Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIX9_LEIBR

TriTrypDb:

LbrM.35.3881 , LBRM2903_350049000

Length:

198

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIX9

PDB structure(s): 7aih_Z , 7am2_Z , 7ane_Z

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.535
CLV_NRD_NRD_1	162	164	PF00675	0.505
CLV_NRD_NRD_1	80	82	PF00675	0.619
CLV_PCSK_KEX2_1	192	194	PF00082	0.516
CLV_PCSK_KEX2_1	8	10	PF00082	0.538
CLV_PCSK_KEX2_1	80	82	PF00082	0.529
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.516
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.456
CLV_PCSK_PC7_1	76	82	PF00082	0.515
CLV_PCSK_SKI1_1	192	196	PF00082	0.507
CLV_PCSK_SKI1_1	41	45	PF00082	0.657
CLV_PCSK_SKI1_1	9	13	PF00082	0.588
CLV_Separin_Metazoa	85	89	PF03568	0.593
DEG_Nend_Nbox_1	1	3	PF02207	0.558
DEG_SPOP_SBC_1	178	182	PF00917	0.531
DOC_CYCLIN_yClb1_LxF_4	102	107	PF00134	0.603
DOC_MAPK_gen_1	151	160	PF00069	0.495
DOC_MAPK_MEF2A_6	151	160	PF00069	0.515
DOC_PP1_RVXF_1	102	108	PF00149	0.499
DOC_PP1_RVXF_1	190	197	PF00149	0.492
DOC_PP4_FxxP_1	142	145	PF00568	0.512
DOC_PP4_FxxP_1	21	24	PF00568	0.539
DOC_USP7_MATH_1	113	117	PF00917	0.469
DOC_USP7_UBL2_3	100	104	PF12436	0.494
DOC_USP7_UBL2_3	151	155	PF12436	0.547
DOC_USP7_UBL2_3	188	192	PF12436	0.529
DOC_WW_Pin1_4	25	30	PF00397	0.555
LIG_deltaCOP1_diTrp_1	46	52	PF00928	0.530
LIG_FHA_1	38	44	PF00498	0.635
LIG_FHA_1	67	73	PF00498	0.537
LIG_FHA_2	178	184	PF00498	0.661
LIG_FHA_2	26	32	PF00498	0.565
LIG_HP1_1	156	160	PF01393	0.502
LIG_LIR_Apic_2	141	145	PF02991	0.643
LIG_PCNA_yPIPBox_3	88	98	PF02747	0.588
LIG_Pex14_2	21	25	PF04695	0.545
LIG_REV1ctd_RIR_1	193	198	PF16727	0.564
LIG_SH2_PTP2	157	160	PF00017	0.505
LIG_SH2_STAT5	106	109	PF00017	0.509
LIG_SH2_STAT5	120	123	PF00017	0.455
LIG_SH2_STAT5	157	160	PF00017	0.505
LIG_SH3_3	109	115	PF00018	0.506
LIG_SH3_3	130	136	PF00018	0.542
LIG_SH3_4	188	195	PF00018	0.514
LIG_SxIP_EBH_1	79	88	PF03271	0.522
LIG_TRAF2_1	159	162	PF00917	0.522
LIG_UBA3_1	165	173	PF00899	0.595
LIG_UBA3_1	190	198	PF00899	0.623
LIG_WRPW_2	154	157	PF00400	0.503
MOD_CK1_1	181	187	PF00069	0.586
MOD_CK2_1	177	183	PF00069	0.567
MOD_CMANNOS	49	52	PF00535	0.464
MOD_GlcNHglycan	100	103	PF01048	0.500
MOD_GlcNHglycan	175	178	PF01048	0.674
MOD_GSK3_1	173	180	PF00069	0.671
MOD_GSK3_1	66	73	PF00069	0.558
MOD_N-GLC_1	66	71	PF02516	0.589
MOD_NEK2_1	1	6	PF00069	0.595
MOD_NEK2_1	37	42	PF00069	0.643
MOD_NEK2_1	66	71	PF00069	0.547
MOD_Plk_4	14	20	PF00069	0.524
MOD_ProDKin_1	25	31	PF00069	0.560
MOD_SUMO_rev_2	181	190	PF00179	0.577
TRG_ENDOCYTIC_2	157	160	PF00928	0.505
TRG_ER_diArg_1	34	37	PF00400	0.704
TRG_ER_diArg_1	79	81	PF00400	0.610
TRG_NES_CRM1_1	85	95	PF08389	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4T5	Leptomonas seymouri	84%	100%
A0A0S4J3L6	Bodo saltans	66%	97%
A0A1X0P3A9	Trypanosomatidae	70%	100%
A0A3Q8IP77	Leishmania donovani	92%	100%
A0A422MY87	Trypanosoma rangeli	67%	98%
A4ID33	Leishmania infantum	92%	100%
D0A8I6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
E9ATE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q152	Leishmania major	92%	99%