BSD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

BSD domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AJ93_LEIMU

TriTrypDb:

LmxM.01.0070

Length:

599

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AJ93

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJ93

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	130	132	PF00675	0.616
CLV_NRD_NRD_1	140	142	PF00675	0.531
CLV_NRD_NRD_1	478	480	PF00675	0.598
CLV_NRD_NRD_1	552	554	PF00675	0.809
CLV_PCSK_KEX2_1	130	132	PF00082	0.589
CLV_PCSK_KEX2_1	470	472	PF00082	0.362
CLV_PCSK_PC1ET2_1	470	472	PF00082	0.362
CLV_PCSK_SKI1_1	181	185	PF00082	0.490
CLV_PCSK_SKI1_1	375	379	PF00082	0.229
CLV_PCSK_SKI1_1	425	429	PF00082	0.448
CLV_PCSK_SKI1_1	462	466	PF00082	0.538
CLV_PCSK_SKI1_1	51	55	PF00082	0.340
CLV_Separin_Metazoa	422	426	PF03568	0.500
DEG_APCC_DBOX_1	576	584	PF00400	0.465
DEG_ODPH_VHL_1	321	334	PF01847	0.250
DEG_SIAH_1	560	568	PF03145	0.563
DEG_SPOP_SBC_1	143	147	PF00917	0.483
DEG_SPOP_SBC_1	41	45	PF00917	0.421
DEG_SPOP_SBC_1	95	99	PF00917	0.744
DOC_CKS1_1	417	422	PF01111	0.433
DOC_CYCLIN_yCln2_LP_2	417	423	PF00134	0.423
DOC_MAPK_gen_1	29	38	PF00069	0.386
DOC_MAPK_HePTP_8	394	406	PF00069	0.392
DOC_MAPK_MEF2A_6	181	189	PF00069	0.489
DOC_MAPK_MEF2A_6	397	406	PF00069	0.456
DOC_PP1_RVXF_1	489	496	PF00149	0.389
DOC_PP2B_LxvP_1	406	409	PF13499	0.344
DOC_PP2B_LxvP_1	75	78	PF13499	0.399
DOC_PP4_FxxP_1	38	41	PF00568	0.382
DOC_USP7_MATH_1	116	120	PF00917	0.633
DOC_USP7_MATH_1	157	161	PF00917	0.301
DOC_USP7_MATH_1	240	244	PF00917	0.587
DOC_USP7_MATH_1	246	250	PF00917	0.574
DOC_USP7_MATH_1	409	413	PF00917	0.502
DOC_USP7_MATH_1	86	90	PF00917	0.716
DOC_USP7_MATH_1	94	98	PF00917	0.672
DOC_WW_Pin1_4	118	123	PF00397	0.589
DOC_WW_Pin1_4	252	257	PF00397	0.620
DOC_WW_Pin1_4	265	270	PF00397	0.536
DOC_WW_Pin1_4	416	421	PF00397	0.591
DOC_WW_Pin1_4	530	535	PF00397	0.581
DOC_WW_Pin1_4	541	546	PF00397	0.676
DOC_WW_Pin1_4	553	558	PF00397	0.739
DOC_WW_Pin1_4	572	577	PF00397	0.547
DOC_WW_Pin1_4	60	65	PF00397	0.615
LIG_14-3-3_CanoR_1	141	151	PF00244	0.614
LIG_14-3-3_CanoR_1	411	421	PF00244	0.443
LIG_14-3-3_CanoR_1	571	576	PF00244	0.750
LIG_14-3-3_CanoR_1	581	589	PF00244	0.617
LIG_Actin_WH2_2	410	427	PF00022	0.301
LIG_Actin_WH2_2	565	583	PF00022	0.483
LIG_AP2alpha_2	67	69	PF02296	0.416
LIG_BIR_II_1	1	5	PF00653	0.544
