF01048	0.517
MOD_GlcNHglycan	184	187	PF01048	0.304
MOD_GlcNHglycan	196	199	PF01048	0.225
MOD_GlcNHglycan	222	225	PF01048	0.252
MOD_GlcNHglycan	245	248	PF01048	0.377
MOD_GlcNHglycan	351	354	PF01048	0.247
MOD_GlcNHglycan	394	397	PF01048	0.278
MOD_GlcNHglycan	62	65	PF01048	0.478
MOD_GSK3_1	108	115	PF00069	0.341
MOD_GSK3_1	243	250	PF00069	0.182
MOD_GSK3_1	388	395	PF00069	0.312
MOD_GSK3_1	407	414	PF00069	0.287
MOD_GSK3_1	425	432	PF00069	0.373
MOD_GSK3_1	474	481	PF00069	0.287
MOD_GSK3_1	655	662	PF00069	0.433
MOD_GSK3_1	68	75	PF00069	0.551
MOD_N-GLC_1	411	416	PF02516	0.330
MOD_N-GLC_1	608	613	PF02516	0.475
MOD_N-GLC_2	127	129	PF02516	0.443
MOD_NEK2_1	161	166	PF00069	0.305
MOD_NEK2_1	176	181	PF00069	0.303
MOD_NEK2_1	217	222	PF00069	0.268
MOD_NEK2_1	308	313	PF00069	0.274
MOD_NEK2_1	315	320	PF00069	0.259
MOD_NEK2_1	349	354	PF00069	0.252
MOD_NEK2_1	429	434	PF00069	0.339
MOD_NEK2_1	440	445	PF00069	0.318
MOD_NEK2_1	474	479	PF00069	0.330
MOD_NEK2_1	523	528	PF00069	0.252
MOD_NEK2_1	608	613	PF00069	0.397
MOD_NEK2_1	695	700	PF00069	0.370
MOD_NEK2_2	685	690	PF00069	0.459
MOD_PIKK_1	367	373	PF00454	0.145
MOD_PKA_1	60	66	PF00069	0.597
MOD_PKA_2	60	66	PF00069	0.489
MOD_PKA_2	642	648	PF00069	0.419
MOD_PKA_2	707	713	PF00069	0.344
MOD_Plk_1	620	626	PF00069	0.369
MOD_Plk_1	663	669	PF00069	0.554
MOD_Plk_1	685	691	PF00069	0.452
MOD_Plk_2-3	138	144	PF00069	0.397
MOD_Plk_2-3	39	45	PF00069	0.404
MOD_Plk_4	191	197	PF00069	0.409
MOD_Plk_4	394	400	PF00069	0.269
MOD_Plk_4	443	449	PF00069	0.287
MOD_Plk_4	478	484	PF00069	0.288
MOD_Plk_4	620	626	PF00069	0.369
MOD_Plk_4	648	654	PF00069	0.398
MOD_Plk_4	663	669	PF00069	0.477
MOD_ProDKin_1	388	394	PF00069	0.252
MOD_ProDKin_1	407	413	PF00069	0.297
MOD_ProDKin_1	615	621	PF00069	0.306
MOD_ProDKin_1	655	661	PF00069	0.405
MOD_ProDKin_1	77	83	PF00069	0.487
MOD_SUMO_for_1	569	572	PF00179	0.388
MOD_SUMO_rev_2	185	195	PF00179	0.327
MOD_SUMO_rev_2	556	565	PF00179	0.395
TRG_ENDOCYTIC_2	162	165	PF00928	0.256
TRG_ENDOCYTIC_2	499	502	PF00928	0.273
TRG_ENDOCYTIC_2	574	577	PF00928	0.517
TRG_ENDOCYTIC_2	652	655	PF00928	0.422
TRG_ENDOCYTIC_2	709	712	PF00928	0.487
TRG_ER_diArg_1	58	61	PF00400	0.501
TRG_NLS_MonoExtN_4	363	369	PF00514	0.312
TRG_Pf-PMV_PEXEL_1	472	476	PF00026	0.268
TRG_Pf-PMV_PEXEL_1	599	603	PF00026	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6P9	Leptomonas seymouri	78%	100%
A0A0N1IHR6	Leptomonas seymouri	27%	66%
A0A0N1IJL2	Leptomonas seymouri	24%	87%
A0A0S4IKD3	Bodo saltans	58%	100%
A0A0S4IL39	Bodo saltans	54%	100%
A0A0S4JG93	Bodo saltans	24%	91%
A0A0S4JSW7	Bodo saltans	25%	89%
A0A1X0NSH7	Trypanosomatidae	26%	83%
A0A1X0P2R6	Trypanosomatidae	64%	100%
A0A3Q8IH43	Leishmania donovani	24%	87%
A0A3R7KRB4	Trypanosoma rangeli	24%	85%
A0A422NY59	Trypanosoma rangeli	67%	100%
A0A451EJ75	Leishmania donovani	96%	100%
A4H342	Leishmania braziliensis	86%	100%
A4HKY2	Leishmania braziliensis	23%	87%
A4HRD9	Leishmania infantum	96%	100%
C9ZY92	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	82%
D0AAR0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	84%
E9AC07	Leishmania major	95%	100%
E9AHM3	Leishmania infantum	24%	87%
E9B3C0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	87%
O18894	Oryctolagus cuniculus	33%	94%
O35454	Mus musculus	28%	89%
O60159	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
O70496	Mus musculus	27%	96%
O94287	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
P21564	Torpedo marmorata	26%	96%
P35522	Tetronarce californica	26%	95%
P35523	Homo sapiens	28%	78%
P35524	Rattus norvegicus	28%	77%
P35525	Rattus norvegicus	28%	85%
P37020	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	99%
P51788	Homo sapiens	28%	86%
P51789	Oryctolagus cuniculus	27%	86%
P51790	Homo sapiens	33%	94%
P51791	Mus musculus	33%	94%
P51792	Rattus norvegicus	33%	94%
P51793	Homo sapiens	32%	100%
P51794	Rattus norvegicus	32%	100%
P51795	Homo sapiens	32%	94%
P51796	Rattus norvegicus	31%	94%
P51797	Homo sapiens	27%	89%
P51798	Homo sapiens	28%	96%
P51799	Rattus norvegicus	27%	96%
P51800	Homo sapiens	28%	100%
P51801	Homo sapiens	27%	100%
P51802	Rattus norvegicus	27%	100%
P51803	Oryctolagus cuniculus	26%	100%
P51804	Oryctolagus cuniculus	27%	100%
P60300	Arabidopsis thaliana	25%	100%
P92941	Arabidopsis thaliana	26%	99%
P92942	Arabidopsis thaliana	25%	99%
P92943	Arabidopsis thaliana	27%	97%
Q06393	Rattus norvegicus	27%	100%
Q4PKH3	Bos taurus	28%	95%
Q4Q4T5	Leishmania major	24%	88%
Q54AX6	Dictyostelium discoideum	27%	89%
Q54C67	Dictyostelium discoideum	26%	95%
Q5RBK4	Pongo abelii	32%	94%
Q5RDJ7	Pongo abelii	32%	96%
Q61418	Mus musculus	32%	100%
Q64347	Mus musculus	28%	77%
Q75JF3	Dictyostelium discoideum	29%	100%
Q86AZ6	Dictyostelium discoideum	29%	94%
Q96282	Arabidopsis thaliana	25%	99%
Q99P66	Cavia porcellus	32%	100%
Q9BMK9	Caenorhabditis elegans	30%	77%
Q9GKE7	Sus scrofa	32%	94%
Q9MZT1	Canis lupus familiaris	28%	79%
Q9R0A1	Mus musculus	28%	85%
Q9R279	Cavia porcellus	33%	94%
Q9TT16	Oryctolagus cuniculus	27%	89%
Q9TTU3	Oryctolagus cuniculus	32%	94%
Q9W701	Xenopus laevis	26%	100%
Q9WU45	Cavia porcellus	28%	85%
Q9WUB6	Mus musculus	28%	100%
Q9WUB7	Mus musculus	27%	100%
Q9WVD4	Mus musculus	32%	94%
V5AY77	Trypanosoma cruzi	27%	79%
V5BEI7	Trypanosoma cruzi	66%	100%
V5BVK3	Trypanosoma cruzi	23%	85%