Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AJA3_LEIMU

TriTrypDb:

LmxM.01.0170

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJA3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.472
CLV_C14_Caspase3-7	400	404	PF00656	0.486
CLV_C14_Caspase3-7	82	86	PF00656	0.606
CLV_MEL_PAP_1	287	293	PF00089	0.535
CLV_NRD_NRD_1	193	195	PF00675	0.595
CLV_NRD_NRD_1	197	199	PF00675	0.568
CLV_NRD_NRD_1	289	291	PF00675	0.533
CLV_NRD_NRD_1	30	32	PF00675	0.665
CLV_NRD_NRD_1	48	50	PF00675	0.509
CLV_PCSK_KEX2_1	193	195	PF00082	0.591
CLV_PCSK_KEX2_1	197	199	PF00082	0.573
CLV_PCSK_KEX2_1	289	291	PF00082	0.533
CLV_PCSK_KEX2_1	30	32	PF00082	0.667
CLV_PCSK_KEX2_1	324	326	PF00082	0.619
CLV_PCSK_KEX2_1	422	424	PF00082	0.651
CLV_PCSK_KEX2_1	50	52	PF00082	0.606
CLV_PCSK_PC1ET2_1	324	326	PF00082	0.619
CLV_PCSK_PC1ET2_1	422	424	PF00082	0.520
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.606
CLV_PCSK_PC7_1	193	199	PF00082	0.536
CLV_PCSK_SKI1_1	273	277	PF00082	0.455
DEG_APCC_DBOX_1	218	226	PF00400	0.462
DEG_SPOP_SBC_1	125	129	PF00917	0.611
DEG_SPOP_SBC_1	408	412	PF00917	0.484
DOC_ANK_TNKS_1	147	154	PF00023	0.605
DOC_CKS1_1	294	299	PF01111	0.554
DOC_CYCLIN_RxL_1	61	70	PF00134	0.514
DOC_MAPK_gen_1	434	443	PF00069	0.626
DOC_MAPK_gen_1	49	57	PF00069	0.521
DOC_MAPK_MEF2A_6	239	247	PF00069	0.472
DOC_PP1_RVXF_1	287	294	PF00149	0.380
DOC_PP1_RVXF_1	94	101	PF00149	0.514
DOC_PP2B_LxvP_1	115	118	PF13499	0.561
DOC_USP7_MATH_1	125	129	PF00917	0.475
DOC_USP7_MATH_1	163	167	PF00917	0.647
DOC_USP7_MATH_1	305	309	PF00917	0.584
DOC_USP7_MATH_1	330	334	PF00917	0.569
DOC_USP7_MATH_1	362	366	PF00917	0.599
DOC_USP7_MATH_1	387	391	PF00917	0.573
DOC_USP7_MATH_1	397	401	PF00917	0.609
DOC_USP7_MATH_1	402	406	PF00917	0.614
DOC_USP7_UBL2_3	46	50	PF12436	0.599
DOC_WW_Pin1_4	100	105	PF00397	0.607
DOC_WW_Pin1_4	109	114	PF00397	0.587
DOC_WW_Pin1_4	182	187	PF00397	0.471
DOC_WW_Pin1_4	22	27	PF00397	0.653
DOC_WW_Pin1_4	293	298	PF00397	0.627
DOC_WW_Pin1_4	367	372	PF00397	0.655
DOC_WW_Pin1_4	414	419	PF00397	0.585
LIG_14-3-3_CanoR_1	219	225	PF00244	0.585
LIG_14-3-3_CanoR_1	232	236	PF00244	0.403
LIG_14-3-3_CanoR_1	314	323	PF00244	0.578
LIG_14-3-3_CanoR_1	361	368	PF00244	0.562
LIG_14-3-3_CanoR_1	391	397	PF00244	0.575
LIG_14-3-3_CanoR_1	437	442	PF00244	0.660
LIG_14-3-3_CanoR_1	80	85	PF00244	0.565
LIG_BIR_III_2	312	316	PF00653	0.509
