Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIV5_LEIBR

TriTrypDb:

LbrM.33.1641 , LBRM2903_330022100

Length:

420

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIV5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIV5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.549
CLV_C14_Caspase3-7	302	306	PF00656	0.683
CLV_C14_Caspase3-7	415	419	PF00656	0.597
CLV_NRD_NRD_1	174	176	PF00675	0.616
CLV_NRD_NRD_1	207	209	PF00675	0.691
CLV_NRD_NRD_1	225	227	PF00675	0.537
CLV_NRD_NRD_1	298	300	PF00675	0.692
CLV_NRD_NRD_1	349	351	PF00675	0.628
CLV_NRD_NRD_1	409	411	PF00675	0.597
CLV_NRD_NRD_1	81	83	PF00675	0.459
CLV_PCSK_KEX2_1	174	176	PF00082	0.539
CLV_PCSK_KEX2_1	207	209	PF00082	0.631
CLV_PCSK_KEX2_1	225	227	PF00082	0.609
CLV_PCSK_KEX2_1	298	300	PF00082	0.788
CLV_PCSK_KEX2_1	348	350	PF00082	0.631
CLV_PCSK_KEX2_1	409	411	PF00082	0.597
CLV_PCSK_KEX2_1	81	83	PF00082	0.459
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.539
CLV_PCSK_PC1ET2_1	207	209	PF00082	0.631
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.631
CLV_PCSK_SKI1_1	176	180	PF00082	0.532
DEG_SPOP_SBC_1	95	99	PF00917	0.555
DOC_CKS1_1	156	161	PF01111	0.545
DOC_CKS1_1	65	70	PF01111	0.405
DOC_CYCLIN_yCln2_LP_2	54	60	PF00134	0.352
DOC_MAPK_gen_1	172	183	PF00069	0.535
DOC_MAPK_gen_1	284	292	PF00069	0.600
DOC_MAPK_MEF2A_6	174	183	PF00069	0.535
DOC_MAPK_NFAT4_5	176	184	PF00069	0.536
DOC_PP2B_LxvP_1	290	293	PF13499	0.529
DOC_PP2B_LxvP_1	54	57	PF13499	0.338
DOC_USP7_MATH_1	116	120	PF00917	0.552
DOC_USP7_MATH_1	122	126	PF00917	0.535
DOC_USP7_MATH_1	250	254	PF00917	0.794
DOC_USP7_MATH_1	26	30	PF00917	0.500
DOC_USP7_MATH_1	282	286	PF00917	0.701
DOC_USP7_MATH_1	365	369	PF00917	0.543
DOC_USP7_MATH_1	372	376	PF00917	0.530
DOC_USP7_MATH_1	60	64	PF00917	0.409
DOC_USP7_MATH_1	84	88	PF00917	0.545
DOC_USP7_MATH_1	95	99	PF00917	0.529
DOC_USP7_UBL2_3	172	176	PF12436	0.614
DOC_WW_Pin1_4	152	157	PF00397	0.572
DOC_WW_Pin1_4	227	232	PF00397	0.642
DOC_WW_Pin1_4	260	265	PF00397	0.686
DOC_WW_Pin1_4	349	354	PF00397	0.706
DOC_WW_Pin1_4	388	393	PF00397	0.731
DOC_WW_Pin1_4	64	69	PF00397	0.399
LIG_14-3-3_CanoR_1	115	123	PF00244	0.572
LIG_14-3-3_CanoR_1	18	22	PF00244	0.387
LIG_14-3-3_CanoR_1	298	307	PF00244	0.640
LIG_14-3-3_CanoR_1	373	380	PF00244	0.552
LIG_14-3-3_CanoR_1	38	44	PF00244	0.561
LIG_14-3-3_CanoR_1	394	400	PF00244	0.628
LIG_14-3-3_CanoR_1	404	409	PF00244	0.513
LIG_14-3-3_CanoR_1	71	75	PF00244	0.553
LIG_BIR_II_1	1	5	PF00653	0.395
LIG_BIR_III_4	59	63	PF00653	0.421
LIG_BRCT_BRCA1_1	200	204	PF00533	0.555
LIG_BRCT_BRCA1_2	200	206	PF00533	0.550
LIG_Clathr_ClatBox_1	55	59	PF01394	0.418
LIG_FHA_1	152	158	PF00498	0.550
LIG_FHA_1	260	266	PF00498	0.687
LIG_FHA_1	356	362	PF00498	0.544
LIG_FHA_1	380	386	PF00498	0.663
LIG_FHA_1	403	409	PF00498	0.639
LIG_FHA_1	71	77	PF00498	0.474
LIG_FHA_2	195	201	PF00498	0.548
LIG_FHA_2	268	274	PF00498	0.736
LIG_FHA_2	335	341	PF00498	0.548
LIG_FHA_2	413	419	PF00498	0.599
LIG_LIR_Apic_2	327	332	PF02991	0.538
LIG_LIR_Nem_3	20	24	PF02991	0.494
LIG_SH2_CRK	72	76	PF00017	0.402
LIG_SH2_STAP1	72	76	PF00017	0.416
LIG_SH2_STAT3	320	323	PF00017	0.641
LIG_SH2_STAT5	5	8	PF00017	0.380
LIG_SH2_STAT5	72	75	PF00017	0.459
LIG_SH3_2	293	298	PF14604	0.608
LIG_SH3_3	142	148	PF00018	0.677
LIG_SH3_3	153	159	PF00018	0.548
LIG_SH3_3	190	196	PF00018	0.590
LIG_SH3_3	262	268	PF00018	0.686
