LeishMANIAdb
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RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
RING-type domain-containing protein
Gene product:
Ring finger domain containing protein, putative
Species:
Leishmania braziliensis
UniProt:
E9AIW3_LEIBR
TriTrypDb:
LbrM.34.2450 , LBRM2903_340032200 *
Length:
396

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIW3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIW3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 159 161 PF00675 0.521
CLV_NRD_NRD_1 212 214 PF00675 0.550
CLV_NRD_NRD_1 245 247 PF00675 0.578
CLV_NRD_NRD_1 262 264 PF00675 0.666
CLV_NRD_NRD_1 287 289 PF00675 0.653
CLV_NRD_NRD_1 90 92 PF00675 0.241
CLV_PCSK_KEX2_1 235 237 PF00082 0.442
CLV_PCSK_KEX2_1 287 289 PF00082 0.630
CLV_PCSK_KEX2_1 62 64 PF00082 0.390
CLV_PCSK_KEX2_1 90 92 PF00082 0.241
CLV_PCSK_PC1ET2_1 235 237 PF00082 0.506
CLV_PCSK_PC1ET2_1 62 64 PF00082 0.384
CLV_PCSK_PC7_1 231 237 PF00082 0.461
CLV_PCSK_SKI1_1 213 217 PF00082 0.494
CLV_PCSK_SKI1_1 287 291 PF00082 0.575
CLV_PCSK_SKI1_1 62 66 PF00082 0.382
CLV_PCSK_SKI1_1 85 89 PF00082 0.238
DEG_Nend_UBRbox_4 1 3 PF02207 0.391
DOC_CYCLIN_yCln2_LP_2 175 181 PF00134 0.524
DOC_MAPK_gen_1 235 242 PF00069 0.469
DOC_MAPK_gen_1 90 98 PF00069 0.497
DOC_MAPK_MEF2A_6 37 45 PF00069 0.338
DOC_MAPK_RevD_3 75 91 PF00069 0.441
DOC_PP2B_LxvP_1 175 178 PF13499 0.543
DOC_USP7_MATH_1 166 170 PF00917 0.576
DOC_USP7_MATH_1 181 185 PF00917 0.328
DOC_USP7_UBL2_3 243 247 PF12436 0.454
DOC_USP7_UBL2_3 95 99 PF12436 0.304
LIG_14-3-3_CanoR_1 115 123 PF00244 0.362
LIG_14-3-3_CanoR_1 203 208 PF00244 0.561
LIG_14-3-3_CanoR_1 246 253 PF00244 0.620
LIG_BIR_III_4 39 43 PF00653 0.440
LIG_BRCT_BRCA1_1 16 20 PF00533 0.348
LIG_CaM_IQ_9 77 93 PF13499 0.429
LIG_deltaCOP1_diTrp_1 152 159 PF00928 0.484
LIG_FHA_1 104 110 PF00498 0.442
LIG_FHA_1 178 184 PF00498 0.501
LIG_FHA_1 274 280 PF00498 0.550
LIG_FHA_1 45 51 PF00498 0.460
LIG_FHA_2 214 220 PF00498 0.470
LIG_Integrin_RGD_1 6 8 PF01839 0.373
LIG_LIR_Gen_1 117 125 PF02991 0.479
LIG_LIR_Gen_1 152 163 PF02991 0.411
LIG_LIR_Gen_1 313 324 PF02991 0.568
LIG_LIR_Nem_3 117 123 PF02991 0.365
LIG_LIR_Nem_3 152 158 PF02991 0.374
LIG_LIR_Nem_3 22 28 PF02991 0.330
LIG_LIR_Nem_3 313 319 PF02991 0.550
LIG_PCNA_yPIPBox_3 74 88 PF02747 0.524
LIG_SH2_CRK 93 97 PF00017 0.381
LIG_SH2_STAT5 108 111 PF00017 0.353
LIG_SH2_STAT5 195 198 PF00017 0.423
LIG_SH2_STAT5 31 34 PF00017 0.399
LIG_SH2_STAT5 349 352 PF00017 0.378
LIG_SH2_STAT5 93 96 PF00017 0.360
LIG_SH3_3 160 166 PF00018 0.484
LIG_SH3_3 182 188 PF00018 0.507
LIG_SH3_3 262 268 PF00018 0.676
LIG_TRAF2_1 125 128 PF00917 0.480
LIG_WRC_WIRS_1 25 30 PF05994 0.384
MOD_CK1_1 167 173 PF00069 0.567
MOD_CK1_1 266 272 PF00069 0.553
MOD_CK2_1 266 272 PF00069 0.473
MOD_GlcNHglycan 116 119 PF01048 0.429
MOD_GlcNHglycan 165 169 PF01048 0.622
MOD_GlcNHglycan 171 174 PF01048 0.631
MOD_GlcNHglycan 299 302 PF01048 0.691
MOD_GlcNHglycan 3 6 PF01048 0.545
MOD_GlcNHglycan 320 323 PF01048 0.769
MOD_GlcNHglycan 328 331 PF01048 0.681
MOD_GlcNHglycan 339 342 PF01048 0.361
MOD_GlcNHglycan 388 391 PF01048 0.370
MOD_GSK3_1 167 174 PF00069 0.709
MOD_GSK3_1 177 184 PF00069 0.691
MOD_GSK3_1 199 206 PF00069 0.406
MOD_GSK3_1 259 266 PF00069 0.593
MOD_GSK3_1 283 290 PF00069 0.503
MOD_GSK3_1 314 321 PF00069 0.542
MOD_N-GLC_2 382 384 PF02516 0.352
MOD_NEK2_1 1 6 PF00069 0.550
MOD_NEK2_1 14 19 PF00069 0.290
MOD_PIKK_1 19 25 PF00454 0.372
MOD_PIKK_1 287 293 PF00454 0.544
MOD_PIKK_1 54 60 PF00454 0.490
MOD_PK_1 332 338 PF00069 0.434
MOD_PKA_1 213 219 PF00069 0.422
MOD_PKA_1 246 252 PF00069 0.504
MOD_PKA_1 263 269 PF00069 0.500
MOD_PKA_1 287 293 PF00069 0.528
MOD_PKA_2 114 120 PF00069 0.345
MOD_PKA_2 245 251 PF00069 0.620
MOD_PKA_2 287 293 PF00069 0.535
MOD_PKA_2 363 369 PF00069 0.486
MOD_Plk_1 127 133 PF00069 0.329
MOD_Plk_4 332 338 PF00069 0.554
TRG_ENDOCYTIC_2 358 361 PF00928 0.418
TRG_ENDOCYTIC_2 93 96 PF00928 0.355
TRG_ER_diArg_1 287 289 PF00400 0.525
TRG_Pf-PMV_PEXEL_1 213 218 PF00026 0.558

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I8I6 Leptomonas seymouri 48% 72%
A0A1X0P5K1 Trypanosomatidae 36% 89%
A0A3Q8IGA8 Leishmania donovani 71% 100%
A0A3S5IR12 Trypanosoma rangeli 35% 92%
A4IBG1 Leishmania infantum 71% 100%
C9ZZA3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 75%
E9AF75 Leishmania major 69% 100%
E9B6D1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 72% 100%
V5B3S2 Trypanosoma cruzi 36% 91%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS