RNA editing complex protein MP67

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA editing complex protein MP67

Species:

Leishmania braziliensis

UniProt:

E9AIX5_LEIBR

TriTrypDb:

LbrM.35.1040 , LBRM2903_350016100

Length:

575

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AIX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIX5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006396	RNA processing	6	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004518	nuclease activity	4	10
GO:0004519	endonuclease activity	5	10
GO:0004521	RNA endonuclease activity	5	10
GO:0004525	ribonuclease III activity	6	10
GO:0004540	RNA nuclease activity	4	10
GO:0016787	hydrolase activity	2	10
GO:0016788	hydrolase activity, acting on ester bonds	3	10
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	10
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	10
GO:0032296	double-stranded RNA-specific ribonuclease activity	5	10
GO:0140098	catalytic activity, acting on RNA	3	10
GO:0140640	catalytic activity, acting on a nucleic acid	2	10
GO:0004129	cytochrome-c oxidase activity	4	1
GO:0005215	transporter activity	1	1
GO:0008324	monoatomic cation transmembrane transporter activity	4	1
GO:0009055	electron transfer activity	3	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	1
GO:0015078	proton transmembrane transporter activity	5	1
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	1
GO:0015399	primary active transmembrane transporter activity	4	1
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	5	1
GO:0016491	oxidoreductase activity	2	2
GO:0016675	oxidoreductase activity, acting on a heme group of donors	3	1
GO:0022804	active transmembrane transporter activity	3	1
GO:0022853	active monoatomic ion transmembrane transporter activity	4	1
GO:0022857	transmembrane transporter activity	2	1
GO:0022890	inorganic cation transmembrane transporter activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	16	18	PF00675	0.706
CLV_NRD_NRD_1	171	173	PF00675	0.570
CLV_NRD_NRD_1	203	205	PF00675	0.410
CLV_NRD_NRD_1	46	48	PF00675	0.361
CLV_NRD_NRD_1	465	467	PF00675	0.747
CLV_NRD_NRD_1	478	480	PF00675	0.608
CLV_NRD_NRD_1	549	551	PF00675	0.611
CLV_PCSK_KEX2_1	111	113	PF00082	0.770
CLV_PCSK_KEX2_1	171	173	PF00082	0.452
CLV_PCSK_KEX2_1	183	185	PF00082	0.526
CLV_PCSK_KEX2_1	203	205	PF00082	0.222
CLV_PCSK_KEX2_1	37	39	PF00082	0.554
CLV_PCSK_KEX2_1	46	48	PF00082	0.387
CLV_PCSK_KEX2_1	465	467	PF00082	0.741
CLV_PCSK_KEX2_1	549	551	PF00082	0.581
CLV_PCSK_KEX2_1	76	78	PF00082	0.496
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.775
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.484
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.630
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.496
CLV_PCSK_SKI1_1	111	115	PF00082	0.662
CLV_PCSK_SKI1_1	150	154	PF00082	0.633
CLV_PCSK_SKI1_1	208	212	PF00082	0.409
CLV_PCSK_SKI1_1	217	221	PF00082	0.408
CLV_PCSK_SKI1_1	25	29	PF00082	0.660
CLV_PCSK_SKI1_1	259	263	PF00082	0.513
CLV_PCSK_SKI1_1	329	333	PF00082	0.493
CLV_PCSK_SKI1_1	450	454	PF00082	0.758
CLV_PCSK_SKI1_1	550	554	PF00082	0.720
CLV_PCSK_SKI1_1	71	75	PF00082	0.519
DEG_APCC_DBOX_1	207	215	PF00400	0.427
DEG_APCC_DBOX_1	349	357	PF00400	0.353
DEG_APCC_DBOX_1	549	557	PF00400	0.745
DEG_SCF_FBW7_1	538	545	PF00400	0.551
DOC_CDC14_PxL_1	422	430	PF14671	0.629
DOC_CKS1_1	93	98	PF01111	0.529
DOC_MAPK_gen_1	183	189	PF00069	0.688
DOC_MAPK_gen_1	203	213	PF00069	0.211
DOC_MAPK_gen_1	215	222	PF00069	0.443
DOC_MAPK_gen_1	76	83	PF00069	0.569
DOC_MAPK_MEF2A_6	161	170	PF00069	0.534
DOC_MAPK_MEF2A_6	215	224	PF00069	0.308
DOC_MAPK_MEF2A_6	76	85	PF00069	0.578
DOC_PP1_RVXF_1	327	334	PF00149	0.501
DOC_USP7_MATH_1	127	131	PF00917	0.727
DOC_USP7_MATH_1	436	440	PF00917	0.690
DOC_USP7_MATH_1	469	473	PF00917	0.749
DOC_USP7_MATH_1	511	515	PF00917	0.629
DOC_USP7_MATH_1	520	524	PF00917	0.796
DOC_USP7_MATH_1	536	540	PF00917	0.513
DOC_USP7_UBL2_3	111	115	PF12436	0.526
DOC_WW_Pin1_4	136	141	PF00397	0.481
DOC_WW_Pin1_4	259	264	PF00397	0.568
DOC_WW_Pin1_4	456	461	PF00397	0.704
DOC_WW_Pin1_4	538	543	PF00397	0.702
DOC_WW_Pin1_4	89	94	PF00397	0.651
LIG_14-3-3_CanoR_1	156	161	PF00244	0.623
LIG_14-3-3_CanoR_1	172	178	PF00244	0.410
LIG_14-3-3_CanoR_1	184	190	PF00244	0.588
LIG_14-3-3_CanoR_1	191	196	PF00244	0.399
LIG_14-3-3_CanoR_1	221	227	PF00244	0.550
LIG_14-3-3_CanoR_1	25	33	PF00244	0.630
LIG_14-3-3_CanoR_1	350	354	PF00244	0.576
LIG_14-3-3_CanoR_1	435	441	PF00244	0.717
LIG_14-3-3_CanoR_1	77	82	PF00244	0.313
LIG_Actin_WH2_2	207	223	PF00022	0.402
LIG_Actin_WH2_2	373	391	PF00022	0.532
LIG_Actin_WH2_2	62	78	PF00022	0.363
LIG_APCC_ABBA_1	530	535	PF00400	0.558
LIG_BRCT_BRCA1_1	138	142	PF00533	0.635
LIG_BRCT_BRCA1_1	185	189	PF00533	0.684
LIG_eIF4E_1	136	142	PF01652	0.636
LIG_eIF4E_1	447	453	PF01652	0.539
LIG_FHA_1	276	282	PF00498	0.466
LIG_FHA_1	447	453	PF00498	0.736
LIG_FHA_1	564	570	PF00498	0.590
LIG_FHA_2	157	163	PF00498	0.572
LIG_FHA_2	26	32	PF00498	0.638
