Pentapeptide repeat-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Pentapeptide repeats (9 copies), putative

Species:

Leishmania braziliensis

UniProt:

E9AIX8_LEIBR

TriTrypDb:

LbrM.35.2930 , LBRM2903_350037300

Length:

284

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIX8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	74	78	PF00656	0.452
CLV_NRD_NRD_1	107	109	PF00675	0.586
CLV_NRD_NRD_1	159	161	PF00675	0.501
CLV_NRD_NRD_1	185	187	PF00675	0.487
CLV_NRD_NRD_1	240	242	PF00675	0.407
CLV_NRD_NRD_1	3	5	PF00675	0.554
CLV_PCSK_KEX2_1	185	187	PF00082	0.487
CLV_PCSK_KEX2_1	240	242	PF00082	0.407
CLV_PCSK_KEX2_1	3	5	PF00082	0.554
CLV_PCSK_SKI1_1	58	62	PF00082	0.568
DOC_ANK_TNKS_1	220	227	PF00023	0.350
DOC_CYCLIN_RxL_1	55	64	PF00134	0.519
DOC_PP1_RVXF_1	238	245	PF00149	0.394
DOC_USP7_MATH_1	248	252	PF00917	0.648
DOC_USP7_MATH_1	272	276	PF00917	0.611
DOC_USP7_MATH_1	35	39	PF00917	0.570
DOC_USP7_MATH_1	86	90	PF00917	0.663
DOC_USP7_MATH_1	92	96	PF00917	0.692
DOC_USP7_MATH_2	271	277	PF00917	0.605
LIG_14-3-3_CanoR_1	129	135	PF00244	0.400
LIG_14-3-3_CanoR_1	186	194	PF00244	0.249
LIG_14-3-3_CanoR_1	221	225	PF00244	0.509
LIG_14-3-3_CanoR_1	247	253	PF00244	0.469
LIG_Actin_WH2_2	6	23	PF00022	0.583
LIG_BIR_II_1	1	5	PF00653	0.635
LIG_BIR_III_4	203	207	PF00653	0.334
LIG_BRCT_BRCA1_1	130	134	PF00533	0.316
LIG_BRCT_BRCA1_1	170	174	PF00533	0.259
LIG_deltaCOP1_diTrp_1	201	209	PF00928	0.290
LIG_FHA_1	151	157	PF00498	0.272
LIG_FHA_1	226	232	PF00498	0.393
LIG_FHA_1	262	268	PF00498	0.552
LIG_FHA_2	111	117	PF00498	0.378
LIG_FHA_2	213	219	PF00498	0.392
LIG_FHA_2	50	56	PF00498	0.508
LIG_FHA_2	72	78	PF00498	0.722
LIG_Pex14_2	210	214	PF04695	0.441
LIG_SH2_STAP1	170	174	PF00017	0.189
LIG_SH2_STAT3	41	44	PF00017	0.506
LIG_SH2_STAT5	148	151	PF00017	0.330
LIG_SH3_3	227	233	PF00018	0.367
LIG_SH3_3	242	248	PF00018	0.390
LIG_SUMO_SIM_anti_2	76	85	PF11976	0.465
LIG_UBA3_1	81	85	PF00899	0.480
MOD_CK1_1	137	143	PF00069	0.275
MOD_CK1_1	217	223	PF00069	0.353
MOD_CK1_1	33	39	PF00069	0.597
MOD_CK1_1	47	53	PF00069	0.554
MOD_CK1_1	64	70	PF00069	0.336
MOD_CK1_1	73	79	PF00069	0.478
MOD_CK1_1	95	101	PF00069	0.734
MOD_CK2_1	110	116	PF00069	0.393
MOD_CK2_1	248	254	PF00069	0.564
MOD_CK2_1	64	70	PF00069	0.536
MOD_GlcNHglycan	101	104	PF01048	0.574
MOD_GlcNHglycan	124	128	PF01048	0.432
MOD_GlcNHglycan	130	133	PF01048	0.365
MOD_GlcNHglycan	178	182	PF01048	0.555
MOD_GlcNHglycan	31	35	PF01048	0.622
MOD_GlcNHglycan	49	52	PF01048	0.426
MOD_GlcNHglycan	66	69	PF01048	0.632
MOD_GlcNHglycan	94	97	PF01048	0.731
MOD_GSK3_1	130	137	PF00069	0.344
MOD_GSK3_1	170	177	PF00069	0.317
MOD_GSK3_1	210	217	PF00069	0.449
MOD_GSK3_1	261	268	PF00069	0.536
MOD_GSK3_1	35	42	PF00069	0.605
MOD_GSK3_1	71	78	PF00069	0.558
MOD_GSK3_1	88	95	PF00069	0.683
MOD_GSK3_1	97	104	PF00069	0.463
MOD_N-GLC_1	134	139	PF02516	0.469
MOD_N-GLC_1	261	266	PF02516	0.505
MOD_N-GLC_2	155	157	PF02516	0.502
MOD_NEK2_1	125	130	PF00069	0.412
MOD_NEK2_1	144	149	PF00069	0.283
MOD_NEK2_1	19	24	PF00069	0.524
MOD_NEK2_1	210	215	PF00069	0.457
MOD_NEK2_1	61	66	PF00069	0.462
MOD_NEK2_1	99	104	PF00069	0.638
MOD_NEK2_2	205	210	PF00069	0.302
MOD_NEK2_2	248	253	PF00069	0.532
MOD_PIKK_1	40	46	PF00454	0.502
MOD_PIKK_1	71	77	PF00454	0.555
MOD_PKA_2	128	134	PF00069	0.351
MOD_PKA_2	20	26	PF00069	0.561
MOD_PKA_2	220	226	PF00069	0.470
MOD_PKA_2	61	67	PF00069	0.358
MOD_Plk_1	217	223	PF00069	0.332
MOD_Plk_1	76	82	PF00069	0.495
MOD_Plk_2-3	110	116	PF00069	0.381
MOD_Plk_4	110	116	PF00069	0.381
MOD_Plk_4	144	150	PF00069	0.330
MOD_Plk_4	170	176	PF00069	0.266
MOD_Plk_4	205	211	PF00069	0.247
MOD_Plk_4	226	232	PF00069	0.372
MOD_Plk_4	61	67	PF00069	0.367
MOD_Plk_4	77	83	PF00069	0.506
TRG_DiLeu_BaEn_1	15	20	PF01217	0.562
TRG_ER_diArg_1	105	108	PF00400	0.589
TRG_ER_diArg_1	240	242	PF00400	0.395
TRG_ER_diArg_1	3	5	PF00400	0.572
TRG_Pf-PMV_PEXEL_1	58	63	PF00026	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIJ6	Leptomonas seymouri	57%	100%
A0A1X0NM60	Trypanosomatidae	39%	100%
A0A3Q8IKT7	Leishmania donovani	81%	88%
A0A422N6R3	Trypanosoma rangeli	42%	100%
A4ICH5	Leishmania infantum	81%	88%
E9AT46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	89%
Q4Q1F2	Leishmania major	82%	100%
V5BPS4	Trypanosoma cruzi	43%	100%