Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Kinesin-13 1, putative

Species:

Leishmania mexicana

UniProt:

E9AJ89_LEIMU

TriTrypDb:

LmxM.01.0030

Length:

672

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	21
GO:0099080	supramolecular complex	2	21
GO:0099081	supramolecular polymer	3	21
GO:0099512	supramolecular fiber	4	21
GO:0099513	polymeric cytoskeletal fiber	5	21
GO:0110165	cellular anatomical entity	1	21
GO:0000922	spindle pole	2	1
GO:0005634	nucleus	5	1
GO:0005819	spindle	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

E9AJ89

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJ89

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	21
GO:0007018	microtubule-based movement	3	21
GO:0009987	cellular process	1	21
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007019	microtubule depolymerization	5	2
GO:0007051	spindle organization	3	1
GO:0007052	mitotic spindle organization	4	1
GO:0016043	cellular component organization	3	2
GO:0022402	cell cycle process	2	1
GO:0022411	cellular component disassembly	4	2
GO:0031109	microtubule polymerization or depolymerization	4	2
GO:0032984	protein-containing complex disassembly	5	2
GO:0043933	protein-containing complex organization	4	2
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051261	protein depolymerization	6	2
GO:0051983	regulation of chromosome segregation	4	1
GO:0065007	biological regulation	1	1
GO:0071840	cellular component organization or biogenesis	2	2
GO:0097435	supramolecular fiber organization	4	2
GO:1902850	microtubule cytoskeleton organization involved in mitosis	4	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	21
GO:0003774	cytoskeletal motor activity	1	21
GO:0003777	microtubule motor activity	2	21
GO:0005488	binding	1	21
GO:0005515	protein binding	2	21
GO:0005524	ATP binding	5	21
GO:0008017	microtubule binding	5	21
GO:0008092	cytoskeletal protein binding	3	21
GO:0015631	tubulin binding	4	21
GO:0017076	purine nucleotide binding	4	21
GO:0030554	adenyl nucleotide binding	5	21
GO:0032553	ribonucleotide binding	3	21
GO:0032555	purine ribonucleotide binding	4	21
GO:0032559	adenyl ribonucleotide binding	5	21
GO:0035639	purine ribonucleoside triphosphate binding	4	21
GO:0036094	small molecule binding	2	21
GO:0043167	ion binding	2	21
GO:0043168	anion binding	3	21
GO:0097159	organic cyclic compound binding	2	21
GO:0097367	carbohydrate derivative binding	2	21
GO:0140657	ATP-dependent activity	1	21
GO:1901265	nucleoside phosphate binding	3	21
GO:1901363	heterocyclic compound binding	2	21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	152	156	PF00656	0.315