LIG_FHA_2	361	367	PF00498	0.460
LIG_FHA_2	51	57	PF00498	0.436
LIG_FHA_2	82	88	PF00498	0.607
LIG_GBD_Chelix_1	320	328	PF00786	0.254
LIG_HP1_1	70	74	PF01393	0.552
LIG_Integrin_RGD_1	227	229	PF01839	0.435
LIG_LIR_Apic_2	342	347	PF02991	0.645
LIG_LIR_Gen_1	130	140	PF02991	0.707
LIG_LIR_Gen_1	162	170	PF02991	0.555
LIG_LIR_Gen_1	186	195	PF02991	0.589
LIG_LIR_Gen_1	245	253	PF02991	0.508
LIG_LIR_Gen_1	410	420	PF02991	0.496
LIG_LIR_Nem_3	130	135	PF02991	0.677
LIG_LIR_Nem_3	162	166	PF02991	0.511
LIG_LIR_Nem_3	186	192	PF02991	0.576
LIG_LIR_Nem_3	245	250	PF02991	0.514
LIG_LIR_Nem_3	255	261	PF02991	0.451
LIG_LIR_Nem_3	299	303	PF02991	0.390
LIG_LIR_Nem_3	342	346	PF02991	0.700
LIG_LIR_Nem_3	410	416	PF02991	0.503
LIG_MAD2	25	33	PF02301	0.684
LIG_NRBOX	327	333	PF00104	0.494
LIG_Pex14_1	205	209	PF04695	0.433
LIG_Pex14_1	339	343	PF04695	0.672
LIG_REV1ctd_RIR_1	255	262	PF16727	0.546
LIG_RPA_C_Fungi	199	211	PF08784	0.557
LIG_SH2_CRK	154	158	PF00017	0.649
LIG_SH2_CRK	298	302	PF00017	0.483
LIG_SH2_CRK	344	348	PF00017	0.664
LIG_SH2_CRK	422	426	PF00017	0.617
LIG_SH2_NCK_1	344	348	PF00017	0.664
LIG_SH2_SRC	136	139	PF00017	0.690
LIG_SH2_STAT5	209	212	PF00017	0.463
LIG_SH2_STAT5	283	286	PF00017	0.492
LIG_SH2_STAT5	300	303	PF00017	0.314
LIG_SH2_STAT5	310	313	PF00017	0.440
LIG_SH2_STAT5	355	358	PF00017	0.432
LIG_SH2_STAT5	395	398	PF00017	0.580
LIG_SH3_1	421	427	PF00018	0.694
LIG_SH3_2	460	465	PF14604	0.770
LIG_SH3_3	421	427	PF00018	0.694
LIG_SH3_3	454	460	PF00018	0.702
LIG_SH3_3	528	534	PF00018	0.766
LIG_SH3_3	90	96	PF00018	0.696
LIG_SUMO_SIM_anti_2	164	170	PF11976	0.512
LIG_SUMO_SIM_par_1	190	199	PF11976	0.573
LIG_SUMO_SIM_par_1	293	299	PF11976	0.444
LIG_TRAF2_1	9	12	PF00917	0.728
LIG_UBA3_1	210	215	PF00899	0.531
LIG_UBA3_1	324	329	PF00899	0.256
LIG_WRC_WIRS_1	82	87	PF05994	0.562
MOD_CDK_SPxK_1	259	265	PF00069	0.563
MOD_CK1_1	194	200	PF00069	0.467
MOD_CK1_1	514	520	PF00069	0.720
MOD_CK1_1	58	64	PF00069	0.560
MOD_CK1_1	91	97	PF00069	0.723
MOD_CK2_1	156	162	PF00069	0.622
MOD_CK2_1	193	199	PF00069	0.617
MOD_CK2_1	360	366	PF00069	0.438
MOD_CK2_1	408	414	PF00069	0.612
MOD_CK2_1	50	56	PF00069	0.357
MOD_CK2_1	81	87	PF00069	0.581
MOD_GlcNHglycan	115	118	PF01048	0.709
MOD_GlcNHglycan	229	234	PF01048	0.596
MOD_GlcNHglycan	333	336	PF01048	0.327
MOD_GlcNHglycan	507	510	PF01048	0.530
MOD_GlcNHglycan	513	516	PF01048	0.737
MOD_GlcNHglycan	526	529	PF01048	0.776
MOD_GSK3_1	103	110	PF00069	0.692
MOD_GSK3_1	118	125	PF00069	0.656
