Glycosyl transferase family 11

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Glycosyl transferase family 11, putative

Species:

Leishmania mexicana

UniProt:

E9AJ96_LEIMU

TriTrypDb:

LmxM.01.0100

Length:

315

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9AJ96

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJ96

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0006486	protein glycosylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0019538	protein metabolic process	3	1
GO:0036065	fucosylation	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043413	macromolecule glycosylation	3	1
GO:0070085	glycosylation	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008107	galactoside 2-alpha-L-fucosyltransferase activity	7	12
GO:0008417	fucosyltransferase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016757	glycosyltransferase activity	3	12
GO:0016758	hexosyltransferase activity	4	12
GO:0031127	alpha-(1,2)-fucosyltransferase activity	6	12
GO:0016787	hydrolase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	137	139	PF00675	0.321
CLV_NRD_NRD_1	177	179	PF00675	0.399
CLV_NRD_NRD_1	287	289	PF00675	0.236
CLV_NRD_NRD_1	73	75	PF00675	0.508
CLV_PCSK_KEX2_1	137	139	PF00082	0.321
CLV_PCSK_KEX2_1	177	179	PF00082	0.399
CLV_PCSK_KEX2_1	287	289	PF00082	0.236
CLV_PCSK_PC7_1	283	289	PF00082	0.369
CLV_PCSK_SKI1_1	162	166	PF00082	0.464
CLV_PCSK_SKI1_1	253	257	PF00082	0.317
DEG_APCC_DBOX_1	161	169	PF00400	0.424
DEG_APCC_DBOX_1	252	260	PF00400	0.307
DEG_APCC_DBOX_1	282	290	PF00400	0.388
DEG_SCF_FBW7_1	24	31	PF00400	0.305
DEG_SPOP_SBC_1	28	32	PF00917	0.433
DOC_MAPK_gen_1	219	228	PF00069	0.354
DOC_MAPK_MEF2A_6	221	230	PF00069	0.343
DOC_MAPK_MEF2A_6	253	260	PF00069	0.302
DOC_MAPK_NFAT4_5	253	261	PF00069	0.318
DOC_USP7_MATH_1	182	186	PF00917	0.622
DOC_USP7_MATH_1	244	248	PF00917	0.645
DOC_USP7_MATH_1	28	32	PF00917	0.409
DOC_WW_Pin1_4	169	174	PF00397	0.497
DOC_WW_Pin1_4	24	29	PF00397	0.502
DOC_WW_Pin1_4	245	250	PF00397	0.602
DOC_WW_Pin1_4	56	61	PF00397	0.464
LIG_14-3-3_CanoR_1	143	151	PF00244	0.349
LIG_14-3-3_CanoR_1	209	215	PF00244	0.321
LIG_14-3-3_CanoR_1	243	249	PF00244	0.528
LIG_14-3-3_CanoR_1	283	287	PF00244	0.429
LIG_AP2alpha_1	144	148	PF02296	0.476
LIG_APCC_ABBA_1	201	206	PF00400	0.279
LIG_BRCT_BRCA1_1	292	296	PF00533	0.276
LIG_BRCT_BRCA1_1	93	97	PF00533	0.305
LIG_BRCT_BRCA1_2	292	298	PF00533	0.388
LIG_EH1_1	5	13	PF00400	0.283
LIG_FHA_1	129	135	PF00498	0.338
LIG_FHA_1	188	194	PF00498	0.501
LIG_FHA_1	68	74	PF00498	0.545
LIG_FHA_2	64	70	PF00498	0.369
LIG_Integrin_RGD_1	138	140	PF01839	0.322
LIG_LIR_Gen_1	140	148	PF02991	0.328
LIG_LIR_Gen_1	39	48	PF02991	0.297
LIG_LIR_Nem_3	140	144	PF02991	0.332
LIG_LIR_Nem_3	145	151	PF02991	0.318
LIG_LIR_Nem_3	275	280	PF02991	0.242
LIG_LIR_Nem_3	39	44	PF02991	0.328
LIG_NRBOX	164	170	PF00104	0.459
LIG_PCNA_PIPBox_1	150	159	PF02747	0.362
LIG_PCNA_yPIPBox_3	143	157	PF02747	0.382
LIG_PDZ_Class_2	310	315	PF00595	0.276
LIG_Pex14_1	276	280	PF04695	0.242
