Putative adaptin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative adaptin

Gene product:

Adaptor protein complex AP-3 subunit beta-3

Species:

Leishmania braziliensis

UniProt:

E9AIY1_LEIBR

TriTrypDb:

LbrM.35.5510 , LBRM2903_350066400

Length:

846

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0030119	AP-type membrane coat adaptor complex	3	10
GO:0030123	AP-3 adaptor complex	4	10
GO:0032991	protein-containing complex	1	10
GO:0098796	membrane protein complex	2	10
GO:0005794	Golgi apparatus	5	1
GO:0005905	clathrin-coated pit	4	1
GO:0016020	membrane	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098590	plasma membrane region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AIY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIY1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0006886	intracellular protein transport	4	10
GO:0008104	protein localization	4	10
GO:0009987	cellular process	1	10
GO:0015031	protein transport	4	10
GO:0016192	vesicle-mediated transport	4	10
GO:0033036	macromolecule localization	2	10
GO:0045184	establishment of protein localization	3	10
GO:0046907	intracellular transport	3	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10
GO:0051641	cellular localization	2	10
GO:0051649	establishment of localization in cell	3	10
GO:0070727	cellular macromolecule localization	3	10
GO:0071702	organic substance transport	4	10
GO:0071705	nitrogen compound transport	4	10
GO:0006950	response to stress	2	1
GO:0006970	response to osmotic stress	3	1
GO:0009628	response to abiotic stimulus	2	1
GO:0033554	cellular response to stress	3	1
GO:0042221	response to chemical	2	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0062197	cellular response to chemical stress	4	1
GO:0070887	cellular response to chemical stimulus	3	1
GO:0071214	cellular response to abiotic stimulus	3	1
GO:0071470	cellular response to osmotic stress	4	1
GO:0104004	cellular response to environmental stimulus	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	62	66	PF00656	0.309
CLV_C14_Caspase3-7	686	690	PF00656	0.635
CLV_C14_Caspase3-7	724	728	PF00656	0.783
CLV_C14_Caspase3-7	733	737	PF00656	0.710
CLV_C14_Caspase3-7	763	767	PF00656	0.682
CLV_C14_Caspase3-7	822	826	PF00656	0.554
CLV_NRD_NRD_1	159	161	PF00675	0.295
CLV_NRD_NRD_1	170	172	PF00675	0.205
CLV_NRD_NRD_1	233	235	PF00675	0.311
CLV_NRD_NRD_1	259	261	PF00675	0.394
CLV_NRD_NRD_1	266	268	PF00675	0.311
CLV_NRD_NRD_1	52	54	PF00675	0.275
CLV_NRD_NRD_1	693	695	PF00675	0.525
CLV_NRD_NRD_1	98	100	PF00675	0.250
CLV_PCSK_KEX2_1	233	235	PF00082	0.367
CLV_PCSK_KEX2_1	259	261	PF00082	0.394
CLV_PCSK_KEX2_1	266	268	PF00082	0.311
CLV_PCSK_KEX2_1	52	54	PF00082	0.285
CLV_PCSK_KEX2_1	564	566	PF00082	0.309
CLV_PCSK_KEX2_1	574	576	PF00082	0.309
