SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIY5_LEIBR

TriTrypDb:

LbrM.35.7180 , LBRM2903_350085000

Length:

357

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AIY5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIY5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	165	169	PF00656	0.441
CLV_C14_Caspase3-7	89	93	PF00656	0.329
CLV_NRD_NRD_1	128	130	PF00675	0.419
CLV_NRD_NRD_1	260	262	PF00675	0.431
CLV_PCSK_KEX2_1	128	130	PF00082	0.416
CLV_PCSK_SKI1_1	142	146	PF00082	0.449
CLV_PCSK_SKI1_1	249	253	PF00082	0.509
DEG_Nend_Nbox_1	1	3	PF02207	0.364
DOC_CKS1_1	243	248	PF01111	0.531
DOC_CYCLIN_yCln2_LP_2	17	23	PF00134	0.453
DOC_MAPK_FxFP_2	345	348	PF00069	0.445
DOC_MAPK_gen_1	63	73	PF00069	0.490
DOC_MAPK_MEF2A_6	66	75	PF00069	0.478
DOC_MAPK_MEF2A_6	8	17	PF00069	0.471
DOC_PP2B_LxvP_1	17	20	PF13499	0.460
DOC_PP2B_LxvP_1	240	243	PF13499	0.584
DOC_PP4_FxxP_1	345	348	PF00568	0.445
DOC_USP7_MATH_1	147	151	PF00917	0.577
DOC_USP7_MATH_1	282	286	PF00917	0.424
DOC_WW_Pin1_4	242	247	PF00397	0.531
LIG_14-3-3_CanoR_1	142	151	PF00244	0.533
LIG_14-3-3_CanoR_1	159	167	PF00244	0.294
LIG_14-3-3_CanoR_1	24	29	PF00244	0.479
LIG_14-3-3_CanoR_1	273	282	PF00244	0.412
LIG_14-3-3_CanoR_1	81	87	PF00244	0.534
LIG_Actin_WH2_2	10	26	PF00022	0.386
LIG_APCC_ABBA_1	272	277	PF00400	0.494
LIG_BRCT_BRCA1_1	162	166	PF00533	0.507
LIG_Clathr_ClatBox_1	288	292	PF01394	0.413
LIG_Clathr_ClatBox_1	52	56	PF01394	0.436
LIG_FHA_1	125	131	PF00498	0.457
LIG_FHA_1	282	288	PF00498	0.431
LIG_FHA_1	319	325	PF00498	0.598
LIG_FHA_2	163	169	PF00498	0.357
LIG_FHA_2	170	176	PF00498	0.325
LIG_FHA_2	333	339	PF00498	0.573
LIG_FHA_2	87	93	PF00498	0.413
LIG_IRF3_LxIS_1	71	76	PF10401	0.397
LIG_LIR_Apic_2	342	348	PF02991	0.441
LIG_LIR_Gen_1	103	114	PF02991	0.255
LIG_LIR_Gen_1	231	240	PF02991	0.449
LIG_LIR_Gen_1	297	305	PF02991	0.528
LIG_LIR_Gen_1	335	343	PF02991	0.596
LIG_LIR_Gen_1	76	87	PF02991	0.331
LIG_LIR_Nem_3	103	109	PF02991	0.319
LIG_LIR_Nem_3	217	223	PF02991	0.412
LIG_LIR_Nem_3	226	230	PF02991	0.426
LIG_LIR_Nem_3	231	236	PF02991	0.421
LIG_LIR_Nem_3	266	272	PF02991	0.275
LIG_LIR_Nem_3	297	302	PF02991	0.652
LIG_LIR_Nem_3	335	339	PF02991	0.570
LIG_LIR_Nem_3	76	82	PF02991	0.332
LIG_SH2_CRK	299	303	PF00017	0.530
LIG_SH2_CRK	79	83	PF00017	0.372
LIG_SH2_SRC	97	100	PF00017	0.461
LIG_SH2_STAT5	156	159	PF00017	0.445
LIG_SH2_STAT5	299	302	PF00017	0.565
LIG_SH2_STAT5	60	63	PF00017	0.442
LIG_SH2_STAT5	97	100	PF00017	0.329
