Putative ATPase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative ATPase

Gene product:

ATPase, putative

Species:

Leishmania braziliensis

UniProt:

E9AIY4_LEIBR

TriTrypDb:

LbrM.35.7150 , LBRM2903_350084700

Length:

525

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AIY4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIY4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0016887	ATP hydrolysis activity	7	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	104	106	PF00675	0.512
CLV_NRD_NRD_1	158	160	PF00675	0.291
CLV_NRD_NRD_1	184	186	PF00675	0.349
CLV_NRD_NRD_1	30	32	PF00675	0.515
CLV_NRD_NRD_1	314	316	PF00675	0.308
CLV_PCSK_FUR_1	287	291	PF00082	0.168
CLV_PCSK_KEX2_1	104	106	PF00082	0.535
CLV_PCSK_KEX2_1	128	130	PF00082	0.372
CLV_PCSK_KEX2_1	157	159	PF00082	0.287
CLV_PCSK_KEX2_1	183	185	PF00082	0.330
CLV_PCSK_KEX2_1	19	21	PF00082	0.385
CLV_PCSK_KEX2_1	289	291	PF00082	0.292
CLV_PCSK_KEX2_1	314	316	PF00082	0.314
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.372
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.249
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.544
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.292
CLV_PCSK_SKI1_1	104	108	PF00082	0.581
CLV_PCSK_SKI1_1	115	119	PF00082	0.491
CLV_PCSK_SKI1_1	141	145	PF00082	0.168
CLV_PCSK_SKI1_1	413	417	PF00082	0.249
CLV_PCSK_SKI1_1	42	46	PF00082	0.372
DEG_APCC_DBOX_1	240	248	PF00400	0.394
DEG_APCC_DBOX_1	490	498	PF00400	0.460
DEG_Nend_Nbox_1	1	3	PF02207	0.633
DEG_SCF_TRCP1_1	109	114	PF00400	0.421
DOC_MAPK_gen_1	172	180	PF00069	0.392
DOC_MAPK_gen_1	197	206	PF00069	0.287
DOC_MAPK_JIP1_4	200	206	PF00069	0.168
DOC_MAPK_MEF2A_6	197	206	PF00069	0.271
DOC_PP1_RVXF_1	411	417	PF00149	0.249
DOC_PP4_FxxP_1	300	303	PF00568	0.249
DOC_USP7_MATH_1	453	457	PF00917	0.694
DOC_WW_Pin1_4	150	155	PF00397	0.264
DOC_WW_Pin1_4	186	191	PF00397	0.419
DOC_WW_Pin1_4	210	215	PF00397	0.282
DOC_WW_Pin1_4	46	51	PF00397	0.309
DOC_WW_Pin1_4	65	70	PF00397	0.545
LIG_14-3-3_CanoR_1	158	166	PF00244	0.347
LIG_14-3-3_CanoR_1	183	190	PF00244	0.391
LIG_14-3-3_CanoR_1	259	265	PF00244	0.325
LIG_14-3-3_CanoR_1	8	12	PF00244	0.381
LIG_14-3-3_CanoR_1	96	100	PF00244	0.490
LIG_BRCT_BRCA1_1	260	264	PF00533	0.264
LIG_BRCT_BRCA1_1	396	400	PF00533	0.278
LIG_CtBP_PxDLS_1	201	205	PF00389	0.278
LIG_deltaCOP1_diTrp_1	326	336	PF00928	0.347
LIG_FHA_1	112	118	PF00498	0.511
LIG_FHA_1	140	146	PF00498	0.283
LIG_FHA_1	211	217	PF00498	0.283
LIG_FHA_1	221	227	PF00498	0.222
LIG_FHA_1	378	384	PF00498	0.264
LIG_FHA_1	415	421	PF00498	0.249
LIG_FHA_1	47	53	PF00498	0.326
LIG_FHA_2	165	171	PF00498	0.260
