Endonuclease/exonuclease protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endonuclease/exonuclease protein-like protein

Species:

Leishmania braziliensis

UniProt:

E9AIY2_LEIBR

TriTrypDb:

LbrM.35.5520 , LBRM2903_350066500 , LBRM2903_350066600

Length:

745

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AIY2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIY2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006259	DNA metabolic process	4	10
GO:0006281	DNA repair	5	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0006950	response to stress	2	10
GO:0006974	DNA damage response	4	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0033554	cellular response to stress	3	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0046483	heterocycle metabolic process	3	10
GO:0050896	response to stimulus	1	10
GO:0051716	cellular response to stimulus	2	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:0006284	base-excision repair	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003677	DNA binding	4	10
GO:0003824	catalytic activity	1	10
GO:0004518	nuclease activity	4	10
GO:0004519	endonuclease activity	5	10
GO:0004527	exonuclease activity	5	7
GO:0005488	binding	1	10
GO:0016787	hydrolase activity	2	10
GO:0016788	hydrolase activity, acting on ester bonds	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	4	3
GO:0004529	DNA exonuclease activity	5	1
GO:0004536	DNA nuclease activity	4	1
GO:0008081	phosphoric diester hydrolase activity	5	1
GO:0008296	3'-5'-DNA exonuclease activity	7	1
GO:0008309	double-stranded DNA exodeoxyribonuclease activity	7	1
GO:0008311	double-stranded DNA 3'-5' DNA exonuclease activity	8	1
GO:0008408	3'-5' exonuclease activity	6	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016895	DNA exonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0140097	catalytic activity, acting on DNA	3	3
GO:0140640	catalytic activity, acting on a nucleic acid	2	3
GO:0016829	lyase activity	2	2
GO:0016835	carbon-oxygen lyase activity	3	2
GO:0140078	class I DNA-(apurinic or apyrimidinic site) endonuclease activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	241	245	PF00656	0.253
CLV_C14_Caspase3-7	452	456	PF00656	0.336
CLV_C14_Caspase3-7	679	683	PF00656	0.524
CLV_NRD_NRD_1	132	134	PF00675	0.298
CLV_NRD_NRD_1	225	227	PF00675	0.297
CLV_NRD_NRD_1	497	499	PF00675	0.333
CLV_NRD_NRD_1	536	538	PF00675	0.633
CLV_NRD_NRD_1	65	67	PF00675	0.391
CLV_NRD_NRD_1	698	700	PF00675	0.472
CLV_NRD_NRD_1	82	84	PF00675	0.391
CLV_PCSK_FUR_1	495	499	PF00082	0.298
CLV_PCSK_KEX2_1	225	227	PF00082	0.274
CLV_PCSK_KEX2_1	260	262	PF00082	0.460
CLV_PCSK_KEX2_1	497	499	PF00082	0.274
CLV_PCSK_KEX2_1	536	538	PF00082	0.724
CLV_PCSK_KEX2_1	65	67	PF00082	0.391
CLV_PCSK_KEX2_1	697	699	PF00082	0.734
CLV_PCSK_KEX2_1	81	83	PF00082	0.391
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.336
