Putative UDP-N-acetylglucosamine pyrophosphorylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UDP-N-acetylglucosamine pyrophosphorylase, putative

Species:

Leishmania braziliensis

UniProt:

E9AIV6_LEIBR

TriTrypDb:

LbrM.33.2790 , LBRM2903_330035700

Length:

550

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AIV6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIV6

Function

Biological processes
Term	Name	Level	Count
GO:0006040	amino sugar metabolic process	4	1
GO:0006047	UDP-N-acetylglucosamine metabolic process	4	1
GO:0006048	UDP-N-acetylglucosamine biosynthetic process	5	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009225	nucleotide-sugar metabolic process	4	1
GO:0009226	nucleotide-sugar biosynthetic process	5	1
GO:0009987	cellular process	1	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046349	amino sugar biosynthetic process	5	1
GO:0046483	heterocycle metabolic process	3	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901137	carbohydrate derivative biosynthetic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0003977	UDP-N-acetylglucosamine diphosphorylase activity	6	8
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016779	nucleotidyltransferase activity	4	12
GO:0070569	uridylyltransferase activity	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	287	293	PF00089	0.265
CLV_NRD_NRD_1	160	162	PF00675	0.232
CLV_NRD_NRD_1	387	389	PF00675	0.253
CLV_NRD_NRD_1	536	538	PF00675	0.363
CLV_PCSK_KEX2_1	536	538	PF00082	0.382
CLV_PCSK_SKI1_1	138	142	PF00082	0.223
CLV_PCSK_SKI1_1	150	154	PF00082	0.232
CLV_PCSK_SKI1_1	353	357	PF00082	0.152
CLV_PCSK_SKI1_1	4	8	PF00082	0.491
CLV_PCSK_SKI1_1	412	416	PF00082	0.253
CLV_PCSK_SKI1_1	537	541	PF00082	0.485
DEG_APCC_DBOX_1	179	187	PF00400	0.375
DEG_APCC_DBOX_1	53	61	PF00400	0.490
DEG_SPOP_SBC_1	186	190	PF00917	0.434
DOC_CDC14_PxL_1	89	97	PF14671	0.513
DOC_MAPK_gen_1	274	284	PF00069	0.513
DOC_MAPK_MEF2A_6	180	187	PF00069	0.479
DOC_MAPK_NFAT4_5	180	188	PF00069	0.465
DOC_PP1_RVXF_1	351	357	PF00149	0.431
DOC_USP7_MATH_1	125	129	PF00917	0.410
DOC_USP7_MATH_1	145	149	PF00917	0.318
DOC_USP7_MATH_1	259	263	PF00917	0.497
DOC_USP7_MATH_1	313	317	PF00917	0.439
DOC_USP7_MATH_1	341	345	PF00917	0.384
DOC_USP7_MATH_1	481	485	PF00917	0.518
DOC_USP7_MATH_1	518	522	PF00917	0.332
DOC_USP7_MATH_1	539	543	PF00917	0.476
DOC_USP7_MATH_1	74	78	PF00917	0.600
DOC_USP7_UBL2_3	310	314	PF12436	0.410
DOC_WW_Pin1_4	454	459	PF00397	0.500
DOC_WW_Pin1_4	514	519	PF00397	0.334
DOC_WW_Pin1_4	79	84	PF00397	0.513
LIG_14-3-3_CanoR_1	500	507	PF00244	0.490
LIG_14-3-3_CanoR_1	536	544	PF00244	0.362
LIG_BIR_II_1	1	5	PF00653	0.361
LIG_BRCT_BRCA1_1	366	370	PF00533	0.427
LIG_BRCT_BRCA1_1	440	444	PF00533	0.448
