Leucine_Rich_repeat

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Leucine_Rich_repeat

Gene product:

Leucine Rich Repeat, putative

Species:

Leishmania braziliensis

UniProt:

E9AIX7_LEIBR

TriTrypDb:

LbrM.35.1700 , LBRM2903_350023600

Length:

498

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	6
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1

Expansion

Sequence features

E9AIX7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIX7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.563
CLV_C14_Caspase3-7	324	328	PF00656	0.567
CLV_C14_Caspase3-7	90	94	PF00656	0.590
CLV_NRD_NRD_1	231	233	PF00675	0.381
CLV_NRD_NRD_1	263	265	PF00675	0.603
CLV_NRD_NRD_1	386	388	PF00675	0.662
CLV_NRD_NRD_1	432	434	PF00675	0.725
CLV_PCSK_KEX2_1	231	233	PF00082	0.352
CLV_PCSK_KEX2_1	263	265	PF00082	0.395
CLV_PCSK_KEX2_1	386	388	PF00082	0.664
CLV_PCSK_KEX2_1	432	434	PF00082	0.725
CLV_PCSK_SKI1_1	257	261	PF00082	0.580
CLV_PCSK_SKI1_1	263	267	PF00082	0.507
CLV_PCSK_SKI1_1	445	449	PF00082	0.720
DEG_APCC_DBOX_1	249	257	PF00400	0.360
DOC_CDC14_PxL_1	143	151	PF14671	0.425
DOC_CDC14_PxL_1	461	469	PF14671	0.586
DOC_CDC14_PxL_1	67	75	PF14671	0.489
DOC_CYCLIN_RxL_1	195	204	PF00134	0.560
DOC_MAPK_gen_1	231	239	PF00069	0.337
DOC_MAPK_gen_1	263	273	PF00069	0.652
DOC_MAPK_gen_1	432	439	PF00069	0.702
DOC_MAPK_MEF2A_6	360	368	PF00069	0.543
DOC_MAPK_MEF2A_6	432	441	PF00069	0.644
DOC_PP1_RVXF_1	267	274	PF00149	0.542
DOC_PP2B_LxvP_1	416	419	PF13499	0.479
DOC_PP2B_LxvP_1	448	451	PF13499	0.653
DOC_USP7_MATH_1	12	16	PF00917	0.629
DOC_USP7_MATH_1	226	230	PF00917	0.318
DOC_USP7_MATH_1	344	348	PF00917	0.669
DOC_USP7_MATH_1	378	382	PF00917	0.559
DOC_USP7_MATH_1	427	431	PF00917	0.602
DOC_WW_Pin1_4	23	28	PF00397	0.640
DOC_WW_Pin1_4	404	409	PF00397	0.719
LIG_14-3-3_CanoR_1	110	119	PF00244	0.565
LIG_14-3-3_CanoR_1	175	179	PF00244	0.500
LIG_14-3-3_CanoR_1	231	240	PF00244	0.585
LIG_14-3-3_CanoR_1	386	395	PF00244	0.563
LIG_Actin_RPEL_3	243	262	PF02755	0.353
LIG_BIR_II_1	1	5	PF00653	0.643
LIG_BRCT_BRCA1_1	112	116	PF00533	0.464
LIG_BRCT_BRCA1_1	208	212	PF00533	0.536
LIG_BRCT_BRCA1_1	364	368	PF00533	0.628
LIG_EH1_1	190	198	PF00400	0.315
LIG_FHA_1	110	116	PF00498	0.463
LIG_FHA_1	208	214	PF00498	0.385
LIG_FHA_1	215	221	PF00498	0.419
LIG_FHA_1	332	338	PF00498	0.634
LIG_FHA_1	344	350	PF00498	0.599
LIG_FHA_1	361	367	PF00498	0.476
LIG_FHA_1	369	375	PF00498	0.537
LIG_FHA_1	458	464	PF00498	0.674
LIG_FHA_2	136	142	PF00498	0.537
LIG_FHA_2	275	281	PF00498	0.434
LIG_FHA_2	34	40	PF00498	0.509
LIG_FHA_2	490	496	PF00498	0.555
LIG_FHA_2	88	94	PF00498	0.581
LIG_IBAR_NPY_1	50	52	PF08397	0.636
LIG_Integrin_isoDGR_2	471	473	PF01839	0.672
LIG_KLC1_Yacidic_2	128	133	PF13176	0.288
LIG_LIR_Gen_1	113	124	PF02991	0.470
LIG_LIR_Gen_1	38	47	PF02991	0.358
LIG_LIR_Gen_1	410	421	PF02991	0.642
LIG_LIR_Nem_3	113	119	PF02991	0.462
LIG_LIR_Nem_3	38	44	PF02991	0.507
LIG_LIR_Nem_3	410	416	PF02991	0.637
LIG_NRBOX	255	261	PF00104	0.384
LIG_Pex14_2	148	152	PF04695	0.546
LIG_SH2_CRK	41	45	PF00017	0.352
LIG_SH2_STAP1	413	417	PF00017	0.504
LIG_SH2_STAT3	97	100	PF00017	0.591
