Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJA1_LEIMU

TriTrypDb:

LmxM.01.0150

Length:

116

Annotations

LeishMANIAdb annotations

A protein with dubious structure and function. It might not even be a membrane protein.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9AJA1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJA1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	75	79	PF00656	0.583
CLV_NRD_NRD_1	54	56	PF00675	0.499
CLV_PCSK_FUR_1	69	73	PF00082	0.432
CLV_PCSK_KEX2_1	45	47	PF00082	0.378
CLV_PCSK_KEX2_1	71	73	PF00082	0.424
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.378
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.443
CLV_PCSK_PC7_1	41	47	PF00082	0.367
DEG_SCF_FBW7_1	89	94	PF00400	0.606
DOC_CKS1_1	86	91	PF01111	0.603
DOC_PP1_RVXF_1	15	21	PF00149	0.284
DOC_USP7_MATH_1	4	8	PF00917	0.452
DOC_WW_Pin1_4	85	90	PF00397	0.602
LIG_Actin_WH2_2	21	38	PF00022	0.328
LIG_BIR_II_1	1	5	PF00653	0.389
LIG_BIR_III_1	1	5	PF00653	0.492
LIG_BIR_III_3	1	5	PF00653	0.492
LIG_FHA_1	81	87	PF00498	0.708
LIG_LIR_Gen_1	48	58	PF02991	0.565
LIG_LIR_Gen_1	7	13	PF02991	0.440
LIG_LIR_Nem_3	48	54	PF02991	0.565
LIG_Pex14_2	30	34	PF04695	0.284
LIG_SH2_CRK	32	36	PF00017	0.284
MOD_CK1_1	24	30	PF00069	0.413
MOD_CK2_1	4	10	PF00069	0.463
MOD_GSK3_1	87	94	PF00069	0.608
MOD_NEK2_1	21	26	PF00069	0.284
MOD_NEK2_1	35	40	PF00069	0.440
MOD_NEK2_1	80	85	PF00069	0.607
MOD_Plk_4	35	41	PF00069	0.516
MOD_ProDKin_1	85	91	PF00069	0.603
MOD_SUMO_for_1	44	47	PF00179	0.567
TRG_ENDOCYTIC_2	32	35	PF00928	0.283
TRG_ENDOCYTIC_2	51	54	PF00928	0.503
TRG_ENDOCYTIC_2	9	12	PF00928	0.374

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P726	Leptomonas seymouri	89%	100%
A0A0S4JLP7	Bodo saltans	63%	100%
A0A1X0P346	Trypanosomatidae	77%	99%
A0A3S5H4T5	Leishmania donovani	97%	100%
A0A422NY34	Trypanosoma rangeli	76%	99%
A4H330	Leishmania braziliensis	92%	100%
A4HRD6	Leishmania infantum	97%	100%
C9ZXG1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	99%
E9AC04	Leishmania major	96%	100%
V5B2R4	Trypanosoma cruzi	75%	99%