CLV_PCSK_PC1ET2_1	697	699	PF00082	0.734
CLV_PCSK_SKI1_1	134	138	PF00082	0.284
CLV_PCSK_SKI1_1	179	183	PF00082	0.354
CLV_PCSK_SKI1_1	256	260	PF00082	0.284
CLV_PCSK_SKI1_1	324	328	PF00082	0.371
CLV_PCSK_SKI1_1	74	78	PF00082	0.189
CLV_PCSK_SKI1_1	82	86	PF00082	0.323
DEG_APCC_DBOX_1	225	233	PF00400	0.298
DEG_APCC_DBOX_1	323	331	PF00400	0.336
DEG_Nend_Nbox_1	1	3	PF02207	0.298
DOC_CKS1_1	606	611	PF01111	0.335
DOC_CKS1_1	68	73	PF01111	0.189
DOC_CYCLIN_RxL_1	403	413	PF00134	0.256
DOC_CYCLIN_yCln2_LP_2	333	336	PF00134	0.336
DOC_MAPK_gen_1	536	544	PF00069	0.472
DOC_MAPK_MEF2A_6	406	414	PF00069	0.394
DOC_MAPK_MEF2A_6	645	654	PF00069	0.529
DOC_MAPK_RevD_3	67	82	PF00069	0.189
DOC_PP1_RVXF_1	132	139	PF00149	0.298
DOC_PP1_RVXF_1	591	598	PF00149	0.402
DOC_PP2B_LxvP_1	333	336	PF13499	0.336
DOC_PP2B_PxIxI_1	203	209	PF00149	0.391
DOC_PP4_FxxP_1	376	379	PF00568	0.189
DOC_PP4_FxxP_1	606	609	PF00568	0.329
DOC_USP7_MATH_1	289	293	PF00917	0.387
DOC_USP7_MATH_1	301	305	PF00917	0.366
DOC_USP7_MATH_1	336	340	PF00917	0.428
DOC_USP7_MATH_1	94	98	PF00917	0.386
DOC_USP7_UBL2_3	256	260	PF12436	0.481
DOC_WW_Pin1_4	287	292	PF00397	0.280
DOC_WW_Pin1_4	293	298	PF00397	0.230
DOC_WW_Pin1_4	414	419	PF00397	0.232
DOC_WW_Pin1_4	461	466	PF00397	0.480
DOC_WW_Pin1_4	49	54	PF00397	0.391
DOC_WW_Pin1_4	605	610	PF00397	0.330
DOC_WW_Pin1_4	67	72	PF00397	0.391
DOC_WW_Pin1_4	700	705	PF00397	0.599
DOC_WW_Pin1_4	709	714	PF00397	0.607
LIG_14-3-3_CanoR_1	133	139	PF00244	0.298
LIG_14-3-3_CanoR_1	155	165	PF00244	0.298
LIG_14-3-3_CanoR_1	411	419	PF00244	0.403
LIG_14-3-3_CanoR_1	536	546	PF00244	0.617
LIG_14-3-3_CanoR_1	74	79	PF00244	0.223
LIG_APCC_ABBA_1	393	398	PF00400	0.298
LIG_BRCT_BRCA1_1	399	403	PF00533	0.298
LIG_CtBP_PxDLS_1	353	357	PF00389	0.336
LIG_deltaCOP1_diTrp_1	109	117	PF00928	0.277
LIG_deltaCOP1_diTrp_1	244	251	PF00928	0.214
LIG_EVH1_1	575	579	PF00568	0.494
LIG_EVH1_2	576	580	PF00568	0.511
LIG_FHA_1	261	267	PF00498	0.225
LIG_FHA_1	304	310	PF00498	0.454
LIG_FHA_1	427	433	PF00498	0.243
LIG_FHA_1	444	450	PF00498	0.380
LIG_FHA_1	726	732	PF00498	0.503
LIG_FHA_2	144	150	PF00498	0.253
LIG_FHA_2	239	245	PF00498	0.288
LIG_FHA_2	30	36	PF00498	0.282
LIG_FHA_2	487	493	PF00498	0.274
LIG_FHA_2	502	508	PF00498	0.274
LIG_FHA_2	546	552	PF00498	0.542
LIG_FHA_2	627	633	PF00498	0.493
LIG_FHA_2	68	74	PF00498	0.298
LIG_FHA_2	75	81	PF00498	0.278
LIG_Integrin_RGD_1	734	736	PF01839	0.518
LIG_IRF3_LxIS_1	291	296	PF10401	0.189
LIG_LIR_Apic_2	375	379	PF02991	0.189
LIG_LIR_Apic_2	603	609	PF02991	0.327
LIG_LIR_Gen_1	109	117	PF02991	0.298
LIG_LIR_Gen_1	162	172	PF02991	0.264
LIG_LIR_Gen_1	383	393	PF02991	0.294
LIG_LIR_Gen_1	441	449	PF02991	0.253
LIG_LIR_Gen_1	507	516	PF02991	0.274
LIG_LIR_Gen_1	551	562	PF02991	0.400
LIG_LIR_Nem_3	109	114	PF02991	0.277
LIG_LIR_Nem_3	162	167	PF02991	0.264
LIG_LIR_Nem_3	20	25	PF02991	0.274
LIG_LIR_Nem_3	214	218	PF02991	0.235
LIG_LIR_Nem_3	248	254	PF02991	0.326
LIG_LIR_Nem_3	383	388	PF02991	0.292
LIG_LIR_Nem_3	441	447	PF02991	0.253
LIG_LIR_Nem_3	507	511	PF02991	0.274
LIG_LIR_Nem_3	551	557	PF02991	0.426
LIG_LIR_Nem_3	594	600	PF02991	0.450
LIG_MYND_1	478	482	PF01753	0.391
LIG_NRBOX	228	234	PF00104	0.391
LIG_OCRL_FandH_1	21	33	PF00620	0.313
LIG_PCNA_yPIPBox_3	374	388	PF02747	0.333
LIG_Pex14_1	247	251	PF04695	0.195
LIG_Pex14_2	182	186	PF04695	0.298
LIG_Pex14_2	2	6	PF04695	0.314
LIG_PTB_Apo_2	569	576	PF02174	0.486
LIG_PTB_Phospho_1	569	575	PF10480	0.485
LIG_Rb_pABgroove_1	354	362	PF01858	0.336
LIG_SH2_CRK	385	389	PF00017	0.332
LIG_SH2_CRK	648	652	PF00017	0.420
LIG_SH2_NCK_1	349	353	PF00017	0.391
LIG_SH2_PTP2	508	511	PF00017	0.274
LIG_SH2_STAP1	218	222	PF00017	0.189
LIG_SH2_STAP1	368	372	PF00017	0.391
LIG_SH2_STAP1	591	595	PF00017	0.284
LIG_SH2_STAT5	170	173	PF00017	0.307
LIG_SH2_STAT5	483	486	PF00017	0.291
LIG_SH2_STAT5	488	491	PF00017	0.257
LIG_SH2_STAT5	508	511	PF00017	0.274
LIG_SH3_1	479	485	PF00018	0.336
LIG_SH3_3	166	172	PF00018	0.391
LIG_SH3_3	288	294	PF00018	0.391
LIG_SH3_3	472	478	PF00018	0.328
LIG_SH3_3	479	485	PF00018	0.279
LIG_SH3_3	573	579	PF00018	0.406
LIG_SH3_3	604	610	PF00018	0.368
LIG_SH3_3	65	71	PF00018	0.462
LIG_SUMO_SIM_par_1	204	210	PF11976	0.298
LIG_SUMO_SIM_par_1	73	80	PF11976	0.189
LIG_SUMO_SIM_par_1	740	745	PF11976	0.662
LIG_TRAF2_1	189	192	PF00917	0.189
LIG_TRAF2_1	77	80	PF00917	0.307
LIG_TRAF2_2	609	614	PF00917	0.337
LIG_TYR_ITIM	506	511	PF00017	0.274
LIG_UBA3_1	36	43	PF00899	0.391
LIG_WRC_WIRS_1	114	119	PF05994	0.229
LIG_WRC_WIRS_1	128	133	PF05994	0.325
LIG_WRC_WIRS_1	654	659	PF05994	0.520
LIG_WRC_WIRS_1	706	711	PF05994	0.575
LIG_WW_3	334	338	PF00397	0.336
MOD_CDC14_SPxK_1	417	420	PF00782	0.189
MOD_CDK_SPxK_1	414	420	PF00069	0.189
MOD_CDK_SPxxK_3	67	74	PF00069	0.189
MOD_CDK_SPxxK_3	709	716	PF00069	0.481
MOD_CK1_1	113	119	PF00069	0.337
MOD_CK1_1	12	18	PF00069	0.333
MOD_CK1_1	21	27	PF00069	0.333
MOD_CK1_1	284	290	PF00069	0.342
MOD_CK1_1	303	309	PF00069	0.375
MOD_CK1_1	310	316	PF00069	0.426
MOD_CK1_1	339	345	PF00069	0.400
MOD_CK1_1	397	403	PF00069	0.403
MOD_CK1_1	413	419	PF00069	0.470
MOD_CK1_1	538	544	PF00069	0.609
MOD_CK1_1	708	714	PF00069	0.728
MOD_CK1_1	93	99	PF00069	0.395
MOD_CK2_1	143	149	PF00069	0.240
MOD_CK2_1	626	632	PF00069	0.489
MOD_CK2_1	67	73	PF00069	0.189
MOD_CK2_1	721	727	PF00069	0.668
MOD_CK2_1	74	80	PF00069	0.177
MOD_GlcNHglycan	117	120	PF01048	0.298
MOD_GlcNHglycan	161	164	PF01048	0.264
MOD_GlcNHglycan	175	178	PF01048	0.357
MOD_GlcNHglycan	282	286	PF01048	0.391
MOD_GlcNHglycan	303	306	PF01048	0.412
MOD_GlcNHglycan	338	341	PF01048	0.403
MOD_GlcNHglycan	398	402	PF01048	0.391
MOD_GlcNHglycan	512	515	PF01048	0.343
MOD_GlcNHglycan	636	639	PF01048	0.688
MOD_GlcNHglycan	713	716	PF01048	0.688
MOD_GlcNHglycan	86	89	PF01048	0.271
