Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIX6_LEIBR

TriTrypDb:

LbrM.35.1400 , LBRM2903_350020000

Length:

190

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AIX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIX6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.500
CLV_NRD_NRD_1	114	116	PF00675	0.469
CLV_NRD_NRD_1	121	123	PF00675	0.537
CLV_NRD_NRD_1	30	32	PF00675	0.601
CLV_PCSK_FUR_1	112	116	PF00082	0.343
CLV_PCSK_KEX2_1	103	105	PF00082	0.500
CLV_PCSK_KEX2_1	113	115	PF00082	0.621
CLV_PCSK_KEX2_1	12	14	PF00082	0.648
CLV_PCSK_KEX2_1	121	123	PF00082	0.627
CLV_PCSK_KEX2_1	30	32	PF00082	0.425
CLV_PCSK_KEX2_1	45	47	PF00082	0.649
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.459
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.618
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.674
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.649
CLV_PCSK_SKI1_1	103	107	PF00082	0.589
CLV_PCSK_SKI1_1	12	16	PF00082	0.633
DOC_CKS1_1	92	97	PF01111	0.379
DOC_CYCLIN_yCln2_LP_2	35	41	PF00134	0.592
DOC_PP2B_LxvP_1	26	29	PF13499	0.491
DOC_USP7_MATH_1	4	8	PF00917	0.544
DOC_USP7_UBL2_3	134	138	PF12436	0.528
DOC_USP7_UBL2_3	153	157	PF12436	0.455
DOC_WW_Pin1_4	12	17	PF00397	0.543
DOC_WW_Pin1_4	125	130	PF00397	0.558
DOC_WW_Pin1_4	88	93	PF00397	0.700
LIG_14-3-3_CanoR_1	25	29	PF00244	0.584
LIG_14-3-3_CanoR_1	46	52	PF00244	0.559
LIG_14-3-3_CterR_2	185	190	PF00244	0.431
LIG_AP2alpha_2	37	39	PF02296	0.528
LIG_BIR_II_1	1	5	PF00653	0.606
LIG_BIR_III_1	1	5	PF00653	0.468
LIG_BIR_III_3	1	5	PF00653	0.468
LIG_FHA_1	169	175	PF00498	0.512
LIG_FHA_1	42	48	PF00498	0.592
LIG_FHA_1	54	60	PF00498	0.423
LIG_FHA_2	13	19	PF00498	0.586
LIG_FHA_2	92	98	PF00498	0.533
LIG_LIR_Apic_2	161	166	PF02991	0.485
LIG_LIR_Gen_1	3	9	PF02991	0.540
LIG_LIR_Nem_3	3	8	PF02991	0.541
LIG_SH2_CRK	126	130	PF00017	0.537
LIG_SH2_STAP1	160	164	PF00017	0.522
LIG_SH2_STAP1	5	9	PF00017	0.499
LIG_SH2_STAP1	60	64	PF00017	0.519
LIG_SH2_STAT5	158	161	PF00017	0.501
LIG_SH2_STAT5	163	166	PF00017	0.503
LIG_SH2_STAT5	60	63	PF00017	0.501
LIG_SH3_3	89	95	PF00018	0.650
LIG_TRAF2_1	15	18	PF00917	0.543
LIG_WRC_WIRS_1	137	142	PF05994	0.336
MOD_CDK_SPxxK_3	125	132	PF00069	0.413
MOD_CK1_1	53	59	PF00069	0.555
MOD_CK1_1	7	13	PF00069	0.656
MOD_CK1_1	91	97	PF00069	0.598
MOD_CK2_1	12	18	PF00069	0.595
MOD_GlcNHglycan	47	50	PF01048	0.416
MOD_GlcNHglycan	88	91	PF01048	0.625
MOD_GSK3_1	164	171	PF00069	0.473
MOD_GSK3_1	41	48	PF00069	0.518
MOD_NEK2_1	159	164	PF00069	0.585
MOD_PIKK_1	58	64	PF00454	0.510
MOD_PKA_1	152	158	PF00069	0.613
MOD_PKA_1	45	51	PF00069	0.353
MOD_PKA_2	24	30	PF00069	0.536
MOD_PKA_2	45	51	PF00069	0.559
MOD_PKA_2	83	89	PF00069	0.694
MOD_Plk_1	98	104	PF00069	0.531
MOD_Plk_4	136	142	PF00069	0.338
MOD_Plk_4	159	165	PF00069	0.524
MOD_ProDKin_1	12	18	PF00069	0.538
MOD_ProDKin_1	125	131	PF00069	0.558
MOD_ProDKin_1	88	94	PF00069	0.690
TRG_ENDOCYTIC_2	146	149	PF00928	0.432
TRG_ENDOCYTIC_2	5	8	PF00928	0.539
TRG_ER_diArg_1	112	115	PF00400	0.346
TRG_ER_diArg_1	120	122	PF00400	0.610
TRG_ER_diArg_1	29	31	PF00400	0.573
TRG_NLS_Bipartite_1	103	117	PF00514	0.346
TRG_NLS_MonoExtC_3	112	118	PF00514	0.492
TRG_NLS_MonoExtN_4	112	117	PF00514	0.343

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P774	Leptomonas seymouri	28%	100%
A0A0N1HS21	Leptomonas seymouri	51%	96%
A0A0S4IZ88	Bodo saltans	23%	98%
A0A0S4KEQ5	Bodo saltans	27%	98%
A0A1X0P828	Trypanosomatidae	31%	100%
A0A3Q8IJ52	Leishmania donovani	27%	97%
A0A3R7K1K7	Trypanosoma rangeli	34%	100%
A0A3S7XAJ8	Leishmania donovani	76%	98%
A4HQ43	Leishmania braziliensis	29%	100%
A4ICK7	Leishmania infantum	76%	98%
A4IDV0	Leishmania infantum	27%	97%
D0A2V5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
D0A8S1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	99%
E9ASP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	98%
E9ATW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	97%
P17960	Trypanosoma brucei brucei	37%	100%
Q4Q0N3	Leishmania major	29%	100%