FYVE-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIX0_LEIBR

TriTrypDb:

LbrM.34.4240 , LBRM2903_340052400

Length:

377

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIX0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIX0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.502
CLV_C14_Caspase3-7	244	248	PF00656	0.729
CLV_NRD_NRD_1	136	138	PF00675	0.544
CLV_NRD_NRD_1	141	143	PF00675	0.555
CLV_NRD_NRD_1	184	186	PF00675	0.567
CLV_NRD_NRD_1	189	191	PF00675	0.538
CLV_NRD_NRD_1	192	194	PF00675	0.530
CLV_NRD_NRD_1	306	308	PF00675	0.559
CLV_NRD_NRD_1	85	87	PF00675	0.509
CLV_NRD_NRD_1	92	94	PF00675	0.502
CLV_PCSK_FUR_1	182	186	PF00082	0.525
CLV_PCSK_FUR_1	190	194	PF00082	0.572
CLV_PCSK_KEX2_1	136	138	PF00082	0.553
CLV_PCSK_KEX2_1	140	142	PF00082	0.539
CLV_PCSK_KEX2_1	184	186	PF00082	0.541
CLV_PCSK_KEX2_1	189	191	PF00082	0.564
CLV_PCSK_KEX2_1	192	194	PF00082	0.562
CLV_PCSK_KEX2_1	306	308	PF00082	0.500
CLV_PCSK_KEX2_1	353	355	PF00082	0.430
CLV_PCSK_KEX2_1	92	94	PF00082	0.538
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.569
CLV_PCSK_PC1ET2_1	353	355	PF00082	0.430
CLV_PCSK_PC7_1	136	142	PF00082	0.541
CLV_PCSK_PC7_1	185	191	PF00082	0.428
CLV_PCSK_SKI1_1	204	208	PF00082	0.621
CLV_PCSK_SKI1_1	310	314	PF00082	0.484
CLV_PCSK_SKI1_1	37	41	PF00082	0.514
CLV_PCSK_SKI1_1	80	84	PF00082	0.496
DOC_MAPK_gen_1	306	314	PF00069	0.486
DOC_MAPK_MEF2A_6	70	79	PF00069	0.337
DOC_PP2B_LxvP_1	266	269	PF13499	0.665
DOC_PP4_FxxP_1	292	295	PF00568	0.502
DOC_USP7_MATH_1	270	274	PF00917	0.604
DOC_USP7_MATH_1	287	291	PF00917	0.465
DOC_USP7_MATH_1	348	352	PF00917	0.430
DOC_USP7_UBL2_3	217	221	PF12436	0.583
DOC_WW_Pin1_4	279	284	PF00397	0.512
DOC_WW_Pin1_4	4	9	PF00397	0.691
LIG_14-3-3_CanoR_1	263	267	PF00244	0.495
LIG_14-3-3_CanoR_1	307	313	PF00244	0.364
LIG_14-3-3_CanoR_1	34	40	PF00244	0.564
LIG_Actin_WH2_2	250	265	PF00022	0.688
LIG_BIR_II_1	1	5	PF00653	0.641
LIG_deltaCOP1_diTrp_1	228	232	PF00928	0.668
LIG_eIF4E_1	240	246	PF01652	0.523
LIG_FHA_1	309	315	PF00498	0.354
LIG_FHA_2	253	259	PF00498	0.508
LIG_LIR_Apic_2	290	295	PF02991	0.501
LIG_LIR_Apic_2	298	302	PF02991	0.476
LIG_LIR_Apic_2	359	365	PF02991	0.430
LIG_LIR_Gen_1	22	32	PF02991	0.530
LIG_LIR_Gen_1	228	237	PF02991	0.683
LIG_LIR_Gen_1	52	60	PF02991	0.444
LIG_LIR_Gen_1	73	83	PF02991	0.473
LIG_LIR_Nem_3	22	28	PF02991	0.556
LIG_LIR_Nem_3	228	232	PF02991	0.543
LIG_LIR_Nem_3	52	56	PF02991	0.443
LIG_LIR_Nem_3	73	79	PF02991	0.482
LIG_PTB_Apo_2	302	309	PF02174	0.359
LIG_PTB_Phospho_1	302	308	PF10480	0.356
LIG_SH2_CRK	362	366	PF00017	0.430
LIG_SH2_NCK_1	362	366	PF00017	0.249