CLV_PCSK_KEX2_1	63	65	PF00082	0.222
CLV_PCSK_KEX2_1	68	70	PF00082	0.187
CLV_PCSK_KEX2_1	693	695	PF00082	0.525
CLV_PCSK_PC1ET2_1	564	566	PF00082	0.309
CLV_PCSK_PC1ET2_1	574	576	PF00082	0.309
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.261
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.238
CLV_PCSK_PC7_1	560	566	PF00082	0.309
CLV_PCSK_PC7_1	64	70	PF00082	0.309
CLV_PCSK_SKI1_1	126	130	PF00082	0.315
CLV_PCSK_SKI1_1	195	199	PF00082	0.383
CLV_PCSK_SKI1_1	237	241	PF00082	0.433
CLV_PCSK_SKI1_1	252	256	PF00082	0.304
CLV_PCSK_SKI1_1	337	341	PF00082	0.275
CLV_PCSK_SKI1_1	397	401	PF00082	0.352
CLV_PCSK_SKI1_1	405	409	PF00082	0.254
CLV_PCSK_SKI1_1	418	422	PF00082	0.300
CLV_PCSK_SKI1_1	476	480	PF00082	0.309
CLV_PCSK_SKI1_1	575	579	PF00082	0.250
CLV_PCSK_SKI1_1	639	643	PF00082	0.314
CLV_PCSK_SKI1_1	81	85	PF00082	0.241
DEG_APCC_DBOX_1	336	344	PF00400	0.275
DEG_COP1_1	824	834	PF00400	0.501
DEG_Nend_UBRbox_3	1	3	PF02207	0.554
DEG_SCF_FBW7_1	477	483	PF00400	0.367
DEG_SCF_TRCP1_1	733	739	PF00400	0.722
DEG_SPOP_SBC_1	297	301	PF00917	0.369
DEG_SPOP_SBC_1	737	741	PF00917	0.598
DOC_CKS1_1	477	482	PF01111	0.367
DOC_CYCLIN_RxL_1	192	200	PF00134	0.376
DOC_CYCLIN_RxL_1	497	508	PF00134	0.367
DOC_MAPK_DCC_7	147	156	PF00069	0.309
DOC_MAPK_DCC_7	89	98	PF00069	0.367
DOC_MAPK_FxFP_2	408	411	PF00069	0.173
DOC_MAPK_gen_1	171	178	PF00069	0.250
DOC_MAPK_gen_1	511	521	PF00069	0.357
DOC_MAPK_gen_1	574	580	PF00069	0.290
DOC_MAPK_gen_1	99	106	PF00069	0.367
DOC_MAPK_MEF2A_6	514	523	PF00069	0.367
DOC_MAPK_MEF2A_6	794	801	PF00069	0.583
DOC_MAPK_MEF2A_6	89	98	PF00069	0.265
DOC_MAPK_MEF2A_6	99	106	PF00069	0.274
DOC_MAPK_RevD_3	146	161	PF00069	0.274
DOC_PP1_RVXF_1	335	342	PF00149	0.315
DOC_PP4_FxxP_1	262	265	PF00568	0.250
DOC_PP4_FxxP_1	408	411	PF00568	0.348
DOC_USP7_MATH_1	274	278	PF00917	0.331
DOC_USP7_MATH_1	297	301	PF00917	0.314
DOC_USP7_MATH_1	435	439	PF00917	0.173
DOC_USP7_MATH_1	737	741	PF00917	0.586
DOC_USP7_MATH_1	770	774	PF00917	0.759
DOC_USP7_MATH_1	788	792	PF00917	0.546
DOC_USP7_UBL2_3	794	798	PF12436	0.775
DOC_WW_Pin1_4	203	208	PF00397	0.246
DOC_WW_Pin1_4	476	481	PF00397	0.397
DOC_WW_Pin1_4	485	490	PF00397	0.428
DOC_WW_Pin1_4	807	812	PF00397	0.563
DOC_WW_Pin1_4	824	829	PF00397	0.611
LIG_14-3-3_CanoR_1	141	147	PF00244	0.274
LIG_14-3-3_CanoR_1	160	170	PF00244	0.181
LIG_14-3-3_CanoR_1	171	179	PF00244	0.240
LIG_14-3-3_CanoR_1	199	209	PF00244	0.367
LIG_14-3-3_CanoR_1	373	383	PF00244	0.318
LIG_14-3-3_CanoR_1	485	489	PF00244	0.315
LIG_14-3-3_CanoR_1	52	60	PF00244	0.367
LIG_14-3-3_CanoR_1	527	531	PF00244	0.392
LIG_14-3-3_CanoR_1	575	581	PF00244	0.315
LIG_14-3-3_CanoR_1	622	628	PF00244	0.369
LIG_14-3-3_CanoR_1	630	638	PF00244	0.366
LIG_14-3-3_CanoR_1	693	697	PF00244	0.437
LIG_Actin_WH2_2	37	54	PF00022	0.484
LIG_BIR_III_2	825	829	PF00653	0.524