LIG_BRCT_BRCA1_1	128	132	PF00533	0.487
LIG_BRCT_BRCA1_1	184	188	PF00533	0.474
LIG_deltaCOP1_diTrp_1	182	188	PF00928	0.635
LIG_deltaCOP1_diTrp_1	254	264	PF00928	0.453
LIG_FHA_1	162	168	PF00498	0.548
LIG_FHA_1	232	238	PF00498	0.303
LIG_FHA_1	410	416	PF00498	0.576
LIG_FHA_1	419	425	PF00498	0.604
LIG_FHA_1	442	448	PF00498	0.585
LIG_FHA_2	171	177	PF00498	0.544
LIG_FHA_2	335	341	PF00498	0.632
LIG_FHA_2	40	46	PF00498	0.601
LIG_FHA_2	80	86	PF00498	0.585
LIG_Integrin_isoDGR_2	109	111	PF01839	0.494
LIG_Integrin_RGD_1	71	73	PF01839	0.609
LIG_LIR_Apic_2	180	186	PF02991	0.584
LIG_LIR_Gen_1	173	179	PF02991	0.612
LIG_LIR_Gen_1	240	249	PF02991	0.439
LIG_LIR_Nem_3	173	177	PF02991	0.612
LIG_LIR_Nem_3	240	245	PF02991	0.434
LIG_LIR_Nem_3	414	419	PF02991	0.534
LIG_PDZ_Class_1	443	448	PF00595	0.465
LIG_Pex14_2	57	61	PF04695	0.436
LIG_PROFILIN_1	297	303	PF00235	0.493
LIG_SH2_CRK	416	420	PF00017	0.537
LIG_SH2_NCK_1	336	340	PF00017	0.628
LIG_SH2_NCK_1	416	420	PF00017	0.530
LIG_SH2_STAT3	226	229	PF00017	0.390
LIG_SH2_STAT5	122	125	PF00017	0.574
LIG_SH2_STAT5	336	339	PF00017	0.738
LIG_SH3_1	295	301	PF00018	0.703
LIG_SH3_2	26	31	PF14604	0.535
LIG_SH3_3	157	163	PF00018	0.653
LIG_SH3_3	23	29	PF00018	0.645
LIG_SH3_3	294	300	PF00018	0.698
LIG_SH3_3	301	307	PF00018	0.637
LIG_SH3_3	396	402	PF00018	0.609
LIG_SUMO_SIM_anti_2	221	226	PF11976	0.425
LIG_SUMO_SIM_par_1	155	161	PF11976	0.653
LIG_SUMO_SIM_par_1	264	269	PF11976	0.403
LIG_SUMO_SIM_par_1	409	417	PF11976	0.483
LIG_SUMO_SIM_par_1	64	70	PF11976	0.488
LIG_UBA3_1	65	69	PF00899	0.521
LIG_WW_2	26	29	PF00397	0.493
LIG_WW_2	304	307	PF00397	0.486
MOD_CK1_1	124	130	PF00069	0.555
MOD_CK1_1	161	167	PF00069	0.562
MOD_CK1_1	21	27	PF00069	0.728
MOD_CK1_1	255	261	PF00069	0.459
MOD_CK1_1	406	412	PF00069	0.585
MOD_CK1_1	414	420	PF00069	0.562
MOD_CK2_1	153	159	PF00069	0.761
MOD_CK2_1	170	176	PF00069	0.464
MOD_CK2_1	178	184	PF00069	0.575
MOD_CK2_1	39	45	PF00069	0.667
MOD_Cter_Amidation	191	194	PF01082	0.652
MOD_GlcNHglycan	123	126	PF01048	0.570
MOD_GlcNHglycan	200	203	PF01048	0.532
MOD_GlcNHglycan	307	310	PF01048	0.515
MOD_GlcNHglycan	343	346	PF01048	0.463
MOD_GlcNHglycan	383	386	PF01048	0.632
MOD_GlcNHglycan	394	397	PF01048	0.537
MOD_GlcNHglycan	399	402	PF01048	0.502
MOD_GlcNHglycan	51	54	PF01048	0.588
MOD_GlcNHglycan	75	78	PF01048	0.513
MOD_GSK3_1	121	128	PF00069	0.554
