Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIW7_LEIBR

TriTrypDb:

LbrM.34.2650 , LBRM2903_340034700

Length:

588

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIW7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIW7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	157	159	PF00675	0.402
CLV_NRD_NRD_1	270	272	PF00675	0.479
CLV_NRD_NRD_1	371	373	PF00675	0.357
CLV_NRD_NRD_1	479	481	PF00675	0.479
CLV_PCSK_KEX2_1	157	159	PF00082	0.416
CLV_PCSK_KEX2_1	270	272	PF00082	0.583
CLV_PCSK_KEX2_1	371	373	PF00082	0.622
CLV_PCSK_KEX2_1	398	400	PF00082	0.458
CLV_PCSK_KEX2_1	479	481	PF00082	0.479
CLV_PCSK_PC1ET2_1	398	400	PF00082	0.458
CLV_PCSK_SKI1_1	152	156	PF00082	0.399
CLV_PCSK_SKI1_1	157	161	PF00082	0.388
CLV_PCSK_SKI1_1	286	290	PF00082	0.553
CLV_PCSK_SKI1_1	325	329	PF00082	0.493
CLV_PCSK_SKI1_1	348	352	PF00082	0.365
CLV_PCSK_SKI1_1	5	9	PF00082	0.442
CLV_PCSK_SKI1_1	65	69	PF00082	0.413
CLV_Separin_Metazoa	552	556	PF03568	0.487
DEG_APCC_DBOX_1	156	164	PF00400	0.432
DEG_APCC_DBOX_1	481	489	PF00400	0.499
DEG_MDM2_SWIB_1	67	74	PF02201	0.393
DEG_Nend_UBRbox_2	1	3	PF02207	0.429
DEG_SPOP_SBC_1	41	45	PF00917	0.412
DOC_MAPK_gen_1	479	487	PF00069	0.492
DOC_MAPK_gen_1	569	578	PF00069	0.462
DOC_MAPK_MEF2A_6	508	515	PF00069	0.452
DOC_MAPK_MEF2A_6	569	578	PF00069	0.382
DOC_MAPK_MEF2A_6	92	99	PF00069	0.435
DOC_PP2B_LxvP_1	123	126	PF13499	0.522
DOC_USP7_MATH_1	180	184	PF00917	0.582
DOC_USP7_MATH_1	260	264	PF00917	0.592
DOC_USP7_MATH_1	287	291	PF00917	0.462
DOC_USP7_MATH_1	41	45	PF00917	0.484
DOC_USP7_MATH_1	500	504	PF00917	0.580
DOC_USP7_MATH_1	58	62	PF00917	0.370
DOC_USP7_MATH_1	95	99	PF00917	0.387
DOC_WW_Pin1_4	188	193	PF00397	0.582
DOC_WW_Pin1_4	79	84	PF00397	0.360
DOC_WW_Pin1_4	91	96	PF00397	0.416
LIG_14-3-3_CanoR_1	134	143	PF00244	0.545
LIG_14-3-3_CanoR_1	247	254	PF00244	0.473
LIG_14-3-3_CanoR_1	259	267	PF00244	0.449
LIG_14-3-3_CanoR_1	286	296	PF00244	0.465
LIG_14-3-3_CanoR_1	70	75	PF00244	0.323
LIG_Actin_WH2_2	478	496	PF00022	0.372
LIG_BRCT_BRCA1_1	497	501	PF00533	0.460
LIG_Clathr_ClatBox_1	96	100	PF01394	0.448
LIG_eIF4E_1	533	539	PF01652	0.486
LIG_FHA_1	118	124	PF00498	0.512
LIG_FHA_1	142	148	PF00498	0.525
LIG_FHA_1	218	224	PF00498	0.678
LIG_FHA_1	473	479	PF00498	0.338
LIG_FHA_1	488	494	PF00498	0.348
LIG_FHA_1	533	539	PF00498	0.425
LIG_FHA_1	80	86	PF00498	0.420
LIG_FHA_2	189	195	PF00498	0.515
LIG_FHA_2	219	225	PF00498	0.581
LIG_LIR_Gen_1	73	83	PF02991	0.404
LIG_LIR_Nem_3	50	55	PF02991	0.512
LIG_LIR_Nem_3	73	78	PF02991	0.408
LIG_LIR_Nem_3	82	87	PF02991	0.331
LIG_Pex14_1	71	75	PF04695	0.379
LIG_Pex14_2	578	582	PF04695	0.407
LIG_Pex14_2	67	71	PF04695	0.396
LIG_PTB_Apo_2	61	68	PF02174	0.392
LIG_RPA_C_Fungi	265	277	PF08784	0.442
LIG_SH2_CRK	52	56	PF00017	0.342
LIG_SH2_NCK_1	75	79	PF00017	0.394
LIG_SH2_STAP1	407	411	PF00017	0.415
LIG_SH2_STAP1	75	79	PF00017	0.394
LIG_SH2_STAT3	533	536	PF00017	0.492
LIG_SH2_STAT5	17	20	PF00017	0.335
LIG_SH2_STAT5	37	40	PF00017	0.315
LIG_SH2_STAT5	84	87	PF00017	0.521
LIG_SH3_1	168	174	PF00018	0.508
LIG_SH3_3	168	174	PF00018	0.508
LIG_SH3_3	208	214	PF00018	0.792
LIG_SH3_3	22	28	PF00018	0.475