LIG_FHA_2	19	25	PF00498	0.386
LIG_FHA_2	511	517	PF00498	0.416
LIG_Integrin_isoDGR_2	434	436	PF01839	0.444
LIG_LIR_Apic_2	297	303	PF02991	0.185
LIG_LIR_Gen_1	219	229	PF02991	0.249
LIG_LIR_Gen_1	24	34	PF02991	0.386
LIG_LIR_Gen_1	261	271	PF02991	0.308
LIG_LIR_Gen_1	355	362	PF02991	0.261
LIG_LIR_Gen_1	397	408	PF02991	0.372
LIG_LIR_Gen_1	486	494	PF02991	0.356
LIG_LIR_Gen_1	514	525	PF02991	0.430
LIG_LIR_Nem_3	219	224	PF02991	0.249
LIG_LIR_Nem_3	24	29	PF02991	0.402
LIG_LIR_Nem_3	261	267	PF02991	0.283
LIG_LIR_Nem_3	355	359	PF02991	0.249
LIG_LIR_Nem_3	397	403	PF02991	0.372
LIG_LIR_Nem_3	486	490	PF02991	0.425
LIG_LIR_Nem_3	506	510	PF02991	0.493
LIG_LIR_Nem_3	514	520	PF02991	0.399
LIG_LRP6_Inhibitor_1	90	96	PF00058	0.354
LIG_PCNA_yPIPBox_3	197	210	PF02747	0.335
LIG_Pex14_2	236	240	PF04695	0.306
LIG_SH2_STAP1	472	476	PF00017	0.509
LIG_SH2_STAP1	59	63	PF00017	0.431
LIG_SH2_STAT3	54	57	PF00017	0.322
LIG_SH2_STAT3	83	86	PF00017	0.370
LIG_SH2_STAT5	132	135	PF00017	0.311
LIG_SH2_STAT5	430	433	PF00017	0.374
LIG_SH2_STAT5	502	505	PF00017	0.334
LIG_SH2_STAT5	510	513	PF00017	0.367
LIG_SH2_STAT5	54	57	PF00017	0.376
LIG_SH2_STAT5	70	73	PF00017	0.432
LIG_SH3_3	339	345	PF00018	0.392
LIG_Sin3_3	400	407	PF02671	0.168
LIG_SUMO_SIM_par_1	142	149	PF11976	0.322
LIG_SUMO_SIM_par_1	379	384	PF11976	0.283
LIG_SUMO_SIM_par_1	400	406	PF11976	0.249
LIG_WRC_WIRS_1	162	167	PF05994	0.291
LIG_WRC_WIRS_1	221	226	PF05994	0.264
LIG_WRC_WIRS_1	416	421	PF05994	0.168
LIG_WRC_WIRS_1	484	489	PF05994	0.379
LIG_WW_3	75	79	PF00397	0.410
MOD_CDK_SPK_2	186	191	PF00069	0.325
MOD_CDK_SPxxK_3	150	157	PF00069	0.343
MOD_CDK_SPxxK_3	186	193	PF00069	0.325
MOD_CDK_SPxxK_3	65	72	PF00069	0.531
MOD_CK1_1	10	16	PF00069	0.476
MOD_CK1_1	164	170	PF00069	0.283
MOD_CK1_1	186	192	PF00069	0.426
MOD_CK1_1	68	74	PF00069	0.636
MOD_CK2_1	164	170	PF00069	0.412
MOD_CK2_1	18	24	PF00069	0.393
MOD_CK2_1	186	192	PF00069	0.330
MOD_CK2_1	460	466	PF00069	0.552
MOD_CMANNOS	9	12	PF00535	0.348
MOD_GlcNHglycan	109	112	PF01048	0.547
MOD_GlcNHglycan	185	188	PF01048	0.339
MOD_GlcNHglycan	260	263	PF01048	0.392
MOD_GlcNHglycan	367	370	PF01048	0.419
MOD_GlcNHglycan	451	454	PF01048	0.586
MOD_GlcNHglycan	466	472	PF01048	0.456
MOD_GlcNHglycan	516	520	PF01048	0.326
MOD_GSK3_1	107	114	PF00069	0.651
MOD_GSK3_1	157	164	PF00069	0.326
MOD_GSK3_1	377	384	PF00069	0.314
MOD_GSK3_1	390	397	PF00069	0.327
MOD_GSK3_1	426	433	PF00069	0.507
MOD_GSK3_1	449	456	PF00069	0.684
MOD_GSK3_1	7	14	PF00069	0.467
MOD_GSK3_1	91	98	PF00069	0.568
MOD_N-GLC_1	390	395	PF02516	0.405
MOD_NEK2_1	178	183	PF00069	0.364
MOD_NEK2_1	245	250	PF00069	0.271
