Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania mexicana

UniProt:

E9AJ87_LEIMU

TriTrypDb:

LmxM.01.0010

Length:

334

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 15, no: 2
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

E9AJ87

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AJ87

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	321	325	PF00656	0.691
CLV_NRD_NRD_1	275	277	PF00675	0.419
CLV_NRD_NRD_1	283	285	PF00675	0.450
CLV_PCSK_KEX2_1	161	163	PF00082	0.566
CLV_PCSK_KEX2_1	274	276	PF00082	0.465
CLV_PCSK_KEX2_1	281	283	PF00082	0.502
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.620
CLV_PCSK_PC1ET2_1	281	283	PF00082	0.530
CLV_PCSK_SKI1_1	106	110	PF00082	0.652
CLV_PCSK_SKI1_1	113	117	PF00082	0.579
CLV_PCSK_SKI1_1	2	6	PF00082	0.589
CLV_PCSK_SKI1_1	234	238	PF00082	0.694
DEG_APCC_DBOX_1	1	9	PF00400	0.303
DEG_Nend_UBRbox_1	1	4	PF02207	0.426
DEG_SPOP_SBC_1	24	28	PF00917	0.458
DEG_SPOP_SBC_1	60	64	PF00917	0.297
DOC_MAPK_MEF2A_6	2	10	PF00069	0.318
DOC_PP1_RVXF_1	116	123	PF00149	0.257
DOC_USP7_MATH_1	205	209	PF00917	0.491
DOC_USP7_MATH_1	211	215	PF00917	0.479
DOC_USP7_MATH_1	298	302	PF00917	0.660
DOC_USP7_MATH_1	329	333	PF00917	0.788
DOC_USP7_MATH_1	70	74	PF00917	0.444
LIG_14-3-3_CanoR_1	307	312	PF00244	0.701
LIG_BRCT_BRCA1_1	177	181	PF00533	0.425
LIG_deltaCOP1_diTrp_1	101	109	PF00928	0.397
LIG_eIF4E_1	158	164	PF01652	0.440
LIG_FHA_1	110	116	PF00498	0.461
LIG_FHA_1	133	139	PF00498	0.409
LIG_FHA_1	180	186	PF00498	0.363
LIG_FHA_2	141	147	PF00498	0.386
LIG_FHA_2	297	303	PF00498	0.742
LIG_FHA_2	96	102	PF00498	0.424
LIG_GBD_Chelix_1	252	260	PF00786	0.463
LIG_IRF3_LxIS_1	259	266	PF10401	0.303
LIG_LIR_Apic_2	233	238	PF02991	0.507
LIG_LIR_Gen_1	139	150	PF02991	0.480
LIG_LIR_Gen_1	178	189	PF02991	0.435
LIG_LIR_Gen_1	46	56	PF02991	0.399
LIG_LIR_Nem_3	101	105	PF02991	0.392
LIG_LIR_Nem_3	139	145	PF02991	0.477
LIG_LIR_Nem_3	152	156	PF02991	0.418
LIG_LIR_Nem_3	178	184	PF02991	0.376
LIG_LIR_Nem_3	187	191	PF02991	0.361
LIG_LIR_Nem_3	46	52	PF02991	0.343
LIG_PDZ_Class_1	329	334	PF00595	0.610
LIG_SH2_CRK	105	109	PF00017	0.464
LIG_SH2_GRB2like	142	145	PF00017	0.360
LIG_SH2_GRB2like	291	294	PF00017	0.806
LIG_SH2_PTP2	257	260	PF00017	0.332
LIG_SH2_SRC	189	192	PF00017	0.493
LIG_SH2_STAP1	25	29	PF00017	0.333
LIG_SH2_STAP1	330	334	PF00017	0.611
LIG_SH2_STAT3	291	294	PF00017	0.668
LIG_SH2_STAT5	142	145	PF00017	0.443
LIG_SH2_STAT5	189	192	PF00017	0.412
LIG_SH2_STAT5	220	223	PF00017	0.539
LIG_SH2_STAT5	257	260	PF00017	0.458
LIG_SH2_STAT5	29	32	PF00017	0.308
LIG_SH3_1	199	205	PF00018	0.433