LIG_SH2_PTP2	53	56	PF00017	0.514
LIG_SH2_SRC	362	365	PF00017	0.249
LIG_SH2_STAP1	63	67	PF00017	0.567
LIG_SH2_STAT5	281	284	PF00017	0.420
LIG_SH2_STAT5	53	56	PF00017	0.514
LIG_SH3_3	311	317	PF00018	0.376
LIG_SUMO_SIM_par_1	6	12	PF11976	0.511
LIG_TRAF2_1	110	113	PF00917	0.547
LIG_TRAF2_1	128	131	PF00917	0.620
LIG_TRAF2_1	153	156	PF00917	0.600
LIG_TRAF2_1	165	168	PF00917	0.574
LIG_TRAF2_1	169	172	PF00917	0.575
LIG_TRAF2_1	176	179	PF00917	0.563
LIG_TRFH_1	373	377	PF08558	0.614
LIG_TYR_ITIM	51	56	PF00017	0.521
LIG_UBA3_1	35	40	PF00899	0.508
LIG_WW_3	294	298	PF00397	0.380
MOD_CK1_1	3	9	PF00069	0.751
MOD_CK2_1	252	258	PF00069	0.510
MOD_GlcNHglycan	80	83	PF01048	0.523
MOD_GSK3_1	275	282	PF00069	0.574
MOD_GSK3_1	61	68	PF00069	0.562
MOD_N-GLC_1	318	323	PF02516	0.249
MOD_N-GLC_1	348	353	PF02516	0.430
MOD_NEK2_1	1	6	PF00069	0.591
MOD_NEK2_1	232	237	PF00069	0.632
MOD_NEK2_1	262	267	PF00069	0.744
MOD_NEK2_1	277	282	PF00069	0.541
MOD_NEK2_1	35	40	PF00069	0.499
MOD_NEK2_2	19	24	PF00069	0.724
MOD_NEK2_2	308	313	PF00069	0.364
MOD_PKA_2	210	216	PF00069	0.407
MOD_PKA_2	262	268	PF00069	0.493
MOD_PKA_2	332	338	PF00069	0.430
MOD_PKB_1	124	132	PF00069	0.453
MOD_Plk_2-3	52	58	PF00069	0.474
MOD_Plk_4	252	258	PF00069	0.510
MOD_ProDKin_1	279	285	PF00069	0.500
MOD_ProDKin_1	4	10	PF00069	0.694
MOD_SUMO_rev_2	199	206	PF00179	0.459
TRG_DiLeu_BaEn_1	46	51	PF01217	0.476
TRG_DiLeu_BaEn_4	202	208	PF01217	0.526
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.473
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.566
TRG_ENDOCYTIC_2	53	56	PF00928	0.484
TRG_ENDOCYTIC_2	63	66	PF00928	0.468
TRG_ER_diArg_1	140	142	PF00400	0.563
TRG_ER_diArg_1	182	185	PF00400	0.547
TRG_ER_diArg_1	190	193	PF00400	0.550
TRG_ER_diArg_1	306	308	PF00400	0.559
TRG_ER_diArg_1	373	376	PF00400	0.526
TRG_NES_CRM1_1	46	58	PF08389	0.467
TRG_NLS_MonoCore_2	188	193	PF00514	0.542
TRG_NLS_MonoExtC_3	188	193	PF00514	0.542
TRG_NLS_MonoExtC_3	216	221	PF00514	0.432
TRG_NLS_MonoExtN_4	188	193	PF00514	0.546
TRG_NLS_MonoExtN_4	217	222	PF00514	0.517
TRG_Pf-PMV_PEXEL_1	102	107	PF00026	0.639
TRG_Pf-PMV_PEXEL_1	141	146	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	198	202	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	354	358	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	37	42	PF00026	0.667

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3I7	Leptomonas seymouri	78%	95%
A0A0S4JE94	Bodo saltans	54%	100%
A0A3S5H806	Leishmania donovani	88%	100%
A4IBW6	Leishmania infantum	88%	100%
E9AFQ3	Leishmania major	87%	100%
E9B6V6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%