Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJ99_LEIMU

TriTrypDb:

LmxM.01.0130

Length:

364

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AJ99

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJ99

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	22	26	PF00656	0.671
CLV_NRD_NRD_1	113	115	PF00675	0.610
CLV_NRD_NRD_1	240	242	PF00675	0.677
CLV_NRD_NRD_1	290	292	PF00675	0.492
CLV_NRD_NRD_1	311	313	PF00675	0.671
CLV_NRD_NRD_1	327	329	PF00675	0.697
CLV_PCSK_FUR_1	110	114	PF00082	0.459
CLV_PCSK_KEX2_1	112	114	PF00082	0.618
CLV_PCSK_KEX2_1	240	242	PF00082	0.677
CLV_PCSK_KEX2_1	311	313	PF00082	0.672
CLV_PCSK_KEX2_1	327	329	PF00082	0.697
CLV_PCSK_SKI1_1	299	303	PF00082	0.637
DEG_APCC_DBOX_1	83	91	PF00400	0.423
DEG_SCF_FBW7_2	231	237	PF00400	0.500
DEG_SPOP_SBC_1	261	265	PF00917	0.732
DEG_SPOP_SBC_1	353	357	PF00917	0.688
DOC_CKS1_1	231	236	PF01111	0.690
DOC_CYCLIN_RxL_1	333	344	PF00134	0.593
DOC_PIKK_1	283	290	PF02985	0.639
DOC_PP2B_LxvP_1	175	178	PF13499	0.521
DOC_USP7_MATH_1	213	217	PF00917	0.624
DOC_USP7_MATH_1	221	225	PF00917	0.711
DOC_USP7_MATH_1	307	311	PF00917	0.686
DOC_USP7_MATH_1	315	319	PF00917	0.670
DOC_USP7_MATH_1	336	340	PF00917	0.555
DOC_USP7_MATH_1	349	353	PF00917	0.683
DOC_USP7_MATH_1	47	51	PF00917	0.576
DOC_USP7_MATH_1	65	69	PF00917	0.424
DOC_USP7_MATH_2	234	240	PF00917	0.583
DOC_WW_Pin1_4	230	235	PF00397	0.692
DOC_WW_Pin1_4	37	42	PF00397	0.751
LIG_14-3-3_CanoR_1	149	154	PF00244	0.428
LIG_14-3-3_CanoR_1	279	287	PF00244	0.489
LIG_14-3-3_CanoR_1	311	315	PF00244	0.531
LIG_14-3-3_CanoR_1	338	343	PF00244	0.709
LIG_14-3-3_CanoR_1	345	354	PF00244	0.575
LIG_Actin_WH2_2	134	151	PF00022	0.440
LIG_Actin_WH2_2	72	90	PF00022	0.563
LIG_BIR_II_1	1	5	PF00653	0.612
LIG_BRCT_BRCA1_1	151	155	PF00533	0.431
LIG_FHA_1	25	31	PF00498	0.518
LIG_FHA_1	296	302	PF00498	0.415
LIG_FHA_1	38	44	PF00498	0.693
LIG_FHA_2	231	237	PF00498	0.675
LIG_FHA_2	52	58	PF00498	0.472
LIG_LIR_Gen_1	68	76	PF02991	0.451
LIG_LIR_Nem_3	68	72	PF02991	0.447
LIG_NRP_CendR_1	363	364	PF00754	0.700
LIG_Pex14_2	155	159	PF04695	0.443
LIG_PTB_Apo_2	168	175	PF02174	0.486
LIG_PTB_Phospho_1	168	174	PF10480	0.488
LIG_SH2_SRC	23	26	PF00017	0.728
LIG_SH2_STAP1	238	242	PF00017	0.516
LIG_SH2_STAT3	250	253	PF00017	0.520
LIG_SH2_STAT5	174	177	PF00017	0.522
LIG_SH3_3	228	234	PF00018	0.620
LIG_TRAF2_1	132	135	PF00917	0.424
LIG_TRAF2_1	161	164	PF00917	0.443
LIG_TRAF2_1	234	237	PF00917	0.502
LIG_UBA3_1	286	292	PF00899	0.509
LIG_WRC_WIRS_1	52	57	PF05994	0.457
LIG_WRC_WIRS_1	66	71	PF05994	0.425