LIG_SH3_3	290	296	PF00018	0.603
LIG_SH3_3	394	400	PF00018	0.591
LIG_SH3_3	62	68	PF00018	0.348
LIG_SUMO_SIM_anti_2	73	80	PF11976	0.534
LIG_SUMO_SIM_par_1	177	182	PF11976	0.532
LIG_SUMO_SIM_par_1	73	80	PF11976	0.440
LIG_TRAF2_1	337	340	PF00917	0.690
MOD_CDC14_SPxK_1	391	394	PF00782	0.675
MOD_CDK_SPxK_1	388	394	PF00069	0.683
MOD_CDK_SPxxK_3	260	267	PF00069	0.545
MOD_CDK_SPxxK_3	349	356	PF00069	0.676
MOD_CDK_SPxxK_3	64	71	PF00069	0.467
MOD_CK1_1	230	236	PF00069	0.620
MOD_CK1_1	253	259	PF00069	0.576
MOD_CK1_1	260	266	PF00069	0.607
MOD_CK1_1	29	35	PF00069	0.526
MOD_CK1_1	300	306	PF00069	0.762
MOD_CK1_1	321	327	PF00069	0.647
MOD_CK1_1	344	350	PF00069	0.623
MOD_CK1_1	360	366	PF00069	0.604
MOD_CK1_1	375	381	PF00069	0.566
MOD_CK1_1	39	45	PF00069	0.457
MOD_CK1_1	402	408	PF00069	0.668
MOD_CK1_1	99	105	PF00069	0.691
MOD_CK2_1	179	185	PF00069	0.604
MOD_CK2_1	194	200	PF00069	0.550
MOD_CK2_1	267	273	PF00069	0.739
MOD_CK2_1	282	288	PF00069	0.565
MOD_CK2_1	334	340	PF00069	0.578
MOD_CK2_1	349	355	PF00069	0.652
MOD_GlcNHglycan	118	121	PF01048	0.563
MOD_GlcNHglycan	134	137	PF01048	0.535
MOD_GlcNHglycan	270	273	PF01048	0.768
MOD_GlcNHglycan	323	326	PF01048	0.581
MOD_GlcNHglycan	343	346	PF01048	0.566
MOD_GlcNHglycan	50	53	PF01048	0.412
MOD_GlcNHglycan	86	89	PF01048	0.699
MOD_GlcNHglycan	98	101	PF01048	0.608
MOD_GSK3_1	105	112	PF00069	0.566
MOD_GSK3_1	151	158	PF00069	0.550
MOD_GSK3_1	194	201	PF00069	0.618
MOD_GSK3_1	251	258	PF00069	0.629
MOD_GSK3_1	297	304	PF00069	0.703
MOD_GSK3_1	334	341	PF00069	0.559
MOD_GSK3_1	351	358	PF00069	0.642
MOD_GSK3_1	375	382	PF00069	0.592
MOD_GSK3_1	395	402	PF00069	0.617
MOD_GSK3_1	412	419	PF00069	0.540
MOD_GSK3_1	60	67	PF00069	0.406
MOD_GSK3_1	95	102	PF00069	0.678
MOD_N-GLC_1	36	41	PF02516	0.503
MOD_NEK2_1	179	184	PF00069	0.539
MOD_NEK2_1	297	302	PF00069	0.646
MOD_NEK2_1	319	324	PF00069	0.501
MOD_NEK2_2	381	386	PF00069	0.671
MOD_OFUCOSY	25	30	PF10250	0.379
MOD_PIKK_1	251	257	PF00454	0.671
MOD_PIKK_1	319	325	PF00454	0.584
MOD_PIKK_1	373	379	PF00454	0.557
MOD_PK_1	357	363	PF00069	0.541
MOD_PKA_2	17	23	PF00069	0.397
MOD_PKA_2	297	303	PF00069	0.615
MOD_PKA_2	341	347	PF00069	0.692
MOD_PKA_2	37	43	PF00069	0.585
MOD_PKA_2	372	378	PF00069	0.549
MOD_PKA_2	403	409	PF00069	0.601
MOD_PKA_2	70	76	PF00069	0.440
MOD_PKA_2	77	83	PF00069	0.462
MOD_Plk_1	179	185	PF00069	0.541
MOD_Plk_2-3	414	420	PF00069	0.602
MOD_Plk_4	39	45	PF00069	0.392
MOD_Plk_4	60	66	PF00069	0.409
MOD_Plk_4	70	76	PF00069	0.427
MOD_ProDKin_1	152	158	PF00069	0.571
MOD_ProDKin_1	227	233	PF00069	0.641
MOD_ProDKin_1	260	266	PF00069	0.687
MOD_ProDKin_1	349	355	PF00069	0.707
MOD_ProDKin_1	388	394	PF00069	0.732
MOD_ProDKin_1	64	70	PF00069	0.398
MOD_SUMO_rev_2	352	358	PF00179	0.544
TRG_ENDOCYTIC_2	72	75	PF00928	0.395
TRG_ER_diArg_1	297	299	PF00400	0.566
TRG_ER_diArg_1	408	410	PF00400	0.605
TRG_NLS_MonoCore_2	171	176	PF00514	0.533
TRG_NLS_MonoCore_2	205	210	PF00514	0.621
TRG_NLS_MonoExtC_3	171	176	PF00514	0.533
TRG_NLS_MonoExtC_3	205	210	PF00514	0.621
TRG_NLS_MonoExtN_4	172	178	PF00514	0.532
TRG_NLS_MonoExtN_4	206	211	PF00514	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWS2	Leptomonas seymouri	41%	99%
A0A3S7X6S8	Leishmania donovani	67%	99%
A4I909	Leishmania infantum	67%	99%
E9B3X4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	98%
Q4Q450	Leishmania major	66%	98%