MOD_GlcNHglycan	92	95	PF01048	0.292
MOD_GlcNHglycan	96	99	PF01048	0.305
MOD_GSK3_1	280	287	PF00069	0.397
MOD_GSK3_1	289	296	PF00069	0.321
MOD_GSK3_1	297	304	PF00069	0.414
MOD_GSK3_1	310	317	PF00069	0.389
MOD_GSK3_1	410	417	PF00069	0.240
MOD_GSK3_1	426	433	PF00069	0.247
MOD_GSK3_1	443	450	PF00069	0.430
MOD_GSK3_1	705	712	PF00069	0.751
MOD_GSK3_1	721	728	PF00069	0.625
MOD_GSK3_1	90	97	PF00069	0.395
MOD_N-GLC_1	211	216	PF02516	0.274
MOD_N-GLC_1	49	54	PF02516	0.253
MOD_NEK2_1	2	7	PF00069	0.291
MOD_NEK2_1	211	216	PF00069	0.280
MOD_NEK2_1	281	286	PF00069	0.373
MOD_NEK2_1	299	304	PF00069	0.237
MOD_NEK2_1	372	377	PF00069	0.368
MOD_NEK2_1	410	415	PF00069	0.267
MOD_NEK2_1	438	443	PF00069	0.393
MOD_NEK2_1	510	515	PF00069	0.336
MOD_NEK2_1	580	585	PF00069	0.417
MOD_NEK2_1	634	639	PF00069	0.587
MOD_NEK2_2	220	225	PF00069	0.333
MOD_NEK2_2	653	658	PF00069	0.606
MOD_OFUCOSY	484	490	PF10250	0.335
MOD_PIKK_1	12	18	PF00454	0.370
MOD_PIKK_1	143	149	PF00454	0.306
MOD_PKA_1	260	266	PF00069	0.189
MOD_PKA_1	536	542	PF00069	0.475
MOD_PKA_1	82	88	PF00069	0.211
MOD_PKA_2	18	24	PF00069	0.328
MOD_PKA_2	260	266	PF00069	0.189
MOD_PKA_2	336	342	PF00069	0.455
MOD_PKA_2	410	416	PF00069	0.280
MOD_PKA_2	535	541	PF00069	0.640
MOD_PKA_2	82	88	PF00069	0.344
MOD_Plk_1	211	217	PF00069	0.274
MOD_Plk_1	281	287	PF00069	0.200
MOD_Plk_4	110	116	PF00069	0.314
MOD_Plk_4	443	449	PF00069	0.333
MOD_Plk_4	653	659	PF00069	0.522
MOD_ProDKin_1	287	293	PF00069	0.280
MOD_ProDKin_1	414	420	PF00069	0.232
MOD_ProDKin_1	461	467	PF00069	0.480
MOD_ProDKin_1	49	55	PF00069	0.391
MOD_ProDKin_1	605	611	PF00069	0.334
MOD_ProDKin_1	67	73	PF00069	0.391
MOD_ProDKin_1	700	706	PF00069	0.602
MOD_ProDKin_1	709	715	PF00069	0.607
MOD_SUMO_rev_2	35	45	PF00179	0.274
MOD_SUMO_rev_2	637	647	PF00179	0.573
MOD_SUMO_rev_2	678	686	PF00179	0.627
TRG_AP2beta_CARGO_1	551	561	PF09066	0.439
TRG_DiLeu_BaLyEn_6	403	408	PF01217	0.391
TRG_DiLeu_BaLyEn_6	462	467	PF01217	0.336
TRG_DiLeu_BaLyEn_6	701	706	PF01217	0.470
TRG_ENDOCYTIC_2	385	388	PF00928	0.332
TRG_ENDOCYTIC_2	508	511	PF00928	0.274
TRG_ER_diArg_1	224	226	PF00400	0.275
TRG_ER_diArg_1	440	443	PF00400	0.268
TRG_ER_diArg_1	495	498	PF00400	0.231
TRG_ER_diArg_1	65	67	PF00400	0.391
TRG_ER_diArg_1	698	700	PF00400	0.472
TRG_ER_diArg_1	81	83	PF00400	0.391
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.245
TRG_Pf-PMV_PEXEL_1	357	361	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	497	502	PF00026	0.336

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB73	Leptomonas seymouri	63%	100%
A0A1X0P3V4	Trypanosomatidae	38%	100%
A0A3R7M024	Trypanosoma rangeli	42%	100%
A0A3S7XBT9	Leishmania donovani	79%	100%
A4IDU8	Leishmania infantum	79%	100%
D0A8S3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9ATW1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q0N5	Leishmania major	80%	99%