LIG_WW_3	324	328	PF00397	0.759
MOD_CDK_SPK_2	230	235	PF00069	0.581
MOD_CK1_1	189	195	PF00069	0.751
MOD_CK1_1	203	209	PF00069	0.588
MOD_CK1_1	222	228	PF00069	0.756
MOD_CK1_1	262	268	PF00069	0.698
MOD_CK1_1	271	277	PF00069	0.582
MOD_CK1_1	310	316	PF00069	0.744
MOD_CK1_1	341	347	PF00069	0.607
MOD_CK1_1	352	358	PF00069	0.789
MOD_CK1_1	51	57	PF00069	0.460
MOD_CK2_1	136	142	PF00069	0.494
MOD_CK2_1	158	164	PF00069	0.464
MOD_CK2_1	230	236	PF00069	0.676
MOD_CK2_1	317	323	PF00069	0.602
MOD_CK2_1	65	71	PF00069	0.432
MOD_GlcNHglycan	209	212	PF01048	0.606
MOD_GlcNHglycan	215	218	PF01048	0.616
MOD_GlcNHglycan	221	224	PF01048	0.604
MOD_GlcNHglycan	270	273	PF01048	0.653
MOD_GlcNHglycan	319	322	PF01048	0.763
MOD_GlcNHglycan	347	350	PF01048	0.606
MOD_GlcNHglycan	37	40	PF01048	0.617
MOD_GlcNHglycan	7	10	PF01048	0.770
MOD_GSK3_1	1	8	PF00069	0.549
MOD_GSK3_1	184	191	PF00069	0.725
MOD_GSK3_1	203	210	PF00069	0.499
MOD_GSK3_1	268	275	PF00069	0.720
MOD_GSK3_1	334	341	PF00069	0.657
MOD_GSK3_1	345	352	PF00069	0.780
MOD_GSK3_1	353	360	PF00069	0.766
MOD_GSK3_1	37	44	PF00069	0.622
MOD_GSK3_1	47	54	PF00069	0.425
MOD_GSK3_1	75	82	PF00069	0.560
MOD_N-GLC_1	149	154	PF02516	0.428
MOD_NEK2_1	1	6	PF00069	0.586
MOD_NEK2_1	148	153	PF00069	0.349
MOD_NEK2_1	260	265	PF00069	0.770
MOD_NEK2_1	340	345	PF00069	0.559
MOD_NEK2_1	354	359	PF00069	0.751
MOD_NEK2_1	79	84	PF00069	0.554
MOD_OFUCOSY	270	276	PF10250	0.582
MOD_PIKK_1	1	7	PF00454	0.583
MOD_PIKK_1	186	192	PF00454	0.727
MOD_PIKK_1	193	199	PF00454	0.644
MOD_PIKK_1	82	88	PF00454	0.446
MOD_PK_1	149	155	PF00069	0.432
MOD_PKA_2	148	154	PF00069	0.430
MOD_PKA_2	310	316	PF00069	0.661
MOD_PKA_2	344	350	PF00069	0.563
MOD_Plk_1	141	147	PF00069	0.426
MOD_Plk_1	149	155	PF00069	0.453
MOD_Plk_1	19	25	PF00069	0.593
MOD_Plk_4	133	139	PF00069	0.559
MOD_Plk_4	200	206	PF00069	0.711
MOD_Plk_4	349	355	PF00069	0.682
MOD_ProDKin_1	230	236	PF00069	0.692
MOD_ProDKin_1	37	43	PF00069	0.743
MOD_SUMO_rev_2	161	167	PF00179	0.425
TRG_DiLeu_BaLyEn_6	282	287	PF01217	0.538
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.605
TRG_ER_diArg_1	109	112	PF00400	0.571
TRG_ER_diArg_1	240	242	PF00400	0.521
TRG_ER_diArg_1	296	299	PF00400	0.563
TRG_ER_diArg_1	326	328	PF00400	0.697
TRG_ER_diArg_1	331	334	PF00400	0.653
TRG_Pf-PMV_PEXEL_1	299	304	PF00026	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6P3	Leptomonas seymouri	50%	92%
A0A3S5H4T3	Leishmania donovani	89%	100%
A4H328	Leishmania braziliensis	67%	100%
A4HRD4	Leishmania infantum	89%	100%
E9AC02	Leishmania major	84%	100%