CLV_C14_Caspase3-7	79	83	PF00656	0.567
CLV_C14_Caspase3-7	95	99	PF00656	0.569
CLV_NRD_NRD_1	105	107	PF00675	0.687
CLV_NRD_NRD_1	127	129	PF00675	0.463
CLV_NRD_NRD_1	136	138	PF00675	0.334
CLV_NRD_NRD_1	17	19	PF00675	0.540
CLV_NRD_NRD_1	173	175	PF00675	0.382
CLV_NRD_NRD_1	277	279	PF00675	0.399
CLV_NRD_NRD_1	396	398	PF00675	0.261
CLV_NRD_NRD_1	457	459	PF00675	0.532
CLV_NRD_NRD_1	481	483	PF00675	0.667
CLV_NRD_NRD_1	503	505	PF00675	0.548
CLV_NRD_NRD_1	632	634	PF00675	0.548
CLV_PCSK_KEX2_1	104	106	PF00082	0.694
CLV_PCSK_KEX2_1	127	129	PF00082	0.462
CLV_PCSK_KEX2_1	138	140	PF00082	0.346
CLV_PCSK_KEX2_1	17	19	PF00082	0.540
CLV_PCSK_KEX2_1	277	279	PF00082	0.406
CLV_PCSK_KEX2_1	342	344	PF00082	0.406
CLV_PCSK_KEX2_1	451	453	PF00082	0.481
CLV_PCSK_KEX2_1	457	459	PF00082	0.521
CLV_PCSK_KEX2_1	481	483	PF00082	0.667
CLV_PCSK_KEX2_1	545	547	PF00082	0.624
CLV_PCSK_KEX2_1	569	571	PF00082	0.732
CLV_PCSK_KEX2_1	631	633	PF00082	0.505
CLV_PCSK_PC1ET2_1	127	129	PF00082	0.472
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.353
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.242
CLV_PCSK_PC1ET2_1	451	453	PF00082	0.437
CLV_PCSK_PC1ET2_1	545	547	PF00082	0.624
CLV_PCSK_PC1ET2_1	569	571	PF00082	0.658
CLV_PCSK_PC1ET2_1	631	633	PF00082	0.469
CLV_PCSK_PC7_1	477	483	PF00082	0.555
CLV_PCSK_PC7_1	565	571	PF00082	0.664
CLV_PCSK_SKI1_1	181	185	PF00082	0.238
CLV_PCSK_SKI1_1	246	250	PF00082	0.370
CLV_PCSK_SKI1_1	293	297	PF00082	0.371
CLV_PCSK_SKI1_1	35	39	PF00082	0.463
CLV_PCSK_SKI1_1	381	385	PF00082	0.313
CLV_PCSK_SKI1_1	448	452	PF00082	0.427
CLV_Separin_Metazoa	409	413	PF03568	0.277
DEG_APCC_DBOX_1	276	284	PF00400	0.225
DEG_SPOP_SBC_1	667	671	PF00917	0.471
DOC_CKS1_1	527	532	PF01111	0.549
DOC_CYCLIN_RxL_1	378	388	PF00134	0.313
DOC_MAPK_gen_1	127	136	PF00069	0.397
DOC_MAPK_gen_1	165	173	PF00069	0.372
DOC_MAPK_MEF2A_6	127	136	PF00069	0.406
DOC_MAPK_MEF2A_6	165	173	PF00069	0.372
DOC_MAPK_MEF2A_6	330	339	PF00069	0.348
DOC_USP7_MATH_1	156	160	PF00917	0.405
DOC_USP7_MATH_1	27	31	PF00917	0.348
DOC_USP7_MATH_1	503	507	PF00917	0.662
DOC_USP7_MATH_1	547	551	PF00917	0.671
DOC_USP7_MATH_1	560	564	PF00917	0.587
DOC_USP7_MATH_1	580	584	PF00917	0.558
DOC_USP7_MATH_1	634	638	PF00917	0.518
DOC_USP7_MATH_1	667	671	PF00917	0.471
DOC_USP7_MATH_1	73	77	PF00917	0.622
DOC_USP7_UBL2_3	338	342	PF12436	0.358
DOC_USP7_UBL2_3	346	350	PF12436	0.181
DOC_WW_Pin1_4	425	430	PF00397	0.313
DOC_WW_Pin1_4	515	520	PF00397	0.673
DOC_WW_Pin1_4	526	531	PF00397	0.759
DOC_WW_Pin1_4	90	95	PF00397	0.790
LIG_14-3-3_CanoR_1	105	115	PF00244	0.541
LIG_14-3-3_CanoR_1	174	183	PF00244	0.378
LIG_14-3-3_CanoR_1	23	32	PF00244	0.329