LIG_BRCT_BRCA1_1	100	104	PF00533	0.571
LIG_BRCT_BRCA1_1	2	6	PF00533	0.573
LIG_BRCT_BRCA1_1	34	38	PF00533	0.371
LIG_BRCT_BRCA1_1	65	69	PF00533	0.390
LIG_Clathr_ClatBox_1	114	118	PF01394	0.272
LIG_Clathr_ClatBox_1	345	349	PF01394	0.441
LIG_CSL_BTD_1	38	41	PF09270	0.397
LIG_deltaCOP1_diTrp_1	289	298	PF00928	0.430
LIG_deltaCOP1_diTrp_1	338	346	PF00928	0.484
LIG_FHA_1	109	115	PF00498	0.356
LIG_FHA_1	171	177	PF00498	0.496
LIG_FHA_1	182	188	PF00498	0.381
LIG_FHA_1	210	216	PF00498	0.627
LIG_FHA_1	220	226	PF00498	0.522
LIG_FHA_1	515	521	PF00498	0.554
LIG_FHA_1	560	566	PF00498	0.568
LIG_FHA_1	83	89	PF00498	0.593
LIG_FHA_2	417	423	PF00498	0.470
LIG_FXI_DFP_1	345	349	PF00024	0.441
LIG_LIR_Apic_2	35	41	PF02991	0.378
LIG_LIR_Gen_1	202	211	PF02991	0.491
LIG_LIR_Gen_1	297	306	PF02991	0.506
LIG_LIR_Gen_1	448	458	PF02991	0.486
LIG_LIR_Nem_3	160	164	PF02991	0.457
LIG_LIR_Nem_3	202	208	PF02991	0.480
LIG_LIR_Nem_3	297	301	PF02991	0.444
LIG_LIR_Nem_3	338	343	PF02991	0.398
LIG_LIR_Nem_3	378	383	PF02991	0.291
LIG_LIR_Nem_3	448	453	PF02991	0.459
LIG_LIR_Nem_3	66	72	PF02991	0.412
LIG_PDZ_Class_3	594	599	PF00595	0.551
LIG_Pex14_1	380	384	PF04695	0.289
LIG_PTB_Apo_2	169	176	PF02174	0.400
LIG_PTB_Phospho_1	169	175	PF10480	0.496
LIG_Rb_pABgroove_1	340	348	PF01858	0.425
LIG_SH2_CRK	367	371	PF00017	0.274
LIG_SH2_STAP1	496	500	PF00017	0.456
LIG_SH2_STAT5	175	178	PF00017	0.527
LIG_SH2_STAT5	383	386	PF00017	0.304
LIG_SH3_3	156	162	PF00018	0.434
LIG_SH3_3	253	259	PF00018	0.477
LIG_SH3_3	500	506	PF00018	0.581
LIG_SH3_3	586	592	PF00018	0.423
LIG_SH3_3	75	81	PF00018	0.512
LIG_TRAF2_1	123	126	PF00917	0.598
LIG_TRAF2_1	287	290	PF00917	0.572
LIG_TRAF2_1	592	595	PF00917	0.453
LIG_TRFH_1	367	371	PF08558	0.274
MOD_CDK_SPK_2	572	577	PF00069	0.547
MOD_CDK_SPxK_1	541	547	PF00069	0.755
MOD_CDK_SPxxK_3	265	272	PF00069	0.466
MOD_CK1_1	206	212	PF00069	0.572
MOD_CK1_1	232	238	PF00069	0.544
MOD_CK1_1	257	263	PF00069	0.680
MOD_CK1_1	412	418	PF00069	0.371
MOD_CK1_1	494	500	PF00069	0.544
MOD_CK1_1	89	95	PF00069	0.692
MOD_CK1_1	97	103	PF00069	0.627
MOD_CK2_1	416	422	PF00069	0.525
MOD_CK2_1	484	490	PF00069	0.517
MOD_GlcNHglycan	100	103	PF01048	0.662
MOD_GlcNHglycan	118	121	PF01048	0.393
MOD_GlcNHglycan	2	5	PF01048	0.578
MOD_GlcNHglycan	20	24	PF01048	0.506
MOD_GlcNHglycan	242	245	PF01048	0.575