LIG_BRCT_BRCA1_1	299	303	PF00533	0.246
LIG_BRCT_BRCA1_1	437	441	PF00533	0.315
LIG_BRCT_BRCA1_1	594	598	PF00533	0.293
LIG_BRCT_BRCA1_1	631	635	PF00533	0.388
LIG_Clathr_ClatBox_1	409	413	PF01394	0.363
LIG_EVH1_1	834	838	PF00568	0.484
LIG_FHA_1	171	177	PF00498	0.257
LIG_FHA_1	22	28	PF00498	0.522
LIG_FHA_1	334	340	PF00498	0.418
LIG_FHA_1	472	478	PF00498	0.290
LIG_FHA_1	505	511	PF00498	0.281
LIG_FHA_1	518	524	PF00498	0.212
LIG_FHA_1	568	574	PF00498	0.315
LIG_FHA_2	286	292	PF00498	0.315
LIG_FHA_2	375	381	PF00498	0.359
LIG_FHA_2	431	437	PF00498	0.315
LIG_FHA_2	710	716	PF00498	0.638
LIG_FHA_2	724	730	PF00498	0.752
LIG_FHA_2	817	823	PF00498	0.532
LIG_FHA_2	838	844	PF00498	0.632
LIG_Integrin_RGD_1	316	318	PF01839	0.173
LIG_LIR_Apic_2	406	411	PF02991	0.274
LIG_LIR_Gen_1	223	232	PF02991	0.297
LIG_LIR_Gen_1	665	674	PF02991	0.503
LIG_LIR_Gen_1	695	704	PF02991	0.372
LIG_LIR_Nem_3	223	228	PF02991	0.297
LIG_LIR_Nem_3	243	248	PF02991	0.129
LIG_LIR_Nem_3	38	44	PF02991	0.396
LIG_LIR_Nem_3	398	403	PF02991	0.293
LIG_LIR_Nem_3	406	410	PF02991	0.309
LIG_LIR_Nem_3	438	444	PF02991	0.243
LIG_LIR_Nem_3	557	562	PF02991	0.253
LIG_LIR_Nem_3	595	601	PF02991	0.258
LIG_LIR_Nem_3	632	638	PF02991	0.409
LIG_LIR_Nem_3	665	669	PF02991	0.440
LIG_MYND_1	832	836	PF01753	0.561
LIG_NRBOX	249	255	PF00104	0.277
LIG_NRBOX	328	334	PF00104	0.367
LIG_PCNA_yPIPBox_3	240	254	PF02747	0.302
LIG_Pex14_2	562	566	PF04695	0.274
LIG_SH2_CRK	217	221	PF00017	0.412
LIG_SH2_CRK	232	236	PF00017	0.202
LIG_SH2_CRK	390	394	PF00017	0.309
LIG_SH2_CRK	602	606	PF00017	0.449
LIG_SH2_NCK_1	448	452	PF00017	0.315
LIG_SH2_PTP2	103	106	PF00017	0.297
LIG_SH2_PTP2	95	98	PF00017	0.258
LIG_SH2_STAP1	390	394	PF00017	0.367
LIG_SH2_STAP1	611	615	PF00017	0.331
LIG_SH2_STAP1	655	659	PF00017	0.527
LIG_SH2_STAP1	744	748	PF00017	0.630
LIG_SH2_STAT3	312	315	PF00017	0.173
LIG_SH2_STAT3	444	447	PF00017	0.367
LIG_SH2_STAT5	103	106	PF00017	0.243
LIG_SH2_STAT5	403	406	PF00017	0.323
LIG_SH2_STAT5	444	447	PF00017	0.250
LIG_SH2_STAT5	604	607	PF00017	0.252
LIG_SH2_STAT5	725	728	PF00017	0.579
LIG_SH2_STAT5	95	98	PF00017	0.264
LIG_SH3_3	262	268	PF00018	0.309
LIG_SH3_3	648	654	PF00018	0.540
LIG_SH3_3	673	679	PF00018	0.398
LIG_SH3_3	766	772	PF00018	0.645
LIG_SH3_3	803	809	PF00018	0.772
LIG_SH3_3	829	835	PF00018	0.753
LIG_SH3_3	838	844	PF00018	0.575
LIG_SUMO_SIM_anti_2	328	336	PF11976	0.367
LIG_SUMO_SIM_anti_2	391	396	PF11976	0.173
LIG_SUMO_SIM_anti_2	494	500	PF11976	0.277
LIG_SUMO_SIM_anti_2	520	526	PF11976	0.367
LIG_SUMO_SIM_par_1	116	122	PF11976	0.251
LIG_SUMO_SIM_par_1	328	336	PF11976	0.367
LIG_SUMO_SIM_par_1	486	494	PF11976	0.173
LIG_SUMO_SIM_par_1	519	526	PF11976	0.367
LIG_TRAF2_1	185	188	PF00917	0.249
LIG_TRAF2_1	695	698	PF00917	0.517
LIG_TRFH_1	407	411	PF08558	0.303