LIG_14-3-3_CanoR_1	251	260	PF00244	0.366
LIG_14-3-3_CanoR_1	452	460	PF00244	0.677
LIG_14-3-3_CanoR_1	481	487	PF00244	0.570
LIG_14-3-3_CanoR_1	504	509	PF00244	0.683
LIG_14-3-3_CanoR_1	512	518	PF00244	0.669
LIG_14-3-3_CanoR_1	625	635	PF00244	0.523
LIG_Actin_WH2_1	47	62	PF00022	0.329
LIG_BIR_II_1	1	5	PF00653	0.460
LIG_BRCT_BRCA1_1	668	672	PF00533	0.479
LIG_FHA_1	111	117	PF00498	0.475
LIG_FHA_1	254	260	PF00498	0.360
LIG_FHA_1	406	412	PF00498	0.313
LIG_FHA_1	419	425	PF00498	0.313
LIG_FHA_1	482	488	PF00498	0.630
LIG_FHA_1	537	543	PF00498	0.475
LIG_FHA_2	120	126	PF00498	0.436
LIG_FHA_2	206	212	PF00498	0.324
LIG_FHA_2	299	305	PF00498	0.216
LIG_FHA_2	306	312	PF00498	0.186
LIG_FHA_2	31	37	PF00498	0.517
LIG_FHA_2	350	356	PF00498	0.277
LIG_FHA_2	370	376	PF00498	0.384
LIG_FHA_2	451	457	PF00498	0.414
LIG_FHA_2	638	644	PF00498	0.532
LIG_Integrin_isoDGR_2	275	277	PF01839	0.238
LIG_LIR_Gen_1	147	156	PF02991	0.441
LIG_LIR_Gen_1	247	255	PF02991	0.245
LIG_LIR_Gen_1	352	357	PF02991	0.308
LIG_LIR_Nem_3	147	153	PF02991	0.441
LIG_LIR_Nem_3	247	252	PF02991	0.244
LIG_LIR_Nem_3	261	266	PF02991	0.342
LIG_LIR_Nem_3	352	356	PF02991	0.309
LIG_LIR_Nem_3	43	48	PF02991	0.439
LIG_LIR_Nem_3	587	592	PF02991	0.477
LIG_NRBOX	269	275	PF00104	0.280
LIG_PCNA_TLS_4	632	639	PF02747	0.525
LIG_PDZ_Class_1	667	672	PF00595	0.476
LIG_Pex14_2	184	188	PF04695	0.277
LIG_Pex14_2	24	28	PF04695	0.474
LIG_RPA_C_Fungi	620	632	PF08784	0.523
LIG_SH2_NCK_1	198	202	PF00017	0.216
LIG_SH2_NCK_1	241	245	PF00017	0.277
LIG_SH2_STAP1	241	245	PF00017	0.277
LIG_SH2_STAP1	443	447	PF00017	0.313
LIG_SH2_STAT5	108	111	PF00017	0.506
LIG_SH2_STAT5	11	14	PF00017	0.493
LIG_SH2_STAT5	176	179	PF00017	0.313
LIG_SH2_STAT5	592	595	PF00017	0.392
LIG_SH2_STAT5	65	68	PF00017	0.374
LIG_SH3_2	530	535	PF14604	0.786
LIG_SH3_3	457	463	PF00018	0.755
LIG_SH3_3	527	533	PF00018	0.780
LIG_SH3_3	556	562	PF00018	0.544
LIG_SH3_3	661	667	PF00018	0.439
LIG_SUMO_SIM_par_1	382	388	PF11976	0.277
LIG_TRAF2_1	122	125	PF00917	0.422
LIG_UBA3_1	132	138	PF00899	0.412
LIG_UBA3_1	334	342	PF00899	0.238
LIG_UBA3_1	383	387	PF00899	0.313
LIG_WRC_WIRS_1	259	264	PF05994	0.277
LIG_WRC_WIRS_1	635	640	PF05994	0.530
LIG_WW_3	501	505	PF00397	0.439
MOD_CDK_SPK_2	526	531	PF00069	0.739
MOD_CDK_SPxxK_3	90	97	PF00069	0.582
MOD_CK1_1	119	125	PF00069	0.514
MOD_CK1_1	225	231	PF00069	0.313
MOD_CK1_1	30	36	PF00069	0.423
MOD_CK1_1	318	324	PF00069	0.283
MOD_CK1_1	328	334	PF00069	0.364
MOD_CK1_1	405	411	PF00069	0.313
MOD_CK1_1	476	482	PF00069	0.587
MOD_CK1_1	495	501	PF00069	0.579
MOD_CK1_1	510	516	PF00069	0.610
MOD_CK1_1	518	524	PF00069	0.668
MOD_CK1_1	637	643	PF00069	0.559