MOD_GlcNHglycan	259	262	PF01048	0.567
MOD_GlcNHglycan	302	305	PF01048	0.333
MOD_GlcNHglycan	358	361	PF01048	0.350
MOD_GlcNHglycan	509	512	PF01048	0.478
MOD_GlcNHglycan	88	91	PF01048	0.705
MOD_GSK3_1	181	188	PF00069	0.487
MOD_GSK3_1	199	206	PF00069	0.390
MOD_GSK3_1	207	214	PF00069	0.546
MOD_GSK3_1	229	236	PF00069	0.512
MOD_GSK3_1	255	262	PF00069	0.714
MOD_GSK3_1	270	277	PF00069	0.667
MOD_GSK3_1	412	419	PF00069	0.486
MOD_GSK3_1	514	521	PF00069	0.676
MOD_GSK3_1	553	560	PF00069	0.725
MOD_GSK3_1	82	89	PF00069	0.598
MOD_GSK3_1	94	101	PF00069	0.651
MOD_N-GLC_1	133	138	PF02516	0.472
MOD_N-GLC_1	233	238	PF02516	0.460
MOD_N-GLC_1	252	257	PF02516	0.594
MOD_N-GLC_1	41	46	PF02516	0.532
MOD_N-GLC_1	86	91	PF02516	0.542
MOD_NEK2_1	170	175	PF00069	0.460
MOD_NEK2_1	207	212	PF00069	0.563
MOD_NEK2_1	218	223	PF00069	0.525
MOD_NEK2_1	309	314	PF00069	0.488
MOD_NEK2_2	12	17	PF00069	0.520
MOD_NEK2_2	341	346	PF00069	0.475
MOD_NEK2_2	409	414	PF00069	0.430
MOD_PIKK_1	581	587	PF00454	0.641
MOD_PKA_2	12	18	PF00069	0.470
MOD_PKA_2	229	235	PF00069	0.578
MOD_PKA_2	570	576	PF00069	0.669
MOD_Plk_1	233	239	PF00069	0.409
MOD_Plk_1	317	323	PF00069	0.469
MOD_Plk_1	375	381	PF00069	0.417
MOD_Plk_4	12	18	PF00069	0.451
MOD_Plk_4	233	239	PF00069	0.521
MOD_Plk_4	297	303	PF00069	0.486
MOD_Plk_4	341	347	PF00069	0.424
MOD_Plk_4	375	381	PF00069	0.400
MOD_Plk_4	491	497	PF00069	0.526
MOD_ProDKin_1	118	124	PF00069	0.599
MOD_ProDKin_1	252	258	PF00069	0.620
MOD_ProDKin_1	265	271	PF00069	0.536
MOD_ProDKin_1	416	422	PF00069	0.585
MOD_ProDKin_1	530	536	PF00069	0.583
MOD_ProDKin_1	541	547	PF00069	0.678
MOD_ProDKin_1	553	559	PF00069	0.738
MOD_ProDKin_1	572	578	PF00069	0.547
MOD_ProDKin_1	60	66	PF00069	0.613
TRG_DiLeu_BaEn_1	297	302	PF01217	0.393
TRG_ENDOCYTIC_2	343	346	PF00928	0.421
TRG_ENDOCYTIC_2	367	370	PF00928	0.274
TRG_Pf-PMV_PEXEL_1	425	429	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	56	60	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILJ7	Leptomonas seymouri	47%	96%
A0A0S4JIQ1	Bodo saltans	31%	79%
A0A1X0P2Y2	Trypanosomatidae	30%	100%
A0A3R7LAJ1	Trypanosoma rangeli	31%	100%
A0A451EJ65	Leishmania donovani	80%	100%
A4H322	Leishmania braziliensis	73%	100%
A4HRC8	Leishmania infantum	80%	100%
C9ZXG8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9ABZ6	Leishmania major	84%	99%
V5AME8	Trypanosoma cruzi	30%	100%