MOD_GSK3_1	127	134	PF00069	0.528
MOD_GSK3_1	191	198	PF00069	0.447
MOD_GSK3_1	253	260	PF00069	0.522
MOD_GSK3_1	501	508	PF00069	0.652
MOD_GSK3_1	520	527	PF00069	0.760
MOD_GSK3_1	538	545	PF00069	0.668
MOD_GSK3_1	58	65	PF00069	0.579
MOD_GSK3_1	77	84	PF00069	0.257
MOD_GSK3_1	87	94	PF00069	0.611
MOD_N-GLC_2	492	494	PF02516	0.456
MOD_NEK2_1	107	112	PF00069	0.745
MOD_NEK2_1	113	118	PF00069	0.778
MOD_NEK2_1	193	198	PF00069	0.557
MOD_NEK2_1	213	218	PF00069	0.226
MOD_NEK2_1	220	225	PF00069	0.473
MOD_NEK2_1	257	262	PF00069	0.511
MOD_NEK2_1	367	372	PF00069	0.518
MOD_NEK2_1	376	381	PF00069	0.389
MOD_NEK2_1	501	506	PF00069	0.653
MOD_NEK2_1	55	60	PF00069	0.523
MOD_NEK2_1	75	80	PF00069	0.232
MOD_NEK2_1	81	86	PF00069	0.497
MOD_NEK2_2	131	136	PF00069	0.584
MOD_NEK2_2	173	178	PF00069	0.529
MOD_PKA_1	183	189	PF00069	0.690
MOD_PKA_2	183	189	PF00069	0.690
MOD_PKA_2	220	226	PF00069	0.336
MOD_PKA_2	349	355	PF00069	0.579
MOD_PKA_2	511	517	PF00069	0.649
MOD_Plk_1	229	235	PF00069	0.467
MOD_Plk_1	284	290	PF00069	0.298
MOD_Plk_1	376	382	PF00069	0.468
MOD_Plk_4	131	137	PF00069	0.589
MOD_Plk_4	253	259	PF00069	0.523
MOD_Plk_4	349	355	PF00069	0.503
MOD_Plk_4	367	373	PF00069	0.525
MOD_Plk_4	81	87	PF00069	0.521
MOD_ProDKin_1	136	142	PF00069	0.475
MOD_ProDKin_1	259	265	PF00069	0.563
MOD_ProDKin_1	456	462	PF00069	0.702
MOD_ProDKin_1	538	544	PF00069	0.704
MOD_ProDKin_1	89	95	PF00069	0.663
MOD_SUMO_for_1	406	409	PF00179	0.482
MOD_SUMO_for_1	441	444	PF00179	0.530
MOD_SUMO_rev_2	322	331	PF00179	0.518
TRG_DiLeu_BaEn_1	327	332	PF01217	0.486
TRG_DiLeu_BaEn_1	349	354	PF01217	0.370
TRG_DiLeu_BaLyEn_6	109	114	PF01217	0.523
TRG_DiLeu_BaLyEn_6	188	193	PF01217	0.632
TRG_DiLeu_BaLyEn_6	424	429	PF01217	0.615
TRG_ENDOCYTIC_2	298	301	PF00928	0.372
TRG_ENDOCYTIC_2	343	346	PF00928	0.568
TRG_ENDOCYTIC_2	422	425	PF00928	0.614
TRG_ER_diArg_1	170	172	PF00400	0.567
TRG_ER_diArg_1	202	204	PF00400	0.309
TRG_ER_diArg_1	205	208	PF00400	0.393
TRG_ER_diArg_1	433	436	PF00400	0.790
TRG_ER_diArg_1	464	466	PF00400	0.796
TRG_ER_diArg_1	548	550	PF00400	0.667
TRG_Pf-PMV_PEXEL_1	47	52	PF00026	0.337

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7V7	Leptomonas seymouri	39%	91%
A0A1X0P8F1	Trypanosomatidae	34%	89%
A0A3S7XAF0	Leishmania donovani	77%	99%
A4ICP2	Leishmania infantum	77%	99%
D0A2S0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	96%
E9ASL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	99%
Q4Q1Y4	Leishmania major	75%	100%
V5BZV5	Trypanosoma cruzi	35%	97%