LIG_TYR_ITIM	101	106	PF00017	0.242
LIG_TYR_ITIM	388	393	PF00017	0.367
LIG_TYR_ITIM	93	98	PF00017	0.262
LIG_UBA3_1	118	126	PF00899	0.250
LIG_WRC_WIRS_1	198	203	PF05994	0.315
LIG_WRC_WIRS_1	404	409	PF05994	0.349
LIG_WRC_WIRS_1	663	668	PF05994	0.417
MOD_CK1_1	203	209	PF00069	0.173
MOD_CK1_1	22	28	PF00069	0.450
MOD_CK1_1	277	283	PF00069	0.319
MOD_CK1_1	301	307	PF00069	0.330
MOD_CK1_1	342	348	PF00069	0.274
MOD_CK1_1	376	382	PF00069	0.173
MOD_CK1_1	431	437	PF00069	0.288
MOD_CK1_1	483	489	PF00069	0.397
MOD_CK1_1	54	60	PF00069	0.367
MOD_CK1_1	592	598	PF00069	0.418
MOD_CK1_1	720	726	PF00069	0.667
MOD_CK1_1	731	737	PF00069	0.546
MOD_CK1_1	740	746	PF00069	0.611
MOD_CK1_1	749	755	PF00069	0.621
MOD_CK1_1	758	764	PF00069	0.634
MOD_CK1_1	783	789	PF00069	0.601
MOD_CK1_1	807	813	PF00069	0.592
MOD_CK2_1	374	380	PF00069	0.346
MOD_CK2_1	430	436	PF00069	0.315
MOD_CK2_1	692	698	PF00069	0.555
MOD_CK2_1	709	715	PF00069	0.496
MOD_CK2_1	723	729	PF00069	0.495
MOD_CK2_1	749	755	PF00069	0.570
MOD_CK2_1	816	822	PF00069	0.546
MOD_CK2_1	837	843	PF00069	0.637
MOD_GlcNHglycan	121	124	PF01048	0.250
MOD_GlcNHglycan	280	283	PF01048	0.410
MOD_GlcNHglycan	369	372	PF01048	0.348
MOD_GlcNHglycan	430	433	PF01048	0.173
MOD_GlcNHglycan	530	534	PF01048	0.253
MOD_GlcNHglycan	701	704	PF01048	0.497
MOD_GlcNHglycan	712	715	PF01048	0.573
MOD_GlcNHglycan	717	720	PF01048	0.598
MOD_GlcNHglycan	732	736	PF01048	0.470
MOD_GlcNHglycan	740	743	PF01048	0.579
MOD_GlcNHglycan	748	751	PF01048	0.597
MOD_GlcNHglycan	757	760	PF01048	0.573
MOD_GlcNHglycan	782	785	PF01048	0.645
MOD_GSK3_1	19	26	PF00069	0.435
MOD_GSK3_1	274	281	PF00069	0.373
MOD_GSK3_1	297	304	PF00069	0.305
MOD_GSK3_1	339	346	PF00069	0.422
MOD_GSK3_1	363	370	PF00069	0.292
MOD_GSK3_1	423	430	PF00069	0.274
MOD_GSK3_1	431	438	PF00069	0.289
MOD_GSK3_1	476	483	PF00069	0.367
MOD_GSK3_1	529	536	PF00069	0.274
MOD_GSK3_1	543	550	PF00069	0.274
MOD_GSK3_1	629	636	PF00069	0.327
MOD_GSK3_1	688	695	PF00069	0.434
MOD_GSK3_1	717	724	PF00069	0.662
MOD_GSK3_1	736	743	PF00069	0.645
MOD_GSK3_1	744	751	PF00069	0.604
MOD_GSK3_1	755	762	PF00069	0.531
MOD_GSK3_1	779	786	PF00069	0.689
MOD_GSK3_1	800	807	PF00069	0.682
MOD_GSK3_1	814	821	PF00069	0.521
MOD_N-GLC_1	114	119	PF02516	0.315
MOD_N-GLC_1	22	27	PF02516	0.473
MOD_N-GLC_1	333	338	PF02516	0.467
MOD_N-GLC_1	343	348	PF02516	0.222
MOD_N-GLC_1	543	548	PF02516	0.367
MOD_N-GLC_1	699	704	PF02516	0.486
MOD_N-GLC_1	720	725	PF02516	0.655
MOD_N-GLC_1	755	760	PF02516	0.604
MOD_NEK2_1	119	124	PF00069	0.290
MOD_NEK2_1	142	147	PF00069	0.295
MOD_NEK2_1	197	202	PF00069	0.367
MOD_NEK2_1	332	337	PF00069	0.251
MOD_NEK2_1	339	344	PF00069	0.252
MOD_NEK2_1	363	368	PF00069	0.414
MOD_NEK2_1	374	379	PF00069	0.394
MOD_NEK2_1	428	433	PF00069	0.352
MOD_NEK2_1	481	486	PF00069	0.315
MOD_NEK2_1	51	56	PF00069	0.367