MOD_NEK2_1	257	262	PF00069	0.241
MOD_NEK2_1	407	412	PF00069	0.264
MOD_NEK2_1	414	419	PF00069	0.347
MOD_NEK2_1	515	520	PF00069	0.428
MOD_NEK2_1	91	96	PF00069	0.568
MOD_PIKK_1	178	184	PF00454	0.252
MOD_PKA_1	157	163	PF00069	0.343
MOD_PKA_1	183	189	PF00069	0.392
MOD_PKA_2	157	163	PF00069	0.314
MOD_PKA_2	183	189	PF00069	0.318
MOD_PKA_2	258	264	PF00069	0.325
MOD_PKA_2	7	13	PF00069	0.416
MOD_PKA_2	95	101	PF00069	0.489
MOD_Plk_1	331	337	PF00069	0.339
MOD_Plk_1	515	521	PF00069	0.406
MOD_Plk_2-3	220	226	PF00069	0.249
MOD_Plk_2-3	460	466	PF00069	0.649
MOD_Plk_4	161	167	PF00069	0.304
MOD_Plk_4	324	330	PF00069	0.286
MOD_Plk_4	331	337	PF00069	0.298
MOD_Plk_4	377	383	PF00069	0.264
MOD_Plk_4	415	421	PF00069	0.278
MOD_Plk_4	498	504	PF00069	0.399
MOD_ProDKin_1	150	156	PF00069	0.264
MOD_ProDKin_1	186	192	PF00069	0.419
MOD_ProDKin_1	210	216	PF00069	0.282
MOD_ProDKin_1	46	52	PF00069	0.307
MOD_ProDKin_1	65	71	PF00069	0.553
TRG_DiLeu_BaLyEn_6	308	313	PF01217	0.354
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.301
TRG_DiLeu_BaLyEn_6	86	91	PF01217	0.347
TRG_ENDOCYTIC_2	26	29	PF00928	0.331
TRG_ER_diArg_1	103	105	PF00400	0.502
TRG_ER_diArg_1	183	185	PF00400	0.346
TRG_ER_diArg_1	313	315	PF00400	0.308
TRG_ER_diArg_1	490	493	PF00400	0.479
TRG_NLS_MonoExtN_4	154	161	PF00514	0.310
TRG_Pf-PMV_PEXEL_1	115	119	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	436	440	PF00026	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P494	Leptomonas seymouri	28%	100%
A0A0N1I0J7	Leptomonas seymouri	64%	100%
A0A0S4J9H9	Bodo saltans	27%	100%
A0A0S4JPV5	Bodo saltans	43%	100%
A0A1X0NK74	Trypanosomatidae	27%	100%
A0A1X0NN10	Trypanosomatidae	45%	100%
A0A3R7K771	Trypanosoma rangeli	27%	100%
A0A3R7L848	Trypanosoma rangeli	45%	100%
A0A3S5H5L6	Leishmania donovani	28%	100%
A0A3S7XCB8	Leishmania donovani	80%	99%
A4H4F1	Leishmania braziliensis	29%	100%
A4HSM8	Leishmania infantum	28%	100%
A4ICB9	Leishmania infantum	81%	99%
C9ZU69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A3Q2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AKL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AUB4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	98%
O42895	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
P32317	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
P46441	Haematobia irritans	28%	100%
Q32PX9	Rattus norvegicus	31%	100%
Q3V384	Mus musculus	30%	100%
Q4Q076	Leishmania major	80%	100%
Q4QJ96	Leishmania major	28%	100%
Q5TYS0	Danio rerio	27%	100%
Q8WV93	Homo sapiens	30%	100%
V5BD25	Trypanosoma cruzi	46%	100%
V5D7E6	Trypanosoma cruzi	27%	99%