Galactokinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Galactokinase

Gene product:

galactokinase-like protein

Species:

Leishmania braziliensis

UniProt:

E9AIW9_LEIBR

TriTrypDb:

LbrM.34.2640 , LBRM2903_340045900

Length:

214

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIW9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIW9

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	2
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2
GO:0005975	carbohydrate metabolic process	3	1
GO:0005996	monosaccharide metabolic process	3	1
GO:0006012	galactose metabolic process	5	1
GO:0019318	hexose metabolic process	4	1
GO:0044238	primary metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016301	kinase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	3
GO:0000166	nucleotide binding	3	1
GO:0004335	galactokinase activity	5	1
GO:0005488	binding	1	1
GO:0005524	ATP binding	5	1
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	1
GO:0017076	purine nucleotide binding	4	1
GO:0019200	carbohydrate kinase activity	5	1
GO:0030554	adenyl nucleotide binding	5	1
GO:0032553	ribonucleotide binding	3	1
GO:0032555	purine ribonucleotide binding	4	1
GO:0032559	adenyl ribonucleotide binding	5	1
GO:0035639	purine ribonucleoside triphosphate binding	4	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:0097367	carbohydrate derivative binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	186	188	PF00082	0.592
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.592
CLV_PCSK_SKI1_1	150	154	PF00082	0.600
CLV_PCSK_SKI1_1	187	191	PF00082	0.591
CLV_PCSK_SKI1_1	197	201	PF00082	0.399
CLV_PCSK_SKI1_1	54	58	PF00082	0.590
DOC_MAPK_MEF2A_6	62	70	PF00069	0.598
DOC_PP4_FxxP_1	84	87	PF00568	0.564
DOC_USP7_MATH_1	18	22	PF00917	0.567
DOC_USP7_MATH_1	29	33	PF00917	0.383
DOC_USP7_MATH_1	7	11	PF00917	0.477
LIG_APCC_ABBAyCdc20_2	54	60	PF00400	0.583
LIG_FHA_1	128	134	PF00498	0.629
LIG_FHA_2	118	124	PF00498	0.695
LIG_FHA_2	163	169	PF00498	0.619
LIG_LIR_Gen_1	151	162	PF02991	0.603
LIG_LIR_Gen_1	73	80	PF02991	0.449
LIG_LIR_Gen_1	88	94	PF02991	0.504
LIG_LIR_Nem_3	151	157	PF02991	0.587
LIG_LIR_Nem_3	175	179	PF02991	0.605
LIG_LIR_Nem_3	60	66	PF02991	0.480
LIG_LIR_Nem_3	73	77	PF02991	0.442
LIG_LIR_Nem_3	88	92	PF02991	0.491
LIG_Pex14_2	172	176	PF04695	0.575
LIG_SH2_CRK	63	67	PF00017	0.605
LIG_SH2_CRK	89	93	PF00017	0.594
LIG_SH2_SRC	38	41	PF00017	0.699
LIG_SH2_STAT5	154	157	PF00017	0.579
LIG_SH2_STAT5	160	163	PF00017	0.532
LIG_SH2_STAT5	38	41	PF00017	0.608
LIG_SH2_STAT5	63	66	PF00017	0.604
LIG_SH3_3	204	210	PF00018	0.642
LIG_TRFH_1	22	26	PF08558	0.621
LIG_TYR_ITIM	152	157	PF00017	0.579
LIG_TYR_ITSM	59	66	PF00017	0.594
LIG_WRC_WIRS_1	119	124	PF05994	0.700
LIG_WRC_WIRS_1	19	24	PF05994	0.610
LIG_WRC_WIRS_1	91	96	PF05994	0.594
MOD_CK1_1	148	154	PF00069	0.616
MOD_CK1_1	178	184	PF00069	0.595
MOD_CK1_1	205	211	PF00069	0.656
MOD_CK1_1	41	47	PF00069	0.584
MOD_CK2_1	3	9	PF00069	0.624
MOD_GlcNHglycan	147	150	PF01048	0.635
MOD_GlcNHglycan	5	8	PF01048	0.464
MOD_GSK3_1	205	212	PF00069	0.656
MOD_GSK3_1	29	36	PF00069	0.682
MOD_GSK3_1	3	10	PF00069	0.452
MOD_N-GLC_1	100	105	PF02516	0.596
MOD_NEK2_1	3	8	PF00069	0.525
MOD_NEK2_1	58	63	PF00069	0.595
MOD_NMyristoyl	1	7	PF02799	0.651
MOD_PIKK_1	178	184	PF00454	0.500
MOD_PKA_2	145	151	PF00069	0.629
MOD_PKA_2	50	56	PF00069	0.586
MOD_Plk_4	175	181	PF00069	0.595
TRG_ENDOCYTIC_2	154	157	PF00928	0.579
TRG_ENDOCYTIC_2	63	66	PF00928	0.604
TRG_ENDOCYTIC_2	89	92	PF00928	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
C9ZN90	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	75%