MOD_NEK2_1	699	704	PF00069	0.577
MOD_NEK2_1	709	714	PF00069	0.697
MOD_NEK2_2	403	408	PF00069	0.367
MOD_NEK2_2	471	476	PF00069	0.315
MOD_PIKK_1	357	363	PF00454	0.173
MOD_PKA_2	170	176	PF00069	0.250
MOD_PKA_2	274	280	PF00069	0.304
MOD_PKA_2	484	490	PF00069	0.315
MOD_PKA_2	51	57	PF00069	0.367
MOD_PKA_2	510	516	PF00069	0.300
MOD_PKA_2	526	532	PF00069	0.254
MOD_PKA_2	621	627	PF00069	0.375
MOD_PKA_2	629	635	PF00069	0.388
MOD_PKA_2	692	698	PF00069	0.497
MOD_PKA_2	710	716	PF00069	0.575
MOD_Plk_1	114	120	PF00069	0.349
MOD_Plk_1	22	28	PF00069	0.470
MOD_Plk_1	343	349	PF00069	0.173
MOD_Plk_1	624	630	PF00069	0.545
MOD_Plk_1	720	726	PF00069	0.540
MOD_Plk_1	744	750	PF00069	0.634
MOD_Plk_4	114	120	PF00069	0.367
MOD_Plk_4	23	29	PF00069	0.370
MOD_Plk_4	343	349	PF00069	0.343
MOD_Plk_4	403	409	PF00069	0.395
MOD_Plk_4	533	539	PF00069	0.305
MOD_Plk_4	8	14	PF00069	0.447
MOD_ProDKin_1	203	209	PF00069	0.246
MOD_ProDKin_1	476	482	PF00069	0.397
MOD_ProDKin_1	485	491	PF00069	0.428
MOD_ProDKin_1	807	813	PF00069	0.564
MOD_ProDKin_1	824	830	PF00069	0.612
TRG_DiLeu_BaEn_1	223	228	PF01217	0.173
TRG_DiLeu_BaEn_1	97	102	PF01217	0.250
TRG_DiLeu_BaEn_2	7	13	PF01217	0.467
TRG_DiLeu_BaLyEn_6	249	254	PF01217	0.367
TRG_DiLeu_BaLyEn_6	335	340	PF01217	0.280
TRG_DiLeu_BaLyEn_6	370	375	PF01217	0.256
TRG_DiLeu_BaLyEn_6	477	482	PF01217	0.318
TRG_ENDOCYTIC_2	103	106	PF00928	0.176
TRG_ENDOCYTIC_2	217	220	PF00928	0.388
TRG_ENDOCYTIC_2	232	235	PF00928	0.181
TRG_ENDOCYTIC_2	390	393	PF00928	0.309
TRG_ENDOCYTIC_2	467	470	PF00928	0.260
TRG_ENDOCYTIC_2	602	605	PF00928	0.353
TRG_ENDOCYTIC_2	95	98	PF00928	0.250
TRG_ER_diArg_1	232	234	PF00400	0.367
TRG_ER_diArg_1	265	267	PF00400	0.173
TRG_ER_diArg_1	51	53	PF00400	0.309
TRG_ER_diArg_1	692	694	PF00400	0.528
TRG_NES_CRM1_1	97	111	PF08389	0.309
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.309
TRG_Pf-PMV_PEXEL_1	500	505	PF00026	0.274
TRG_Pf-PMV_PEXEL_1	53	58	PF00026	0.293

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P434	Leptomonas seymouri	67%	96%
A0A0S4KGY6	Bodo saltans	45%	98%
A0A3S7XBV8	Leishmania donovani	85%	100%
A0A422NM75	Trypanosoma rangeli	46%	97%
A4IDU7	Leishmania infantum	85%	100%
D0A8S4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	92%
E9ATW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
O00203	Homo sapiens	32%	77%
O13939	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
P46682	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
Q13367	Homo sapiens	34%	78%
Q32PG1	Bos taurus	33%	78%
Q4Q0N6	Leishmania major	83%	100%
Q556J8	Dictyostelium discoideum	30%	76%
Q759E2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	28%	100%
Q7YRF1	Canis lupus familiaris	32%	78%
Q9JME5	Mus musculus	34%	78%
Q9M2T1	Arabidopsis thaliana	27%	86%
Q9Z1T1	Mus musculus	33%	77%