LIG_FHA_1	180	186	PF00498	0.465
LIG_FHA_1	227	233	PF00498	0.427
LIG_FHA_1	316	322	PF00498	0.482
LIG_FHA_1	349	355	PF00498	0.435
LIG_FHA_1	468	474	PF00498	0.352
LIG_FHA_1	499	505	PF00498	0.474
LIG_FHA_1	65	71	PF00498	0.514
LIG_FHA_2	481	487	PF00498	0.539
LIG_FHA_2	494	500	PF00498	0.505
LIG_LIR_Gen_1	21	28	PF02991	0.467
LIG_LIR_Gen_1	328	339	PF02991	0.437
LIG_LIR_Gen_1	367	378	PF02991	0.435
LIG_LIR_LC3C_4	182	187	PF02991	0.352
LIG_LIR_Nem_3	203	209	PF02991	0.460
LIG_LIR_Nem_3	21	26	PF02991	0.469
LIG_LIR_Nem_3	293	299	PF02991	0.432
LIG_LIR_Nem_3	328	334	PF02991	0.416
LIG_LIR_Nem_3	335	339	PF02991	0.403
LIG_LIR_Nem_3	367	373	PF02991	0.424
LIG_LIR_Nem_3	441	447	PF02991	0.417
LIG_REV1ctd_RIR_1	198	206	PF16727	0.425
LIG_SH2_CRK	23	27	PF00017	0.439
LIG_SH2_GRB2like	41	44	PF00017	0.415
LIG_SH2_NCK_1	225	229	PF00017	0.465
LIG_SH2_NCK_1	336	340	PF00017	0.410
LIG_SH2_NCK_1	41	45	PF00017	0.508
LIG_SH2_PTP2	278	281	PF00017	0.414
LIG_SH2_SRC	225	228	PF00017	0.513
LIG_SH2_STAP1	251	255	PF00017	0.520
LIG_SH2_STAP1	413	417	PF00017	0.465
LIG_SH2_STAT3	155	158	PF00017	0.465
LIG_SH2_STAT3	495	498	PF00017	0.431
LIG_SH2_STAT5	278	281	PF00017	0.415
LIG_SH2_STAT5	295	298	PF00017	0.453
LIG_SH2_STAT5	336	339	PF00017	0.410
LIG_SH2_STAT5	41	44	PF00017	0.463
LIG_SH2_STAT5	495	498	PF00017	0.449
LIG_SH2_STAT5	530	533	PF00017	0.419
LIG_SH3_3	131	137	PF00018	0.456
LIG_SH3_3	288	294	PF00018	0.479
LIG_SUMO_SIM_par_1	182	190	PF11976	0.458
LIG_SUMO_SIM_par_1	280	285	PF11976	0.513
LIG_SUMO_SIM_par_1	464	470	PF11976	0.395
LIG_TRAF2_1	14	17	PF00917	0.436
LIG_TRAF2_1	29	32	PF00917	0.441
LIG_TRAF2_1	483	486	PF00917	0.531
LIG_TRAF2_1	496	499	PF00917	0.525
LIG_TYR_ITIM	276	281	PF00017	0.414
LIG_TYR_ITIM	334	339	PF00017	0.410
LIG_UBA3_1	464	471	PF00899	0.321
MOD_CK1_1	148	154	PF00069	0.513
MOD_CK1_1	258	264	PF00069	0.557
MOD_CK1_1	344	350	PF00069	0.419
MOD_CK2_1	11	17	PF00069	0.436
MOD_CK2_1	24	30	PF00069	0.380
MOD_CK2_1	313	319	PF00069	0.463
MOD_CK2_1	329	335	PF00069	0.374
MOD_CK2_1	416	422	PF00069	0.465
MOD_CK2_1	480	486	PF00069	0.569
MOD_CK2_1	493	499	PF00069	0.431
MOD_CK2_1	509	515	PF00069	0.408
MOD_GlcNHglycan	127	130	PF01048	0.195
MOD_GlcNHglycan	13	16	PF01048	0.427
MOD_GlcNHglycan	147	150	PF01048	0.118
MOD_GlcNHglycan	189	192	PF01048	0.180
MOD_GlcNHglycan	257	260	PF01048	0.286
MOD_GlcNHglycan	26	29	PF01048	0.457
MOD_GlcNHglycan	261	264	PF01048	0.278
MOD_GlcNHglycan	315	318	PF01048	0.302
MOD_GlcNHglycan	343	346	PF01048	0.306
MOD_GlcNHglycan	459	462	PF01048	0.498
MOD_GlcNHglycan	491	494	PF01048	0.561
MOD_GlcNHglycan	537	540	PF01048	0.487
MOD_GlcNHglycan	541	544	PF01048	0.492
MOD_GlcNHglycan	76	79	PF01048	0.526
MOD_GSK3_1	22	29	PF00069	0.501
MOD_GSK3_1	255	262	PF00069	0.545