LIG_SH3_3	323	329	PF00018	0.502
LIG_SH3_3	518	524	PF00018	0.430
LIG_Sin3_3	248	255	PF02671	0.470
LIG_SUMO_SIM_par_1	144	151	PF11976	0.440
LIG_SUMO_SIM_par_1	94	101	PF11976	0.366
LIG_TRAF2_1	343	346	PF00917	0.393
LIG_TRAF2_1	410	413	PF00917	0.409
LIG_TRAF2_1	440	443	PF00917	0.443
LIG_TYR_ITIM	15	20	PF00017	0.328
LIG_UBA3_1	559	564	PF00899	0.479
LIG_WRC_WIRS_1	99	104	PF05994	0.507
MOD_CK1_1	136	142	PF00069	0.582
MOD_CK1_1	44	50	PF00069	0.397
MOD_CK1_1	98	104	PF00069	0.427
MOD_CK2_1	188	194	PF00069	0.495
MOD_CK2_1	218	224	PF00069	0.526
MOD_CK2_1	262	268	PF00069	0.519
MOD_CK2_1	340	346	PF00069	0.391
MOD_CK2_1	437	443	PF00069	0.444
MOD_CK2_1	44	50	PF00069	0.390
MOD_CK2_1	70	76	PF00069	0.356
MOD_GlcNHglycan	136	139	PF01048	0.573
MOD_GlcNHglycan	177	180	PF01048	0.637
MOD_GlcNHglycan	239	242	PF01048	0.525
MOD_GlcNHglycan	248	251	PF01048	0.469
MOD_GlcNHglycan	264	267	PF01048	0.533
MOD_GlcNHglycan	373	377	PF01048	0.482
MOD_GlcNHglycan	502	505	PF01048	0.609
MOD_GSK3_1	133	140	PF00069	0.583
MOD_GSK3_1	148	155	PF00069	0.309
MOD_GSK3_1	175	182	PF00069	0.688
MOD_GSK3_1	214	221	PF00069	0.585
MOD_GSK3_1	314	321	PF00069	0.596
MOD_GSK3_1	37	44	PF00069	0.396
MOD_GSK3_1	489	496	PF00069	0.394
MOD_GSK3_1	578	585	PF00069	0.518
MOD_GSK3_1	91	98	PF00069	0.361
MOD_LATS_1	105	111	PF00433	0.498
MOD_N-GLC_1	340	345	PF02516	0.372
MOD_N-GLC_1	463	468	PF02516	0.467
MOD_N-GLC_1	63	68	PF02516	0.390
MOD_NEK2_1	196	201	PF00069	0.504
MOD_NEK2_1	493	498	PF00069	0.450
MOD_NEK2_1	532	537	PF00069	0.491
MOD_NEK2_1	578	583	PF00069	0.407
MOD_PIKK_1	419	425	PF00454	0.381
MOD_PIKK_1	527	533	PF00454	0.510
MOD_PKA_2	133	139	PF00069	0.609
MOD_PKA_2	246	252	PF00069	0.475
MOD_PKA_2	493	499	PF00069	0.459
MOD_Plk_1	206	212	PF00069	0.539
MOD_Plk_1	218	224	PF00069	0.492
MOD_Plk_1	41	47	PF00069	0.359
MOD_Plk_1	463	469	PF00069	0.469
MOD_Plk_1	63	69	PF00069	0.388
MOD_Plk_2-3	489	495	PF00069	0.526
MOD_Plk_4	70	76	PF00069	0.484
MOD_ProDKin_1	188	194	PF00069	0.582
MOD_ProDKin_1	79	85	PF00069	0.365
MOD_ProDKin_1	91	97	PF00069	0.414
MOD_SUMO_for_1	200	203	PF00179	0.515
MOD_SUMO_for_1	288	291	PF00179	0.464
MOD_SUMO_rev_2	489	498	PF00179	0.405
TRG_DiLeu_BaEn_1	2	7	PF01217	0.413
TRG_DiLeu_BaEn_4	345	351	PF01217	0.366
TRG_DiLeu_BaEn_4	358	364	PF01217	0.332
TRG_ENDOCYTIC_2	16	19	PF00928	0.333
TRG_ENDOCYTIC_2	36	39	PF00928	0.257
TRG_ENDOCYTIC_2	52	55	PF00928	0.310
TRG_ENDOCYTIC_2	75	78	PF00928	0.413
TRG_ENDOCYTIC_2	84	87	PF00928	0.332
TRG_ER_diArg_1	296	299	PF00400	0.538
TRG_ER_diArg_1	370	372	PF00400	0.364
TRG_ER_diArg_1	478	480	PF00400	0.429
TRG_ER_diArg_1	481	484	PF00400	0.418
TRG_Pf-PMV_PEXEL_1	278	282	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	299	304	PF00026	0.635
TRG_Pf-PMV_PEXEL_1	348	352	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	409	413	PF00026	0.338
TRG_Pf-PMV_PEXEL_1	469	473	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	479	483	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Q8	Leptomonas seymouri	38%	100%
A0A3Q8IJI3	Leishmania donovani	66%	99%
E9AF99	Leishmania major	62%	100%
E9B6F4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%