LIG_SH3_3	240	246	PF00018	0.582
LIG_SUMO_SIM_anti_2	284	290	PF11976	0.286
LIG_SUMO_SIM_par_1	206	212	PF11976	0.466
LIG_SUMO_SIM_par_1	321	328	PF11976	0.636
LIG_TRAF2_1	215	218	PF00917	0.319
LIG_TRAF2_1	232	235	PF00917	0.395
LIG_WRC_WIRS_1	179	184	PF05994	0.367
MOD_CDK_SPxxK_3	242	249	PF00069	0.531
MOD_CK1_1	146	152	PF00069	0.584
MOD_CK1_1	162	168	PF00069	0.364
MOD_CK1_1	178	184	PF00069	0.290
MOD_CK1_1	255	261	PF00069	0.406
MOD_CK1_1	297	303	PF00069	0.585
MOD_CK1_1	322	328	PF00069	0.578
MOD_CK1_1	59	65	PF00069	0.474
MOD_CK2_1	169	175	PF00069	0.291
MOD_CK2_1	228	234	PF00069	0.405
MOD_GlcNHglycan	145	148	PF01048	0.478
MOD_GlcNHglycan	162	165	PF01048	0.286
MOD_GlcNHglycan	201	204	PF01048	0.431
MOD_GlcNHglycan	92	95	PF01048	0.314
MOD_GSK3_1	142	149	PF00069	0.469
MOD_GSK3_1	297	304	PF00069	0.596
MOD_GSK3_1	318	325	PF00069	0.676
MOD_GSK3_1	328	335	PF00069	0.520
MOD_GSK3_1	82	89	PF00069	0.484
MOD_LATS_1	239	245	PF00433	0.431
MOD_NEK2_1	123	128	PF00069	0.321
MOD_NEK2_1	82	87	PF00069	0.363
MOD_PIKK_1	252	258	PF00454	0.565
MOD_PK_1	110	116	PF00069	0.436
MOD_PKA_2	124	130	PF00069	0.332
MOD_PKA_2	160	166	PF00069	0.500
MOD_PKB_1	140	148	PF00069	0.593
MOD_Plk_1	297	303	PF00069	0.453
MOD_Plk_4	162	168	PF00069	0.393
MOD_Plk_4	178	184	PF00069	0.287
MOD_Plk_4	223	229	PF00069	0.455
MOD_Plk_4	282	288	PF00069	0.465
MOD_Plk_4	297	303	PF00069	0.364
MOD_Plk_4	319	325	PF00069	0.650
MOD_Plk_4	82	88	PF00069	0.351
MOD_ProDKin_1	242	248	PF00069	0.530
MOD_SUMO_rev_2	103	112	PF00179	0.438
MOD_SUMO_rev_2	48	53	PF00179	0.488
TRG_DiLeu_BaEn_1	48	53	PF01217	0.488
TRG_DiLeu_BaEn_4	217	223	PF01217	0.326
TRG_ENDOCYTIC_2	227	230	PF00928	0.412
TRG_ENDOCYTIC_2	233	236	PF00928	0.375
TRG_ENDOCYTIC_2	299	302	PF00928	0.565
TRG_ENDOCYTIC_2	3	6	PF00928	0.487
TRG_ENDOCYTIC_2	79	82	PF00928	0.327
TRG_ER_diArg_1	128	130	PF00400	0.433
TRG_ER_diArg_1	139	142	PF00400	0.389
TRG_ER_diArg_1	158	161	PF00400	0.323
TRG_NES_CRM1_1	281	292	PF08389	0.396
TRG_Pf-PMV_PEXEL_1	307	312	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	45	49	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMB0	Leptomonas seymouri	71%	98%
A0A1X0NLD0	Trypanosomatidae	43%	99%
A0A3R7NY74	Trypanosoma rangeli	42%	99%
A0A3S7XCE5	Leishmania donovani	90%	100%
A4ICC2	Leishmania infantum	90%	100%
D0A3Q5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AUB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q073	Leishmania major	89%	100%
V5DDV5	Trypanosoma cruzi	43%	99%