MOD_GSK3_1	344	351	PF00069	0.494
MOD_GSK3_1	360	367	PF00069	0.406
MOD_GSK3_1	481	488	PF00069	0.510
MOD_GSK3_1	489	496	PF00069	0.589
MOD_GSK3_1	514	521	PF00069	0.335
MOD_GSK3_1	535	542	PF00069	0.505
MOD_GSK3_1	60	67	PF00069	0.411
MOD_N-GLC_1	438	443	PF02516	0.191
MOD_N-GLC_1	60	65	PF02516	0.431
MOD_NEK2_1	11	16	PF00069	0.463
MOD_NEK2_1	132	137	PF00069	0.463
MOD_NEK2_1	185	190	PF00069	0.424
MOD_NEK2_1	233	238	PF00069	0.415
MOD_NEK2_1	378	383	PF00069	0.505
MOD_NEK2_1	39	44	PF00069	0.541
MOD_NEK2_1	491	496	PF00069	0.353
MOD_NEK2_1	53	58	PF00069	0.301
MOD_NEK2_1	60	65	PF00069	0.436
MOD_PIKK_1	194	200	PF00454	0.381
MOD_PKA_2	179	185	PF00069	0.552
MOD_PKA_2	387	393	PF00069	0.465
MOD_PKA_2	499	505	PF00069	0.495
MOD_PKA_2	53	59	PF00069	0.402
MOD_PKA_2	535	541	PF00069	0.442
MOD_PKA_2	98	104	PF00069	0.475
MOD_Plk_1	329	335	PF00069	0.352
MOD_Plk_1	378	384	PF00069	0.558
MOD_Plk_1	438	444	PF00069	0.465
MOD_Plk_4	250	256	PF00069	0.378
MOD_Plk_4	263	269	PF00069	0.435
MOD_Plk_4	379	385	PF00069	0.498
MOD_Plk_4	6	12	PF00069	0.424
MOD_Plk_4	85	91	PF00069	0.477
MOD_ProDKin_1	454	460	PF00069	0.496
MOD_ProDKin_1	514	520	PF00069	0.336
MOD_ProDKin_1	79	85	PF00069	0.513
MOD_SUMO_for_1	401	404	PF00179	0.410
TRG_DiLeu_BaEn_1	118	123	PF01217	0.513
TRG_DiLeu_BaEn_1	142	147	PF01217	0.447
TRG_ENDOCYTIC_2	23	26	PF00928	0.505
TRG_ENDOCYTIC_2	251	254	PF00928	0.433
TRG_ENDOCYTIC_2	278	281	PF00928	0.414
TRG_ENDOCYTIC_2	336	339	PF00928	0.417
TRG_ER_diArg_1	237	240	PF00400	0.431
TRG_ER_diArg_1	535	537	PF00400	0.306
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.210
TRG_Pf-PMV_PEXEL_1	68	73	PF00026	0.421

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PG62	Leptomonas seymouri	61%	98%
A0A0S4IVW9	Bodo saltans	39%	100%
A0A1X0P444	Trypanosomatidae	45%	100%
A0A3S7X721	Leishmania donovani	80%	96%
A0A422P028	Trypanosoma rangeli	40%	100%
D0A658	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AHS0	Leishmania infantum	80%	96%
E9B491	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	98%
O64765	Arabidopsis thaliana	34%	100%
O74933	Candida albicans	31%	100%
O94617	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
P43123	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
Q16222	Homo sapiens	32%	100%
Q18493	Caenorhabditis elegans	29%	100%
Q28CH3	Xenopus tropicalis	32%	100%
Q3KQV9	Homo sapiens	35%	100%
Q3TW96	Mus musculus	34%	100%
Q49ZB5	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	27%	100%
Q4L846	Staphylococcus haemolyticus (strain JCSC1435)	28%	100%
Q4Q3T5	Leishmania major	79%	100%
Q54GN5	Dictyostelium discoideum	31%	100%
Q7ZWD4	Danio rerio	32%	100%
Q91YN5	Mus musculus	33%	100%
Q940S3	Arabidopsis thaliana	33%	100%
V5BYI4	Trypanosoma cruzi	43%	92%