MOD_CK2_1	119	125	PF00069	0.447
MOD_CK2_1	139	145	PF00069	0.299
MOD_CK2_1	258	264	PF00069	0.320
MOD_CK2_1	298	304	PF00069	0.242
MOD_CK2_1	369	375	PF00069	0.302
MOD_CK2_1	450	456	PF00069	0.364
MOD_CK2_1	616	622	PF00069	0.525
MOD_CK2_1	89	95	PF00069	0.740
MOD_CK2_1	97	103	PF00069	0.478
MOD_Cter_Amidation	275	278	PF01082	0.401
MOD_GlcNHglycan	1	4	PF01048	0.699
MOD_GlcNHglycan	141	144	PF01048	0.465
MOD_GlcNHglycan	157	161	PF01048	0.246
MOD_GlcNHglycan	224	227	PF01048	0.318
MOD_GlcNHglycan	25	28	PF01048	0.291
MOD_GlcNHglycan	266	269	PF01048	0.234
MOD_GlcNHglycan	313	316	PF01048	0.307
MOD_GlcNHglycan	494	497	PF01048	0.591
MOD_GlcNHglycan	562	565	PF01048	0.694
MOD_GlcNHglycan	75	78	PF01048	0.728
MOD_GSK3_1	106	113	PF00069	0.510
MOD_GSK3_1	144	151	PF00069	0.269
MOD_GSK3_1	23	30	PF00069	0.325
MOD_GSK3_1	293	300	PF00069	0.266
MOD_GSK3_1	311	318	PF00069	0.150
MOD_GSK3_1	324	331	PF00069	0.215
MOD_GSK3_1	452	459	PF00069	0.588
MOD_GSK3_1	473	480	PF00069	0.681
MOD_GSK3_1	481	488	PF00069	0.556
MOD_GSK3_1	492	499	PF00069	0.586
MOD_GSK3_1	503	510	PF00069	0.615
MOD_GSK3_1	513	520	PF00069	0.717
MOD_GSK3_1	522	529	PF00069	0.748
MOD_GSK3_1	531	538	PF00069	0.635
MOD_GSK3_1	560	567	PF00069	0.630
MOD_GSK3_1	662	669	PF00069	0.469
MOD_GSK3_1	71	78	PF00069	0.558
MOD_N-GLC_1	119	124	PF02516	0.379
MOD_N-GLC_1	324	329	PF02516	0.225
MOD_N-GLC_1	379	384	PF02516	0.313
MOD_NEK2_1	205	210	PF00069	0.387
MOD_NEK2_1	28	33	PF00069	0.477
MOD_NEK2_1	402	407	PF00069	0.303
MOD_NEK2_1	411	416	PF00069	0.288
MOD_NEK2_1	450	455	PF00069	0.423
MOD_NEK2_1	492	497	PF00069	0.660
MOD_NEK2_1	508	513	PF00069	0.682
MOD_NEK2_1	541	546	PF00069	0.506
MOD_NEK2_2	213	218	PF00069	0.313
MOD_PIKK_1	5	11	PF00454	0.451
MOD_PIKK_1	518	524	PF00454	0.563
MOD_PIKK_1	637	643	PF00454	0.558
MOD_PIKK_1	662	668	PF00454	0.686
MOD_PKA_1	127	133	PF00069	0.391
MOD_PKA_1	174	180	PF00069	0.351
MOD_PKA_1	342	348	PF00069	0.372
MOD_PKA_1	481	487	PF00069	0.679
MOD_PKA_1	504	510	PF00069	0.616
MOD_PKA_2	110	116	PF00069	0.491
MOD_PKA_2	127	133	PF00069	0.391
MOD_PKA_2	250	256	PF00069	0.372
MOD_PKA_2	342	348	PF00069	0.385
MOD_PKA_2	369	375	PF00069	0.225
MOD_PKA_2	402	408	PF00069	0.313
MOD_PKA_2	411	417	PF00069	0.313
MOD_PKA_2	456	462	PF00069	0.690
MOD_PKA_2	476	482	PF00069	0.598
MOD_PKA_2	485	491	PF00069	0.644
MOD_PKA_2	503	509	PF00069	0.572
MOD_PKA_2	536	542	PF00069	0.571
MOD_PKA_2	547	553	PF00069	0.633
MOD_PKA_2	560	566	PF00069	0.561
MOD_PKB_1	104	112	PF00069	0.539
MOD_PKB_1	137	145	PF00069	0.315
MOD_Plk_1	379	385	PF00069	0.313
MOD_Plk_1	434	440	PF00069	0.280
MOD_Plk_2-3	305	311	PF00069	0.216
MOD_Plk_4	111	117	PF00069	0.475
MOD_Plk_4	205	211	PF00069	0.314
