Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIW4_LEIBR

TriTrypDb:

LbrM.34.2510 , LBRM2903_340032800

Length:

189

Annotations

LeishMANIAdb annotations

Might be an organellar (mitochondrial) protein with transit signal. Localization: Mitochondrial (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9AIW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIW4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	59	63	PF00656	0.420
CLV_NRD_NRD_1	10	12	PF00675	0.707
CLV_NRD_NRD_1	35	37	PF00675	0.772
CLV_PCSK_KEX2_1	10	12	PF00082	0.707
CLV_PCSK_KEX2_1	35	37	PF00082	0.745
CLV_PCSK_SKI1_1	29	33	PF00082	0.594
DEG_Nend_UBRbox_3	1	3	PF02207	0.543
DOC_MAPK_MEF2A_6	53	60	PF00069	0.422
DOC_MAPK_RevD_3	20	36	PF00069	0.389
DOC_PP1_RVXF_1	157	164	PF00149	0.583
DOC_PP2B_PxIxI_1	55	61	PF00149	0.420
DOC_USP7_MATH_1	14	18	PF00917	0.388
DOC_USP7_MATH_1	45	49	PF00917	0.621
DOC_WW_Pin1_4	51	56	PF00397	0.504
LIG_14-3-3_CanoR_1	10	19	PF00244	0.520
LIG_14-3-3_CanoR_1	102	108	PF00244	0.236
LIG_14-3-3_CanoR_1	3	9	PF00244	0.525
LIG_FHA_1	25	31	PF00498	0.385
LIG_FHA_1	91	97	PF00498	0.412
LIG_FHA_2	165	171	PF00498	0.580
LIG_LIR_Gen_1	17	25	PF02991	0.445
LIG_LIR_Nem_3	17	22	PF02991	0.447
LIG_SH2_STAT5	154	157	PF00017	0.589
LIG_SH3_3	28	34	PF00018	0.458
LIG_SUMO_SIM_anti_2	27	34	PF11976	0.389
LIG_TRAF2_1	167	170	PF00917	0.585
LIG_TRAF2_1	74	77	PF00917	0.372
LIG_WRC_WIRS_1	104	109	PF05994	0.236
MOD_CK1_1	48	54	PF00069	0.491
MOD_CK2_1	164	170	PF00069	0.581
MOD_CK2_1	51	57	PF00069	0.434
MOD_GlcNHglycan	12	15	PF01048	0.624
MOD_GlcNHglycan	16	19	PF01048	0.619
MOD_GlcNHglycan	22	25	PF01048	0.542
MOD_GlcNHglycan	40	43	PF01048	0.681
MOD_GlcNHglycan	47	50	PF01048	0.698
MOD_GSK3_1	10	17	PF00069	0.393
MOD_GSK3_1	20	27	PF00069	0.408
MOD_N-GLC_1	45	50	PF02516	0.658
MOD_NEK2_1	128	133	PF00069	0.595
MOD_NEK2_1	20	25	PF00069	0.410
MOD_NEK2_1	9	14	PF00069	0.470
MOD_PIKK_1	148	154	PF00454	0.618
MOD_PIKK_1	61	67	PF00454	0.547
MOD_PKA_1	10	16	PF00069	0.515
MOD_PKA_2	2	8	PF00069	0.565
MOD_PKA_2	25	31	PF00069	0.389
MOD_PKA_2	9	15	PF00069	0.495
MOD_Plk_1	56	62	PF00069	0.422
MOD_Plk_2-3	164	170	PF00069	0.578
MOD_ProDKin_1	51	57	PF00069	0.506
TRG_ER_diArg_1	183	186	PF00400	0.546
TRG_ER_diArg_1	34	36	PF00400	0.541
TRG_ER_diArg_1	9	11	PF00400	0.493
TRG_NLS_MonoCore_2	121	126	PF00514	0.598
TRG_NLS_MonoExtC_3	121	127	PF00514	0.602
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.394
TRG_Pf-PMV_PEXEL_1	159	164	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8R4	Leptomonas seymouri	49%	100%
A0A3Q8IMC4	Leishmania donovani	65%	99%
A4IBG7	Leishmania infantum	65%	99%
E9AF81	Leishmania major	66%	100%
E9B6D7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	99%