Yos1-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Yos1-like protein

Gene product:

Yos1-like, putative

Species:

Leishmania braziliensis

UniProt:

E9AIW2_LEIBR

TriTrypDb:

LbrM.34.2441 , LBRM2903_340032100

Length:

111

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0030134	COPII-coated ER to Golgi transport vesicle	8	1
GO:0030135	coated vesicle	7	1
GO:0031090	organelle membrane	3	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

E9AIW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIW2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	9
GO:0008104	protein localization	4	9
GO:0009987	cellular process	1	9
GO:0015031	protein transport	4	9
GO:0033036	macromolecule localization	2	9
GO:0045184	establishment of protein localization	3	9
GO:0051179	localization	1	9
GO:0051234	establishment of localization	2	9
GO:0051641	cellular localization	2	9
GO:0070727	cellular macromolecule localization	3	9
GO:0071702	organic substance transport	4	9
GO:0071705	nitrogen compound transport	4	9
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051649	establishment of localization in cell	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	57	61	PF00656	0.240
DEG_APCC_DBOX_1	92	100	PF00400	0.357
DOC_CKS1_1	33	38	PF01111	0.492
DOC_MAPK_MEF2A_6	72	81	PF00069	0.438
DOC_MAPK_MEF2A_6	93	101	PF00069	0.399
DOC_PP2B_PxIxI_1	94	100	PF00149	0.357
DOC_WW_Pin1_4	32	37	PF00397	0.492
LIG_14-3-3_CanoR_1	72	78	PF00244	0.492
LIG_EH1_1	85	93	PF00400	0.492
LIG_FHA_2	48	54	PF00498	0.240
LIG_LIR_Gen_1	4	14	PF02991	0.461
LIG_LIR_Gen_1	48	59	PF02991	0.438
LIG_LIR_Nem_3	4	9	PF02991	0.461
LIG_Pex14_1	94	98	PF04695	0.438
LIG_Pex14_2	27	31	PF04695	0.492
LIG_SH2_CRK	6	10	PF00017	0.471
LIG_SH2_NCK_1	6	10	PF00017	0.492
LIG_WRC_WIRS_1	81	86	PF05994	0.240
MOD_CK1_1	4	10	PF00069	0.438
MOD_CK1_1	73	79	PF00069	0.451
MOD_GlcNHglycan	65	68	PF01048	0.378
MOD_GlcNHglycan	9	12	PF01048	0.492
MOD_GSK3_1	22	29	PF00069	0.461
MOD_GSK3_1	80	87	PF00069	0.366
MOD_N-GLC_1	99	104	PF02516	0.431
MOD_NEK2_1	1	6	PF00069	0.506
MOD_NEK2_1	22	27	PF00069	0.475
MOD_NEK2_1	63	68	PF00069	0.448
MOD_NEK2_1	84	89	PF00069	0.461
MOD_Plk_1	99	105	PF00069	0.431
MOD_Plk_4	4	10	PF00069	0.492
MOD_Plk_4	80	86	PF00069	0.438
MOD_ProDKin_1	32	38	PF00069	0.492
TRG_DiLeu_BaLyEn_6	86	91	PF01217	0.406
TRG_DiLeu_BaLyEn_6	92	97	PF01217	0.305
TRG_ENDOCYTIC_2	6	9	PF00928	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P5S0	Trypanosomatidae	47%	100%
A0A3R7KCE1	Trypanosoma rangeli	46%	100%
A0A3S7X9K4	Leishmania donovani	85%	100%
A4IBG0	Leishmania infantum	84%	100%
C9ZZA4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AF74	Leishmania major	84%	100%
E9B6D0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%