MOD_GSK3_1	178	185	PF00069	0.494
MOD_GSK3_1	18	25	PF00069	0.583
MOD_GSK3_1	188	195	PF00069	0.602
MOD_GSK3_1	30	37	PF00069	0.715
MOD_GSK3_1	330	337	PF00069	0.568
MOD_GSK3_1	362	369	PF00069	0.502
MOD_GSK3_1	375	382	PF00069	0.719
MOD_GSK3_1	383	390	PF00069	0.600
MOD_GSK3_1	402	409	PF00069	0.583
MOD_GSK3_1	414	421	PF00069	0.597
MOD_GSK3_1	437	444	PF00069	0.586
MOD_GSK3_1	6	13	PF00069	0.595
MOD_GSK3_1	71	78	PF00069	0.731
MOD_GSK3_1	80	87	PF00069	0.601
MOD_GSK3_1	96	103	PF00069	0.671
MOD_LATS_1	94	100	PF00433	0.512
MOD_N-GLC_1	16	21	PF02516	0.628
MOD_NEK2_1	121	126	PF00069	0.619
MOD_NEK2_1	188	193	PF00069	0.527
MOD_NEK2_1	360	365	PF00069	0.551
MOD_NEK2_1	57	62	PF00069	0.537
MOD_NEK2_1	79	84	PF00069	0.576
MOD_NMyristoyl	1	7	PF02799	0.565
MOD_PIKK_1	158	164	PF00454	0.586
MOD_PIKK_1	85	91	PF00454	0.513
MOD_PKA_1	30	36	PF00069	0.512
MOD_PKA_1	49	55	PF00069	0.537
MOD_PKA_2	192	198	PF00069	0.588
MOD_PKA_2	218	224	PF00069	0.410
MOD_PKA_2	231	237	PF00069	0.405
MOD_PKA_2	30	36	PF00069	0.608
MOD_PKA_2	360	366	PF00069	0.586
MOD_PKA_2	79	85	PF00069	0.646
MOD_PKB_1	198	206	PF00069	0.476
MOD_Plk_1	203	209	PF00069	0.660
MOD_Plk_1	255	261	PF00069	0.459
MOD_Plk_1	325	331	PF00069	0.551
MOD_Plk_1	339	345	PF00069	0.522
MOD_Plk_1	96	102	PF00069	0.511
MOD_Plk_2-3	170	176	PF00069	0.615
MOD_Plk_2-3	178	184	PF00069	0.571
MOD_Plk_4	127	133	PF00069	0.588
MOD_Plk_4	153	159	PF00069	0.588
MOD_Plk_4	220	226	PF00069	0.423
MOD_Plk_4	375	381	PF00069	0.583
MOD_Plk_4	411	417	PF00069	0.621
MOD_Plk_4	57	63	PF00069	0.553
MOD_ProDKin_1	100	106	PF00069	0.608
MOD_ProDKin_1	109	115	PF00069	0.586
MOD_ProDKin_1	182	188	PF00069	0.471
MOD_ProDKin_1	22	28	PF00069	0.652
MOD_ProDKin_1	293	299	PF00069	0.625
MOD_ProDKin_1	367	373	PF00069	0.656
MOD_ProDKin_1	414	420	PF00069	0.582
MOD_SUMO_for_1	323	326	PF00179	0.594
TRG_DiLeu_BaEn_1	283	288	PF01217	0.476
TRG_ENDOCYTIC_2	174	177	PF00928	0.540
TRG_ENDOCYTIC_2	416	419	PF00928	0.540
TRG_ER_diArg_1	197	200	PF00400	0.554
TRG_ER_diArg_1	288	290	PF00400	0.523
TRG_ER_diArg_1	29	31	PF00400	0.605
TRG_ER_diArg_1	436	439	PF00400	0.653
TRG_NLS_MonoExtN_4	46	53	PF00514	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I012	Leptomonas seymouri	33%	100%
A0A3S5H4T6	Leishmania donovani	77%	98%
A4H341	Leishmania braziliensis	52%	100%
A4HRD8	Leishmania infantum	78%	98%
E9AC06	Leishmania major	76%	99%