MOD_Plk_4	227	233	PF00069	0.313
MOD_Plk_4	258	264	PF00069	0.317
MOD_Plk_4	305	311	PF00069	0.384
MOD_Plk_4	379	385	PF00069	0.300
MOD_Plk_4	411	417	PF00069	0.255
MOD_Plk_4	504	510	PF00069	0.688
MOD_Plk_4	634	640	PF00069	0.528
MOD_ProDKin_1	425	431	PF00069	0.313
MOD_ProDKin_1	515	521	PF00069	0.673
MOD_ProDKin_1	526	532	PF00069	0.755
MOD_ProDKin_1	90	96	PF00069	0.783
MOD_SUMO_for_1	600	603	PF00179	0.475
MOD_SUMO_rev_2	161	169	PF00179	0.376
MOD_SUMO_rev_2	331	339	PF00179	0.225
MOD_SUMO_rev_2	445	453	PF00179	0.178
TRG_DiLeu_BaEn_1	622	627	PF01217	0.394
TRG_DiLeu_BaEn_2	387	393	PF01217	0.372
TRG_DiLeu_LyEn_5	622	627	PF01217	0.394
TRG_ENDOCYTIC_2	176	179	PF00928	0.355
TRG_ENDOCYTIC_2	48	51	PF00928	0.433
TRG_ER_diArg_1	104	106	PF00400	0.678
TRG_ER_diArg_1	136	139	PF00400	0.297
TRG_ER_diArg_1	16	18	PF00400	0.534
TRG_ER_diArg_1	277	279	PF00400	0.415
TRG_ER_diArg_1	57	60	PF00400	0.372
TRG_ER_diArg_1	582	585	PF00400	0.546
TRG_ER_diArg_1	623	626	PF00400	0.574
TRG_NLS_Bipartite_1	127	141	PF00514	0.384
TRG_NLS_MonoExtC_3	126	131	PF00514	0.541
TRG_NLS_MonoExtN_4	127	132	PF00514	0.389
TRG_Pf-PMV_PEXEL_1	203	207	PF00026	0.416
TRG_Pf-PMV_PEXEL_1	281	285	PF00026	0.246
TRG_Pf-PMV_PEXEL_1	293	297	PF00026	0.225
TRG_Pf-PMV_PEXEL_1	391	395	PF00026	0.372
TRG_Pf-PMV_PEXEL_1	584	588	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	625	630	PF00026	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6P6	Leptomonas seymouri	73%	100%
A0A0S4IP49	Bodo saltans	26%	83%
A0A0S4JS40	Bodo saltans	52%	79%
A0A1X0P2U1	Trypanosomatidae	47%	96%
A0A3R7MC35	Trypanosoma rangeli	27%	100%
A0A3S5H4S8	Leishmania donovani	96%	100%
A0A3S7WST0	Leishmania donovani	46%	92%
A0A3S7WY84	Leishmania donovani	40%	100%
A0A3S7X9Y1	Leishmania donovani	34%	100%
A0A422NY45	Trypanosoma rangeli	47%	96%
A4H337	Leishmania braziliensis	88%	100%
A4H7F1	Leishmania braziliensis	46%	100%
A4HAQ7	Leishmania braziliensis	26%	100%
A4HDC2	Leishmania braziliensis	40%	100%
A4HND6	Leishmania braziliensis	33%	100%
A4HRC5	Leishmania infantum	96%	100%
A4HSA6	Leishmania infantum	32%	100%
A4HVT9	Leishmania infantum	46%	92%
A4I0Q2	Leishmania infantum	40%	100%
A4IC09	Leishmania infantum	34%	100%
C9ZXH0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	97%
E9ABZ2	Leishmania major	95%	100%
E9AFU7	Leishmania major	34%	100%
E9API5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	93%
E9AWQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9B6Z9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
Q4QFZ3	Leishmania major	46%	100%
Q5R9Y9	Pongo abelii	39%	90%
Q940Y8	Arabidopsis thaliana	40%	98%
V5D311	Trypanosoma cruzi	47%	99%