LIG_SH3_3	199	205	PF00018	0.505
LIG_SUMO_SIM_par_1	43	48	PF11976	0.276
LIG_TYR_ITIM	255	260	PF00017	0.437
MOD_CK1_1	216	222	PF00069	0.508
MOD_CK1_1	315	321	PF00069	0.747
MOD_CK1_1	33	39	PF00069	0.394
MOD_CK2_1	140	146	PF00069	0.445
MOD_CK2_1	296	302	PF00069	0.695
MOD_CK2_1	95	101	PF00069	0.427
MOD_Cter_Amidation	159	162	PF01082	0.642
MOD_Cter_Amidation	223	226	PF01082	0.596
MOD_GlcNHglycan	127	131	PF01048	0.560
MOD_GlcNHglycan	138	141	PF01048	0.738
MOD_GlcNHglycan	168	171	PF01048	0.672
MOD_GlcNHglycan	207	210	PF01048	0.601
MOD_GlcNHglycan	215	218	PF01048	0.783
MOD_GlcNHglycan	32	35	PF01048	0.568
MOD_GlcNHglycan	54	57	PF01048	0.586
MOD_GlcNHglycan	63	66	PF01048	0.576
MOD_GlcNHglycan	72	75	PF01048	0.604
MOD_GlcNHglycan	80	83	PF01048	0.640
MOD_GSK3_1	132	139	PF00069	0.523
MOD_GSK3_1	140	147	PF00069	0.513
MOD_GSK3_1	172	179	PF00069	0.452
MOD_GSK3_1	19	26	PF00069	0.515
MOD_GSK3_1	212	219	PF00069	0.524
MOD_GSK3_1	303	310	PF00069	0.710
MOD_GSK3_1	311	318	PF00069	0.738
MOD_GSK3_1	52	59	PF00069	0.353
MOD_N-GLC_1	154	159	PF02516	0.688
MOD_N-GLC_1	240	245	PF02516	0.730
MOD_NEK2_1	108	113	PF00069	0.438
MOD_NEK2_1	166	171	PF00069	0.317
MOD_NEK2_1	212	217	PF00069	0.418
MOD_NEK2_1	263	268	PF00069	0.367
MOD_NEK2_1	303	308	PF00069	0.671
MOD_NEK2_1	311	316	PF00069	0.663
MOD_NEK2_1	52	57	PF00069	0.301
MOD_NEK2_1	61	66	PF00069	0.308
MOD_PIKK_1	228	234	PF00454	0.537
MOD_PIKK_1	286	292	PF00454	0.696
MOD_PIKK_1	296	302	PF00454	0.681
MOD_PIKK_1	95	101	PF00454	0.412
MOD_PKA_2	109	115	PF00069	0.527
MOD_PKA_2	311	317	PF00069	0.707
MOD_Plk_1	154	160	PF00069	0.480
MOD_Plk_1	240	246	PF00069	0.473
MOD_Plk_2-3	322	328	PF00069	0.767
MOD_Plk_4	154	160	PF00069	0.460
MOD_Plk_4	246	252	PF00069	0.316
MOD_Plk_4	312	318	PF00069	0.740
TRG_ENDOCYTIC_2	105	108	PF00928	0.427
TRG_ENDOCYTIC_2	142	145	PF00928	0.395
TRG_ENDOCYTIC_2	257	260	PF00928	0.424
TRG_ER_diArg_1	273	276	PF00400	0.688
TRG_ER_diArg_1	282	284	PF00400	0.770

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P471	Leptomonas seymouri	37%	100%
A0A0N1I022	Leptomonas seymouri	48%	98%
A0A1X0NWG7	Trypanosomatidae	25%	91%
A0A1X0NWG9	Trypanosomatidae	26%	92%
A0A1X0NXT1	Trypanosomatidae	23%	92%
A0A1X0NY10	Trypanosomatidae	28%	100%
A0A3Q8IBH3	Leishmania donovani	35%	100%
A0A3S5H4S6	Leishmania donovani	93%	100%
A4H335	Leishmania braziliensis	86%	100%
A4HRC3	Leishmania infantum	93%	100%
A4HYN5	Leishmania infantum	34%	100%
E9ABZ0	Leishmania major	94%	100%
E9AI94	Leishmania braziliensis	34%	100%
E9AUH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
Q4QD05	Leishmania major	34%	100%
V5DS51	Trypanosoma cruzi	29%	94%