LIG_SH2_STAT5	131	134	PF00017	0.292
LIG_SH2_STAT5	457	460	PF00017	0.572
LIG_SH2_STAT5	57	60	PF00017	0.586
LIG_SUMO_SIM_anti_2	241	247	PF11976	0.341
LIG_SUMO_SIM_anti_2	258	263	PF11976	0.315
LIG_SUMO_SIM_anti_2	361	369	PF11976	0.545
LIG_SUMO_SIM_anti_2	460	465	PF11976	0.566
LIG_SxIP_EBH_1	384	398	PF03271	0.543
LIG_TRAF2_1	313	316	PF00917	0.590
LIG_TRAF2_1	36	39	PF00917	0.525
LIG_TRAF2_1	451	454	PF00917	0.644
LIG_TYR_ITAM	38	55	PF00017	0.368
LIG_UBA3_1	259	266	PF00899	0.386
MOD_CK1_1	215	221	PF00069	0.359
MOD_CK1_1	241	247	PF00069	0.341
MOD_CK1_1	26	32	PF00069	0.493
MOD_CK1_1	321	327	PF00069	0.671
MOD_CK1_1	336	342	PF00069	0.612
MOD_CK1_1	362	368	PF00069	0.684
MOD_CK1_1	42	48	PF00069	0.549
MOD_CK2_1	12	18	PF00069	0.546
MOD_CK2_1	215	221	PF00069	0.345
MOD_CK2_1	274	280	PF00069	0.421
MOD_CK2_1	310	316	PF00069	0.716
MOD_CK2_1	33	39	PF00069	0.511
MOD_CK2_1	353	359	PF00069	0.557
MOD_CK2_1	489	495	PF00069	0.584
MOD_GlcNHglycan	121	124	PF01048	0.517
MOD_GlcNHglycan	167	170	PF01048	0.365
MOD_GlcNHglycan	233	236	PF01048	0.578
MOD_GlcNHglycan	252	256	PF01048	0.310
MOD_GlcNHglycan	28	31	PF01048	0.550
MOD_GlcNHglycan	286	289	PF01048	0.577
MOD_GlcNHglycan	323	326	PF01048	0.710
MOD_GlcNHglycan	346	349	PF01048	0.753
MOD_GlcNHglycan	355	358	PF01048	0.779
MOD_GlcNHglycan	368	371	PF01048	0.727
MOD_GlcNHglycan	389	392	PF01048	0.669
MOD_GSK3_1	115	122	PF00069	0.315
MOD_GSK3_1	321	328	PF00069	0.579
MOD_GSK3_1	331	338	PF00069	0.713
MOD_GSK3_1	339	346	PF00069	0.811
MOD_GSK3_1	358	365	PF00069	0.674
MOD_GSK3_1	4	11	PF00069	0.569
MOD_GSK3_1	57	64	PF00069	0.466
MOD_LATS_1	108	114	PF00433	0.472
MOD_N-GLC_1	489	494	PF02516	0.503
MOD_NEK2_1	119	124	PF00069	0.323
MOD_NEK2_1	150	155	PF00069	0.544
MOD_NEK2_1	212	217	PF00069	0.403
MOD_NEK2_1	358	363	PF00069	0.623
MOD_NEK2_1	366	371	PF00069	0.622
MOD_NEK2_1	397	402	PF00069	0.678
MOD_NEK2_1	40	45	PF00069	0.599
MOD_NEK2_1	55	60	PF00069	0.348
MOD_NEK2_2	226	231	PF00069	0.327
MOD_NEK2_2	427	432	PF00069	0.472
MOD_PKA_1	231	237	PF00069	0.330
MOD_PKA_2	109	115	PF00069	0.566
MOD_PKA_2	171	177	PF00069	0.347
MOD_PKA_2	231	237	PF00069	0.330
MOD_Plk_1	33	39	PF00069	0.613
MOD_Plk_4	241	247	PF00069	0.492
MOD_Plk_4	362	368	PF00069	0.667
MOD_Plk_4	420	426	PF00069	0.605
MOD_Plk_4	459	465	PF00069	0.569
MOD_Plk_4	481	487	PF00069	0.457
MOD_ProDKin_1	23	29	PF00069	0.638
MOD_ProDKin_1	404	410	PF00069	0.720
TRG_DiLeu_BaEn_2	143	149	PF01217	0.456
TRG_DiLeu_BaEn_2	419	425	PF01217	0.623
TRG_DiLeu_BaEn_4	453	459	PF01217	0.478
TRG_DiLeu_BaLyEn_6	470	475	PF01217	0.500
TRG_ENDOCYTIC_2	41	44	PF00928	0.468
TRG_ENDOCYTIC_2	413	416	PF00928	0.653
TRG_ENDOCYTIC_2	52	55	PF00928	0.605
TRG_ENDOCYTIC_2	76	79	PF00928	0.472
TRG_ER_diArg_1	230	232	PF00400	0.349
TRG_ER_diArg_1	262	264	PF00400	0.398
TRG_ER_diArg_1	385	387	PF00400	0.556
TRG_ER_diArg_1	431	433	PF00400	0.487
TRG_NES_CRM1_1	238	252	PF08389	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P712	Leptomonas seymouri	49%	100%
A0A3Q8IIX2	Leishmania donovani	67%	99%
A4IDC5	Leishmania infantum	67%	99%
E9ASS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	99%
Q4Q1S0	Leishmania major	67%	100%