LIG_Pex14_1	41	45	PF04695	0.313
LIG_Pex14_2	144	148	PF04695	0.425
LIG_PTB_Apo_2	268	275	PF02174	0.336
LIG_SH2_GRB2like	280	283	PF00017	0.242
LIG_SH2_SRC	23	26	PF00017	0.417
LIG_SH2_STAP1	157	161	PF00017	0.248
LIG_SH2_STAT5	141	144	PF00017	0.350
LIG_SH2_STAT5	217	220	PF00017	0.312
LIG_SH2_STAT5	23	26	PF00017	0.417
LIG_SH2_STAT5	280	283	PF00017	0.257
LIG_SH2_STAT5	308	311	PF00017	0.276
LIG_SH3_3	192	198	PF00018	0.433
LIG_SH3_3	246	252	PF00018	0.498
LIG_SH3_3	286	292	PF00018	0.242
LIG_SH3_3	294	300	PF00018	0.242
LIG_SH3_3	57	63	PF00018	0.430
LIG_SUMO_SIM_anti_2	149	155	PF11976	0.383
LIG_SUMO_SIM_anti_2	254	260	PF11976	0.321
LIG_SUMO_SIM_par_1	63	70	PF11976	0.461
LIG_SxIP_EBH_1	101	110	PF03271	0.317
LIG_WW_2	60	63	PF00397	0.445
MOD_CK1_1	128	134	PF00069	0.449
MOD_CK1_1	238	244	PF00069	0.503
MOD_CK1_1	247	253	PF00069	0.531
MOD_CK1_1	272	278	PF00069	0.266
MOD_CK2_1	112	118	PF00069	0.271
MOD_CK2_1	28	34	PF00069	0.393
MOD_CK2_1	63	69	PF00069	0.370
MOD_GlcNHglycan	114	117	PF01048	0.365
MOD_GlcNHglycan	125	128	PF01048	0.331
MOD_GlcNHglycan	184	187	PF01048	0.659
MOD_GlcNHglycan	236	240	PF01048	0.484
MOD_GlcNHglycan	31	34	PF01048	0.518
MOD_GSK3_1	11	18	PF00069	0.361
MOD_GSK3_1	119	126	PF00069	0.285
MOD_GSK3_1	238	245	PF00069	0.550
MOD_GSK3_1	24	31	PF00069	0.395
MOD_GSK3_1	36	43	PF00069	0.492
MOD_GSK3_1	63	70	PF00069	0.496
MOD_N-GLC_1	270	275	PF02516	0.242
MOD_NEK2_1	11	16	PF00069	0.339
MOD_NEK2_1	112	117	PF00069	0.423
MOD_NEK2_1	210	215	PF00069	0.378
MOD_NEK2_1	259	264	PF00069	0.298
MOD_NEK2_1	269	274	PF00069	0.277
MOD_NEK2_1	55	60	PF00069	0.556
MOD_NEK2_1	91	96	PF00069	0.243
MOD_NEK2_2	125	130	PF00069	0.409
MOD_NEK2_2	40	45	PF00069	0.309
MOD_PIKK_1	259	265	PF00454	0.418
MOD_PKA_2	142	148	PF00069	0.357
MOD_PKA_2	242	248	PF00069	0.507
MOD_PKA_2	282	288	PF00069	0.419
MOD_PKA_2	36	42	PF00069	0.436
MOD_Plk_1	139	145	PF00069	0.393
MOD_Plk_1	235	241	PF00069	0.472
MOD_Plk_1	270	276	PF00069	0.242
MOD_Plk_4	103	109	PF00069	0.378
MOD_Plk_4	119	125	PF00069	0.408
MOD_Plk_4	171	177	PF00069	0.466
MOD_Plk_4	210	216	PF00069	0.229
MOD_Plk_4	226	232	PF00069	0.373
MOD_Plk_4	36	42	PF00069	0.362
MOD_ProDKin_1	169	175	PF00069	0.500
MOD_ProDKin_1	24	30	PF00069	0.498
MOD_ProDKin_1	245	251	PF00069	0.583
MOD_ProDKin_1	56	62	PF00069	0.461
TRG_DiLeu_BaLyEn_6	192	197	PF01217	0.478
TRG_ENDOCYTIC_2	141	144	PF00928	0.333
TRG_ER_diArg_1	136	138	PF00400	0.300
TRG_ER_diArg_1	176	178	PF00400	0.379
TRG_ER_diArg_1	286	288	PF00400	0.240
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.337

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYE7	Leptomonas seymouri	58%	97%
A0A0S4JMG1	Bodo saltans	38%	75%
A0A1X0P2U6	Trypanosomatidae	50%	98%
A0A3S5H4T0	Leishmania donovani	91%	99%
A0A422NY61	Trypanosoma rangeli	52%	100%
A4H325	Leishmania braziliensis	83%	100%
A4HRD1	Leishmania infantum	91%	99%
C9ZXG6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9ABZ9	Leishmania major	92%	100%
Q58YV9	Escherichia coli	24%	100%
V5BBV1	Trypanosoma cruzi	54%	100%