PHB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AJ94_LEIMU

TriTrypDb:

LmxM.01.0080

Length:

237

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9AJ94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJ94

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	199	201	PF00675	0.686
CLV_NRD_NRD_1	62	64	PF00675	0.674
CLV_PCSK_KEX2_1	199	201	PF00082	0.670
CLV_PCSK_KEX2_1	62	64	PF00082	0.692
CLV_PCSK_SKI1_1	119	123	PF00082	0.687
CLV_PCSK_SKI1_1	200	204	PF00082	0.751
CLV_PCSK_SKI1_1	53	57	PF00082	0.719
CLV_PCSK_SKI1_1	64	68	PF00082	0.638
CLV_Separin_Metazoa	74	78	PF03568	0.353
DEG_APCC_DBOX_1	76	84	PF00400	0.536
DOC_CYCLIN_yCln2_LP_2	105	108	PF00134	0.523
DOC_PP2B_LxvP_1	104	107	PF13499	0.504
DOC_PP4_FxxP_1	115	118	PF00568	0.440
DOC_PP4_FxxP_1	203	206	PF00568	0.478
DOC_USP7_MATH_1	125	129	PF00917	0.526
DOC_USP7_MATH_1	187	191	PF00917	0.557
DOC_USP7_MATH_1	19	23	PF00917	0.633
DOC_USP7_MATH_1	2	6	PF00917	0.704
DOC_USP7_MATH_1	227	231	PF00917	0.417
DOC_USP7_MATH_1	76	80	PF00917	0.492
DOC_USP7_MATH_1	81	85	PF00917	0.504
LIG_14-3-3_CanoR_1	53	58	PF00244	0.503
LIG_14-3-3_CanoR_1	62	67	PF00244	0.469
LIG_14-3-3_CanoR_1	82	90	PF00244	0.518
LIG_APCC_ABBA_1	204	209	PF00400	0.541
LIG_BRCT_BRCA1_1	108	112	PF00533	0.490
LIG_BRCT_BRCA1_1	88	92	PF00533	0.543
LIG_eIF4E_1	91	97	PF01652	0.457
LIG_EVH1_2	107	111	PF00568	0.449
LIG_FHA_1	100	106	PF00498	0.488
LIG_FHA_1	210	216	PF00498	0.530
LIG_FHA_1	5	11	PF00498	0.698
LIG_FHA_2	196	202	PF00498	0.551
LIG_FHA_2	67	73	PF00498	0.487
LIG_LIR_Apic_2	148	154	PF02991	0.435
LIG_LIR_Apic_2	201	206	PF02991	0.472
LIG_LIR_Gen_1	152	163	PF02991	0.511
LIG_LIR_Nem_3	109	115	PF02991	0.452
LIG_LIR_Nem_3	148	153	PF02991	0.509
LIG_MLH1_MIPbox_1	108	112	PF16413	0.502
LIG_MLH1_MIPbox_1	88	92	PF16413	0.543
LIG_Pex14_2	111	115	PF04695	0.463
LIG_SH2_CRK	151	155	PF00017	0.433
LIG_SH2_NCK_1	151	155	PF00017	0.516
LIG_SH2_STAT5	151	154	PF00017	0.449
LIG_SH2_STAT5	161	164	PF00017	0.466
LIG_SH2_STAT5	91	94	PF00017	0.453
LIG_SH3_3	164	170	PF00018	0.460
LIG_SH3_3	22	28	PF00018	0.537
LIG_SH3_3	46	52	PF00018	0.502
LIG_SH3_3	7	13	PF00018	0.694
LIG_SUMO_SIM_anti_2	229	235	PF11976	0.497
LIG_SUMO_SIM_par_1	229	235	PF11976	0.541
LIG_UBA3_1	36	41	PF00899	0.475
MOD_CK2_1	117	123	PF00069	0.527
MOD_CK2_1	195	201	PF00069	0.536
MOD_GlcNHglycan	188	192	PF01048	0.741
MOD_GlcNHglycan	21	24	PF01048	0.552
MOD_GlcNHglycan	69	72	PF01048	0.732
MOD_GlcNHglycan	93	96	PF01048	0.697
MOD_GSK3_1	113	120	PF00069	0.506
MOD_GSK3_1	145	152	PF00069	0.533
MOD_GSK3_1	210	217	PF00069	0.462
MOD_GSK3_1	58	65	PF00069	0.451
MOD_LATS_1	51	57	PF00433	0.535
MOD_N-GLC_1	86	91	PF02516	0.737
MOD_NEK2_1	145	150	PF00069	0.429
MOD_NEK2_1	195	200	PF00069	0.537
MOD_NEK2_1	86	91	PF00069	0.497
MOD_NEK2_1	97	102	PF00069	0.387
MOD_PK_1	139	145	PF00069	0.483
MOD_PKA_1	62	68	PF00069	0.461
MOD_PKA_2	62	68	PF00069	0.461
MOD_PKA_2	76	82	PF00069	0.449
MOD_Plk_1	86	92	PF00069	0.516
MOD_Plk_4	107	113	PF00069	0.479
MOD_Plk_4	145	151	PF00069	0.503
MOD_Plk_4	227	233	PF00069	0.531
MOD_Plk_4	53	59	PF00069	0.453
MOD_Plk_4	62	68	PF00069	0.461
MOD_Plk_4	86	92	PF00069	0.499
TRG_DiLeu_BaEn_1	218	223	PF01217	0.526
TRG_DiLeu_BaEn_1	229	234	PF01217	0.474
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.519
TRG_ER_diArg_1	101	104	PF00400	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDU2	Leptomonas seymouri	77%	100%
A0A0S4JQK8	Bodo saltans	33%	90%
A0A1X0P2T1	Trypanosomatidae	47%	99%
A0A3S5ISA4	Trypanosoma rangeli	50%	100%
A0A451EJ66	Leishmania donovani	95%	100%
A4H323	Leishmania braziliensis	88%	100%
A4HRC9	Leishmania infantum	95%	100%
C9ZXG7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	89%
E9ABZ7	Leishmania major	92%	100%
V5B2Q8	Trypanosoma cruzi	49%	91%