LeishMANIAdb
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Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Download

Quick info

Protein:
Transmembrane protein
Gene product:
Present in the outer mitochondrial membrane proteome 8
Species:
Leishmania braziliensis
UniProt:
E9AIW5_LEIBR
TriTrypDb:
LbrM.34.2561 * , LBRM2903_340033400 *
Length:
122

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 1
NetGPI no yes: 0, no: 1
Cellular components
Term Name Level Count
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

E9AIW5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIW5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 14 18 PF00656 0.795
CLV_NRD_NRD_1 36 38 PF00675 0.583
CLV_PCSK_KEX2_1 117 119 PF00082 0.599
CLV_PCSK_KEX2_1 36 38 PF00082 0.583
CLV_PCSK_PC1ET2_1 117 119 PF00082 0.599
DOC_CYCLIN_RxL_1 33 43 PF00134 0.781
LIG_14-3-3_CanoR_1 118 122 PF00244 0.688
LIG_14-3-3_CanoR_1 79 85 PF00244 0.554
LIG_14-3-3_CanoR_1 89 97 PF00244 0.324
LIG_APCC_ABBA_1 72 77 PF00400 0.650
LIG_BIR_II_1 1 5 PF00653 0.800
LIG_deltaCOP1_diTrp_1 111 121 PF00928 0.776
LIG_FHA_1 89 95 PF00498 0.449
LIG_FHA_2 12 18 PF00498 0.798
LIG_LIR_Gen_1 91 101 PF02991 0.549
LIG_LIR_Nem_3 52 56 PF02991 0.549
LIG_LIR_Nem_3 91 96 PF02991 0.549
LIG_PDZ_Wminus1_1 120 122 PF00595 0.693
LIG_SH2_CRK 53 57 PF00017 0.549
LIG_SH2_STAT5 107 110 PF00017 0.549
LIG_SH2_STAT5 82 85 PF00017 0.537
LIG_SUMO_SIM_anti_2 6 14 PF11976 0.800
LIG_TYR_ITIM 51 56 PF00017 0.549
MOD_CK1_1 6 12 PF00069 0.798
MOD_GlcNHglycan 58 61 PF01048 0.549
MOD_GlcNHglycan 67 70 PF01048 0.392
MOD_GSK3_1 113 120 PF00069 0.781
MOD_GSK3_1 20 27 PF00069 0.628
MOD_GSK3_1 6 13 PF00069 0.800
MOD_N-GLC_1 80 85 PF02516 0.752
MOD_NEK2_1 11 16 PF00069 0.703
MOD_NEK2_1 113 118 PF00069 0.772
MOD_NEK2_1 3 8 PF00069 0.792
MOD_NEK2_1 56 61 PF00069 0.549
MOD_NEK2_1 75 80 PF00069 0.313
MOD_NEK2_1 88 93 PF00069 0.352
MOD_PK_1 20 26 PF00069 0.803
MOD_PKA_2 6 12 PF00069 0.798
MOD_PKA_2 88 94 PF00069 0.449
MOD_Plk_1 3 9 PF00069 0.793
MOD_Plk_1 80 86 PF00069 0.546
MOD_Plk_4 27 33 PF00069 0.792
MOD_Plk_4 70 76 PF00069 0.637
TRG_ENDOCYTIC_2 53 56 PF00928 0.549
TRG_ER_diArg_1 36 38 PF00400 0.782
TRG_Pf-PMV_PEXEL_1 36 41 PF00026 0.578

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS